公开(公告)号：NO20012570D0

公开(公告)日：2001-05-25

申请号：NO20012570

申请日：2001-05-25

Applicant: BASF AG

Inventor： LUBISCH WILFRED ,  KOCK MICHAEL ,  HOEGER THOMAS ,  SCHULT SABINE ,  GRANDEL ROLAND ,  MUELLER REINHOLD

IPC: A61K20060101 ,  A61K31/4184 ,  A61K31/454 ,  A61K31/496 ,  A61P20060101 ,  A61P3/12 ,  A61P9/00 ,  A61P9/10 ,  A61P13/12 ,  A61P17/02 ,  A61P25/00 ,  A61P25/08 ,  A61P25/14 ,  A61P25/16 ,  A61P25/28 ,  A61P29/00 ,  A61P31/04 ,  A61P35/00 ,  A61P43/00 ,  C07D20060101 ,  C07D235/30 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D

Abstract: Compounds of the formula Ia or IB where A is a saturated or monounsaturated heterocyclic, 4 - to 8-membered ring which contains one or two nitrogen atoms, and their tautomeric forms, possible enantiomeric and diastereomeric forms, their prodrugs and possible physiologically tolerated salts are useful as inhibitors of the enzyme poly(ADP-ribose)polymerase.

公开(公告)号：NO20012567L

公开(公告)日：2001-06-25

申请号：NO20012567

申请日：2001-05-25

Applicant: BASF AG

Inventor： LUBISCH WILFRED ,  KOCK MICHAEL ,  HOEGER THOMAS ,  SCHULT SABINE ,  GRANDEL ROLAND ,  MUELLER REINHOLD

IPC: A61K31/55 ,  A61P3/10 ,  A61P9/10 ,  A61P11/00 ,  A61P13/12 ,  A61P19/02 ,  A61P25/00 ,  A61P25/08 ,  A61P25/10 ,  A61P25/14 ,  A61P25/16 ,  A61P25/28 ,  A61P29/00 ,  A61P35/00 ,  C07D487/06

Abstract: The invention relates to compounds of formula (I) as well as to the tautomeric forms thereof, possible enantiomeric and diastereomeric forms and the prodrugs thereof, the production and use thereof, whereby the values have the meaning as given in the description.

公开(公告)号：NO20012570A

公开(公告)日：2001-07-13

申请号：NO20012570

申请日：2001-05-25

Applicant: BASF AG

Inventor： LUBISCH WILFRED ,  KOCK MICHAEL ,  HOEGER THOMAS ,  SCHULT SABINE ,  GRANDEL ROLAND ,  MUELLER REINHOLD

IPC: A61K20060101 ,  A61K31/4184 ,  A61K31/454 ,  A61K31/496 ,  A61P20060101 ,  A61P3/12 ,  A61P9/00 ,  A61P9/10 ,  A61P13/12 ,  A61P17/02 ,  A61P25/00 ,  A61P25/08 ,  A61P25/14 ,  A61P25/16 ,  A61P25/28 ,  A61P29/00 ,  A61P31/04 ,  A61P35/00 ,  A61P43/00 ,  C07D20060101 ,  C07D235/30 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04

CPC classification number: C07D401/04 ,  C07D235/30 ,  C07D401/14 ,  C07D403/04

公开(公告)号：NO20012567D0

公开(公告)日：2001-05-25

申请号：NO20012567

申请日：2001-05-25

Applicant: BASF AG

Inventor： LUBISCH WILFRED ,  KOCK MICHAEL ,  HOEGER THOMAS ,  SCHULT SABINE ,  GRANDEL ROLAND ,  MUELLER REINHOLD

IPC: A61K31/55 ,  A61P3/10 ,  A61P9/10 ,  A61P11/00 ,  A61P13/12 ,  A61P19/02 ,  A61P25/00 ,  A61P25/08 ,  A61P25/10 ,  A61P25/14 ,  A61P25/16 ,  A61P25/28 ,  A61P29/00 ,  A61P35/00 ,  C07D487/06 ,  C07D

Abstract: The invention relates to compounds of formula (I) as well as to the tautomeric forms thereof, possible enantiomeric and diastereomeric forms and the prodrugs thereof, the production and use thereof, whereby the values have the meaning as given in the description.

公开(公告)号：AU660799B2

公开(公告)日：1995-07-06

申请号：AU3988793

申请日：1993-05-28

Applicant: BASF AG

Inventor： LUBISCH WILFRED ,  BEHL BERTHOLD ,  HOFMANN HANS PETER

IPC: A61K31/495 ,  A61K31/498 ,  A61P25/00 ,  A61P25/08 ,  A61P25/20 ,  A61P25/22 ,  A61P25/24 ,  A61P25/26 ,  C07D241/44 ,  C07D241/52 ,  C07D401/04 ,  C07D403/04 ,  C07D487/12 ,  C07D487/14 ,  C07D403/10

