公开(公告)号：NO20000787A

公开(公告)日：2000-02-17

申请号：NO20000787

申请日：2000-02-17

Applicant: BASF AG

Inventor： MERKLE HANS RUPERT ,  WOERZ OTTO ,  FRETSCHNER ERICH ,  HANSEN HANSPETER ,  MUELLER ALBRECHT ,  BENZ KURT

IPC: C07D285/24 ,  C07D285/16

CPC classification number: C07D285/16

公开(公告)号：ZA9805405B

公开(公告)日：2000-01-10

申请号：ZA9805405

申请日：1998-06-22

Applicant: BASF AG

Inventor： MERKLE HANS RUPERT ,  FRETSCHNER ERICH

IPC: C07D231/12 ,  C07D20060101 ,  C07D231/10 ,  C07D

CPC classification number: C07D231/12

公开(公告)号：AT178581T

公开(公告)日：1999-04-15

申请号：AT96900560

申请日：1996-01-04

Applicant: BASF AG

Inventor： MERKLE HANS RUPERT ,  FRETSCHNER ERICH ,  HANSEN HANSPETER ,  ZIPPERER BERNHARD

IPC: C07B57/00 ,  C07C51/09 ,  C07C51/487 ,  C07C53/19

Abstract: PCT No. PCT/EP96/00012 Sec. 371 Date Jan. 7, 1997 Sec. 102(e) Date Jan. 7, 1997 PCT Filed Jan. 4, 1996 PCT Pub. No. WO96/22272 PCT Pub. Date Jul. 25, 1996The present invention relates to a process for the preparation of optically active 2-halopropionic acids, in which the corresponding optically active alkyl 2-halopropionates are caused to react with a carboxylic acid at elevated temperature in a transacylation reaction with the formation of the optically active 2-halopropionic acid and the alkyl carboxylate, and the optically active 2-halopropionic acid obtained is separated from the reaction mixture. The optically active products produced are important intermediates for the preparation of plant protectants and pharmaceuticals.

公开(公告)号：AU703688B2

公开(公告)日：1999-04-01

申请号：AU4436796

申请日：1996-01-04

Applicant: BASF AG

Inventor： MERKLE HANS RUPERT ,  FRETSCHNER ERICH

IPC: C07D231/12

Abstract: PCT No. PCT/EP96/00011 Sec. 371 Date Jul. 3, 1997 Sec. 102(e) Date Jul. 3, 1997 PCT Filed Jan. 4, 1996 PCT Pub. No. WO96/21650 PCT Pub. Date Jul. 18, 1996A process for preparing 3,5-diarylpyrazoles of the general formula I I where the substituents have the following meanings: R1 and R3 are unsubstituted or substituted aryl radicals, R2 is hydrogen, C1-C8-alkyl or unsubstituted or substituted aryl, in which hydrazine hydrate is reacted with a 1,3-diarylpropenone of the general formula II II where the substituents R1, R2 and R3 have the abovementioned meanings, in sulfuric acid in the presence of iodine or an iodine compound, is described.

公开(公告)号：AU698827B2

公开(公告)日：1998-11-05

申请号：AU4941896

申请日：1996-02-27

Applicant: BASF AG

Inventor： MERKLE HANS RUPERT ,  FRETSCHNER ERICH ,  SCHRODER JURGEN

IPC: C07D231/12 ,  C07D521/00

Abstract: PCT No. PCT/EP96/00790 Sec. 371 Date Aug. 20, 1997 Sec. 102(e) Date Aug. 20, 1997 PCT Filed Feb. 27, 1996 PCT Pub. No. WO96/27589 PCT Pub. Date Sep. 12, 1996A process for the preparation of an N-alkyl- or N-phenylalkyl-substituted pyrazole I by reacting the corresponding N-unsubstituted pyrazole II with an alcohol III of the formula R1-OH where R1 is the same alkyl or phenylalkyl group to be added to the unsubstituted nitrogen group -NH- of the pyrazole reactant. Both of the reactants, i.e. the pyrazole II and alcohol III compounds, are catalytically reacted in the liquid phase in a molar ratio of from 0.001:1 to 1:1, at temperatures of 50 DEG -400 DEG C. and under a subatmosheric pressure of from 0.8 bar up to a superatmospheric pressure of 250 bar. The catalyst required for this liquid phase reaction is selected as being at least one or more non-heterogeneous acid catalysts, their alkyl esters or their acid anhydrides.

