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    METHODS AND COMPOSITIONS FOR IMMUNIZATION AGAINST VIRUS
    11.
    发明申请
    METHODS AND COMPOSITIONS FOR IMMUNIZATION AGAINST VIRUS 审中-公开
    用于免疫病毒的方法和组合物

    公开(公告)号：WO2010111687A3

    公开(公告)日：2012-07-05

    申请号：PCT/US2010028968

    申请日：2010-03-26

    Applicant: ACADEMIA SINICA ,  WONG CHI-HUEY ,  MA CHE ,  WANG CHENG-CHI ,  CHEN JUINE-RUEY

    Inventor： WONG CHI-HUEY ,  MA CHE ,  WANG CHENG-CHI ,  CHEN JUINE-RUEY

    IPC: A61K39/12

    CPC classification number: A61K39/145 ,  A61K39/12 ,  A61K2039/55505 ,  C07K16/1018 ,  C07K2317/76 ,  C12N7/00 ,  C12N2740/11034 ,  C12N2740/16034 ,  C12N2760/16122 ,  C12N2760/16134 ,  C12N2760/16171 ,  C12N2770/24134

    Abstract: Immunogenic compositions comprising partially glycosylated viral glycoproteins for use as vaccines against viruses are provided. Vaccines formulated using mono-, di-, or tri-glycosylated viral surface glycoproteins and polypeptides provide potent and broad protection against viruses, even across strains. Pharmaceutical compositions comprising monoglycosylated hemagglutinin polypeptides and vaccines generated therefrom and methods of their use for prophylaxis or treatment of viral infections are disclosed. Methods and compositions are disclosed for influenza virus HA, NA and M2, RSV proteins F, G and SH, Dengue virus glycoproteins M or E, hepatitis C virus glycoprotein E1 or E2 and HIV glycoproteins gp120 and gp41.

    Abstract translation: 提供了包含部分糖基化的病毒糖蛋白的免疫原性组合物，其用作抗病毒疫苗。 使用单糖，二糖或三糖基化的病毒表面糖蛋白和多肽配制的疫苗甚至可以跨毒株提供有效和广泛的防病毒保护。 公开了包含单糖基化血凝素多肽和由其产生的疫苗的药物组合物及其用于预防或治疗病毒感染的方法。 公开了用于流感病毒HA，NA和M2，RSV蛋白F，G和SH，登革病毒糖蛋白M或E，丙型肝炎病毒糖蛋白E1或E2和HIV糖蛋白gp120和gp41的方法和组合物。

    REISHI-MEDIATED ENHANCEMENT OF HUMAN TISSUE PROGENITOR CELL ADHESION AND DIFFERENTIATION
    13.
    发明申请
    REISHI-MEDIATED ENHANCEMENT OF HUMAN TISSUE PROGENITOR CELL ADHESION AND DIFFERENTIATION 审中-公开
    人体组织细胞粘附和分化的神经介导的增强

    公开(公告)号：WO2008036421A3

    公开(公告)日：2008-09-25

    申请号：PCT/US2007020628

    申请日：2007-09-21

    Applicant: ACADEMIA SINICA ,  TZU-BI SHIN DANIEL ,  CHEN WAN-YU ,  WONG CHI-HUEY

    Inventor： TZU-BI SHIN DANIEL ,  CHEN WAN-YU ,  WONG CHI-HUEY

    IPC: A61K36/074 ,  A01N65/00 ,  A61K36/09

    CPC classification number: A61K36/074

    Abstract: The present disclosure provides medicinally active extracts and fractions, and methods for using the same to increase eukaryotic cell adhesion, to increase differentiation of eukaryotic cells to produce increased numbers of B cells dendritic cells and chodrocytes, and to maintain undifferentiated hematopoietic cells. These methods are useful for modulating immune response, modulating hematopoietic activity, and engineering certain types of eukaryotic tissues.

