公开(公告)号：WO2006042728A2

公开(公告)日：2006-04-27

申请号：PCT/EP2005011147

申请日：2005-10-17

Applicant: BASF AG ,  KRAEMER KLAUS ,  HAUNERT FRANK ,  MATUSCHECK MARKUS ,  HASSELWANDER OLIVER ,  KLATT MARTIN JOCHEN

Inventor： KRAEMER KLAUS ,  HAUNERT FRANK ,  MATUSCHECK MARKUS ,  HASSELWANDER OLIVER ,  KLATT MARTIN JOCHEN

IPC: A61K31/44 ,  A61P1/18

CPC classification number: A61K31/44

Abstract: The invention relates to the use of stable ammonium a-liponate salts for the treatment of a series of disease states, in particular, diabetic disorders and disorders of diabetic origin. The salts (Lp) (A) are formed from a-liponic acid (Lp) and ammonium compounds (A) of general formula (II) or (III). Further application of the salts are related to the treatment of cardiovascular disorders, neurodegenerative disorders and diseases related to chronic kidney failure and/or dialysis treatment, retinopathies, nephropathies, proteinurias, hyperlipidaemias, hypertriglyceridaemias, hypercholesterinaemias, proliferations of smooth muscle cells in arteries, collagenoses, arthritis, fibromyalgias, kidney stones, inflammation, cancer, amyloidoses, osteoporoses, excess weight and obesity, HIV infections and AIDS, metabolic syndrome, oxidative stress and related diseases and the aging process.

Abstract translation: 本发明涉及使用aLiponsäure的稳定铵盐用于治疗多种疾病状态，包括，特别是糖尿病病症和病症包括糖尿病原点。 盐（LP）（A）是由α-硫辛酸（LP）和通式（II）或（III）形成通式的氨基化合物（A）的。 盐的其它用途是在特定心血管疾病，神经变性疾病和慢性肾功能衰竭和/或透析治疗相关的疾病的治疗; 视网膜病，肾病，蛋白尿，高脂血症，高甘油三酯血症，高胆固醇血症，动脉的平滑肌细胞，结缔组织疾病，关节炎，纤维肌痛，肾结石，炎症，癌症，淀粉样变性，骨质疏松症，肥胖和肥胖，HIV感染和AIDS的增殖; 代谢综合征; 氧化应激和相关疾病; 并通过老化过程定向。

公开(公告)号：DE10318045A1

公开(公告)日：2004-11-04

申请号：DE10318045

申请日：2003-04-17

Applicant: BASF AG

Inventor： KLATT MARTIN JOCHEN ,  HAUNERT FRANK ,  KRAEMER KLAUS

IPC: A23K1/16 ,  A23L1/30 ,  A61K8/36 ,  A61K8/49 ,  A61Q19/00 ,  C07D213/38 ,  C07D339/04 ,  C07D213/02 ,  C07D213/52 ,  A61K31/4425 ,  A61K7/00

Abstract: The invention relates to ammonium salts of alpha-liponic acid of general formula (I): (Lp) (A), formed from alpha-liponic acid (Lp) and amino compounds (A)=of general formula (II) or general formula (III). The invention also relates to a method for producing said salts, and to the use of said salts as constituents in pharmaceutical, dermatological and cosmetic agents, foodstuffs, animal feed supplements or food supplements. The invention also relates to pharmaceutical, dermatological and cosmetic agents, foodstuffs, animal feed supplements or food supplements in which the inventive salts are used.

公开(公告)号：DE102005057178A1

公开(公告)日：2007-07-19

申请号：DE102005057178

申请日：2005-11-30

Applicant: BASF AG

Inventor： KLATT MARTIN JOCHEN ,  HASSELWANDER OLIVER ,  MATUSCHEK MARKUS ,  HAUNERT FRANK

IPC: A61K31/385 ,  A61P3/00

公开(公告)号：DE102004050353A1

公开(公告)日：2006-04-20

申请号：DE102004050353

申请日：2004-10-15

Applicant: BASF AG

Inventor： KRAEMER KLAUS ,  HAUNERT FRANK ,  MATUSCHEK MARKUS ,  HASSELWANDER OLIVER ,  KLATT MARTIN JOCHEN

IPC: A61K31/385 ,  A61K31/4436 ,  A61P3/10

公开(公告)号：CA2522470A1

公开(公告)日：2004-10-28

申请号：CA2522470

申请日：2004-04-14

Applicant: BASF AG

Inventor： KRAEMER KLAUS ,  KLATT MARTIN JOCHEN ,  HAUNERT FRANK

IPC: A23K1/16 ,  A23L1/30 ,  A61K8/36 ,  A61K8/49 ,  A61Q19/00 ,  C07D213/38 ,  C07D339/04 ,  A61K31/385

Abstract: The invention relates to ammonium salts of .alpha.-liponic acid of general formula (I): (Lp) (A), formed from .alpha.-liponic acid (Lp) and amino compounds (A) of general formula (II) or general formula (III). The inventio n also relates to a method for producing said salts, and to the use of said salts as constituents in pharmaceutical, dermatological and cosmetic agents, foodstuffs, animal feed supplements or food supplements. The invention also relates to pharmaceutical, dermatological and cosmetic agents, foodstuffs, animal feed supplements or food supplements in which the inventive salts are used.