公开(公告)号：WO2006063178A2

公开(公告)日：2006-06-15

申请号：PCT/US2005/044500

申请日：2005-12-07

Applicant: ABBOTT LABORATORIES ,  TURNER, Sean, C. ,  JINKERSON, Tammie, K. ,  GOMTSYAN, Arthur, R. ,  LEE, Chih-hung

Inventor： TURNER, Sean, C. ,  JINKERSON, Tammie, K. ,  GOMTSYAN, Arthur, R. ,  LEE, Chih-hung

IPC: C07D495/04 ,  A61K31/4365 ,  A61P13/10 ,  A61P29/00

CPC classification number: C07D495/04 ,  C07D498/04

Abstract: The present invention discloses fused thienopyridyl compounds of general formula (I), wherein X 1 -X 6 , R 5 -R 7 , Z 1 and L are as defined in the description. The resent invention also discloses a method for inhibiting the VR1 receptor in mammals using these compounds, a method for controlling pain, urinary incontinence, bladder overactivity, and inflammatory thermal hyperalgesia in mammals, and pharmaceutical compositions including those compounds.

Abstract translation: 本发明公开了通式（I）的稠合噻吩并吡啶基化合物，其中X 1 -X 6 -X 6，R 5 -R 7 Z 1，L 1和L如说明书中所定义。 本发明还公开了使用这些化合物抑制哺乳动物中的VR1受体的方法，用于控制哺乳动物中的疼痛，尿失禁，膀胱过度活动和炎性热痛觉过敏的方法，以及包括那些化合物的药物组合物。

公开(公告)号：WO2005007642A2

公开(公告)日：2005-01-27

申请号：PCT/US2004/021836

申请日：2004-07-09

Applicant: ABBOTT LABORATORIES ,  ZHENG, Guo Zhu ,  BROWN, Brian, S. ,  TURNER, Sean, C. ,  WHITE, Tammie, K. ,  SCHMIDT, Robert, G. ,  KOENIG, John, R. ,  LEE, Chih-Hung

Inventor： ZHENG, Guo Zhu ,  BROWN, Brian, S. ,  TURNER, Sean, C. ,  WHITE, Tammie, K. ,  SCHMIDT, Robert, G. ,  KOENIG, John, R. ,  LEE, Chih-Hung

IPC: C07D401/04

CPC classification number: C07D401/04 ,  C07D487/08

Abstract: The present invention relates to compounds of formula (I-VII) (I), or a pharmaceutically acceptable salt or prodrug thereof, in which A, L, R 6 , R 7 and R 8 are defined herein. The present invention also relates to methods of trating pain using these compounds and pharmaceutical compositions including these compounds.

Abstract translation: 本发明涉及式（I-VII）（I）化合物或其药学上可接受的盐或前药，其中A，L，R 6，R 7和R 8如本文所定义。 本发明还涉及使用这些化合物和包括这些化合物的药物组合物来治疗疼痛的方法。

公开(公告)号：WO2003089404A1

公开(公告)日：2003-10-30

申请号：PCT/US2003/012023

申请日：2003-04-17

Applicant: ABBOTT LABORATORIES

Inventor： TURNER, Sean, C. ,  CASTLE, Neil, A. ,  CARROLL, William, A. ,  WHITE, Tammie, K.

IPC: C07C233/25

CPC classification number: C07D213/81 ,  C07C233/25 ,  C07C233/27 ,  C07C233/29 ,  C07C233/60 ,  C07C233/75 ,  C07C235/16 ,  C07C255/60 ,  C07C271/30 ,  C07C275/32 ,  C07C309/51 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/14 ,  C07D241/44 ,  C07D261/18 ,  C07D307/68 ,  C07D333/38 ,  C07D333/70

Abstract: The present invention relates to naphthylamide compounds and their ability to act as potassium channel openers.

Abstract translation: 本发明涉及萘酰胺化合物及其作为钾通道开放剂的能力。

公开(公告)号：WO2010135560A1

公开(公告)日：2010-11-25

申请号：PCT/US2010/035626

申请日：2010-05-20

Applicant: ABBOTT LABORATORIES ,  AKRITOPOULOU-ZANZE, Irini ,  BRAJE, Wilfried ,  DJURIC, Stevan, W. ,  WILSON, Noel, S. ,  TURNER, Sean, C. ,  KRUGER, Albert, W. ,  RELO, Ana-Lucia ,  SHEKHAR, Shashank ,  WELCH, Dennie, S. ,  ZHAO, Hongyu ,  GANDARILLA, Jorge ,  GASIECKI, Alan, F. ,  LI, Huanqiu ,  THOMPSON, Christina, M. ,  ZHANG, Min

