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公开(公告)号：BG106035A
公开(公告)日：2002-06-28
申请号：BG10603501
申请日：2001-10-22
Applicant: BASF AG
Inventor： LUBISCH WILFRIED , KOCK MICHAEL , HOEGER THOMAS , GRANDEL ROLANG , HOLZENKAMP UTA , SCHULT SABINE , MUELLER REINHOLD
IPC: C07D235/20 , A61K31/415 , A61K31/4184 , A61K31/422 , A61K31/427 , A61K31/437 , A61K31/4439 , A61K31/4709 , A61K31/496 , A61K31/497 , A61P3/10 , A61P9/00 , A61P13/12 , A61P19/02 , A61P25/00 , A61P25/08 , A61P25/10 , A61P25/16 , A61P25/28 , A61P29/00 , A61P31/04 , A61P35/00 , A61P43/00 , C07D235/18 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/04 , C07D409/04 , C07D413/04 , C07D413/14 , C07D417/04 , C07D471/04
Abstract: The present invention relates to novel benzimiazoles, the production thereof and the utilization as inhibitors of the enzyme poly(ADP-ribose)polymerase of PARP (EC 2.4.2.30) for producing medicaments. 22 claims
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公开(公告)号：PL347885A1
公开(公告)日：2002-04-22
申请号：PL34788500
申请日：2000-09-15
Applicant: BASF AG
Inventor： LUBISCH WILFRIED , KOCK MICHAEL , HOEGER THOMAS , SCHULT SABINE , GRANDEL ROLAND , MUELLER REINHOLD
IPC: A61K31/55 , A61P3/10 , A61P9/10 , A61P11/00 , A61P13/12 , A61P19/02 , A61P25/00 , A61P25/08 , A61P25/10 , A61P25/14 , A61P25/16 , A61P25/28 , A61P29/00 , A61P35/00 , C07D487/06
Abstract: The invention relates to compounds of formula (I) as well as to the tautomeric forms thereof, possible enantiomeric and diastereomeric forms and the prodrugs thereof, the production and use thereof, whereby the values have the meaning as given in the description.
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公开(公告)号：NO20015362A
公开(公告)日：2001-11-02
申请号：NO20015362
申请日：2001-11-02
Applicant: BASF AG
Inventor： LUBISCH WILFRIED , KOCK MICHAEL , HOEGER THOMAS , GRANDEL ROLAND , HOLZENKAMP UTA , SCHULT SABINE , MUELLER REINHOLD
IPC: C07D235/20 , A61K31/415 , A61K31/4184 , A61K31/422 , A61K31/427 , A61K31/437 , A61K31/4439 , A61K31/4709 , A61K31/496 , A61K31/497 , A61P3/10 , A61P9/00 , A61P13/12 , A61P19/02 , A61P25/00 , A61P25/08 , A61P25/10 , A61P25/16 , A61P25/28 , A61P29/00 , A61P31/04 , A61P35/00 , A61P43/00 , C07D235/18 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/04 , C07D409/04 , C07D413/04 , C07D413/14 , C07D417/04 , C07D471/04
CPC classification number: C07D401/04 , C07D235/18 , C07D403/04
Abstract: The present invention relates to novel benzimidazoles, their preparation and their use as inhibitors of the enzyme poly(ADP-ribose) polymerase or PARP (EC 2.4.2.30) for producing drugs.
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公开(公告)号：NO20012570L
公开(公告)日：2001-07-13
申请号：NO20012570
申请日：2001-05-25
Applicant: BASF AG
Inventor： LUBISCH WILFRED , KOCK MICHAEL , HOEGER THOMAS , SCHULT SABINE , GRANDEL ROLAND , MUELLER REINHOLD
IPC: A61K20060101 , A61K31/4184 , A61K31/454 , A61K31/496 , A61P20060101 , A61P3/12 , A61P9/00 , A61P9/10 , A61P13/12 , A61P17/02 , A61P25/00 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/28 , A61P29/00 , A61P31/04 , A61P35/00 , A61P43/00 , C07D20060101 , C07D235/30 , C07D401/04 , C07D401/14 , C07D403/04
Abstract: Compounds of the formula Ia or IB where A is a saturated or monounsaturated heterocyclic, 4 - to 8-membered ring which contains one or two nitrogen atoms, and their tautomeric forms, possible enantiomeric and diastereomeric forms, their prodrugs and possible physiologically tolerated salts are useful as inhibitors of the enzyme poly(ADP-ribose)polymerase.