    Abstract translation: 本公开提供了药物活性提取物和级分，以及使用其提高真核细胞粘附的方法，以增加真核细胞的分化以产生增加的B细胞树突状细胞和chodro细胞的数量，并保持未分化的造血细胞。 这些方法可用于调节免疫应答，调节造血活性和工程化某些类型的真核组织。

    CRYSTAL STRUCTURE OF BIFUNCTIONAL TRANSGLYCOSYLASE PBP1B FROM E.COLI AND INHIBITORS THEREOF
    16.
    发明申请
    CRYSTAL STRUCTURE OF BIFUNCTIONAL TRANSGLYCOSYLASE PBP1B FROM E.COLI AND INHIBITORS THEREOF 审中-公开
    来自大肠杆菌及其抑制剂的双功能转移酶PBP1B的晶体结构

    公开(公告)号：WO2010011304A3

    公开(公告)日：2010-05-06

    申请号：PCT/US2009004246

    申请日：2009-07-21

    Applicant: ACADEMIA SINICA ,  WONG CHI-HUEY ,  MA CHE ALEX ,  CHENG TING-JEN RACHEL ,  CHENG WEI-CHIEH

    Inventor： WONG CHI-HUEY ,  MA CHE ALEX ,  CHENG TING-JEN RACHEL ,  CHENG WEI-CHIEH

    IPC: C12Q1/48 ,  C12Q1/00 ,  G01N33/50 ,  G01N33/53

    CPC classification number: C07C235/64 ,  C07C235/84 ,  C07K2299/00 ,  C12Q1/18 ,  C12Q1/48 ,  G01N2333/91102 ,  G01N2500/00

    Abstract: The crystal structure at 2.16 A resolution of the full-length bacterial bifunctional transglycosylase penicillin-binding protein Ib (PBPIb) from Escherichia coli, in complex with its inhibitor moenomycin, is provided. The atomic coordinates of the complex as well as the moenomycin binding site are provided. Three dimensional structures of amino acid residues involved in moenomycin binding and transglycosylation activity are identified. Binding site for peptidoglycan synthesis inhibitors comprising inhibitor- binding site comprises amino acid residues from at least one of transglycosylase (TG), UvrB domain 2 homolog (UB2H) and transmembrane (TM) domains of PBPIb are identified at an atomic level of resolution. Methods for rational drug design based on the atomic coordinates are provided. Methods for screening for antibiotics based on anisotropic binding assay and transglycosylase inhibitor assays are provided. Novel antibiotics based on the screening assays of the invention are disclosed.

    Abstract translation: 提供了大肠杆菌全长细菌双功能转糖苷酶青霉素结合蛋白Ib（PBPIb）与其抑制剂新霉素复合物的分辨率为2.16A的晶体结构。 提供复合物的原子坐标以及霉酚霉素结合位点。 鉴定了涉及霉酚霉素结合和转糖基化活性的氨基酸残基的三维结构。 包含抑制剂结合位点的肽聚糖合成抑制剂的结合位点包含在原子级别的分辨率下鉴定来自至少一种转糖糖基化酶（TG），UvrB结构域2同源物（UB2H）和跨膜（TM）结构域）的氨基酸残基。 提供了基于原子坐标的合理药物设计方法。 提供了基于各向异性结合测定法和转糖苷酶抑制剂测定法筛选抗生素的方法。 公开了基于本发明筛选试验的新型抗生素。

    ALPHA-GALACTOSYL CERAMIDE ANALOGS AND THEIR USE AS IMMUNOTHERAPIES, ADJUVANTS, AND INTIVIRAL, ANTIBACTERIAL, AND ANTICANCER AGENTS
    17.
    发明申请
    ALPHA-GALACTOSYL CERAMIDE ANALOGS AND THEIR USE AS IMMUNOTHERAPIES, ADJUVANTS, AND INTIVIRAL, ANTIBACTERIAL, AND ANTICANCER AGENTS 审中-公开
    ALPHA-GALACTOSYL CERAMIDE ANALOGS及其作为免疫抑制剂，调节剂和杀虫剂，抗真菌剂和抗原剂的用途

    公开(公告)号：WO2010006315A3

    公开(公告)日：2010-03-25

    申请号：PCT/US2009050328

    申请日：2009-07-10

    Applicant: ACADEMIA SINICA ,  WONG CHI-HUEY ,  YU ALICE ,  CHANG YA-JEN ,  LIN KUN-HSIEN ,  CHENG Y S EDMOND ,  JAN JIA-TSRONG ,  LIN YI-LING ,  HUNG JUNG-TUNG

