公开(公告)号：JP2007252388A

公开(公告)日：2007-10-04

申请号：JP2007141287

申请日：2007-05-29

Applicant: Basf Ag ,  ビーエーエスエフ アクチェンゲゼルシャフトBASF Aktiengesellschaft

Inventor： POMPEJUS MARKUS ,  KROEGER BURKHARD ,  SCHROEDER HARTWIG ,  ZELDER OSKAR ,  HABERHAUER GREGOR

IPC: C12N15/09 ,  G01N33/53 ,  C07K20060101 ,  C07K14/34 ,  C12N20060101 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/00 ,  C12N9/12 ,  C12N9/18 ,  C12N9/88 ,  C12N15/31 ,  C12N15/55 ,  C12P20060101 ,  C12P13/04 ,  C12P13/06 ,  C12P13/08 ,  C12P13/10 ,  C12P13/12 ,  C12P13/14 ,  C12P21/02 ,  C12Q20060101 ,  C12Q1/68 ,  C12R1/15 ,  G01N33/566 ,  G01N33/569

CPC classification number: C12N9/88 ,  C07K14/34 ,  C12N9/16 ,  C12N9/18

Abstract: PROBLEM TO BE SOLVED: To provide SMP nucleic acid and protein molecules, which relate to metabolism of carbon compounds such as sugars and generation of energy molecules, in a process (such as oxidative phosphorylation) of Corynebacterium glutamicum. SOLUTION: Isolated nucleic acid molecules of a specific sequence, or a complement thereof, which nucleic acid molecules are selected from a sequence group relating to metabolism of carbon compounds such as sugars and generation of energy molecules, in a process of Corynebacterium glutamicum, are provided, and cells containing the nucleic acid molecules and of genus Corynebacterium or genus Brevibacterium are provided. A method for producing fine chemicals such as an amino acid by using the cells, and a method for detecting existence and activity of Corynebacterium diphtheriae is provided. COPYRIGHT: (C)2008,JPO&INPIT

Abstract translation: 要解决的问题：在谷氨酸棒杆菌的过程（如氧化磷酸化）中提供涉及碳化合物如糖的代谢和产生能量分子的SMP核酸和蛋白质分子。 解决方案：在谷氨酸棒杆菌的过程中，核酸分子选自与碳化合物的代谢例如糖和能量分子的产生有关的序列组的特异性序列或其互补物的分离的核酸分子 ，并且提供含有核酸分子和棒状杆菌属或短杆菌属的细胞。 提供了通过使用细胞产生氨基酸等精细化学品的方法，以及用于检测白喉杆菌的存在和活性的方法。 版权所有（C）2008，JPO＆INPIT

公开(公告)号：JP2007252384A

公开(公告)日：2007-10-04

申请号：JP2007123626

申请日：2007-05-08

Applicant: Basf Ag ,  ビーエーエスエフ アクチェンゲゼルシャフトBASF Aktiengesellschaft

Inventor： POMPEJUS MARKUS ,  KROEGER BURKHARD ,  SCHROEDER HARTWIG ,  ZELDER OSKAR ,  HABERHAUER GREGOR

IPC: C12N15/09 ,  G01N33/53 ,  C07H21/04 ,  C07K20060101 ,  C07K14/34 ,  C12N20060101 ,  C12N1/15 ,  C12N1/19 ,  C12N1/20 ,  C12N1/21 ,  C12N5/10 ,  C12N9/00 ,  C12N9/10 ,  C12N9/18 ,  C12N9/90 ,  C12N15/31 ,  C12N15/61 ,  C12N15/74 ,  C12P20060101 ,  C12P13/04 ,  C12P13/06 ,  C12P13/08 ,  C12P13/10 ,  C12P13/14 ,  C12P13/20 ,  C12P13/22 ,  C12P13/24 ,  C12P21/02 ,  C12P21/06 ,  C12Q20060101 ,  C12Q1/68 ,  C12R1/15 ,  G01N33/566 ,  G01N33/569

