公开(公告)号：CA2781433A1

公开(公告)日：2011-05-26

申请号：CA2781433

申请日：2010-11-19

Applicant: ACADEMIA SINICA

Inventor： LIANG SHU-MEI ,  CHIU CHING-FENG ,  HUNG SHAO-WEN ,  PENG JEI-MING ,  LIANG CHI-MING

IPC: A61K38/38 ,  A61K35/76 ,  A61K38/16 ,  A61P35/04 ,  C07K14/76

Abstract: Methods are provided for suppressing cancer metastasis. Cancer metastasis is the most common cause of treatment failure and death in cancer patients. Tumor cell invasion and/or migration can be significantly inhibited after fibrillar proteins (rVP1, F-HSA, and F-BSA) treatment in vitro. In addition, rVP1 can significantly suppress murine and human breast cancer metastasis and human prostate and ovarian cancer metastasis in vivo while F-HSA can significantly suppress murine breast cancer metastasis. Compositions of fibrillar proteins as anti-cancer metastasis therapeutics and methods of use thereof are provided herein.

公开(公告)号：CA2781433C

公开(公告)日：2019-04-09

申请号：CA2781433

申请日：2010-11-19

Applicant: ACADEMIA SINICA

Inventor： LIANG SHU-MEI ,  CHIU CHING-FENG ,  HUNG SHAO-WEN ,  PENG JEI-MING ,  LIANG CHI-MING

IPC: A61K38/38 ,  A61K38/16 ,  A61P35/04 ,  C07K14/09 ,  C07K14/76

Abstract: Methods are provided for suppressing cancer metastasis. Cancer metastasis is the most common cause of treatment failure and death in cancer patients. Tumor cell invasion and/or migration can be significantly inhibited after fibrillar proteins (rVP1, F-HSA, and F-BSA) treatment in vitro. In addition, rVP1 can significantly suppress murine and human breast cancer metastasis and human prostate and ovarian cancer metastasis in vivo while F-HSA can significantly suppress murine breast cancer metastasis. Compositions of fibrillar proteins as anti-cancer metastasis therapeutics and methods of use thereof are provided herein.

公开(公告)号：AU2010321830B2

公开(公告)日：2015-06-11

申请号：AU2010321830

申请日：2010-11-19

Applicant: ACADEMIA SINICA

Inventor： LIANG SHU-MEI ,  CHIU CHING-FENG ,  HUNG SHAO-WEN ,  PENG JEI-MING ,  LIANG CHI-MING

IPC: A61K38/38 ,  A61K38/16 ,  A61K47/48 ,  C07K14/76

Abstract: Methods are provided for suppressing cancer metastasis. Cancer metastasis is the most common cause of treatment failure and death in cancer patients. Tumor cell invasion and/or migration can be significantly inhibited after fibrillar proteins (rVP1, F-HSA, and F-BSA) treatment

公开(公告)号：AU2010321830A1

公开(公告)日：2012-07-05

申请号：AU2010321830

申请日：2010-11-19

Applicant: ACADEMIA SINICA

Inventor： LIANG SHU-MEI ,  CHIU CHING-FENG ,  HUNG SHAO-WEN ,  PENG JEI-MING ,  LIANG CHI-MING

IPC: C07K14/76 ,  A61K38/16 ,  A61K38/38 ,  A61K47/48

Abstract: Methods are provided for suppressing cancer metastasis. Cancer metastasis is the most common cause of treatment failure and death in cancer patients. Tumor cell invasion and/or migration can be significantly inhibited after fibrillar proteins (rVP1, F-HSA, and F-BSA) treatment . In addition, rVP1 can significantly suppress murine and human breast cancer metastasis and human prostate and ovarian cancer metastasis while F-HSA can significantly suppress murine breast cancer metastasis. Compositions of fibrillar proteins as anti-cancer metastasis therapeutics and methods of use thereof are provided herein.

公开(公告)号：EP2501402A4

公开(公告)日：2013-05-01

申请号：EP10832290

申请日：2010-11-19

Applicant: ACADEMIA SINICA

Inventor： LIANG SHU-MEI ,  CHIU CHING-FENG ,  HUNG SHAO-WEN ,  PENG JEI-MING ,  LIANG CHI-MING

IPC: A61K38/38 ,  A61K47/48 ,  C07K14/76

CPC classification number: A61K38/385 ,  A61K38/162 ,  A61K38/38 ,  A61K45/06 ,  A61K47/643 ,  A61N5/10 ,  C07K14/765 ,  C12N7/00 ,  C12N2770/32133

Abstract: Fibrillar human serum albumin was shown to be effective in the treatment of various types of cancers. Methods and compositions are disclosed for using fibrillar human serum albumin as a medicament to treat subjects having cancer.