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公开(公告)号：HU0202431A2
公开(公告)日：2002-11-28
申请号：HU0202431
申请日：2000-04-05
Applicant: BASF AG
Inventor： BACKFISCH GISELA , BAUCKE DORIT , DELZER JUERGEN , DR HORNBERGER WILFRIED , DR MACK HELMUT , DR SEITZ WERNER
IPC: C12N9/99 , A61K38/00 , A61K38/55 , A61K47/48 , A61P7/02 , A61P43/00 , C07B43/00 , C07D401/12 , C07K5/062 , C07K5/065
Abstract: The present invention relates to prodrugs of general formula (I). The meaning of said formula is given in the description. Disclosed are the prodrugs of pharmaceutically active, heterocyclic amidines. In vivo compounds which are competitive inhibitors of trypsin-like serine proteases, especially thrombin, are produced from the amidines. The invention also relates to the production and use of the prodrugs as medicaments.
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公开(公告)号：HU0202401A2
公开(公告)日：2002-10-28
申请号：HU0202401
申请日：2000-04-05
Applicant: BASF AG
Inventor： BACKFISCH GISELA , BAUCKE DORIT , DELZER JUERGEN , DR HORNBERGER WILFRIED , DR MACK HELMUT , DR SEITZ WERNER
IPC: C12N9/99 , A61K38/00 , A61K38/55 , A61P7/02 , A61P9/06 , A61P9/10 , A61P25/00 , A61P25/28 , A61P29/00 , A61P35/00 , A61P35/04 , A61P43/00 , C07B43/00 , C07K5/02 , C07K5/062 , C07K5/065
Abstract: The present invention relates to prodrugs of pharmacologically active five-membered heterocyclic amidines from which are produced in vivo compounds which are competitive inhibitors of trypsin-like serine proteases, in particular thrombin and kininogenases such as kallikrein, to the preparation thereof and to the use thereof as medicines. The invention also relates to pharmaceutical compositions which comprise the prodrugs of the active compounds as ingredients, and to the use of the compounds as thrombin inhibitors, anticoagulants and as antiinflammatory agents.
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公开(公告)号：NO20014875A
公开(公告)日：2001-11-13
申请号：NO20014875
申请日：2001-10-08
Applicant: BASF AG
Inventor： BAUCKE DORIT , MACK HELMUT , SEITZ WERNER , HORNBERGER WILFRIED , BACKFISH GISELA , DELZER JUERGEN
IPC: C12N9/99 , A61K38/00 , A61K38/55 , A61P7/02 , A61P9/06 , A61P9/10 , A61P25/00 , A61P25/28 , A61P29/00 , A61P35/00 , A61P35/04 , A61P43/00 , C07B43/00 , C07K5/02 , C07K5/062 , C07K5/065 , A61K38/05
CPC classification number: C07K5/06078 , A61K38/00 , C07B43/00 , C07K5/0222
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公开(公告)号：ES2151741T3
公开(公告)日：2001-01-01
申请号：ES97934552
申请日：1997-07-29
Applicant: BASF AG
Inventor： BAUCKE DORIT , LANGE UDO , MACK HELMUT , PFEIFFER THOMAS , SEITZ WERNER , ZIERKE THOMAS
IPC: A61K31/40 , A61K31/44 , A61K38/00 , A61K38/05 , A61P1/18 , A61P7/02 , A61P11/02 , A61P11/06 , A61P17/00 , A61P19/02 , A61P29/00 , A61P43/00 , C07D207/22 , C07D211/78 , C07K5/00 , C07K5/02 , C07K5/083
Abstract: Compounds of the formula Iwhere R, R1, R2, R3, R4, R5 and R6, and l, m and n have the meanings stated in the description, and their preparation are described. The novel compounds are suitable for controlling diseases.