CPC classification number: C12N9/18 ,  C07K14/34 ,  C12N9/00 ,  C12N9/1096 ,  C12P13/04 ,  C12P13/06 ,  C12P13/08 ,  C12P13/10 ,  C12P13/12 ,  C12P13/14 ,  C12P13/20 ,  C12P13/24 ,  C12Y206/01005

Abstract: PROBLEM TO BE SOLVED: To provide a new bacterial nucleic acid molecule having various applications. SOLUTION: Isolated nucleic acid molecules, designated MP (melabolic pathway) nucleic acid molecules, which encode new MP proteins derived from Corynebacterium glutamicum, are described. Antisense nucleic acid molecules, recombinant expression vectors containing MP nucleic acid molecules, and host cells into which the expression vectors are introduced, are also provided. Further, isolated MP proteins, mutated MP proteins, fusion proteins, antigenic peptides and methods for improving production of a desired compound from C. glutamicum based on genetic engineering of MP genes in the organism, are provided. COPYRIGHT: (C)2008,JPO&INPIT

Abstract translation: 待解决的问题：提供具有各种应用的新的细菌核酸分子。 解决方案：描述编码来自谷氨酸棒杆菌的新MP蛋白质的分离的核酸分子，称为MP（代谢途径）核酸分子。 还提供了反义核酸分子，含有MP核酸分子的重组表达载体和其中引入表达载体的宿主细胞。 此外，提供了基于生物体中MP基因的遗传工程的分离的MP蛋白，突变的MP蛋白，融合蛋白，抗原肽和用于从谷氨酸棒球菌（C.Gyamicum）生产所需化合物的方法。 版权所有（C）2008，JPO＆INPIT

公开(公告)号：JP2007244391A

公开(公告)日：2007-09-27

申请号：JP2007121127

申请日：2007-05-01

Applicant: Basf Ag ,  ビーエーエスエフ アクチェンゲゼルシャフトBASF Aktiengesellschaft

Inventor： POMPEJUS MARKUS ,  KROEGER BURKHARD ,  SCHROEDER HARTWIG ,  ZELDER OSKAR ,  HABERHAUER GREGOR ,  LEE HEUNG-SHICK ,  KIM HYUNG-JOON

IPC: C12N15/09 ,  G01N33/53 ,  C07K20060101 ,  C07K14/34 ,  C12N20060101 ,  C12N1/12 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/00 ,  C12N9/18 ,  C12N15/31 ,  C12P20060101 ,  C12P1/04 ,  C12P13/04 ,  C12P21/02 ,  C12Q20060101 ,  C12Q1/04 ,  C12Q1/68 ,  C12R1/13 ,  C12R1/15 ,  C12R1/16 ,  G01N33/569 ,  G01N37/00

CPC classification number: C12N9/00 ,  C07K14/34 ,  C12N9/18

Abstract: PROBLEM TO BE SOLVED: To provide a stress, resistance and tolerance protein encoding Corynebacterium glutamicum gene used for the discrimination of microorganism for the production of fine chemicals, control of the production of fine chemicals by bacteria, classification or discrimination of bacteria, use as a reference point for the preparation of a genom map and as a label for genetic transformation. SOLUTION: The invention provides an isolated nucleic acid molecule or a designated SRT nucleic acid molecule encoding a new SRT protein derived from Corynebacterium glutamicum. The invention also provides its antisense nucleic acid molecule, a recombinant expression vector containing SRT nucleic acid molecule, and host cell into which the expression vector is to be introduced. The invention still further provides isolated SRT protein, mutated SRT protein, fusion protein, antigenic peptide and method for the improvement of the production of a desired compound from C. glutamicum based on genetic engineering of SRT genes of this organism. COPYRIGHT: (C)2007,JPO&INPIT

