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    PROCESS TO PRODUCE FIBRILLAR PROTEINS AND METHOD OF TREATING USING FIBRILLAR PROTEINS
    12.
    发明申请
    PROCESS TO PRODUCE FIBRILLAR PROTEINS AND METHOD OF TREATING USING FIBRILLAR PROTEINS 审中-公开
    生产纤维蛋白蛋白的方法和使用纤维蛋白蛋白的治疗方法

    公开(公告)号：WO2009114831A3

    公开(公告)日：2009-10-22

    申请号：PCT/US2009037196

    申请日：2009-03-13

    Applicant: ACADEMIA SINICA ,  LIANG SHU MEI ,  LIANG CHI-MING ,  CHEN YEN-PO ,  HUANG CHUN-YUNG

    Inventor： LIANG CHI-MING ,  CHEN YEN-PO ,  HUANG CHUN-YUNG

    IPC: C07K1/107 ,  A61K38/17 ,  A61P35/00 ,  C07K1/14 ,  C07K14/47

    CPC classification number: C07K1/1136 ,  A61K38/162 ,  A61K38/38 ,  A61K38/39 ,  C07K14/765 ,  C07K14/78 ,  C12N2770/32122 ,  C12N2770/32151

    Abstract: A method for changing a globular protein structure into a fibrillar protein structure. The method comprising the steps of providing a globular protein, forming a solution containing the globular protein, adding a detergent to the solution containing the globular protein, applying the solution to a molecular sizing column with a pore size of at least 70 kDa and eluting with a solution containing detergent. A method for changing an unfolded protein structure into a fibrillar protein structure. The method comprising the steps of providing a globular protein, forming a solution containing the globular protein, adding a urea to the solution to unfold the globular protein, applying the solution to a molecular sizing column and eluting with a solution containing detergent. A method for treating cancer comprising the steps of providing a protein, changing the protein into a fibrillar structure, and administering a therapeutically effective amount of the fibrillar structure protein to a patient in need thereof. A method for producing a vaccine adjuvant or antigen adjuvant comprising the steps of providing a protein, and changing the protein into a fibrillar structure.

    Abstract translation: 一种将球状蛋白质结构变为纤维状蛋白质结构的方法。 该方法包括以下步骤：提供球状蛋白质，形成含有球状蛋白质的溶液，向含有球状蛋白质的溶液中加入去污剂，将该溶液应用于孔径至少为70kDa的分子筛分柱，并用 含有清洁剂的溶液。 一种将未折叠的蛋白质结构变为纤维状蛋白质结构的方法。 该方法包括以下步骤：提供球状蛋白质，形成含有球状蛋白质的溶液，向溶液中加入尿素以展开球状蛋白质，将溶液施加到分子大小柱上并用含有去污剂的溶液洗脱。 一种治疗癌症的方法，包括以下步骤：提供蛋白质，将蛋白质变为纤维状结构，并将治疗有效量的纤维状结构蛋白给予有需要的患者。 生产疫苗佐剂或抗原佐剂的方法，包括提供蛋白质和将蛋白质变成纤维状结构的步骤。

    PROCESS TO PRODUCE FIBRILLAR PROTEINS AND METHOD OF TREATING USING FIBRILLAR PROTEINS
    15.
    发明公开
    PROCESS TO PRODUCE FIBRILLAR PROTEINS AND METHOD OF TREATING USING FIBRILLAR PROTEINS 有权
    用于生产类纤维蛋白和采用纤维状蛋白的治疗方法

    公开(公告)号：EP2262825A4

    公开(公告)日：2012-12-26

    申请号：EP09719402

    申请日：2009-03-13

    Applicant: ACADEMIA SINICA

    Inventor： LIANG CHI-MING ,  HUANG CHUN-YUNG

    IPC: C07K1/107 ,  A61K38/16 ,  A61K38/17 ,  A61K38/38 ,  A61K38/39 ,  A61P35/00 ,  C07K1/14 ,  C07K14/09 ,  C07K14/47 ,  C07K14/765 ,  C07K14/78

    CPC classification number: C07K1/1136 ,  A61K38/162 ,  A61K38/38 ,  A61K38/39 ,  C07K14/765 ,  C07K14/78 ,  C12N2770/32122 ,  C12N2770/32151

    Abstract: A method for changing a globular protein structure into a fibrillar protein structure. The method comprising the steps of providing a globular protein, forming a solution containing the globular protein, adding a detergent to the solution containing the globular protein, applying the solution to a molecular sizing column with a pore size of at least 70 kDa and eluting with a solution containing detergent. A method for changing an unfolded protein structure into a fibrillar protein structure. The method comprising the steps of providing a globular protein, forming a solution containing the globular protein, adding a urea to the solution to unfold the globular protein, applying the solution to a molecular sizing column and eluting with a solution containing detergent. A method for treating cancer comprising the steps of providing a protein, changing the protein into a fibrillar structure, and administering a therapeutically effective amount of the fibrillar structure protein to a patient in need thereof. A method for producing a vaccine adjuvant or antigen adjuvant comprising the steps of providing a protein, and changing the protein into a fibrillar structure.

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