公开(公告)号：MX9706651A

公开(公告)日：1997-11-29

申请号：MX9706651

申请日：1996-02-27

Applicant: BASF AG

Inventor： MERKLE HANS RUPERT ,  FRETSCHNER ERICH ,  SCHRODER JURGEN

IPC: C07D231/12 ,  C07D521/00

Abstract: Un proceso para la preparacion de pirazoles sustituidos en N, de la formula general I, en donde R1 es alquilo de C1-C12 o fenilalquilo de C7-C20 y R2 y R4 son, independientemente entre sí, hidrogeno, alquilo de C1-C12-, fenilalquilo de C7-C20 o radicales arilo no sustituidos o sustituidos, mediante la reaccion de los pirazoles de la formula general II; en donde R2, R3 y R4 tienen los significados antes mencionados, con un alcohol de la formula general III, en donde R1 tiene el significado antes mencionado, a 50 - 400 degree C en presencia de un catalizador, en donde la reaccion del pirazol II con el compuesto III en la proporcion molar desde 0.001:1 a 1:1 se lleva a cabo en fase líquida bajo una presion que es ligeramente abajo de la atmosférica o hasta una presion de 250 bar y se utilizan ácidos y/o sus ésteres de alquilo o sus anhídridos, en una relacion molar desde 0.0001:1 hasta 0.5:1 con respecto al pirazol II, como catalizador.

公开(公告)号：SK286290A3

公开(公告)日：1997-04-09

申请号：SK286290

申请日：1990-06-08

Applicant: BASF AG

Inventor： MERKLE HANS R ,  FRETSCHNER ERICH

IPC: C07D231/06 ,  C07D231/12

Abstract: Pyrazole and its derivs. (I) are produced by dehydrogenation of the corresp. 2-pyrazoline (II) with the aid of sulphuric acid in the presence of iodine or an iodine cpd. (III) at 50-250 deg.C. (II) is produced in situ in the reaction medium by reaction of glycerol or acrolein or a deriv. thereof with hydrazine or a hydrazine deriv.; amt. of (III) is 0.01-10 mol. equiv. w.r.t. (II) or the corresp. hydrazine; 30-99 wt.% H2SO4 is used.

公开(公告)号：SK23596A3

公开(公告)日：1996-10-01

申请号：SK23596

申请日：1994-08-13

Applicant: BASF AG

Inventor： MERKLE HANS RUPERT ,  FRETSCHNER ERICH

IPC: C07B35/04 ,  C07D231/12 ,  C07D521/00

Abstract: PCT No. PCT/EP94/02708 Sec. 371 Date Feb. 15, 1996 Sec. 102(e) Date Feb. 15, 1996 PCT Filed Aug. 13, 1994 PCT Pub. No. WO95/06036 PCT Pub. Date Mar. 2, 1995A process for preparing pyrazole and its derivatives of the formula I I where R1, R2, R3 and R4 are each hydrogen, halogen, nitro, carboxyl, sulfonyl or C-organic radicals, from alpha,beta-unsaturated carbonyl compounds of the formula II II and hydrazine or hydrazine derivatives of the formula III H2N-NHR4 III wherein, initially without additional diluent, an alpha,beta-unsaturated carbonyl compound of the formula II is reacted with hydrazine or a hydrazine derivative of the formula III, and the resulting reaction mixture is reacted in another step with a mixture of sulfuric acid and iodine or a compound which liberates iodine or hydrogen iodide.

公开(公告)号：CA2213853A1

公开(公告)日：1996-09-12

申请号：CA2213853

申请日：1996-02-27

Applicant: BASF AG

Inventor： FRETSCHNER ERICH ,  SCHR DER JUERGEN ,  MERKLE HANS RUPERT

IPC: C07D231/12 ,  C07D521/00

Abstract: A process is disclosed for preparing N-substituted pyrazoles having the general formula (I), in which R1 stands for C1 to C12 alkyl or C7 to C20 phenylalkyl, and R2, R3, R4 represent independently from each other hydrogen, C1 to C12 alkyl, C7 to C20 phenylalkyl or optionally substituted aryl residues, by reacting pyrazoles having the general formula (II), in which R2, R3 and R4 have above-said meanings, with an alcohol having the general formula (III) R1-O-H, in which R1 has above-said meanings, at temperatures from 50 to 400 ~C in the presence of a catalyst. The reaction of pyrazole (II) with compound (III) is carried out in a molar ratio from 0.001:1 to 1:1 in the liquid phase at a slight negative pressure up to an overpressure of 250 bars. Acids, their alkyl esters and/or their anhydrides are used as catalysts in a molar ratio from 0.0001:1 to 0.5:1 in relation to pyrazole (II).

公开(公告)号：CA2208538A1

公开(公告)日：1996-07-04

申请号：CA2208538

申请日：1995-12-13

Applicant: BASF AG

Inventor： MERKLE HANS RUPERT ,  BRENNER KARL SIEGFRIED ,  VAN GASTEL ANNE ,  SCH NHERR MICHAEL ,  FRETSCHNER ERICH

IPC: C07C51/41 ,  C07C59/70

Abstract: A process is disclosed for preparing solid, free-flowing water-soluble salts of aryloxy-C1-C4-alkane carboxylic acids. Aryloxy-C1-C4-alkane carboxylic acids are reacted with a salt-forming base. Salts are formed in the melt in the presence or absence of an entrainer suitable for causing azeotropic water separation or in a solution in the presence of an entrainer suitable for causing azeotropic water separation. The entrainer is removed from the reaction mixture during or after the reaction and the solid salts are then isolated in the usual manner.