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公开(公告)号:JPH10158140A
公开(公告)日:1998-06-16
申请号:JP32805297
申请日:1997-11-28
Applicant: BASF AG
Inventor: HABECK THORSTEN DR , AUMUELLER ALEXANDER DR , SCHEHLMANN VOLKER DR , WESTENFELDER HORST , WUENSCH THOMAS DR
IPC: A61K8/30 , A61K8/00 , A61K8/41 , A61K8/42 , A61K8/46 , A61K8/49 , A61K31/13 , A61K31/22 , A61Q1/00 , A61Q1/04 , A61Q17/04 , A61Q19/00 , C07C225/14 , C07C229/30 , C07C229/56 , C07C229/60 , C07C255/30 , C07C255/58 , C07C309/46 , C07D275/02 , C07D275/03 , C07D319/06 , C07D333/38 , A61K7/42 , A61K7/00 , A61K7/48
Abstract: PROBLEM TO BE SOLVED: To obtain a cosmetic and pharmaceutical preparation capable of absorbing rays in UVA region with high absorbance and having light stability by compounding a UV ray-absorbing compound known in cosmetics, etc., for protecting human skin or human hair from sun light with an enamine derivative. SOLUTION: This preparation of the formula [CC double bonds exist in an E- and/or Z-configuration; R is COOR , CONR R , R OP(OR )O, etc.; R is COOR , etc.; R is H, a is an aromatic group having 5-12 ring atoms, etc.; R to R are each H, a
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公开(公告)号:ES2228338T3
公开(公告)日:2005-04-16
申请号:ES00110475
申请日:2000-05-17
Applicant: BASF AG
Inventor: PRECHTL FRANK DR , HABECK THORSTEN DR , WESTENFELDER HORST , WUNSCH THOMAS DR
IPC: A61K8/00 , A61K8/30 , A61K8/35 , A61K8/368 , A61K8/37 , C07D311/58 , A61K8/40 , A61K8/49 , A61K47/08 , A61K47/14 , A61K47/16 , A61Q1/00 , A61Q1/04 , A61Q17/04 , C07C255/34 , C07C261/02 , C07D311/04 , C07D495/04 , C08K5/07 , C08K5/1545 , C08K5/20 , C08K5/315 , C08K5/3435 , C08K5/42 , C08L101/00 , C09K3/00 , C09K15/06 , C09K15/16 , C09K15/20 , C09K15/30 , A61K7/42 , C08K5/16
Abstract: Empleo de compuestos de la **fórmula** en la que X significa un resto divalente del oxígeno, un resto carbonilo, imino en caso dado substituido de manera alifática o el resto -C(R9R10)-, Y significa grupo carbonilo o el resto -C(R9R10)-, R1 y R2 son restos iguales o diferentes, electrófilos, elegidos del grupo formado por ciano, alquil- o arilcarbonilo, alquiloxi- o ariloxicarbonilo, aminocarbonilo en caso dado substituido, alquil- o arilsufinilo, alquil- o arilsulfonilo y aminosulfonilo en caso dado substituido, R3 significa un átomo de hidrógeno, un grupo ciano, hidroxilo, carboxilo o aminocarbonilo o un resto alquilo con 1 a 20 átomos de carbono o un resto arilo con 5 a 20 átomos de carbono enlazados en caso dado a través de un puente de oxígeno, de un puente de aminocarbonilo o de un puente de oxicarbonilo, R4 significa un átomo de hidrógeno, un grupo hidroxilo, un grupo amino o un resto alquilo con 1 a 20 átomos de carbono o un resto arilo con 5 a 20 átomos de carbono enlazado en casodado a través de un puente de oxígeno y R5, R6, R9 y R10 significan, independientemente entre sí, hidrógeno o restos alquilo con 1 a 20 átomos de carbono, R7 y R8 significan, independientemente entre sí, hidrógeno o restos alquilo con 1 a 20 átomos de carbono o junto con el átomo de carbono ceteno significan un grupo carbonilo, como filtros fotoestables frente a los UV en preparaciones cosméticas para la protección de la piel humana y del cabello humano contra la irradiación solar, solos o junto con compuestos en sí conocidos para preparaciones cosméticas, absorbentes en el intervalo de los UV.