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公开(公告)号：HRP20010484B1
公开(公告)日：2010-08-31
申请号：HRP20010484
申请日：2001-06-26
Applicant: BASF AG
Inventor： LUBISCH WILFRIED , KOCK MICHAEL , HOEGER THOMAS , SCHULT SABINE , GRANDEL ROLAND , MUELLER REINHOLD
IPC: C07D235/30 , A61K20060101 , A61K31/4184 , A61K31/454 , A61K31/496 , A61P20060101 , A61P3/12 , A61P9/00 , A61P9/10 , A61P13/12 , A61P17/02 , A61P25/00 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/28 , A61P29/00 , A61P31/04 , A61P35/00 , A61P43/00 , C07D20060101 , C07D401/04 , C07D401/14 , C07D403/04
Abstract: Compounds of the formula Ia or IB where A is a saturated or monounsaturated heterocyclic, 4 - to 8-membered ring which contains one or two nitrogen atoms, and their tautomeric forms, possible enantiomeric and diastereomeric forms, their prodrugs and possible physiologically tolerated salts are useful as inhibitors of the enzyme poly(ADP-ribose)polymerase.
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Patent Agency Ranking
公开(公告)号：BG65513B1
公开(公告)日：2008-10-31
申请号：BG10599301
申请日：2001-10-09
Applicant: BASF AG
Inventor： LUBISCH WILFRIED , KOCK MICHAEL , HOEGER THOMAS , GRANDEL ROLAND , SCHULT SABINE , MUELLER REINHOLD
IPC: C07D235/08 , A61K31/4184 , A61K31/4427 , A61K31/4523 , A61K31/496 , A61K31/551 , A61P3/10 , A61P9/00 , A61P9/10 , A61P13/12 , A61P19/02 , A61P25/00 , A61P25/08 , A61P25/16 , A61P25/28 , A61P29/00 , A61P31/04 , A61P35/00 , A61P35/04 , A61P43/00 , C07D235/10 , C07D235/12 , C07D235/14 , C07D235/16 , C07D401/08 , C07D403/08
Abstract: The invention relates to a compound of formula or wherein A represents a saturated or mono-unsaturated carbocycle containing 3 to 8 carbon atoms which can also have a condensed benzol ring, whereby the rings can also be substituted with one or two different or identical radical; R1 represents hydrogen, chlorine, fluorine, bromine, iodine, branched and unbranched C1-C6-alkyl, OH, nitro, CF3, CN, NR11R12, NH-CO-R13, O-C1-C4 alkyl; and R2 represents hydrogen, branched and unbranched C1-C6 alkyl, C1-C4 alkyl-phenyl. The invention also relates to the tautomeric forms, possible enantiomeric and diasteometric forms, possible cis-trans isomers on the rings in A and their prodrugs. The submitted benzimidazoles are inhibitors of poly(ADP-ribose)polymerase (PARP), or poly(ADP-ribose)synthase (PARS), as it is also known and can be used for the treatment or prophylaxis of diseases which are associated with the increased enzyme activity of this enzyme.
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公开(公告)号：ZA200108204B
公开(公告)日：2004-05-26
申请号：ZA200108204
申请日：2001-10-05
Applicant: BASF AG
Inventor： LUBISCH WILFRIED , KOCK MICHAEL , HOEGER THOMAS , GRANDEL ROLAND , SCHULT SABINE , MUELLER REINHOLD
IPC: C07D235/08 , A61K31/4184 , A61K31/4427 , A61K31/4523 , A61K31/496 , A61K31/551 , A61P3/10 , A61P9/00 , A61P9/10 , A61P13/12 , A61P19/02 , A61P25/00 , A61P25/08 , A61P25/16 , A61P25/28 , A61P29/00 , A61P31/04 , A61P35/00 , A61P35/04 , A61P43/00 , C07D235/10 , C07D235/12 , C07D235/14 , C07D235/16 , C07D401/08 , C07D403/08 , C07D , A61K , A61P
Abstract: Compounds of the formula I or IIand their tautomeric forms, possible enantiomeric and diastereomeric forms, possible cistrans isomers on the rings in A and prodrugs thereof, pharmaceutical compositions containing these compounds and methods of treating neurodegenerative diseases or neuronal damage with these compounds.