Inventor： AKRITOPOULOU-ZANZE, Irini ,  BRAJE, Wilfried ,  DJURIC, Stevan, W. ,  WILSON, Noel, S. ,  TURNER, Sean, C. ,  KRUGER, Albert, W. ,  RELO, Ana-Lucia ,  SHEKHAR, Shashank ,  WELCH, Dennie, S. ,  ZHAO, Hongyu ,  GANDARILLA, Jorge ,  GASIECKI, Alan, F. ,  LI, Huanqiu ,  THOMPSON, Christina, M. ,  ZHANG, Min

IPC: C07D487/04 ,  C07D491/04 ,  C07D495/04 ,  A61P25/00 ,  A61K31/551 ,  A61K31/554 ,  A61K31/553

CPC classification number: C07D513/04 ,  C07D487/04 ,  C07D491/04 ,  C07D491/044 ,  C07D495/04 ,  C07D495/16

Abstract: The present application relates to aryl- and heteroaryl-fused decahydropyrroloazepine, octahydrooxepinopyrrole, octahydropyrrolothiazepine dioxide, decahydrocyclohepta[ c ]pyrrole, and octahydrocyclohepta[ c ]pyrrole derivatives of formula (I), wherein R 1 , R 2 , R 3 , R 4 , R 5 , A, Y 1 , Y 2 , and Y 3 are as defined in the specification. The present application also relates to compositions comprising such compounds, processes for making such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.

Abstract translation: 本申请涉及式（I）的芳基 - 和杂芳基 - 稠合十氢吡咯并氮平，八氢恶庚英吡咯，八氢吡咯并噻吩二恶烷，十氢环庚三烯并[c]吡咯和八氢环庚三烯并[c]吡咯衍生物，其中R1，R2，R3，R4，R5， Y1，Y2和Y3如说明书中所定义。 本申请还涉及包含这些化合物的组合物，制备此类化合物的方法，以及使用这些化合物和组合物治疗疾病状况的方法，以及鉴定这些化合物的方法。

公开(公告)号：WO2005016890A1

公开(公告)日：2005-02-24

申请号：PCT/US2004/025109

申请日：2004-08-04

Applicant: ABBOTT LABORATORIES ,  LEE, Chih-Hung ,  BAYBURT, Erol, K. ,  DIDOMENICO, Stanley, Jr. ,  DRIZIN, Irene ,  GOMTSYAN, Arthur, R. ,  KOENIG, John, R. ,  PENNER, Richard, J. ,  SCHMIDT, Robert, G., Jr. ,  TURNER, Sean, C. ,  WHITE, Tammie, K. ,  ZHENG, Guo Zhu

Inventor： BAYBURT, Erol, K. ,  DIDOMENICO, Stanley, Jr. ,  DRIZIN, Irene ,  GOMTSYAN, Arthur, R. ,  KOENIG, John, R. ,  PENNER, Richard, J. ,  SCHMIDT, Robert, G., Jr. ,  TURNER, Sean, C. ,  WHITE, Tammie, K. ,  ZHENG, Guo Zhu

IPC: C07D217/24

CPC classification number: C07D249/08 ,  C07D209/08 ,  C07D217/02 ,  C07D217/22 ,  C07D217/24 ,  C07D217/26 ,  C07D231/12 ,  C07D231/56 ,  C07D233/56 ,  C07D237/28 ,  C07D401/12 ,  C07D405/12

Abstract: Compounds of Formula (I), are novel VR1 antagonists that are useful in treating pain, inflammatory thermal hyperalgesia, urinary incontinence and bladder overactivity.

Abstract translation: 式（I）化合物是可用于治疗疼痛，炎症性热痛觉过敏，尿失禁和膀胱过度活动的新型VR1拮抗剂。

公开(公告)号：WO2003070247A1

公开(公告)日：2003-08-28

申请号：PCT/US2003/004187

申请日：2003-02-11

Applicant: ABBOTT LABORATORIES

Inventor： LEE, Chih-Hung ,  BAYBURT, Erol, K. ,  DIDOMENICO, Stanley, Jr. ,  DRIZIN, Irene ,  GOMTSYAN, Arthur, R. ,  KOENIG, John, R. ,  PERNER, Richard, J. ,  SCHMIDT, Robert, G. ,  TURNER, Sean, C. ,  WHITE, Tammie, K. ,  ZHENG, Guo, Zhu

IPC: A61K31/502

CPC classification number: C07D249/08 ,  A61K31/404 ,  A61K31/416 ,  A61K31/47 ,  A61K31/472 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/541 ,  C07D209/08 ,  C07D217/02 ,  C07D217/22 ,  C07D217/24 ,  C07D217/26 ,  C07D231/12 ,  C07D231/56 ,  C07D233/56 ,  C07D237/28 ,  C07D401/12 ,  C07D405/12

Abstract: Compounds of formula (I), are novel VR1 antagonists that are useful in treating pain, inflammatory thermal hyperalgesia, urinary incontinence and bladder overactivity.