Abstract: Quinoxaline-2,3-(1H,4H)diones of the general formula I in which the variables have the following meaning: R is hydrogen; an aliphatic radical having up to 12 C atoms, which can carry one of the following substituents: phenyl, cyclopentyl, cyclohexyl or a group -CO-R , -CO-O-R or -CO-NH-R , where R denotes hydrogen, C1-C4-alkyl, phenyl, benzyl or 1-phenylethyl; a cycloaliphatic radical having up to 12 C atoms, or a phenyl group, where the cyclic groups contained in R can carry up to three of the following substituents: C1-C4-alkyl, C1-C4-haloalkyl, C1-C4-alkoxy, C1-C4-haloalkoxy, halogen, nitro, cyano, -CO-O-R and -CO-NH-R ; R is a pyrrol-1-yl group which can carry up to two of the following substituents: C1-C4-alkyl, phenyl, phenylsulphonyl, nitro, cyano and one of the groups -CO-O-R , -CO-NH-R , -CH2-O-R , -O-R and -CH=NO-R ; R is identical or different radicals from the following: C1-C4-alkyl, C1-C4-alkoxy, trifluoromethyl, trichloromethyl, trifluoromethoxy, trichloromethoxy, fluorine, chlorine, bromine, iodine, nitro, cyano and one of the groups -CO-O-R and -CO-NH-R and a fused benzene ring; n is 0 to 3. Quinoxaline-2,3-(1H,4H)diones I' in which R has the meaning mentioned. The compounds I and I' are suitable as medicines for human and veterinary medicine.

公开(公告)号：NO20012570L

公开(公告)日：2001-07-13

申请号：NO20012570

申请日：2001-05-25

Applicant: BASF AG

Inventor： LUBISCH WILFRED ,  KOCK MICHAEL ,  HOEGER THOMAS ,  SCHULT SABINE ,  GRANDEL ROLAND ,  MUELLER REINHOLD

IPC: A61K20060101 ,  A61K31/4184 ,  A61K31/454 ,  A61K31/496 ,  A61P20060101 ,  A61P3/12 ,  A61P9/00 ,  A61P9/10 ,  A61P13/12 ,  A61P17/02 ,  A61P25/00 ,  A61P25/08 ,  A61P25/14 ,  A61P25/16 ,  A61P25/28 ,  A61P29/00 ,  A61P31/04 ,  A61P35/00 ,  A61P43/00 ,  C07D20060101 ,  C07D235/30 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04

Abstract: Compounds of the formula Ia or IB where A is a saturated or monounsaturated heterocyclic, 4 - to 8-membered ring which contains one or two nitrogen atoms, and their tautomeric forms, possible enantiomeric and diastereomeric forms, their prodrugs and possible physiologically tolerated salts are useful as inhibitors of the enzyme poly(ADP-ribose)polymerase.

公开(公告)号：MX9303153A

公开(公告)日：1994-04-29

申请号：MX9303153

申请日：1993-05-27

Applicant: BASF AG

Inventor： LUBISCH WILFRED ,  BEHL BERTHOLD ,  HOFMANN HANS PETER

IPC: A61K31/495 ,  A61K31/498 ,  A61P25/00 ,  A61P25/08 ,  A61P25/20 ,  A61P25/22 ,  A61P25/24 ,  A61P25/26 ,  C07D241/44 ,  C07D241/52 ,  C07D401/04 ,  C07D403/04 ,  C07D487/12 ,  C07D487/14

Abstract: Quinoxaline-2,3-(1H,4H)diones of the general formula I in which the variables have the following meaning: R is hydrogen; an aliphatic radical having up to 12 C atoms, which can carry one of the following substituents: phenyl, cyclopentyl, cyclohexyl or a group -CO-R , -CO-O-R or -CO-NH-R , where R denotes hydrogen, C1-C4-alkyl, phenyl, benzyl or 1-phenylethyl; a cycloaliphatic radical having up to 12 C atoms, or a phenyl group, where the cyclic groups contained in R can carry up to three of the following substituents: C1-C4-alkyl, C1-C4-haloalkyl, C1-C4-alkoxy, C1-C4-haloalkoxy, halogen, nitro, cyano, -CO-O-R and -CO-NH-R ; R is a pyrrol-1-yl group which can carry up to two of the following substituents: C1-C4-alkyl, phenyl, phenylsulphonyl, nitro, cyano and one of the groups -CO-O-R , -CO-NH-R , -CH2-O-R , -O-R and -CH=NO-R ; R is identical or different radicals from the following: C1-C4-alkyl, C1-C4-alkoxy, trifluoromethyl, trichloromethyl, trifluoromethoxy, trichloromethoxy, fluorine, chlorine, bromine, iodine, nitro, cyano and one of the groups -CO-O-R and -CO-NH-R and a fused benzene ring; n is 0 to 3. Quinoxaline-2,3-(1H,4H)diones I' in which R has the meaning mentioned. The compounds I and I' are suitable as medicines for human and veterinary medicine.

