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11.发明专利Stress, resistance and tolerance protein encoding corynebacterium glutamicum gene 审中-公开抗性，耐药性和耐受性蛋白质编码罗非鱼谷蛋白基因
公开(公告)号：JP2007244391A
公开(公告)日：2007-09-27
申请号：JP2007121127
申请日：2007-05-01
Applicant: Basf Ag , ビーエーエスエフ アクチェンゲゼルシャフトBASF Aktiengesellschaft
Inventor： POMPEJUS MARKUS , KROEGER BURKHARD , SCHROEDER HARTWIG , ZELDER OSKAR , HABERHAUER GREGOR , LEE HEUNG-SHICK , KIM HYUNG-JOON
IPC: C12N15/09 , G01N33/53 , C07K20060101 , C07K14/34 , C12N20060101 , C12N1/12 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/00 , C12N9/18 , C12N15/31 , C12P20060101 , C12P1/04 , C12P13/04 , C12P21/02 , C12Q20060101 , C12Q1/04 , C12Q1/68 , C12R1/13 , C12R1/15 , C12R1/16 , G01N33/569 , G01N37/00
Abstract: PROBLEM TO BE SOLVED: To provide a stress, resistance and tolerance protein encoding Corynebacterium glutamicum gene used for the discrimination of microorganism for the production of fine chemicals, control of the production of fine chemicals by bacteria, classification or discrimination of bacteria, use as a reference point for the preparation of a genom map and as a label for genetic transformation. SOLUTION: The invention provides an isolated nucleic acid molecule or a designated SRT nucleic acid molecule encoding a new SRT protein derived from Corynebacterium glutamicum. The invention also provides its antisense nucleic acid molecule, a recombinant expression vector containing SRT nucleic acid molecule, and host cell into which the expression vector is to be introduced. The invention still further provides isolated SRT protein, mutated SRT protein, fusion protein, antigenic peptide and method for the improvement of the production of a desired compound from C. glutamicum based on genetic engineering of SRT genes of this organism. COPYRIGHT: (C)2007,JPO&INPIT
Abstract translation: 要解决的问题：提供用于鉴别用于生产精细化学品的微生物的谷氨酸棒杆菌基因的应力，抗性和耐受蛋白质编码，细菌生产精细化学物质的控制，细菌的分类或鉴别， 用作制备基因图的参考点和作为遗传转化的标签。 解决方案：本发明提供了分离的核酸分子或编码来自谷氨酸棒杆菌的新SRT蛋白的指定的SRT核酸分子。 本发明还提供了其反义核酸分子，含有SRT核酸分子的重组表达载体和其中将引入表达载体的宿主细胞。 本发明还进一步提供了基于该生物体的SRT基因的遗传工程的分离的SRT蛋白，突变的SRT蛋白，融合蛋白，抗原肽和从谷氨酸棒球菌产生所需化合物的方法。 版权所有（C）2007，JPO＆INPIT
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12.发明专利Corynebacterium glutamicum genes encoding phosphoenolpyruvate: sugar phosphotransferase system proteins 审中-公开编码磷酸二氢叶酸的玉米淀粉基因：糖基磷酸化酶系统蛋白
公开(公告)号：JP2007236393A
公开(公告)日：2007-09-20
申请号：JP2007115387
申请日：2007-04-25
Applicant: Basf Ag , ビーエーエスエフ アクチェンゲゼルシャフトBASF Aktiengesellschaft
Inventor： POMPEJUS MARKUS , KROEGER BURKHARD , SCHROEDER HARTWIG , ZELDER OSKAR , HABERHAUER GREGOR
IPC: C12N15/09 , G01N33/53 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/00 , C12N9/10 , C12N9/12 , C12N15/31 , C12N15/54 , C12P1/04 , C12P13/04 , C12Q1/04 , C12Q1/48 , C12Q1/68 , C12R1/13 , C12R1/16 , G01N33/566 , G01N33/569
CPC classification number: C12N9/1223 , C12N9/12 , C12Y207/03009
Abstract: PROBLEM TO BE SOLVED: To provide a novel nucleic acid molecule derived from Corynebacterium glutamicum. SOLUTION: Isolated nucleic acid molecules encoding novel PTS proteins (phosphoenolpyruvate: sugar phosphotransferase) derived from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PTS nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated PTS proteins, mutated PTS proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from C. glutamicum based on genetic engineering of the PTS genes. COPYRIGHT: (C)2007,JPO&INPIT
