公开(公告)号：US06249482B1

公开(公告)日：2001-06-19

申请号：US09498092

申请日：2000-02-04

Applicant: Richard Albon ,  Alan Martin ,  David Johnston

Inventor： Richard Albon ,  Alan Martin ,  David Johnston

IPC: G11C800

CPC classification number: G11C7/22 ,  G11C7/1006

Abstract: A synchronous single port random access memory comprises a core 2 of memory cells 3 arranged as rows and columns. The rows are addressed by a row decoder 5 and the memory cell outputs are connected as columns to a column decoder and multiplexer 7. The decoder and multiplexer 7 selects groups of memory cells 3 from the addressed row and connects these to sense amplifiers 8. Changes in address are propagated immediately to the core 2 so that the selected memory cells 3 are connected as quickly as possible and without any fixed delays to the sense amplifiers 8. Similarly, a read clock “rclk” enables the sense amplifiers 8 immediately upon becoming active.

Abstract translation: 同步单端口随机存取存储器包括排列成行和列的存储器单元3的核心2。 行由行解码器5寻址，并且存储单元输出作为列连接到列解码器和多路复用器7.解码器和多路复用器7从寻址行选择组存储单元3，并将它们连接到读出放大器8.改变 内部地址立即传播到核心2，使得所选择的存储器单元3尽可能快地连接，并且没有任何固定的延迟连接到读出放大器8.类似地，读时钟“rclk”使感测放大器8立即变为有效 。

公开(公告)号：US6065463A

公开(公告)日：2000-05-23

申请号：US174646

申请日：1998-10-19

Applicant: Alan Martin

Inventor： Alan Martin

IPC: A21B1/24 ,  A21B1/48 ,  F24C15/32 ,  A21B1/00

CPC classification number: A21B1/245 ,  A21B1/48 ,  B65G2207/24

Abstract: A forced convective track oven comprises a track conveyor including first and second cylindrical spirals, the first cylindrical spiral for conveying bakery trays and dough products upwardly and the second spiral spiral portion for conveying bakery trays and dough products downwardly, thereby minimizing the number of changes of direction of the bakery trays as they travel along the track conveyor. A plurality of burners discharge heated air through discharge tubes and discharge nozzles into engagement with bakery trays carried by the track conveyor.

Abstract translation: 强制对流轨道烘箱包括轨道输送机，该轨道输送机包括第一和第二圆柱形螺旋，第一圆柱螺旋形用于向上传送面包店托盘和面团产品，以及第二螺旋形螺旋部分，用于向下传送面包店托盘和面团产品，从而最小化 面包店托盘沿轨道输送机行进时的方向。 多个燃烧器通过放电管和排出喷嘴将加热的空气排放到与轨道输送机承载的面包盘相接合。

公开(公告)号：US10077232B2

公开(公告)日：2018-09-18

申请号：US13696999

申请日：2011-05-12

Applicant: James Heyes ,  Mark Wood ,  Alan Martin

Inventor： James Heyes ,  Mark Wood ,  Alan Martin

IPC: A61K47/18 ,  C07C217/28 ,  C07C229/12 ,  C07D317/28 ,  C12N15/11 ,  A61K9/127 ,  A61K9/51 ,  A61K31/7105 ,  A61K31/713

CPC classification number: C07C217/28 ,  A61K9/1272 ,  A61K9/5123 ,  A61K31/7105 ,  A61K31/713 ,  A61K47/18 ,  C07C229/12 ,  C07C2601/02 ,  C07D317/28 ,  C12N15/111 ,  C12N2310/14 ,  C12N2310/3515 ,  C12N2320/32

Abstract: The present invention provides compositions and methods for the delivery of therapeutic agents to cells. In particular, these include novel cationic lipids and nucleic acid-lipid particles that provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic acid to cells in vivo. The compositions of the present invention are highly potent, thereby allowing effective knock-down of a specific target protein at relatively low doses. In addition, the compositions and methods of the present invention are less toxic and provide a greater therapeutic index compared to compositions and methods previously known in the art.