Abstract translation: 要解决的问题：提供用于鉴别用于生产精细化学品的微生物的谷氨酸棒杆菌基因的应力，抗性和耐受蛋白质编码，细菌生产精细化学物质的控制，细菌的分类或鉴别， 用作制备基因图的参考点和作为遗传转化的标签。 解决方案：本发明提供了分离的核酸分子或编码来自谷氨酸棒杆菌的新SRT蛋白的指定的SRT核酸分子。 本发明还提供了其反义核酸分子，含有SRT核酸分子的重组表达载体和其中将引入表达载体的宿主细胞。 本发明还进一步提供了基于该生物体的SRT基因的遗传工程的分离的SRT蛋白，突变的SRT蛋白，融合蛋白，抗原肽和从谷氨酸棒球菌产生所需化合物的方法。 版权所有（C）2007，JPO＆INPIT

公开(公告)号：JP2007236393A

公开(公告)日：2007-09-20

申请号：JP2007115387

申请日：2007-04-25

Applicant: Basf Ag ,  ビーエーエスエフ アクチェンゲゼルシャフトBASF Aktiengesellschaft

Inventor： POMPEJUS MARKUS ,  KROEGER BURKHARD ,  SCHROEDER HARTWIG ,  ZELDER OSKAR ,  HABERHAUER GREGOR

IPC: C12N15/09 ,  G01N33/53 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/00 ,  C12N9/10 ,  C12N9/12 ,  C12N15/31 ,  C12N15/54 ,  C12P1/04 ,  C12P13/04 ,  C12Q1/04 ,  C12Q1/48 ,  C12Q1/68 ,  C12R1/13 ,  C12R1/16 ,  G01N33/566 ,  G01N33/569

CPC classification number: C12N9/1223 ,  C12N9/12 ,  C12Y207/03009

Abstract: PROBLEM TO BE SOLVED: To provide a novel nucleic acid molecule derived from Corynebacterium glutamicum. SOLUTION: Isolated nucleic acid molecules encoding novel PTS proteins (phosphoenolpyruvate: sugar phosphotransferase) derived from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PTS nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated PTS proteins, mutated PTS proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from C. glutamicum based on genetic engineering of the PTS genes. COPYRIGHT: (C)2007,JPO&INPIT

Abstract translation: 待解决的问题：提供源自谷氨酸棒杆菌的新型核酸分子。 解决方案：描述了编码源自谷氨酸棒杆菌的新型PTS蛋白（磷酸烯醇丙酮酸：糖磷酸转移酶）的分离的核酸分子。 本发明还提供反义核酸分子，含有PTS核酸分子的重组表达载体，以及引入了表达载体的宿主细胞。 本发明还进一步提供了基于PTS基因的遗传工程的分离的PTS蛋白，突变的PTS蛋白，融合蛋白，抗原肽和用于从谷氨酸棒球菌（C.GGG）生产所需化合物的方法。 版权所有（C）2007，JPO＆INPIT

公开(公告)号：WO03040681A2

公开(公告)日：2003-05-15

申请号：PCT/EP0212141

申请日：2002-10-31

Applicant: BASF AG ,  ZELDER OSKAR ,  POMPEJUS MARKUS ,  SCHROEDER HARTWIG ,  KROEGER BURKHARD ,  KLOPPROGGE CORINNA ,  HABERHAUER GREGOR

Inventor： ZELDER OSKAR ,  POMPEJUS MARKUS ,  SCHROEDER HARTWIG ,  KROEGER BURKHARD ,  KLOPPROGGE CORINNA ,  HABERHAUER GREGOR

IPC: C12N1/21 ,  C12N15/52 ,  C12N15/77 ,  C12P13/08 ,  G01N

CPC classification number: C12N15/77 ,  C12N15/52 ,  C12P13/08

Abstract: The invention relates to novel nucleic acid molecules, the use thereof in the construction of bio-engineering improved microorganisms and methods for the production of fine chemicals, especially amino acids with the aid of said bio-engineered improved microorganisms.