Abstract translation: 待解决的问题：提供源自谷氨酸棒杆菌的新型核酸分子。 解决方案：描述了编码源自谷氨酸棒杆菌的新型PTS蛋白（磷酸烯醇丙酮酸：糖磷酸转移酶）的分离的核酸分子。 本发明还提供反义核酸分子，含有PTS核酸分子的重组表达载体，以及引入了表达载体的宿主细胞。 本发明还进一步提供了基于PTS基因的遗传工程的分离的PTS蛋白，突变的PTS蛋白，融合蛋白，抗原肽和用于从谷氨酸棒球菌（C.GGG）生产所需化合物的方法。 版权所有（C）2007，JPO＆INPIT
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13.发明专利Corynebacterium glutamicum gene encoding phosphoenolpyruvate: sugar phosphotransferase system protein 审中-公开琥珀酸谷氨酸基因编码磷酸二氢叶酸：蔗糖磷酸化酶系统蛋白
公开(公告)号：JP2007267744A
公开(公告)日：2007-10-18
申请号：JP2007115460
申请日：2007-04-25
Applicant: Basf Ag , ビーエーエスエフ アクチェンゲゼルシャフトBASF Aktiengesellschaft
Inventor： POMPEJUS MARKUS , KROEGER BURKHARD , SCHROEDER HARTWIG , ZELDER OSKAR , HABERHAUER GREGOR
IPC: C12N15/09 , G01N33/53 , C07K14/34 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/00 , C12N9/10 , C12N9/12 , C12N15/31 , C12N15/54 , C12P1/00 , C12P1/04 , C12P13/04 , C12P21/02 , C12Q1/04 , C12Q1/68 , C12R1/13 , C12R1/16 , G01N33/566 , G01N33/569
CPC classification number: C12N9/1223 , C12N9/12 , C12Y207/03009
Abstract: PROBLEM TO BE SOLVED: To provide a Corynebacterium glutamicum gene encoding phosphoenolpyruvate: sugar phosphotransferase system (PTS) protein. SOLUTION: The isolated nucleic acid encoding a novel PTS protein from Corynebacterium glutamicum is isolated. The antisense nucleic acid molecule, the recombinant expression vector containing a PTS nucleic acid molecule, and the host cell into which the expression vector has been introduced are also prepared. The isolated PTS protein, the mutated PTS protein, the fusion protein, the antigenic peptide and the method for the improvement of production of a desired compound from C. glutamicum based on genetic engineering of the PTS gene are also provided. COPYRIGHT: (C)2008,JPO&INPIT
Abstract translation: 待解决的问题：提供编码磷酸烯醇丙酮酸的谷氨酸棒杆菌基因：糖磷酸转移酶系统（PTS）蛋白。 解决方案：分离编码来自谷氨酸棒杆菌的新型PTS蛋白的分离的核酸。 还制备了反义核酸分子，含有PTS核酸分子的重组表达载体，以及引入了表达载体的宿主细胞。 还提供了基于PTS基因的遗传工程的分离的PTS蛋白，突变的PTS蛋白，融合蛋白，抗原肽以及用于从谷氨酸棒球菌的谷氨酸棒球菌生产所需化合物的方法。 版权所有（C）2008，JPO＆INPIT
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14.发明专利Corynebacterium glutamicum genes encoding proteins involved in carbon metabolism and energy production 审中-公开CORYNEBACTERIUM GLUTAMICUM基因编码参与碳代谢和能量生产的蛋白质
公开(公告)号：JP2006141405A
公开(公告)日：2006-06-08
申请号：JP2006011153
申请日：2006-01-19
Applicant: Basf Ag , ビーエーエスエフ アクチェンゲゼルシャフトBASF Aktiengesellschaft
Inventor： POMPEJUS MARKUS , KROEGER BURKHARD , SCHROEDER HARTWIG , ZELDER OSKAR , HABERHAUER GREGOR
IPC: C12N15/09 , G01N33/53 , C07K20060101 , C07K14/34 , C12N20060101 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/00 , C12N9/12 , C12N9/18 , C12N9/88 , C12N15/31 , C12N15/55 , C12P20060101 , C12P13/04 , C12P13/08 , C12P21/02 , C12Q20060101 , C12Q1/68 , C12R1/13 , C12R1/15 , G01N33/566 , G01N33/569
Abstract: PROBLEM TO BE SOLVED: To provide a nucleic acid and protein molecule involved in oxidative phosphorylation (SMP) involved in carbon compound metabolism such as sugars and in the generation of energy molecules in Corynebacterium glutamicum which is a novel microorganism and has a variety of uses. SOLUTION: Disclosed is an isolated Corynebacterium glutamicum nucleic acid molecule selected from the group consisting of sequences represented by specific sequence numbers and not including any specific genes, or a complement thereof. COPYRIGHT: (C)2006,JPO&NCIPI
