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公开(公告)号：NZ310443A
公开(公告)日：1999-10-28
申请号：NZ31044396
申请日：1996-06-03
Applicant: BASF AG
Inventor： HAUPT ANDREAS , EMLING FRANZ , ROMERDAHL CYNTHIA A
Abstract: Novel compounds of the formulaR1R2N-CHX-CO-A-B-D-(E)s-(F)t-(G)U-KIin which R1, R2, A, B, D, E, F, G, K, X, s, t, and u have the meanings stated in the description, and the preparation thereof are described. The novel substances have an antineoplastic effect.
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公开(公告)号：HU9801817A2
公开(公告)日：1998-11-30
申请号：HU9801817
申请日：1996-06-03
Applicant: BASF AG
Inventor： EMLING FRANZ , HAUPT ANDREAS , ROMERDAHL CYNTHIA A
Abstract: Novel compounds of the formulaR1R2N-CHX-CO-A-B-D-(E)s-(F)t-(G)U-KIin which R1, R2, A, B, D, E, F, G, K, X, s, t, and u have the meanings stated in the description, and the preparation thereof are described. The novel substances have an antineoplastic effect.
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公开(公告)号：SK165397A3
公开(公告)日：1998-10-07
申请号：SK165397
申请日：1996-06-03
Applicant: BASF AG
Inventor： HAUPT ANDREAS , EMLING FRANZ , ROMERDAHL CYNTHIA A
Abstract: Peptides of general formula (I), R1R2N - CHX - A - B - D - E - (F)t-K (I), wherein R1 is methyl, ethyl, isopropyl, R2 is hydrogen, methyl or ethyl, R1-N-R2 together pyrrolidine ring, A residues of Valyl, Ile, Leu, 2-terc-butylglycyl, 2-ethylglycyl, norleucyl or norvalyl, B residues of N-methyl-valyl, N-methylleucyl, N-methylisoleucyl, N-methylnorleucyl, N-methyl-2-terc-butylglycyl, N-methyl-3-terc-butylalanyl or N-methyl-2-ethylglycyl, D residues of 3,4-dehydroprolyl, 4-fluoroprolyl, 4,4-difluoroprolyl, azetidine-2-carbonyl, 3-methylprolyl, 4-methylprolyl or 5-methylprolyl, E residues of Pro, homoprolyl, hydroxyprolyl or thiazolidine-4-carbonyl, F residues of Val, 2-tec-butylglycyl, Ile, Leu, 2-cyclohexylglycyl, norleucyl, norvalyl, neopentylglycyl, Ala, Beta-Ala or amino isobutyroyl, X is alkyl, cyclopropyl or cyclopentyl, t is 0 or 1, K is alkoxy group, benzyloxy group, substituted or unsubstituted amino group or their salts with physiologically suitable acids, pharmaceutical preparation containing them and their use in medicine, particularly in treatment of oncological diseases and mammals tumours.
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公开(公告)号：BG102125A
公开(公告)日：1998-09-30
申请号：BG10212597
申请日：1997-12-18
Applicant: BASF AG
Inventor： HAUPT ANDREAS , EMLING FRANZ , ROMERDAHL CYNTHIA A
Abstract: The dolastine derivatives have antineoplastic effect. Theyhave the formulaR1R2N-CHX-A-B-D-E-(F)t-K1 2where R1, R2, A, B, D, E, F, K, X and t have the meanings listedin the description. The invention also relates to the preparationof these compounds.5 claims
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公开(公告)号：TR9701545T1
公开(公告)日：1998-04-21
申请号：TR9701545
申请日：1996-06-03
Applicant: BASF AG
Inventor： HAUPT ANDREAS , EMLING FRANZ , ROMERDAHL CYNTHIA A
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Patent Agency Ranking
公开(公告)号：MX9709147A
公开(公告)日：1998-03-31
申请号：MX9709147
申请日：1996-06-03
Applicant: BASF AG
Inventor： HAUPT ANDREAS , EMLING FRANZ , ROMERDAHL CYNTHIA A
Abstract: La presente invencion se refiere a los compuestos novedosos de la formula: R1R2N-CHX-CO-A-B-D-E-(F)t-K, en donde R1, R2, A, B, D, E, F, K, X, y t tienen los significados mencionados en la descripcion y se describe la preparacion de éstos. Las sustancias novedosas tienen efecto antineoplástico.
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公开(公告)号：CA2219818A1
公开(公告)日：1996-12-19
申请号：CA2219818
申请日：1996-06-03
Applicant: BASF AG
Inventor： HAUPT ANDREAS , ROMERDAHL CYNTHIA A , EMLING FRANZ
Abstract: Novel dolastatin derivatives of the formula (I): R1R2N-CHX-CO-A-B-D-E-(F)t-K in which R1, R2, A, B, D, E, F, K, X and t have the meanings stated in the description, and the preparation thereof are described. The novel substances have an antineoplastic effect.
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公开(公告)号：ID24283A
公开(公告)日：2000-07-13
申请号：ID991021
申请日：1998-03-09
Applicant: BASF AG
Inventor： ROMERDAHL CYNTHIA A
IPC: C07D251/30 , A61K31/505 , A61K31/506 , A61K31/517 , A61K31/519 , A61K31/53 , A61P35/00 , C07D239/60 , C07D405/12 , C07D409/12
Abstract: This invention provides a method for treating cancer in an individual, wherein the cancer is a tumor in which endothelin is upregulated (e.g. tumors of the prostate, lung, liver, breast, brain, stomach, colon, endometrium, testicle, thyroid, pituatary, bladder, kidney, pancreas and meninges) by administering to the individual an effective amount of a compound of Formula I or Formula Ia, as describe herein.
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19.发明专利
公开(公告)号：CZ9903241A3
公开(公告)日：2000-07-12
申请号：CZ324199
申请日：1998-03-09
Applicant: BASF AG
Inventor： ROMERDAHL CYNTHIA A
IPC: A61K31/42 , A61K31/425 , A61K31/495 , A61K31/505 , A61K31/53 , A61K31/535 , A61K31/54 , A61P35/00
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公开(公告)号：BR9609424A
公开(公告)日：2000-03-28
申请号：BR9609424
申请日：1996-06-03
Applicant: BASF AG
Inventor： HAUPT ANDREAS , EMLING FRANZ , ROMERDAHL CYNTHIA A
Abstract: Novel compounds of the formulaR1R2N-CHX-CO-A-B-D-(E)s-(F)t-(G)U-KIin which R1, R2, A, B, D, E, F, G, K, X, s, t, and u have the meanings stated in the description, and the preparation thereof are described. The novel substances have an antineoplastic effect.
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