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    NOVEL TRIALKYL CATIONIC LIPIDS AND METHODS OF USE THEREOF
    1.
    发明申请
    NOVEL TRIALKYL CATIONIC LIPIDS AND METHODS OF USE THEREOF 有权
    新型临床阳离子脂肪及其使用方法

    公开(公告)号：US20120172411A1

    公开(公告)日：2012-07-05

    申请号：US13235253

    申请日：2011-09-16

    Applicant: James Heyes ,  Mark Wood ,  Alan Martin

    Inventor： James Heyes ,  Mark Wood ,  Alan Martin

    IPC: A61K47/44 ,  C07C271/20 ,  C12N5/071 ,  A61K31/7105 ,  A61K31/713 ,  C07C229/12 ,  A61K31/7088

    CPC classification number: A61K47/44 ,  A61K9/1272 ,  A61K31/7088 ,  A61K31/7105 ,  A61K31/713 ,  A61K47/34 ,  C07C229/12 ,  C07C271/20

    Abstract: The present invention provides compositions and methods for the delivery of therapeutic agents to cells. In particular, these include novel cationic lipids and nucleic acid-lipid particles that provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic acid to cells in vivo. The compositions of the present invention are highly potent, thereby allowing effective knock-down of a specific target protein at relatively low doses. In addition, the compositions and methods of the present invention are less toxic and provide a greater therapeutic index compared to compositions and methods previously known in the art.

    Abstract translation: 本发明提供了将治疗剂递送至细胞的组合物和方法。 特别地，这些包括提供核酸的有效包封的新型阳离子脂质和核酸 - 脂质颗粒，并将包封的核酸在体内有效递送至细胞。 本发明的组合物是高度有效的，从而允许以相对低的剂量有效击倒特异性靶蛋白。 此外，与本领域已知的组合物和方法相比，本发明的组合物和方法毒性低，并提供更大的治疗指数。

    System Facilitating Government Mitigation of Damage at Public and Private Facilities
    2.
    发明申请
    System Facilitating Government Mitigation of Damage at Public and Private Facilities 有权

    公开(公告)号：US20220351298A1

    公开(公告)日：2022-11-03

    申请号：US17245676

    申请日：2021-04-30

    Applicant: Alan Martin

    Inventor： Alan Martin

    IPC: G06Q40/08

    Abstract: A method of interoperating between a web server and a variety of recording devices (smart phones, tablet computers, and portable (personal) computers) facilitating the mitigation of damage to public and private facilities caused by transport vehicles is disclosed. More specifically, the disclosed method relates generally to utilizing a software and hardware system (a web server) and interconnected recording devices (smart phones, tablet computers, and portable (personal) computers) used to mitigate damage to public and private facilities caused by automobiles and trucks and automobile and truck drivers and owners. More specifically still, the disclosed method relates to a method of billing of insurance companies for damage to public and private facilities caused by automobiles and trucks and automobile and truck drivers and owners.

    Trialkyl cationic lipids and methods of use thereof
    5.
    发明授权
    Trialkyl cationic lipids and methods of use thereof 有权
    三烷基阳离子脂质及其使用方法

    公开(公告)号：US08466122B2

    公开(公告)日：2013-06-18

    申请号：US13235253

    申请日：2011-09-16

    Applicant: James Heyes ,  Mark Wood ,  Alan Martin

    Inventor： James Heyes ,  Mark Wood ,  Alan Martin

    IPC: C12N15/11 ,  C07H21/02 ,  A61K9/127

    CPC classification number: A61K47/44 ,  A61K9/1272 ,  A61K31/7088 ,  A61K31/7105 ,  A61K31/713 ,  A61K47/34 ,  C07C229/12 ,  C07C271/20

    Abstract: The present invention provides compositions and methods for the delivery of therapeutic agents to cells. In particular, these include novel cationic lipids and nucleic acid-lipid particles that provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic acid to cells in vivo. The compositions of the present invention are highly potent, thereby allowing effective knock-down of a specific target protein at relatively low doses. In addition, the compositions and methods of the present invention are less toxic and provide a greater therapeutic index compared to compositions and methods previously known in the art.