Abstract translation: 待解决的问题：提供涉及碳化合物代谢如糖的氧化磷酸化（SMP）的核酸和蛋白质分子，以及作为新型微生物的谷氨酸棒杆菌中的能量分子的产生，并且具有多种 的用途。 解决方案：公开了一种分离的谷氨酸棒杆菌核酸分子，其选自由特定序列号表示的序列，不包括任何特定基因或其互补物。 版权所有（C）2006，JPO＆NCIPI
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15.发明专利
公开(公告)号：JP2001206844A
公开(公告)日：2001-07-31
申请号：JP2000356650
申请日：2000-11-22
Applicant: BASF AG
Inventor： AUWETER HELMUT DR , BOHN HERIBERT , HASSELWANDER OLIVER , RIEGER JENS , SCHROEDER HARTWIG , WEGNER CHRISTOPH
IPC: A23K1/16 , A23L1/275 , A23L1/30 , A61K8/04 , A61K8/30 , A61K8/35 , A61K9/10 , A61K9/14 , A61K9/50 , A61K9/51 , A61K31/12 , A61P1/16 , A61P3/06 , A61P35/00 , A61K7/00
Abstract: PROBLEM TO BE SOLVED: To provide a new curcumin-formulated agent free from defects of conventional curcumin solution or turmeric oil-containing resin comprising the considerably rapid fading in air resulting in the severe restriction of the use of curcumin in food industry and pharmaceutical preparation owing to the insufficient stability and the water insolubility. SOLUTION: The objective agent contains curcumin showing an X-ray analysis diagram having the most intense reflection line falling within the range of 2θ=13 to 15 deg..
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Patent Agency Ranking16.发明申请USE OF THE REPRESSOR GLXR FOR THE SYNTHESIS OF LYSINE IN CORYNEBACTERIUM GLUTAMICUM 审中-公开使用代谢物GLXR合成玉米淀粉中的赖氨酸
公开(公告)号：WO03097678A2
公开(公告)日：2003-11-27
申请号：PCT/EP0304969
申请日：2003-05-13
Applicant: BASF AG , KLOPPROGGE CORINNA , ZELDER OSKAR , KROEGER BURKHARD , SCHROEDER HARTWIG , HAEFNER STEFAN , LEE HEUNG-SHICK
Inventor： KLOPPROGGE CORINNA , ZELDER OSKAR , KROEGER BURKHARD , SCHROEDER HARTWIG , HAEFNER STEFAN , LEE HEUNG-SHICK
CPC classification number: C07K14/34
Abstract: Isolated polypeptide sequence having the sequence of SEQ ID NO:1 or muteins thereof having the ability to bind cAMP and repress the expression of the aceB gene of C. glutamicum and which can be obtained from SEQ ID NO:1 by inserting, deleting or substituting up to 20% of the amino acids.
Abstract translation: 具有SEQ ID NO：1的序列的分离的多肽序列或其突变蛋白具有结合cAMP的能力并抑制谷氨酸棒杆菌的aceB基因的表达，并且可以通过插入，缺失或替代从SEQ ID NO：1获得 高达20％的氨基酸。
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公开(公告)号：WO2005059093A3
公开(公告)日：2006-03-02
申请号：PCT/EP2004014266
申请日：2004-12-15
Applicant: BASF AG , KROEGER BURKHARD , ZELDER OSKAR , KLOPPROGGE CORINNA , SCHROEDER HARTWIG , HAEFNER STEFAN
Inventor： KROEGER BURKHARD , ZELDER OSKAR , KLOPPROGGE CORINNA , SCHROEDER HARTWIG , HAEFNER STEFAN
IPC: C07K14/34 , C12N20060101 , C12N1/00 , C12N15/63 , C12N15/67 , C12N15/77 , C12P1/00 , C12P13/08 , C12P13/12 , C12N1/21
Abstract: The invention relates to the use of nucleic acid sequences for regulating gene transcription and expression, said novel promoters and expression units, methods for modifying or inducing the gene transcription rate and/or expression rate, expression cassettes containing said expression units, genetically modified microorganisms having a modified or induced transcription rate and/or expression rate, and methods for producing biosynthetic products by cultivating said genetically modified microorganisms.