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公开(公告)号:AU2802701A
公开(公告)日:2002-09-19
申请号:AU2802701
申请日:2001-03-15
Applicant: BASF AG
Inventor: HEIDENFELDER THOMAS DR , WUNSCH THOMAS DR , HABECK THORSTEN DR
IPC: A61K8/00 , A61K8/35 , A61K8/36 , A61K8/37 , A61K8/49 , A61K8/89 , A61K8/893 , A61K8/896 , A61K8/898 , A61K31/121 , A61K31/216 , A61K31/4184 , A61K31/4192 , A61K31/53 , A61K31/695 , A61K31/77 , A61K33/24 , A61K33/30 , A61P17/16 , A61Q1/04 , A61Q17/04 , C08L83/07 , A61K7/44 , A61P39/00
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公开(公告)号:AT339181T
公开(公告)日:2006-10-15
申请号:AT00110272
申请日:2000-05-22
Applicant: BASF AG
Inventor: HABECK THORSTEN DR , PRECHTL FRANK DR , WUENSCH THOMAS DR , WESTENFELDER HORST
IPC: C07D233/64 , A61K8/00 , A61K8/02 , A61K8/06 , A61K8/49 , A61K47/22 , A61Q1/00 , A61Q1/04 , A61Q17/04 , C07D239/70 , C07D263/56 , C07D277/64 , C08K5/47 , C08K5/3447 , C08K5/35 , C07D235/16
Abstract: Use of new and known bicyclic and tricyclic enamines as UV filters in cosmetic and pharmaceutical preparations is new. Also new is their use for the protection of plastics. Use of bicyclic and tricyclic enamines as UV filters in cosmetic and pharmaceutical preparations is new. R and R = CN; alkylcarbonyl; alkoxycarbonyl; aryloxycarbonyl; or optionally substituted aminocarbonyl; R = H; 1-20C alkyl; 3-20C cycloalkyl; or -CH2-CH2-SO3 M ; M = cation; X = -O-; -S-; or -N(R )-; Z' = group of formula (ii) or (iii): R = H; alkyl, cycloalkyl, alkoxy, cycloalkoxy, alkoxycarbonyl, alkyl-NH-CO-, (alkyl)2-NH-CO-, alkyl-NH- or (alkyl)2N- (each with up to 20C); CN; NH2; or SO3 M and more than 1 R can be present. Independent claims are also included for: (1) the use of compounds (I) as light screening agents for the protection of plastics; (2) (I; Z' = (iii); and (3) (I; Z' = (ii); R4 = R40; R1, R2 = R10, R20 respectively) R and R = CN or 2-10C alkoxycarbonyl optionally substituted with -(CH2)n-SO3 M ; R = H; CH3; or -(CH2)n-SO3 M ; R = H; 1-8C alkyl; 1-8C alkoxy; or -SO3 M ; n = 2 or 3; M = H or HN(R )(R )(R ) ; R -R = H lower alkyl optionally substituted with OH; or a metal cation; but at least one -(CH2)n-SO3 M or -SO3 M must be present.
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公开(公告)号:AT276732T
公开(公告)日:2004-10-15
申请号:AT00110475
申请日:2000-05-17
Applicant: BASF AG
Inventor: PRECHTL FRANK DR , HABECK THORSTEN DR , WESTENFELDER HORST , WUENSCH THOMAS DR
IPC: C07D311/58 , A61K8/00 , A61K8/30 , A61K8/35 , A61K8/368 , A61K8/37 , A61K8/40 , A61K8/49 , A61K47/08 , A61K47/14 , A61K47/16 , A61Q1/00 , A61Q1/04 , A61Q17/04 , C07C255/34 , C07C261/02 , C07D311/04 , C07D495/04 , C08K5/07 , C08K5/1545 , C08K5/20 , C08K5/315 , C08K5/3435 , C08K5/42 , C08L101/00 , C09K3/00 , C09K15/06 , C09K15/16 , C09K15/20 , C09K15/30 , A61K7/42 , C08K5/16
Abstract: 6-Vinyl-3,4-dihydro-2H-1-benzopyran, 6-vinyl-1,2,3,4-tetrahydronaphthalene or 6-vinyl-1,2,3,4-tetrahydroquinoline derivatives (I) are used as photostable ultraviolet (UV) filters in cosmetic and pharmaceutical compositions for protecting human skin and hair against solar radiation. Compounds of formula (I) are used as photostable UV filters in cosmetic and pharmaceutical compositions for protecting human skin and hair against solar radiation: X = O, CO, optionally substituted imino or CR9R10; Y = CO or CR9R10; R1, R2 = CN, alkanoyl, aroyl, alkoxycarbonyl, aryloxycarbonyl, optionally substituted carbamoyl, alkylsulfinyl, arylsulfinyl, alkylsulfonyl, arylsulfonyl or optionally substituted sulfamoyl; R3 = H, CN, OH, COOH, CONH2, Q, OQ, CONHQ or COOQ; Q = 1-20C alkyl or 5-20C aryl; R4 = H, OH, NH2, Q or OQ; R5-R10 = H or 1-20C alkyl, or R7+R8 can be oxo. Independent claims are also included for the following: (1) use of (I) as photoprotective agents for stabilizing plastics; (2) cosmetic compositions for protecting human epidermis and hair against UV light of wavelength 280-400 nm, comprising (I) in a carrier; and (3) new compounds of formula (II): R3' = lower alkyl; R4' = H, lower alkyl or lower alkoxy; X' = O or CRR; R = H or lower alkyl.