    Inventor： WONG CHI-HUEY ,  YU ALICE ,  CHANG YA-JEN ,  LIN KUN-HSIEN ,  CHENG Y S EDMOND ,  JAN JIA-TSRONG ,  LIN YI-LING ,  HUNG JUNG-TUNG

    IPC: A61K39/39 ,  A61K31/70 ,  A61P31/04 ,  A61P31/16 ,  A61P35/00

    CPC classification number: C07H15/18 ,  A61K31/7034 ,  A61K39/0011 ,  A61K2039/57

    Abstract: The present disclosure relates to synthetic alpha-galactosyl ceramide (a- GalCer) analogs, and their use as immunotherapies, adjuvants, and antiviral, antibacterial, and anticancer agents. In one aspect, a method of activating a cytokine response in a subject includes administering an effective amount of a compound to a subject, wherein the subject has an adaptive immune system that includes a population of cells, the population including at least one lymphocyte and at least one antigen-presenting cell, and wherein the compound is represented by the structure of formula 1 :; or a pharmaceutically acceptable salt thereof; forming a complex between the compound and the antigen-presenting cell, wherein the formation of the complex results in the activation of a receptor on the lymphocyte; and activating the lymphocyte to produce the cytokine response.

    Abstract translation: 本公开内容涉及合成的α-半乳糖神经酰胺（a-GalCer）类似物，以及它们作为免疫疗法，佐剂和抗病毒，抗菌和抗癌剂的用途。 一方面，在受试者中激活细胞因子应答的方法包括向受试者施用有效量的化合物，其中所述受试者具有包括细胞群的适应性免疫系统，所述群体包括至少一种淋巴细胞和 至少一种抗原呈递细胞，并且其中所述化合物由式1的结构表示： 或其药学上可接受的盐; 在化合物和抗原呈递细胞之间形成复合物，其中复合物的形成导致淋巴细胞上受体的活化; 并激活淋巴细胞以产生细胞因子反应。

    LONGEVITY-PROMOTING EFFECTS OF ACETIC ACID AND REISHI POLYSACCHARIDE
    19.
    发明申请
    LONGEVITY-PROMOTING EFFECTS OF ACETIC ACID AND REISHI POLYSACCHARIDE 审中-公开
    长寿命促进醋酸和食用多糖的促进作用

    公开(公告)号：WO2009129424A3

    公开(公告)日：2009-12-23

    申请号：PCT/US2009040879

    申请日：2009-04-16

    Applicant: ACADEMIA SINICA ,  YANG WEN-BIN ,  WONG CHI-HUEY ,  CHIOU SHYH-HORNG ,  CHUANG MING-HONG

    Inventor： YANG WEN-BIN ,  WONG CHI-HUEY ,  CHIOU SHYH-HORNG ,  CHUANG MING-HONG

    IPC: C12N1/38 ,  C12N1/10 ,  C12N15/01 ,  C12R1/90

    CPC classification number: G01N33/5085 ,  A61K36/07 ,  A61K36/074 ,  G01N2333/43534 ,  G01N2333/70596 ,  A61K2300/00

    Abstract: A composition of acetic acid and a composition of acetic acid and RF3 effecting expression of DAF-16 in C. elegans, wherein the at least acetic acid and the RF3 polysaccharide is effective to increase the life-span of C. elegans or humans. A method of regulating DAF-16 expression, comprising: administering a composition comprising at least acetic acid and RF3 polysaccharide; providing the composition to at least one receptor on a surface of a cell; causing an increase in expression of DAF-16. A method for screening a series of compounds or constituents parts of compounds including some antioxidant vitamins, traditional herb medicines, and vinegars using C. elegans as a live organism model to examine to determine if they have an impact the lifespan of C elegans and the underlying mechanism(s) thereof.

    Abstract translation: 乙酸组合物和乙酸组合物和RF3在秀丽隐杆线虫中实现DAF-16的表达，其中所述至少乙酸和RF3多糖对于增加秀丽隐杆线虫或人的寿命是有效的。 一种调节DAF-16表达的方法，包括：给予至少包含乙酸和RF3多糖的组合物; 将组合物提供给细胞表面上的至少一个受体; 导致DAF-16表达增加。 筛选一系列化合物或化合物的组成部分，包括一些抗氧化维生素，传统草药和醋，使用线虫作为活体生物模型来检查以确定它们是否影响线虫的寿命和潜在的 机制。

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