Abstract translation: 本发明涉及使用核酸序列的调节基因，所述新的启动子和表达单元本身的转录和表达，用于改变或引起转录和/或基因的表达率的速率的方法，含有该表达单元的表达盒，具有改变的遗传修饰的微生物或 引起转录速率和/或表达的速率以及通过培养遗传修饰的微生物的制备生物合成产物的方法。
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18.发明申请METHODS FOR THE PREPARATION OF LYSINE BY FERMENTATION OF CORYNEBACTERIUM GLUTAMICUM 审中-公开通过发酵玉米淀粉制备赖氨酸的方法
公开(公告)号：WO2005059139A3
公开(公告)日：2005-08-11
申请号：PCT/IB2004004429
申请日：2004-12-17
Applicant: BASF AG , ZELDER OSKAR , KLOPPROGGE CORINNA , SCHROEDER HARTWIG , HAEFNER STEFAN , KROEGER BURKHARD , KIEFER PATRICK , HEINZLE ELMAR , WITTMANN CHRISTOPH
Inventor： ZELDER OSKAR , KLOPPROGGE CORINNA , SCHROEDER HARTWIG , HAEFNER STEFAN , KROEGER BURKHARD , KIEFER PATRICK , HEINZLE ELMAR , WITTMANN CHRISTOPH
Abstract: The present invention features methods of increasing the production of a fine chemical, e.g., lysine from a microorganism, e.g., Corynebacterium by way of deregulating an enzyme encoding gene, i.e., fructose- l,6-bisphosphatase. In a preferred embodiment, the invention provides methods of increasing the production of lysine in Corynebacterium glutamicum by way of increasing the expression of fructose-1,6-bisphosphatase activity. The invention also provides a novel process for the production of lysine by way of regulating carbon flux towards oxaloacetate (OAA). In a preferred embodiment, the invention provides methods for the production of lysine by way of utilizing fructose or sucrose as a carbon source.
Abstract translation: 本发明的特征在于通过使酶编码基因（即果糖-1,6-二磷酸酶）失调来增加精细化学品例如来自微生物例如棒状杆菌的赖氨酸的生产方法。 在优选的实施方案中，本发明提供了通过增加果糖-1,6-二磷酸酶活性的表达来增加谷氨酸棒杆菌中赖氨酸的产生的方法。 本发明还提供了通过调节向草酰乙酸（OAA）的碳通量来生产赖氨酸的新方法。 在优选的实施方案中，本发明提供了通过使用果糖或蔗糖作为碳源来生产赖氨酸的方法。
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19.发明申请
公开(公告)号：WO2004024932A3
公开(公告)日：2004-04-22
申请号：PCT/EP0309452
申请日：2003-08-26
Applicant: BASF AG , KROEGER BURKHARD , ZELDER OSKAR , KLOPPROGGE CORINNA , SCHROEDER HARTWIG , HAEFNER STEFAN
Inventor： KROEGER BURKHARD , ZELDER OSKAR , KLOPPROGGE CORINNA , SCHROEDER HARTWIG , HAEFNER STEFAN
Abstract: The invention relates to methods for the zymotic production of fine chemicals, especially L-methionine, containing sulphur using bacteria, wherein a nucleotide sequence coding for a methionine-synthase (methA)-gene is expressed.
Abstract translation: 本发明涉及使用其中表达编码甲硫氨酸合酶（methA）基因核苷酸序列的细菌来发酵生产含硫精细化学品，特别是L-甲硫氨酸的方法。
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20.发明申请GENES CODING FOR DNA REPLICATION PROTEINS AND FOR PROTEINS RELATED TO PATHOGENESIS 审中-公开基因DNA的复制和发病机制的蛋白质编码
公开(公告)号：WO03040289A2
公开(公告)日：2003-05-15
申请号：PCT/EP0212132
申请日：2002-10-31
Applicant: BASF AG , ZELDER OSKAR , POMPEJUS MARKUS , SCHROEDER HARTWIG , KROEGER BURKHARD , KLOPPROGGE CORINNA , HABERHAUER GREGOR
Inventor： ZELDER OSKAR , POMPEJUS MARKUS , SCHROEDER HARTWIG , KROEGER BURKHARD , KLOPPROGGE CORINNA , HABERHAUER GREGOR
Abstract: The invention concerns novel nucleic acid molecules, the use of said molecules for producing by recombination genetically improved micro-organisms, and a method for preparing fine chemical products, in particular amino acids, using said genetically improved micro-organisms.
Abstract translation: 本发明涉及新的核酸分子，它们的遗传改良的微生物以及用于产生精细化学品，在使用这些遗传改良的微生物的特定氨基酸的方法的结构中使用。
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