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    12.
    发明专利
    未知

    公开(公告)号：ES2200449T3

    公开(公告)日：2004-03-01

    申请号：ES99118428

    申请日：1999-09-17

    Applicant: BASF AG

    Inventor： STUERMER RAINER ,  KLATT MARTIN JOCHEN ,  BOERMER ARMIN ,  HOLZ JENS ,  VOSS GUDRUN

    IPC: B01J31/24 ,  C07B53/00 ,  C07B61/00 ,  C07C67/297 ,  C07C67/31 ,  C07C69/67 ,  C07C69/675 ,  C07C69/732

    Abstract: Enantiomerically pure beta -hydroxyesters (I) are prepared by asymmetric hydrogenation of a beta -hydroxyester (II) over a ruthenium complex catalyst (III) containing an optically active bidentate bis-phospholane ligand. Preparation of enantiomerically pure beta -hydroxyesters (I) involves reacting a beta -hydroxyester (II) with hydrogen in presence of a ruthenium complex catalyst of formula (III): LRuX2 (III) X = halo, acetate, allyl, methallyl, 2-phenylallyl, perchlorate, trifluoroacetate, tetrafluoroborate, hexafluoroantimonate, hexafluorophosphate, hexafluoroarsenate or trichloroacetate; L = bidentate bis-phospholane ligand of formula (A) : Y = bridging group providing 1-5C between the two P atoms; R1 = H, 1-6C alkyl, aryl, alkaryl or Si(R2)3; R2 = alkyl or aryl; m = 0 and R3 = OR4; or m = 1 and R3 = H; R4 = as R1.

    Method for producing lipoic acid and dihydrolipoic acid
    14.
    发明专利
    Method for producing lipoic acid and dihydrolipoic acid 未知

    公开(公告)号：AU2957602A

    公开(公告)日：2002-06-11

    申请号：AU2957602

    申请日：2001-11-29

    Applicant: BASF AG

    Inventor： KLATT MARTIN JOCHEN ,  NIEBEL MARKUS ,  PAUST JOACHIM

    IPC: C07D339/04

    Abstract: The present invention relates to a process for the preparation of R- and S-lipoic acid and R- and S-dihydrolipoic acid comprising (a) reaction of where MS is SO 2 -R' and R and R' independently of one another are C 1 -C 6 -alkyl, C 3 -C 8 -cycloalkyl, C 3 -C 8 -cycloalkylalkyl, aryl or aralkyl, with sodium sulfide and sulfur in methanol. The invention especially relates to processes for preparing pure R- or S-dihydrolipoic acid, which is either used directly or processed further to give R- and S-lipoic acid. The process also serves for the production of pharmaceuticals. The present invention further relates to a solution of sodium sulfide trihydrate and sulfur in methanol, the sulfur being present in a molar excess over the sodium sulfide trihydrate, and a kit which comprises the solution according to the invention.

    16.
    发明专利
    未知

    公开(公告)号：DE10045059A1

    公开(公告)日：2002-03-21

    申请号：DE10045059

    申请日：2000-09-12

    Applicant: BASF AG

    Inventor： HASSELWANDER OLIVER ,  KRAEMER KLAUS ,  BALDENIUS KAI-UWE ,  KLATT MARTIN JOCHEN ,  SCHWEIKERT LONI

    IPC: A61K31/381 ,  A23L1/30 ,  A61K31/00 ,  A61K31/202 ,  A61K31/385 ,  A61P3/10 ,  A61P9/10 ,  A61P13/12 ,  A61P25/02 ,  A61P27/02 ,  A61K31/20

    Abstract: The invention relates to the use of lipoic acids, or a physiologically acceptable derivative or salt thereof, and a compound of formula (I): H3C-(CH2)n1-(CH=CH)n3-(CH2)n2-COOH - wherein n1 and n2 independently have the value of a whole number from 3 to 9, n3 has the value of a whole number from 2 to 6, and the number of carbon atoms amounts to 18, 20 or 22 - or a physiologically acceptable derivative or salt thereof, as food supplements, in functional foods and for therapeutic purposes in the treatment of diabetic disorders. The invention also relates to agents having a corresponding active ingredient combination and to agents in the form of commercial packs having corresponding combination preparations or monopreparations for combined use.