    Abstract translation: 本发明提供了将治疗剂递送至细胞的组合物和方法。 特别地，这些包括提供核酸的有效包封的新型阳离子脂质和核酸 - 脂质颗粒，并将包封的核酸在体内有效递送至细胞。 本发明的组合物是高度有效的，从而允许以相对低的剂量有效击倒特异性靶蛋白。 此外，与本领域已知的组合物和方法相比，本发明的组合物和方法毒性低，并提供更大的治疗指数。

    Tool for setting blind fasteners
    6.
    发明授权
    Tool for setting blind fasteners 失效
    用于设置盲人紧固件的工具

    公开(公告)号：US4192163A

    公开(公告)日：1980-03-11

    申请号：US961869

    申请日：1978-11-20

    Applicant: Alan Martin

    Inventor： Alan Martin

    IPC: B21J15/04 ,  B25B27/00 ,  B21J15/34

    CPC classification number: B21J15/386 ,  B21J15/043 ,  B25B27/0007

    Abstract: A rivet nut setting tool having a frame with a head at one end and a grip at the other. A lever is pivotally mounted on the frame and its grip is generally parallel with the frame grip. The lever carries a threaded shaft which extends through an opening in the head. The shaft is rotated to take up the rivet nut to be set, and the grips are squeezed together to set the rivet in the work piece.

    Abstract translation: 一种铆钉螺母固定工具，其具有在一端具有头部的框架和在另一端具有把手。 杠杆枢转地安装在框架上，并且其手柄大体上平行于框架把手。 杠杆带有螺纹轴，其延伸穿过头部中的开口。 旋转轴旋转铆接螺母，将夹具压在一起，将铆钉固定在工件上。

    COMPOSITIONS AND METHODS FOR SILENCING APOLIPOPROTEIN B
    8.
    发明申请
    COMPOSITIONS AND METHODS FOR SILENCING APOLIPOPROTEIN B 有权
    沉淀APOLIPOPROTEIN B的组合物和方法

    公开(公告)号：US20130123339A1

    公开(公告)日：2013-05-16

    申请号：US13697000

    申请日：2011-05-12

    Applicant: James Heyes ,  Mark Wood ,  Alan Martin ,  Amy C.H. Lee ,  Adam Judge ,  Marjorie Robbins ,  Ian MacLachlan

    Inventor： James Heyes ,  Mark Wood ,  Alan Martin ,  Amy C.H. Lee ,  Adam Judge ,  Marjorie Robbins ,  Ian MacLachlan

    IPC: A61K31/713

    CPC classification number: A61K31/713 ,  C12N15/111 ,  C12N15/113 ,  C12N15/88 ,  C12N2310/14 ,  C12N2320/32

    Abstract: The present invention provides compositions and methods for the delivery of interfering RNAs such as siRNAs that silence APOB expression in cells such as liver cells. In particular, the nucleic acid-lipid particles provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic acid to cells such as liver cells in vivo. The compositions of the present invention are highly potent, thereby allowing effective knock-down of APOB at relatively low doses. In addition, the compositions and methods of the present invention are less toxic and provide a greater therapeutic index compared to compositions and methods previously known in the art.

    Abstract translation: 本发明提供用于递送干扰RNA的组合物和方法，例如在细胞如肝细胞中沉默APOB表达的siRNA。 特别地，核酸 - 脂质颗粒提供了核酸的有效包封，并且将体内核酸的活性有效地递送到细胞例如肝细胞。 本发明的组合物是非常有效的，从而允许以相对低的剂量有效地击倒APOB。 此外，与本领域已知的组合物和方法相比，本发明的组合物和方法毒性低，并提供更大的治疗指数。

    HYBRID ENERGY CONVERSION SYSTEM
    10.
    发明申请
    HYBRID ENERGY CONVERSION SYSTEM 审中-公开
    混合能源转换系统

    公开(公告)号：US20110169273A1

    公开(公告)日：2011-07-14

    申请号：US13119239

    申请日：2009-01-24

    Applicant: Alan Martin

    Inventor： Alan Martin

    IPC: H02K7/18

    CPC classification number: B60K6/26 ,  B60K3/00 ,  B60K6/12 ,  B60K6/46 ,  B60K16/00 ,  B60K2016/003 ,  B60K2016/006 ,  B60L50/15 ,  F03D9/25 ,  F05B2240/941 ,  Y02E10/725 ,  Y02T10/6208 ,  Y02T10/6217 ,  Y02T10/6282 ,  Y02T10/7077 ,  Y02T10/90

    Abstract: A hybrid energy conversion system is described which utilizes a drive engine configured to output mechanical energy at a generally uniform rotational speed under varying mechanical load conditions. The mechanical energy is used to turn an electrical generator mechanically coupled to the drive engine. The electrical energy output from the electrical generator is then used to power an electrical motor coupled to a mechanical load.

    Abstract translation: 描述了一种混合能量转换系统，其利用配置成在变化的机械负载条件下以大致均匀的转速输出机械能的驱动发动机。 机械能用于转动机械地联接到驱动发动机的发电机。 然后，从发电机输出的电能用于为耦合到机械负载的电动机供电。

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