公开(公告)号：US20130123338A1

公开(公告)日：2013-05-16

申请号：US13696801

申请日：2011-05-12

Applicant: James Heyes ,  Mark Wood ,  Alan Martin

Inventor： James Heyes ,  Mark Wood ,  Alan Martin

IPC: A61K48/00 ,  C07C217/08 ,  C07C271/20 ,  A61K47/14 ,  C07C237/06 ,  C07D233/60 ,  C07D249/04 ,  A61K47/18 ,  C07C229/12 ,  C07C327/22

CPC classification number: A61K47/18 ,  A61K31/713 ,  A61K47/14 ,  A61K47/183 ,  A61K47/186 ,  A61K47/22 ,  A61K48/0033 ,  C07C217/08 ,  C07C217/46 ,  C07C229/12 ,  C07C229/30 ,  C07C237/06 ,  C07C271/20 ,  C07C327/06 ,  C07C327/22 ,  C07D233/60 ,  C07D249/04 ,  C12N15/111 ,  C12N15/113 ,  C12N2310/14 ,  C12N2320/32

Abstract: The present invention provides compositions and methods for the delivery of therapeutic agents to cells. In particular, these include novel cationic lipids and nucleic acid-lipid particles that provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic acid to cells in vivo. The compositions of the present invention are highly potent, thereby allowing effective knock-down of a specific target protein at relatively low doses. In addition, the compositions and methods of the present invention are less toxic and provide a greater therapeutic index compared to compositions and methods previously known in the art.

Abstract translation: 本发明提供了将治疗剂递送至细胞的组合物和方法。 特别地，这些包括提供核酸的有效包封的新型阳离子脂质和核酸 - 脂质颗粒，并将包封的核酸在体内有效递送至细胞。 本发明的组合物是高度有效的，从而允许以相对低的剂量有效击倒特异性靶蛋白。 此外，与本领域已知的组合物和方法相比，本发明的组合物和方法毒性低，并提供更大的治疗指数。

公开(公告)号：US20130116307A1

公开(公告)日：2013-05-09

申请号：US13696999

申请日：2011-05-12

Applicant: James Heyes ,  Mark Wood ,  Alan Martin

Inventor： James Heyes ,  Mark Wood ,  Alan Martin

IPC: A61K48/00 ,  C07C229/06 ,  A61K38/17

CPC classification number: C07C217/28 ,  A61K9/1272 ,  A61K9/5123 ,  A61K31/7105 ,  A61K31/713 ,  A61K47/18 ,  C07C229/12 ,  C07C2601/02 ,  C07D317/28 ,  C12N15/111 ,  C12N2310/14 ,  C12N2310/3515 ,  C12N2320/32

Abstract: The present invention provides compositions and methods for the delivery of therapeutic agents to cells. In particular, these include novel cationic lipids and nucleic acid-lipid particles that provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic acid to cells in vivo. The compositions of the present invention are highly potent, thereby allowing effective knock-down of a specific target protein at relatively low doses. In addition, the compositions and methods of the present invention are less toxic and provide a greater therapeutic index compared to compositions and methods previously known in the art.

Abstract translation: 本发明提供了将治疗剂递送至细胞的组合物和方法。 特别地，这些包括提供核酸的有效包封的新型阳离子脂质和核酸 - 脂质颗粒，并将包封的核酸在体内有效递送至细胞。 本发明的组合物是高度有效的，从而允许以相对低的剂量有效击倒特异性靶蛋白。 此外，与本领域已知的组合物和方法相比，本发明的组合物和方法毒性低，并提供更大的治疗指数。

公开(公告)号：US5954644A

公开(公告)日：1999-09-21

申请号：US823526

申请日：1997-03-24

Applicant: Allen Dettling ,  Alan Martin ,  Kurt Aronow

Inventor： Allen Dettling ,  Alan Martin ,  Kurt Aronow

IPC: A61B5/00

CPC classification number: A61B5/14552

Abstract: An improved photoplethysmographic measurement system is disclosed in which a portion of a time division multiplexed (TDM) signal represents an ambient light level, and other TDM signal portions represent detected levels of two or more centered wavelengths of transmitted light. The ambient and detected light portions of the signal are simultaneously applied to the inputs of an instrumentation amplifier(s) so as to produce a continuous output voltage that is proportional to a difference in voltage between the ambient and detected light portions of a TDM signal. Such an approach provides for ambient light level subtraction with reduced noise and componentry.

Abstract translation: 公开了一种改进的光电容积描记测量系统，其中时分多路复用（TDM）信号的一部分表示环境光级，并且其他TDM信号部分表示两个或更多个中心波长的透射光的检测电平。 信号的环境和检测光部分同时施加到仪表放大器的输入端，以产生与TDM信号的环境光和检测光部分之间的电压差成比例的连续输出电压。 这种方法提供了降低噪声和分量的环境光级减法。

公开(公告)号：US5649779A

公开(公告)日：1997-07-22

申请号：US638269

申请日：1996-04-26

Applicant: Alan Martin ,  Donnie G. Wells

Inventor： Alan Martin ,  Donnie G. Wells

IPC: F16C11/06 ,  F16J15/52

CPC classification number: F16C11/0671 ,  Y10T403/315 ,  Y10T403/32631 ,  Y10T403/32729

Abstract: An annular constant radial load ring is adapted to be received in an end portion of a dust boot for use with a ball and socket assembly. The ring includes an annular central body with a plurality of generally Y-shaped fingers circumferentially spaced about an inner periphery of the central body. The fingers are biased radially outwardly to promote sealing engagement between the dust boot and its mating component.