    Method for producing lipoic acid and dihydrolipoic acid
    17.
    发明专利
    Method for producing lipoic acid and dihydrolipoic acid 未知

    公开(公告)号：AU9167701A

    公开(公告)日：2002-02-13

    申请号：AU9167701

    申请日：2001-07-24

    Applicant: BASF AG

    Inventor： KLATT MARTIN JOCHEN ,  NIEBEL MARKUS ,  PAUST JOACHIM

    IPC: A61K31/20 ,  A61P3/10 ,  C07B53/00 ,  C07C303/38 ,  C07C309/66 ,  C07C319/08 ,  C07C319/18 ,  C07C319/28 ,  C07C321/04 ,  C07C323/52 ,  C07D339/04 ,  C07D339/00

    Abstract: Processes for the preparation of R-lipoic acid or S-lipoic acid comprising a process step selected from a) distillation of dihydrolipoic acid, b) reaction of or its stereoisomer, where Ms is SO 2 -R' and R and R' independently of one another is [sic] C 1 -C 6 -alkyl, C 3 -C 8 -cycloalkyl, C 3 -C 8 -cycloalkylalkyl, aryl or aralkyl, with sodium sulfide and sulfur in ethanol and reaction with a complex hydride, (c) the extraction of a protic solution of R-dihydrolipoic acid or S-dihydrolipoic acid with organic solvents at a pH from 9 to 10, or (d) the extraction of R-dihydrolipoic acid or S-dihydrolipoic acid with organic solvents from a protic solution at a pH of 4 to 5, or a combination of one or more of steps (a) to (d), and processes for the preparation of dihydrolipoic acid and the compound 1,6,8 [lacuna] octanetriol.

    19.
    发明专利
    未知

    公开(公告)号：DK1567516T3

    公开(公告)日：2006-10-09

    申请号：DK03779948

    申请日：2003-11-17

    Applicant: BASF AG

    Inventor： MAIER ULRIKE ,  KLATT MARTIN JOCHEN

    IPC: C07D339/04 ,  A61K31/385 ,  A61P5/50

    Abstract: The invention relates to a process for purifying lipoic acid, which comprises adding to a solution of lipoic acid at least 0.1 times the amount of an adsorbent, based on the mass of lipoic acid to be purified, and subsequently removing the adsorbent. It is possible in this way to provide racemic or nonracemic lipoic acid with an oligomer content below 1% by weight, for example from 0.1 to 1% by weight.

    20.
    发明专利
    未知

    公开(公告)号：DK1339705T3

    公开(公告)日：2006-10-09

    申请号：DK01990455

    申请日：2001-11-29

    Applicant: BASF AG

    Inventor： KLATT MARTIN JOCHEN ,  PAUST JOACHIM ,  NIEBEL MARKUS

    IPC: C07D339/04

    Abstract: The present invention relates to a process for the preparation of R- and S-lipoic acid and R- and S-dihydrolipoic acid comprising (a) reaction of where MS is SO 2 -R' and R and R' independently of one another are C 1 -C 6 -alkyl, C 3 -C 8 -cycloalkyl, C 3 -C 8 -cycloalkylalkyl, aryl or aralkyl, with sodium sulfide and sulfur in methanol. The invention especially relates to processes for preparing pure R- or S-dihydrolipoic acid, which is either used directly or processed further to give R- and S-lipoic acid. The process also serves for the production of pharmaceuticals. The present invention further relates to a solution of sodium sulfide trihydrate and sulfur in methanol, the sulfur being present in a molar excess over the sodium sulfide trihydrate, and a kit which comprises the solution according to the invention.

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