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公开(公告)号：UA61158C2
公开(公告)日：2003-11-17
申请号：UA01064494
申请日：1999-11-23
Applicant: BASF AG
Inventor： LUBISCH WILFRIED , GRANDEL ROLAND , MUELLER REINHOLD
IPC: A61K20060101 , A61K31/4184 , A61K31/454 , A61K31/496 , A61P20060101 , A61P3/12 , A61P9/00 , A61P9/10 , A61P13/12 , A61P17/02 , A61P25/00 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/28 , A61P29/00 , A61P31/04 , A61P35/00 , A61P43/00 , C07D20060101 , C07D235/30 , C07D401/04 , C07D401/14 , C07D403/04
Abstract: Винахідвідноситьсядосполукзагальноїформули (1а) чи (1б), де R1 і R4 означаютьатомводнючивизначенізамісники, Аозначаєнасиченийчиоднократноненасиченийвідчотирьох- довосьмичленногогетероцикл, щоміститьодинчидваатомиазоту, причомудодатковощеможевключатиатомкиснючисірки, що, далі, можебутизаміщений, атакождоїхніхтаутомернихформ, можливихенантіомернихі діастереомернихформ, їхпроліків, атакождоможливихфізіологічноприйнятнихсолей. Винахідтакожвідноситьсядозастосуванняцихсполукдлялікуваннязахворювань, приякихвиникаєпатологічнопідвищенаактивністьполі(аденозиндифосфатрибоза)полімерази. (1a) (1б)
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公开(公告)号：PL351558A1
公开(公告)日：2003-05-05
申请号：PL35155800
申请日：2000-04-27
Applicant: BASF AG
Inventor： LUBISCH WILFRIED , KOCK MICHAEL , HOEGER THOMAS , GRANDEL ROLAND , HOLZENKAMP UTA , SCHULT SABINE , MUELLER REINHOLD
IPC: A61K31/415 , A61K31/4184 , A61K31/422 , A61K31/427 , A61K31/437 , A61K31/4439 , A61K31/4709 , A61K31/496 , C07D235/20 , A61K31/497 , A61P3/10 , A61P9/00 , A61P13/12 , A61P19/02 , A61P25/00 , A61P25/08 , A61P25/10 , A61P25/16 , A61P25/28 , A61P29/00 , A61P31/04 , A61P35/00 , A61P43/00 , C07D235/18 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/04 , C07D409/04 , C07D413/04 , C07D413/14 , C07D417/04 , C07D471/04 , A61K31/4164
Abstract: The present invention relates to novel benzimidazoles, their preparation and their use as inhibitors of the enzyme poly(ADP-ribose) polymerase or PARP (EC 2.4.2.30) for producing drugs.
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公开(公告)号：PL351557A1
公开(公告)日：2003-05-05
申请号：PL35155700
申请日：2000-04-11
Applicant: BASF AG
Inventor： LUBISCH WILFRIED , KOCK MICHAEL , HOEGER THOMAS , GRANDEL ROLAND , SCHULT SABINE , MUELLER REINHOLD
IPC: C07D235/08 , A61K31/4184 , A61K31/4427 , A61K31/4523 , A61K31/496 , A61K31/551 , A61P3/10 , A61P9/00 , A61P9/10 , A61P13/12 , A61P19/02 , A61P25/00 , A61P25/08 , A61P25/16 , A61P25/28 , A61P29/00 , A61P31/04 , A61P35/00 , A61P35/04 , A61P43/00 , C07D235/10 , C07D235/12 , C07D235/14 , C07D235/16 , C07D401/08 , C07D403/08 , C07D235/06 , A61K31/4164
Abstract: Compounds of the formula I or IIand their tautomeric forms, possible enantiomeric and diastereomeric forms, possible cistrans isomers on the rings in A and prodrugs thereof, pharmaceutical compositions containing these compounds and methods of treating neurodegenerative diseases or neuronal damage with these compounds.
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