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公开(公告)号:ES2201621T3
公开(公告)日:2004-03-16
申请号:ES99122884
申请日:1999-11-18
Applicant: BASF AG
Inventor: HABECK THORSTEN DR , PRECHTL FRANK DR , WUNSCH THOMAS DR , WESTENFELDER HORST
IPC: A61K8/00 , A61K8/30 , A61K8/40 , A61K8/49 , A61K31/275 , A61K31/277 , A61Q1/00 , A61Q1/04 , A61Q17/04 , A61Q19/00 , C07C255/37 , A61K7/42
Abstract: alpha -Alkyl-styryl derivatives (I) are used as photostable UV-filter in cosmetic or pharmaceutical compositions for protecting the human skin or hair against the sun light, optionally combined with other components absorbing in the UV range. alpha -Alkyl-styryl derivatives of formula (I) are used as photostable UV-filter in cosmetic or pharmaceutical compositions for protecting the human skin or hair against the sun light, optionally combined with other components absorbing in the UV range. R , R = H, OH, NH2, 1-12C alkyl, 1-12C alkoxy, 1-12C alkylamino, 1-12C dialkylamino, water soluble substituents such as carboxylate, sulfonate or ammonium residues; R , R = COOR , COR , CONR R or CN; R = 1-12C alkyl; R , R = H, 1-12C alkyl, 2-10C alkenyl, 3-10C cycloalkyl, 3-10C cycloalkenyl, aryl or heteroaryl (all optionally substituted); A = O, S or NR B' = 1-12C alkylene, 4-12C cycloalkylene, 8-22C aralkylene, 9-21C monooxoaralkylene or -(X)n-Y'-; R = H or 1-12C alkyl; X = -(CH2)2-Z-, -(CH2)3-Z-, -CH(CH3)2-CH2-Z-, -(CH2)4-Z- or -CH2-CH(CH2-CH3)-Z-; Y' = -(CH2)2-, -(CH2)3-, -CH(CH3)-CH2-, -(CH2)4- or -CH2-CH(CH2-CH3)-; Z = O or S; n = 1-150; two of R , R and R = form 5- to 6-membered ring fused to the benzene ring. An Independent claim is also included for a sunscreen comprising the cosmetic and pharmaceutical composition for protecting the human epidermis and hair against UV light (280-400 nm) containing (I).
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公开(公告)号:ES2272214T3
公开(公告)日:2007-05-01
申请号:ES00110272
申请日:2000-05-22
Applicant: BASF AG
Inventor: HABECK THORSTEN DR , PRECHTL FRANK DR , WUNSCH THOMAS DR , WESTENFELDER HORST
IPC: A61K8/49 , C07D233/64 , A61K8/00 , A61K8/02 , A61K8/06 , A61K47/22 , A61Q1/00 , A61Q1/04 , A61Q17/04 , C07D235/16 , C07D239/70 , C07D263/56 , C07D277/64 , C08K5/3447 , C08K5/35 , C08K5/47
Abstract: Empleo de compuestos de la fórmula I (Ver fórmula) en la que R1 y R2 son restos iguales o diferentes, electrófilos, elegidos entre el grupo constituido por ciano, alquilcarbonilo o arilcarbonilo, alquiloxicarbonilo o ariloxicarbonilo y aminocarbonilo, substituido en caso dado, R3 significa un átomo de hidrógeno, un resto alquilo con 1 hasta 20 átomos de carbono o un resto cicloalquilo con 3 hasta 20 átomos de carbono o un resto de la fórmula -CH2-CH2-SO3-M+, donde M+ significa un catión, X significa el resto divalente del oxígeno, del azufre o significa el resto (Ver fórmula) donde R3 tiene el significado anteriormente indicado, Z significa el resto divalente de las fórmulas II o III, que forman un sistema anillado con el resto de la fórmula I (Ver fórmula) pudiendo estar enlazado R4 una o varias veces sobre el anillo de bencilideno I o bien del anillo de naftilideno II, y significa hidrógeno, alquilo, cicloalquilo, alquiloxi, cicloalquiloxi, alcoxicarbonilo, monoalquilaminocarbonilo o dialquilaminocarbonilo, alquilamino, dialquilamino, todos ellos respectivamente con hasta 20 átomos de carbono, así como ciano, amino y SO3-M+, donde M+ significa un catión metálico, como filtros fotoestables para los UV en preparaciones cosméticas y farmacéuticas para la protección de la piel humana y del cabello humano contra las irradiaciones solares, solos o junto con compuestos absorbedores en el intervalo de los UV, en sí conocidos para las preparaciones cosméticas y farmacéuticas.