Abstract translation: 环形恒定径向负载环适于容纳在与球窝组件一起使用的防尘罩的端部中。 环包括环形中心体，其具有围绕中心体的内周周向间隔开的多个大致Y形的手指。 手指被径向向外偏压以促进防尘罩与其配合部件之间的密封接合。

公开(公告)号：US5620338A

公开(公告)日：1997-04-15

申请号：US295985

申请日：1994-08-25

Applicant: Jan Stephens ,  Ron Decoteau ,  Alan Martin ,  Steve Bleistein

Inventor： Jan Stephens ,  Ron Decoteau ,  Alan Martin ,  Steve Bleistein

IPC: H01R11/28 ,  H01R13/52

CPC classification number: H01R11/281 ,  H01R11/284

Abstract: A method and apparatus for providing a universal battery cable assembly is shown and described. In a preferred embodiment, a battery terminal and a conductive spacer are seated in a mold and encased in a quantity of insulating, resilient material that cures to form a boot of uniform size and shape, regardless of whether the battery cable assembly will function as a top terminal or as a bottom terminal, and regardless of the number and sizes of conductors that may be coupled to the battery terminal. A battery cable assembly provided in accordance with the present invention has a repeating geometry that allows it to be stacked on and sealingly engage a second battery cable assembly having the same structure.

Abstract translation: 示出并描述了一种用于提供通用电池电缆组件的方法和装置。 在优选实施例中，电池端子和导电间隔件位于模具中并且被封装在一定数量的绝缘的弹性材料中，其固化以形成均匀尺寸和形状的护罩，而不管电池电缆组件是否将作为 顶端或底端，并且不管可以耦合到电池端子的导体的数量和尺寸如何。 根据本发明提供的电池电缆组件具有重复的几何形状，其允许其堆叠并密封地接合具有相同结构的第二电池电缆组件。

公开(公告)号：US5500823A

公开(公告)日：1996-03-19

申请号：US221074

申请日：1994-03-31

Applicant: Alan Martin ,  Richard Albon

Inventor： Alan Martin ,  Richard Albon

IPC: G11C29/44 ,  G11C29/50 ,  G11C29/00

CPC classification number: G11C29/44 ,  G11C29/50 ,  G11C11/41

Abstract: In a static random access memory made up of six-transistor memory cells arranged in rows and columns, an arrangement for detecting open circuit or "soft" defects in the individual inverters of a memory cell includes lowering the supply voltage of a cell under test to overcome the clamping effect of a feedback inverter, applying input signal voltage changes to one of the bit lines associated with the cell, and testing for the expected voltage changes on the other bit line associated with the cell.

Abstract translation: 在以行和列布置的六晶体管存储单元构成的静态随机存取存储器中，用于检测存储单元的各个反相器中的开路或“软”缺陷的布置包括将被测单元的电源电压降低到 克服反馈逆变器的钳位效应，将输入信号电压变化施加到与单元相关联的位线之一，以及测试与单元相关联的另一位线上的预期电压变化。

公开(公告)号：US5466084A

公开(公告)日：1995-11-14

申请号：US260947

申请日：1994-06-16

Applicant: Shane J. Brueggen ,  Alan Martin

Inventor： Shane J. Brueggen ,  Alan Martin

IPC: F16J15/52 ,  F16C11/06 ,  F16D3/84 ,  F16J3/04 ,  F16C11/00

CPC classification number: F16J3/042 ,  F16C11/0671 ,  F16D3/845 ,  Y10T403/31 ,  Y10T403/32729

Abstract: A boot assembly used with a Joint assembly has an elastomeric boot and an annularly shaped retainer ring. The elastomeric boot is approximately cup shaped and has an axis with a cavity therealong. A substantially coaxial first aperture at a base portion of the boot opens to the cavity. The retainer ring is substantially concentric with the first aperture of the boot and is secured to the boot at the base portion. The retainer ring has a plurality of radially inwardly extending fingers. Each finger has a finger aperture therethrough reducing a bending strength of the finger in response to an axial force thereagainst.

Abstract translation: 与联合组件一起使用的靴子组件具有弹性靴和环形保持环。 弹性靴子是大致杯状的并且具有一个具有腔体的轴线。 在护罩的基部处的基本上同轴的第一孔通向空腔。 保持环与护罩的第一孔基本上同心，并且在基部处固定到靴子上。 保持环具有多个径向向内延伸的指状物。 每个手指具有穿过的手指孔，其响应于其上的轴向力而降低手指的弯曲强度。