Abstract translation: 本发明涉及新的核酸分子，它们的遗传改良的微生物以及用于产生精细化学品，在使用这些遗传改良的微生物的特定氨基酸的方法的结构中使用。

公开(公告)号：WO0102583A3

公开(公告)日：2001-07-26

申请号：PCT/IB0000973

申请日：2000-06-27

Applicant: BASF AG

Inventor： POMPEJUS MARKUS ,  KROEGER BURKHARD ,  SCHROEDER HARTWIG ,  ZELDER OSKAR ,  HABERHAUER GREGOR

IPC: G01N33/53 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/00 ,  C12N9/10 ,  C12N9/12 ,  C12N15/09 ,  C12N15/31 ,  C12N15/54 ,  C12P1/04 ,  C12P13/04 ,  C12Q1/04 ,  C12Q1/68 ,  C12R1/13 ,  C12R1/16 ,  G01N33/566 ,  G01N33/569 ,  C12N15/77

CPC classification number: C12N9/1223 ,  C12N9/12 ,  C12Y207/03009

Abstract: Isolated nucleic acid molecules, designated PTS nucleic acid molecules, which encode novel PTS proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PTS nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated PTS proteins, mutated PTS proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from C. glutamicum based on genetic engineering of PTS genes in this organism.

Abstract translation: 描述了编码来自谷氨酸棒杆菌的新型PTS蛋白质的分离的核酸分子，命名为PTS核酸分子。 本发明还提供反义核酸分子，含有PTS核酸分子的重组表达载体，以及引入了表达载体的宿主细胞。 本发明还进一步提供了基于该生物体中PTS基因的遗传工程的分离的PTS蛋白，突变的PTS蛋白，融合蛋白，抗原肽和用于从谷氨酸棒状病毒从谷氨酸棒球菌生产所需化合物的方法。

公开(公告)号：WO03040289A2

公开(公告)日：2003-05-15

申请号：PCT/EP0212132

申请日：2002-10-31

Applicant: BASF AG ,  ZELDER OSKAR ,  POMPEJUS MARKUS ,  SCHROEDER HARTWIG ,  KROEGER BURKHARD ,  KLOPPROGGE CORINNA ,  HABERHAUER GREGOR

Inventor： ZELDER OSKAR ,  POMPEJUS MARKUS ,  SCHROEDER HARTWIG ,  KROEGER BURKHARD ,  KLOPPROGGE CORINNA ,  HABERHAUER GREGOR

IPC: C12N1/21 ,  C12N15/52 ,  C12P13/04 ,  C12N

CPC classification number: C12P13/04 ,  C12N15/52

Abstract: The invention concerns novel nucleic acid molecules, the use of said molecules for producing by recombination genetically improved micro-organisms, and a method for preparing fine chemical products, in particular amino acids, using said genetically improved micro-organisms.

Abstract translation: 本发明涉及新的核酸分子，它们的遗传改良的微生物以及用于产生精细化学品，在使用这些遗传改良的微生物的特定氨基酸的方法的结构中使用。

公开(公告)号：WO0100844A3

公开(公告)日：2001-07-19

申请号：PCT/IB0000943

申请日：2000-06-23

Applicant: BASF AG

Inventor： POMPEJUS MARKUS ,  KROEGER BURKHARD ,  SCHROEDER HARTWIG ,  ZELDER OSKAR ,  HABERHAUER GREGOR

IPC: G01N33/53 ,  C07K20060101 ,  C07K14/34 ,  C12N20060101 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/00 ,  C12N9/12 ,  C12N9/18 ,  C12N9/88 ,  C12N15/09 ,  C12N15/31 ,  C12N15/55 ,  C12P20060101 ,  C12P13/04 ,  C12P13/08 ,  C12P21/02 ,  C12Q20060101 ,  C12Q1/68 ,  C12R1/15 ,  G01N33/566 ,  G01N33/569

CPC classification number: C12N9/88 ,  C07K14/34 ,  C12N9/16 ,  C12N9/18

Abstract: Isolated nucleic acid molecules, designated SMP nucleic acid molecules, which encode novel SMP proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing SMP nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated SMP proteins, mutated SMP proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from C. glutamicum based on genetic engineering of SMP genes in this organism.