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公开(公告)号：CZ20002463A3
公开(公告)日：2000-10-11
申请号：CZ20002463
申请日：1999-01-23
Applicant: BASF AG
Inventor： BAUCKE DORIT , LANGE UDO , MACK HELMUT , SEITZ WERNER , HOEFFKEN HANS WOLFGANG , HORNBERGER WILFRIED
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Patent Agency Ranking
公开(公告)号：NO20003814D0
公开(公告)日：2000-07-25
申请号：NO20003814
申请日：2000-07-25
Applicant: BASF AG
Inventor： BAUCKE DORIT , LANGE UDO , MACK HELMUT , SEITZ WERNER , HOEFFKEN HANS WOLFGANG , HORNBERGER WILFRIED
IPC: A61K38/00 , A61P1/18 , A61P7/02 , A61P11/06 , A61P17/04 , A61P19/02 , A61P27/16 , A61P29/00 , C07K5/06 , C07K5/065 , C07K5/08 , A61K38/06
Abstract: Novel five-membered heterocyclic amidines, their preparation and use as competitive inhibitors of trypsin-like serine proteases, especially thrombin and kininogenases such as kallikrein. Pharmaceutical compositions which contain the compounds as active ingredients, and use of the compounds as thrombin inhibitors, anticoagulants and antiinflammatory agents.
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公开(公告)号：AU717692B2
公开(公告)日：2000-03-30
申请号：AU3771597
申请日：1997-07-29
Applicant: BASF AG
Inventor： BAUCKE DORIT , LANGE UDO , MACK HELMUT , PFEIFFER THOMAS , SEITZ WERNER , ZIERKE THOMAS , HOFFKEN HANS WOLFGANG , HORNBERGER WILFRIED
IPC: A61K31/40 , A61K31/44 , A61K38/00 , A61K38/05 , A61P1/18 , A61P7/02 , A61P11/02 , A61P11/06 , A61P17/00 , A61P19/02 , A61P29/00 , A61P43/00 , C07D207/22 , C07D211/78 , C07K5/00 , C07K5/02 , C07K5/083
Abstract: Compounds of the formula Iwhere R, R1, R2, R3, R4, R5 and R6, and l, m and n have the meanings stated in the description, and their preparation are described. The novel compounds are suitable for controlling diseases.
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公开(公告)号：CZ31199A3
公开(公告)日：1999-06-16
申请号：CZ31199
申请日：1997-07-29
Applicant: BASF AG
Inventor： BAUCKE DORIT , LANGE UDO , MACK HELMUT , PFEIFER THOMAS , SEITZ WERNER , ZIERKE THOMAS , HOFFKEN HANS WOLFGANG , HORNBERGER WILFRIED GOLDENER
IPC: A61K31/40 , A61K31/44 , A61K38/00 , A61K38/05 , A61P1/18 , A61P7/02 , A61P11/02 , A61P11/06 , A61P17/00 , A61P19/02 , A61P29/00 , A61P43/00 , C07D207/22 , C07D211/78 , C07K5/00 , C07K5/02 , C07K5/083 , A61K38/02
Abstract: Compounds of the formula Iwhere R, R1, R2, R3, R4, R5 and R6, and l, m and n have the meanings stated in the description, and their preparation are described. The novel compounds are suitable for controlling diseases.
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公开(公告)号：CZ48699A3
公开(公告)日：1999-05-12
申请号：CZ48699
申请日：1997-07-29
Applicant: BASF AG
Inventor： BAUCKE DORIT , LANGE UDO , MACK HELMUT , SEITZ WERNER , ZIERKE THOMAS , HOFFKEN HANS WOLFGANG , HORNBERGER WILFRIED
IPC: A61K38/00 , A61K38/05 , A61P7/02 , A61P29/00 , A61P35/00 , A61P35/04 , C07K5/06 , C07K5/062 , C07K5/065
Abstract: PCT No. PCT/EP97/04104 Sec. 371 Date Feb. 10, 1999 Sec. 102(e) Date Feb. 10, 1999 PCT Filed Jul. 29, 1997 PCT Pub. No. WO98/06741 PCT Pub. Date Feb. 19, 1998Compounds of the formula where A, B, E and D have the meanings indicated in the description, and their preparation are described. The substances are suitable for controlling diseases.
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公开(公告)号：TR9900310T2
公开(公告)日：1999-04-21
申请号：TR9900310
申请日：1997-07-29
Applicant: BASF AG
Inventor： BAUCKE DORIT , LANGE UDO , MACK HELMUT , SEITZ WERNER , ZIERKE THOMAS , HOEFFKEN HANS WOLFGANG , HORNBERGER WILFRIED
IPC: A61K38/00 , A61K38/05 , A61P7/02 , A61P29/00 , A61P35/00 , A61P35/04 , C07K5/06 , C07K5/062 , C07K5/065
CPC classification number: C07K5/06078 , A61K38/00
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