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公开(公告)号:ES2200415T3
公开(公告)日:2004-03-01
申请号:ES99102204
申请日:1999-02-04
Applicant: BASF AG
Inventor: HABECK THORSTEN DR , KRAUSE ALFRED DR
IPC: C07D319/06 , A61K8/00 , A61K8/49 , A61Q1/00 , A61Q1/04 , A61Q5/00 , A61Q17/04 , C07D319/08 , C07D409/06 , A61K7/42
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公开(公告)号:DE19756778A1
公开(公告)日:1999-06-24
申请号:DE19756778
申请日:1997-12-19
Applicant: BASF AG
Inventor: HABECK THORSTEN DR , HAREMZA SYLKE DR , TRAUTH HUBERT , SCHEHLMANN VOLKER DR , WESTENFELDER HORST
IPC: A61K8/49 , A61K8/00 , A61K31/4035 , A61Q1/00 , A61Q1/04 , A61Q17/04 , C07D209/46 , C08K5/3417 , C08L101/00 , C09D7/12 , C09K3/00 , C09K15/30 , A61K31/405
Abstract: Use of isoindolinone derivatives of formula (I) as stabilizers for organic materials is new, where: R = H, COOR , COR , CONR R , CN, 1-20C alkyl, 2-10C alkenyl, 3-10C cycloalkyl, 3-10C cycloalkenyl, aryl or heteroaryl (optionally substituted); R = COOR , COR , CONR R or CN; or R +R = 7-10C bicycloalkyl or 7-10C bicycloalkenyl; R = H, 1-20C alkyl, 2-10C alkenyl, 3-10C cycloalkyl, 3-10C cycloalkenyl, 1-12C alkoxy, 1-20C alkoxycarbonyl, 1-12C alkylamino, 1-12C dialkylamino, aryl, heteroaryl (optionally substituted) or a water-solubilizing carboxylate, sulfonate or alkylammonium group; R and R = H, 1-20C alkyl, 2-10C alkenyl, 3-10C cycloalkyl, 3-10C cycloalkenyl, aryl or heteroaryl (optionally substituted). An Independent claim is included for compounds (I) as medicaments.
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公开(公告)号:DE19755649A1
公开(公告)日:1999-06-17
申请号:DE19755649
申请日:1997-12-15
Applicant: BASF AG
Inventor: HABECK THORSTEN DR , HAREMZA SYLKE DR , SCHEHLMANN VOLKER DR , WESTENFELDER HORST , WUENSCH THOMAS DR , DROEGEMUELLER MICHAEL DR , BOMM VOLKER DR
IPC: A61K8/35 , A61K8/37 , A61K8/42 , A61Q17/04 , C07C69/602 , C07C69/618 , C07C69/738 , C07C233/11 , C07C235/32 , C07C235/34 , A61K7/42 , A61K7/48 , C07C255/23
Abstract: Use of 4,4-diarylbutadienes (I) as photostable UV filters in cosmetics for protecting the skin and hair from the sun's rays. The use of 4,4-diarylbutadiene derivatives of formula (I) as a cosmetic preparation is new: Where the diene system is Z,Z; Z,E; E,Z or E,E; R1, R2 = H, 1-20C alkyl, 2-10C alkenyl, 3-10C cycloalkyl, 3-10C cycloalkenyl, 1-12C alkoxy, 1-20C alkoxycarbonyl, 1-12C alkylamino, 1-12C dialkylamino, aryl, heteroaryl (optionally substituted by carboxylate, sulfonate or ammonium residues); R3 = H, COOR5, COR5, CONR5,R6, CN, O=S(R5)=O, O=S(OR5)=O, R7OP(OR8)=O, 1-20C alkyl, 2-10C alkenyl, 3-10C cycloalkyl, 7-10C bicycloalkyl, 3-10C cycloalkenyl, 7-10C bicycloalkenyl, aryl or heteroaryl (optionally substituted); R4 = COOR6, COR6, CONR5,R6, CN, O=S(R6)=O, O=S(OR6)=O, R7OP(OR8)=O, 1-20C alkyl, 2-10C alkenyl, 3-10C cycloalkyl, 7-10C bicycloalkyl, 3-10C cycloalkenyl, 7-10C bicycloalkenyl, aryl or heteroaryl (optionally substituted); R5-R8 = H, 1-20C alkyl, 2-10C alkenyl, 3-10C cycloalkyl, 7-10C bicycloalkyl, 3-10C cycloalkenyl, 7-10C bicycloalkenyl, aryl or heteroaryl (optionally substituted); and n = 1-3; where R3-R8 may in each case together with the C atoms to which they are bonded, form a 5- or 6-membered ring which may be further fused.
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