Abstract translation: 描述了分离的核酸分子，称为SMP核酸分子，其编码来自谷氨酸棒状杆菌的新型SMP蛋白质。 本发明还提供了反义核酸分子，含有SMP核酸分子的重组表达载体以及导入了表达载体的宿主细胞。 本发明还进一步提供了分离的SMP蛋白，突变的SMP蛋白，融合蛋白，抗原肽和用于改善从C产生所需化合物的方法。 基于该生物体中SMP基因的遗传工程改造的谷氨酸棒杆菌。

公开(公告)号：WO2005058945A2

公开(公告)日：2005-06-30

申请号：PCT/EP2004014338

申请日：2004-12-16

Applicant: BASF AG ,  KLOPPROGGE CORINNA ,  ZELDER OSKAR ,  KROEGER BURKHARD ,  SCHROEDER HARTWIG ,  HAEFNER STEFAN ,  RUFFER UWE ,  GRAEF CLAUDIA ISABELLA ,  HABERHAUER GREGOR

Inventor： KLOPPROGGE CORINNA ,  ZELDER OSKAR ,  KROEGER BURKHARD ,  SCHROEDER HARTWIG ,  HAEFNER STEFAN ,  RUFFER UWE ,  GRAEF CLAUDIA ISABELLA ,  HABERHAUER GREGOR

IPC: C07K14/34 ,  C07K14/195

CPC classification number: C07K14/34

Abstract: The invention relates to mutant nucleic acids and proteins from the metabolic pathway of fine chemicals, methods for the production of genetically modified production organisms, methods for the production of fine chemicals by cultivating said genetically modified organisms, and said genetically modified organisms.

Abstract translation: 本发明涉及从精细化学品的途径突变型的核酸和蛋白质，通过培养转基因生物，以及经遗传修饰的生物体本身生产的遗传修饰的生物体的生产工艺，用于生产精细化学品的方法。

公开(公告)号：WO0100842A3

公开(公告)日：2001-08-23

申请号：PCT/IB0000911

申请日：2000-06-23

Applicant: BASF AG

Inventor： POMPEJUS MARKUS ,  KROEGER BURKHARD ,  SCHROEDER HARTWIG ,  ZELDER OSKAR ,  HABERHAUER GREGOR

IPC: C12N15/09 ,  C07K20060101 ,  C07K14/34 ,  C12N20060101 ,  C12N1/21 ,  C12N9/00 ,  C12N9/02 ,  C12N9/18 ,  C12N15/31 ,  C12N15/52 ,  C12P20060101 ,  C12P13/04 ,  C12P21/02 ,  C12Q20060101 ,  C12R1/15

CPC classification number: C07K14/34 ,  C12N9/0069 ,  C12P13/04

Abstract: Isolated nucleic acid molecules, designated HA nucleic acid molecules, which encode novel HA proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing HA nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated HA proteins, mutated HA proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from C. glutamicum based on genetic engineering of HA genes in this organism.

Abstract translation: 描述了编码来自谷氨酸棒杆菌的新型HA蛋白质的分离的核酸分子，命名为HA核酸分子。 本发明还提供反义核酸分子，含有HA核酸分子的重组表达载体，以及引入了表达载体的宿主细胞。 本发明还进一步提供了分离的HA蛋白，突变的HA蛋白，融合蛋白，抗原肽以及基于该生物体中HA基因的遗传工程改进从谷氨酸棒球菌生产所需化合物的方法。