公开(公告)号：NZ503604A

公开(公告)日：2002-03-01

申请号：NZ50360498

申请日：1998-10-05

Applicant: BASF AG

Inventor： BACH ALFRED ,  EMLING FRANZ ,  GARCIA-LADONA XAVIER ,  TESCHENDORF HANS-JURGEN ,  WICKE KARSTEN ,  LUBISCH WILFRED ,  DULLWEBER UTA ,  STARCK DOROTHEA ,  STEINER GERD

IPC: A61K31/428 ,  A61P25/24 ,  A61P43/00 ,  C07D275/06 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12 ,  C07D417/14 ,  A61K31/425

Abstract: 2-Substituted 1,2-benzisothiazole derivatives of formula (I) and their enantiomers, diastereomers, tautomers and acid salts are disclosed. R1 and R2 are independently C1-6 alkyl; R3 and R4 are independently H, C1-6 alkyl, OH, C1-6 alkoxy, F, Cl, Br, I, CF3, NR5R6, CO2R7, NO2, CN, pyrrolo, or phenyl-(C1-4 alkyl), which may itself be ring-substituted by F, Cl, Br, I, C1-4 alkyl, C1-4 alkoxy, CF3, OH, NH2, CN or NO2; R5 and R6 are independently H, C1-6 alkyl, benzoyl, CO2-tert.-butyl, (C1-4 alkyl)carbonyl or together form a 5- or 6-membered ring, which may contain a second N atom (e.g. piperazinyl); R7 is H or C1-6 alkyl; A is C1-10 alkylene or C2-10 alkylene containing one or more Z groups; Z is O, S, NR7, cyclopropyl, CHOH, or a double or triple bond; B is 4-piperidine, 4-(1,2,3,6-tetrahydropyridine), 4-piperazine or one of these rings N-bound to A via a methylene group; Ar is phenyl (optionally substituted by C1-6 alkyl, C1-6 alkoxy, OH, F, Cl, Br, I, CF3, NR5R6, CO2R7, CN or phenyl), tetralinyl, indanyl, other condensed aromatic moieties e.g. naphthalinyl (optionally substituted by C1-4 alkyl or C1-4 alkoxy), anthracenyl, or a 5- or 6-membered aromatic heterocycle with 1 or 2 O or N heteroatoms, which can be fused with other aromatic groups.

公开(公告)号：NO20012567A

公开(公告)日：2001-06-25

申请号：NO20012567

申请日：2001-05-25

Applicant: BASF AG

Inventor： LUBISCH WILFRED ,  KOCK MICHAEL ,  HOEGER THOMAS ,  SCHULT SABINE ,  GRANDEL ROLAND ,  MUELLER REINHOLD

IPC: A61K31/55 ,  A61P3/10 ,  A61P9/10 ,  A61P11/00 ,  A61P13/12 ,  A61P19/02 ,  A61P25/00 ,  A61P25/08 ,  A61P25/10 ,  A61P25/14 ,  A61P25/16 ,  A61P25/28 ,  A61P29/00 ,  A61P35/00 ,  C07D487/06

CPC classification number: C07D487/06

公开(公告)号：AU3988793A

公开(公告)日：1993-12-02

申请号：AU3988793

申请日：1993-05-28

Applicant: BASF AG

Inventor： LUBISCH WILFRED ,  BEHL BERTHOLD ,  HOFMANN HANS PETER

IPC: A61K31/495 ,  A61K31/498 ,  A61P25/00 ,  A61P25/08 ,  A61P25/20 ,  A61P25/22 ,  A61P25/24 ,  A61P25/26 ,  C07D241/44 ,  C07D241/52 ,  C07D401/04 ,  C07D403/04 ,  C07D487/12 ,  C07D487/14 ,  C07D403/10

Abstract: Quinoxaline-2,3-(1H,4H)diones of the general formula I in which the variables have the following meaning: R is hydrogen; an aliphatic radical having up to 12 C atoms, which can carry one of the following substituents: phenyl, cyclopentyl, cyclohexyl or a group -CO-R , -CO-O-R or -CO-NH-R , where R denotes hydrogen, C1-C4-alkyl, phenyl, benzyl or 1-phenylethyl; a cycloaliphatic radical having up to 12 C atoms, or a phenyl group, where the cyclic groups contained in R can carry up to three of the following substituents: C1-C4-alkyl, C1-C4-haloalkyl, C1-C4-alkoxy, C1-C4-haloalkoxy, halogen, nitro, cyano, -CO-O-R and -CO-NH-R ; R is a pyrrol-1-yl group which can carry up to two of the following substituents: C1-C4-alkyl, phenyl, phenylsulphonyl, nitro, cyano and one of the groups -CO-O-R , -CO-NH-R , -CH2-O-R , -O-R and -CH=NO-R ; R is identical or different radicals from the following: C1-C4-alkyl, C1-C4-alkoxy, trifluoromethyl, trichloromethyl, trifluoromethoxy, trichloromethoxy, fluorine, chlorine, bromine, iodine, nitro, cyano and one of the groups -CO-O-R and -CO-NH-R and a fused benzene ring; n is 0 to 3. Quinoxaline-2,3-(1H,4H)diones I' in which R has the meaning mentioned. The compounds I and I' are suitable as medicines for human and veterinary medicine.