Abstract translation: 式（I）化合物是可用于治疗疼痛，炎症性热痛觉过敏，尿失禁和膀胱过度活动的新型VR1拮抗剂。

公开(公告)号：EP1646621A2

公开(公告)日：2006-04-19

申请号：EP04777733.9

申请日：2004-07-09

Applicant: ABBOTT LABORATORIES

Inventor： ZHENG, Guo Zhu ,  BROWN, Brian, S. ,  TURNER, Sean, C. ,  WHITE, Tammie, K. ,  SCHMIDT, Robert, G. ,  KOENIG, John, R. ,  LEE, Chih-Hung

IPC: C07D401/04 ,  C07D401/12 ,  C07D487/08 ,  A61K31/4525 ,  A61K31/4995 ,  A61P25/04

CPC classification number: C07D401/04 ,  C07D487/08

Abstract: The present invention relates to compounds of formula (I-VII) (I), or a pharmaceutically acceptable salt or prodrug thereof, in which A, L, R6, R7and R8 are defined herein. The present invention also relates to methods of trating pain using these compounds and pharmaceutical compositions including these compounds.

公开(公告)号：EP2432783B1

公开(公告)日：2013-05-01

申请号：EP10720502.3

申请日：2010-05-20

Applicant: Abbott Laboratories ,  Abbott GmbH & Co. KG

Inventor： WELCH, Dennie, S. ,  AKRITOPOULOU-ZANZE, Irini ,  BRAJE, Wilfried ,  DJURIC, Stevan, W. ,  WILSON, Noel, S. ,  TURNER, Sean, C. ,  KRUGER, Albert, W. ,  RELO, Ana-Lucia ,  SHEKHAR, Shashank ,  ZHAO, Hongyu ,  GANDARILLA, Jorge ,  GASIECKI, Alan, F. ,  LI, Huanqiu ,  THOMPSON, Christina, M. ,  ZHANG, Min

IPC: C07D487/04 ,  C07D491/04 ,  C07D495/04 ,  A61P25/00 ,  A61K31/551 ,  A61K31/554 ,  A61K31/553

CPC classification number: C07D513/04 ,  C07D487/04 ,  C07D491/04 ,  C07D491/044 ,  C07D495/04 ,  C07D495/16

Abstract: The present application relates to processes for making aryl- and heteroaryl-fused decahydropyrroloazepine derivatives of formula (1-5), wherein the variables are as defined in the specification.

公开(公告)号：EP1131322A2

公开(公告)日：2001-09-12

申请号：EP99970991.8

申请日：1999-10-28

Applicant: ABBOTT LABORATORIES

Inventor： CARROLL, William, A. ,  AGRIOS, Konstantinos, A. ,  BASHA, Fatima, Z. ,  CHEN, Yiyuan ,  KORT, Michael, E. ,  KYM, Philip, R. ,  TANG, Rui ,  TURNER, Sean, C. ,  YI, Lin

IPC: C07D471/00 ,  C07D491/04 ,  A61K31/435

CPC classification number: C07D471/04 ,  C07D471/14 ,  C07D491/04 ,  C07D491/14 ,  C07D495/14

Abstract: Compounds having formula (I) are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.

公开(公告)号：EP1824860A2

公开(公告)日：2007-08-29

申请号：EP05853428.0

申请日：2005-12-07

Applicant: ABBOTT LABORATORIES

Inventor： TURNER, Sean, C. ,  JINKERSON, Tammie, K. ,  GOMTSYAN, Arthur, R. ,  LEE, Chih-hung

IPC: C07D495/04 ,  A61K31/4365 ,  A61P13/10 ,  A61P29/00

CPC classification number: C07D495/04 ,  C07D498/04

Abstract: The present invention discloses fused thienopyridyl compounds of general formula (I), wherein X1-X6, R5-R7, Z1 and L are as defined in the description. The resent invention also discloses a method for inhibiting the VR1 receptor in mammals using these compounds, a method for controlling pain, urinary incontinence, bladder overactivity, and inflammatory thermal hyperalgesia in mammals, and pharmaceutical compositions including those compounds.