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    METHODS AND COMPOSITIONS FOR IMMUNIZATION AGAINST VIRUS
    1.
    发明申请
    METHODS AND COMPOSITIONS FOR IMMUNIZATION AGAINST VIRUS 审中-公开
    用于免疫病毒的方法和组合物

    公开(公告)号：WO2010111687A3

    公开(公告)日：2012-07-05

    申请号：PCT/US2010028968

    申请日：2010-03-26

    Applicant: ACADEMIA SINICA ,  WONG CHI-HUEY ,  MA CHE ,  WANG CHENG-CHI ,  CHEN JUINE-RUEY

    Inventor： WONG CHI-HUEY ,  MA CHE ,  WANG CHENG-CHI ,  CHEN JUINE-RUEY

    IPC: A61K39/12

    CPC classification number: A61K39/145 ,  A61K39/12 ,  A61K2039/55505 ,  C07K16/1018 ,  C07K2317/76 ,  C12N7/00 ,  C12N2740/11034 ,  C12N2740/16034 ,  C12N2760/16122 ,  C12N2760/16134 ,  C12N2760/16171 ,  C12N2770/24134

    Abstract: Immunogenic compositions comprising partially glycosylated viral glycoproteins for use as vaccines against viruses are provided. Vaccines formulated using mono-, di-, or tri-glycosylated viral surface glycoproteins and polypeptides provide potent and broad protection against viruses, even across strains. Pharmaceutical compositions comprising monoglycosylated hemagglutinin polypeptides and vaccines generated therefrom and methods of their use for prophylaxis or treatment of viral infections are disclosed. Methods and compositions are disclosed for influenza virus HA, NA and M2, RSV proteins F, G and SH, Dengue virus glycoproteins M or E, hepatitis C virus glycoprotein E1 or E2 and HIV glycoproteins gp120 and gp41.

    Abstract translation: 提供了包含部分糖基化的病毒糖蛋白的免疫原性组合物，其用作抗病毒疫苗。 使用单糖，二糖或三糖基化的病毒表面糖蛋白和多肽配制的疫苗甚至可以跨毒株提供有效和广泛的防病毒保护。 公开了包含单糖基化血凝素多肽和由其产生的疫苗的药物组合物及其用于预防或治疗病毒感染的方法。 公开了用于流感病毒HA，NA和M2，RSV蛋白F，G和SH，登革病毒糖蛋白M或E，丙型肝炎病毒糖蛋白E1或E2和HIV糖蛋白gp120和gp41的方法和组合物。

    CRYSTAL STRUCTURE OF BIFUNCTIONAL TRANSGLYCOSYLASE PBP1B FROM E.COLI AND INHIBITORS THEREOF
    3.
    发明申请
    CRYSTAL STRUCTURE OF BIFUNCTIONAL TRANSGLYCOSYLASE PBP1B FROM E.COLI AND INHIBITORS THEREOF 审中-公开
    来自大肠杆菌及其抑制剂的双功能转移酶PBP1B的晶体结构

    公开(公告)号：WO2010011304A3

    公开(公告)日：2010-05-06

    申请号：PCT/US2009004246

    申请日：2009-07-21

    Applicant: ACADEMIA SINICA ,  WONG CHI-HUEY ,  MA CHE ALEX ,  CHENG TING-JEN RACHEL ,  CHENG WEI-CHIEH

    Inventor： WONG CHI-HUEY ,  MA CHE ALEX ,  CHENG TING-JEN RACHEL ,  CHENG WEI-CHIEH

    IPC: C12Q1/48 ,  C12Q1/00 ,  G01N33/50 ,  G01N33/53

    CPC classification number: C07C235/64 ,  C07C235/84 ,  C07K2299/00 ,  C12Q1/18 ,  C12Q1/48 ,  G01N2333/91102 ,  G01N2500/00

    Abstract: The crystal structure at 2.16 A resolution of the full-length bacterial bifunctional transglycosylase penicillin-binding protein Ib (PBPIb) from Escherichia coli, in complex with its inhibitor moenomycin, is provided. The atomic coordinates of the complex as well as the moenomycin binding site are provided. Three dimensional structures of amino acid residues involved in moenomycin binding and transglycosylation activity are identified. Binding site for peptidoglycan synthesis inhibitors comprising inhibitor- binding site comprises amino acid residues from at least one of transglycosylase (TG), UvrB domain 2 homolog (UB2H) and transmembrane (TM) domains of PBPIb are identified at an atomic level of resolution. Methods for rational drug design based on the atomic coordinates are provided. Methods for screening for antibiotics based on anisotropic binding assay and transglycosylase inhibitor assays are provided. Novel antibiotics based on the screening assays of the invention are disclosed.

    Abstract translation: 提供了大肠杆菌全长细菌双功能转糖苷酶青霉素结合蛋白Ib（PBPIb）与其抑制剂新霉素复合物的分辨率为2.16A的晶体结构。 提供复合物的原子坐标以及霉酚霉素结合位点。 鉴定了涉及霉酚霉素结合和转糖基化活性的氨基酸残基的三维结构。 包含抑制剂结合位点的肽聚糖合成抑制剂的结合位点包含在原子级别的分辨率下鉴定来自至少一种转糖糖基化酶（TG），UvrB结构域2同源物（UB2H）和跨膜（TM）结构域）的氨基酸残基。 提供了基于原子坐标的合理药物设计方法。 提供了基于各向异性结合测定法和转糖苷酶抑制剂测定法筛选抗生素的方法。 公开了基于本发明筛选试验的新型抗生素。

    CRYSTAL STRUCTURE OF BIFUNCTIONAL TRANSGLYCOSYLASE PBP1B FROM E.COLI AND INHIBITORS THEREOF
    4.
    发明申请
    CRYSTAL STRUCTURE OF BIFUNCTIONAL TRANSGLYCOSYLASE PBP1B FROM E.COLI AND INHIBITORS THEREOF 审中-公开
    大肠杆菌双功能转酰基酶PBP1B及其抑制剂的晶体结构

    公开(公告)号：WO2010011304A2

    公开(公告)日：2010-01-28

    申请号：PCT/US2009/004246

    申请日：2009-07-21

    Applicant: ACADEMIA SINICA ,  WONG, Chi-Huey ,  MA, Che, Alex ,  CHENG, Ting-Jen, Rachel ,  CHENG, Wei-Chieh

    Inventor： WONG, Chi-Huey ,  MA, Che, Alex ,  CHENG, Ting-Jen, Rachel ,  CHENG, Wei-Chieh

    IPC: C12Q1/48 ,  C12Q1/00 ,  G01N33/50 ,  G01N33/53

    CPC classification number: C07C235/64 ,  C07C235/84 ,  C07K2299/00 ,  C12Q1/18 ,  C12Q1/48 ,  G01N2333/91102 ,  G01N2500/00

    Abstract: The crystal structure at 2.16 A resolution of the full-length bacterial bifunctional transglycosylase penicillin-binding protein Ib (PBPIb) from Escherichia coli , in complex with its inhibitor moenomycin, is provided. The atomic coordinates of the complex as well as the moenomycin binding site are provided. Three dimensional structures of amino acid residues involved in moenomycin binding and transglycosylation activity are identified. Binding site for peptidoglycan synthesis inhibitors comprising inhibitor- binding site comprises amino acid residues from at least one of transglycosylase (TG), UvrB domain 2 homolog (UB2H) and transmembrane (TM) domains of PBPIb are identified at an atomic level of resolution. Methods for rational drug design based on the atomic coordinates are provided. Methods for screening for antibiotics based on anisotropic binding assay and transglycosylase inhibitor assays are provided. Novel antibiotics based on the screening assays of the invention are disclosed.

    Abstract translation: 来自大肠杆菌的与其抑制剂默诺霉素复合的全长细菌双功能转糖基酶青霉素结合蛋白Ib（PBPIb）的2.16解析度的晶体结构是 提供。 提供了复合物的原子坐标以及默诺霉素结合位点。 鉴定了涉及默诺霉素结合和转糖基活性的氨基酸残基的三维结构。 包含抑制剂结合位点的肽聚糖合成抑制剂的结合位点包含来自PBIPb的转糖基酶（TG），UvrB结构域2同系物（UB2H）和跨膜（TM）结构域中的至少一个的氨基酸残基，其以原子水平的分辨率鉴定。 提供了基于原子坐标的合理药物设计方法。 提供了基于各向异性结合测定法和转糖基酶抑制剂测定法筛选抗生素的方法。 公开了基于本发明筛选测定的新型抗生素。

    METHOD AND APPARATUS FOR DETERMINING METAL FREEZING POINTS
    6.
    发明专利
    METHOD AND APPARATUS FOR DETERMINING METAL FREEZING POINTS 未知

    公开(公告)号：CA2187966A1

    公开(公告)日：1997-04-17

    申请号：CA2187966

    申请日：1996-10-16

    Applicant: MA CHE KEUNG

    Inventor： MA CHE KEUNG

    IPC: G01N25/04 ,  G01N33/20

    Abstract: A method and apparatus for determining the freezing points of a metal by inducing solidification in a cooling liquid metal sample in a supercooled state and utilizing specific detected peak values or changes in slope in a temperature/time plot as the sample cools, begins solidification and recalesces. It was found that the maximum temperature reached after the second rise, if two rises occur, the maximum of a single rise, or the temperature at which the rate of temperature drop decreases, if no temperature rise occurs, provides a useful approximation of the liquidus temperature and hence the freezing point of the sample.

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