公开(公告)号：DE50111739D1

公开(公告)日：2007-02-08

申请号：DE50111739

申请日：2001-05-16

Applicant: BASF AG

Inventor： STECKHAN EBERHARD ,  SCHMID ANDREAS ,  HOLLMANN FRANK ,  HAUER BERNHARD ,  ZELINSKI THOMAS

IPC: C12M1/40 ,  C12P1/00 ,  C12M1/00 ,  C12P7/22 ,  C25B3/25

Abstract: A method comprising the indirect electrochemical regeneration of NAD(P)H in enzymatic substrate conversions which are catalyzed by monooxygenases, for example, is described. In particular, a method for the electroenzymatic preparation of 2,3-dihydroxyphenyl derivatives, which is catalyzed by the enzyme 2-hydroxybiphenyl 3-monooxygenase and in which simultaneously the NAD + formed by reductive cleavage of oxygen is electrochemically reduced, is described.

公开(公告)号：UA75074C2

公开(公告)日：2006-03-15

申请号：UA20021210153

申请日：2001-05-16

Applicant: BASF AG

Inventor： STECKHAN EBERHARD

IPC: C12M1/40 ,  C12P1/00 ,  C12P7/22 ,  C25B3/25

Abstract: The invention relates to a method comprising the indirect electrochemical regeneration of NAD(P)H in enzymatic substrate reactions, that are, for example, catalyzed by monooxygenases. The invention especially relates to a method for the electroenzymatic production of 2,3-dihydroxyphenyl derivatives that is catalyzed by the enzyme 2-hydroxybiphenyl-3-monooxygenase, while at the same time the NAD+ produced by reductive oxygen separation is electrochemically reduced.

公开(公告)号：NO20025503L

公开(公告)日：2002-11-15

申请号：NO20025503

申请日：2002-11-15

Applicant: BASF AG

Inventor： SCHMID ANDREAS ,  HOLLMANN FRANK ,  HAUER BERNHARD ,  ZELINSKI THOMAS ,  STECKHAN EBERHARD

IPC: C12P1/00 ,  C12P7/22 ,  C25B3/25 ,  C12M1/40 ,  C25B3/04 ,  C25B9/00 ,  C12M1/00

Abstract: A method comprising the indirect electrochemical regeneration of NAD(P)H in enzymatic substrate conversions which are catalyzed by monooxygenases, for example, is described. In particular, a method for the electroenzymatic preparation of 2,3-dihydroxyphenyl derivatives, which is catalyzed by the enzyme 2-hydroxybiphenyl 3-monooxygenase and in which simultaneously the NAD + formed by reductive cleavage of oxygen is electrochemically reduced, is described.

公开(公告)号：CA2409339A1

公开(公告)日：2002-11-15

申请号：CA2409339

申请日：2001-05-16

Applicant: BASF AG

Inventor： ZELINSKI THOMAS ,  SCHMID ANDREAS ,  HOLLMANN FRANK ,  HAUER BERNHARD ,  STECKHAN EBERHARD

IPC: C12M1/40 ,  C12P1/00 ,  C12P7/22 ,  C25B3/25 ,  C25B9/00 ,  C12M1/00 ,  C25B3/04

Abstract: A method comprising the indirect electrochemical regeneration of NAD(P)H in enzymatic substrate conversions which are catalyzed by monooxygenases, for example, is described. In particular, a method for the electroenzymatic preparation of 2,3-dihydroxyphenyl derivatives, which is catalyzed by the enzyme 2-hydroxybiphenyl 3-monooxygenase and in which simultaneously the NAD + formed by reductive cleavage of oxygen is electrochemically reduced, is described.

公开(公告)号：DE10024314A1

公开(公告)日：2001-11-22

申请号：DE10024314

申请日：2000-05-17

Applicant: BASF AG

Inventor： HAUER BERNHARD ,  ZELINSKI THOMAS ,  STECKHAN EBERHARD ,  HOLLMANN FRANK ,  SCHMID ANDREAS

IPC: C12M1/40 ,  C12P1/00 ,  C12P7/22 ,  C25B3/25 ,  C12P13/00 ,  C12M1/42 ,  C25B3/04 ,  C07H19/207 ,  C07C255/53 ,  C07C39/08 ,  C07C39/10 ,  C07C39/15 ,  C07C39/28

Abstract: NAD(P)H is regenerated by electrochemical reduction from NAD(P) formed in an oxidative enzymatic reaction of an oxidizable substrate in the presence of NAD(P)H. Regeneration of NAD(P)H from NAD(P) formed in a NAD(P)H-consumed oxidative enzymatic reaction of an oxidizable substrate in the presence of NAD(P)H comprises electrochemical reduction of the NAD(P) .

公开(公告)号：DE19827321A1

公开(公告)日：1999-12-23

申请号：DE19827321

申请日：1998-06-19

Applicant: BASF AG

Inventor： MERK CLAUDIA ,  PUETTER HERMANN ,  STECKHAN EBERHARD ,  KROENER LARS ,  JOERISSEN JAKOB ,  HOORMANN DIRK

IPC: C25B3/23 ,  C25B3/02 ,  C07C43/30 ,  C07C43/205 ,  C07C47/52 ,  C07C49/76

Abstract: Production of aromatic aldehyde, ether, acetal and ester compounds (I) by electrochemical oxidation is carried out in an electrolytic cell with a solid state electrolyte, consisting of one or several superimposed layers of cation exchange membrane, a cathode and an anode in direct contact with this and an electrolysis liquid. Production of aromatic aldehyde, ether, acetal and ester compounds of formula (I) with an oxidation number of 1-9 from aromatic compounds of formula (II) with an oxidation number NOTLESS 1 lower by electrochemical oxidation is carried out in an electrolytic cell with a solid state electrolyte, consisting of one or several superimposed layers of cation exchange membrane, a cathode and an anode in direct contact with this and an electrolysis liquid. The liquid is an organic solution, free from conducting electrolyte, containing 10-90 wt. % methanol, 1-50 wt. % compounds selected from (I) and (II), including NOTLESS 1 mol. % (II), 1-50 wt. % optionally N-alkylated 1-15 carbon (C) carbonamide or 3-15 C N-alkylated urea and 0-30 wt. % other inert solvent. R = hydrogen (H), 2-4 C alkyl, 1-4 C alkoxy or halogen; A, X = methylene, carbonyl or methoxymethylene (-CH(OCH3)-); B, Y = H or methoxy (OCH3); m = 0-3; n = 1-3. The oxidation numbers of (I) and (II) are obtained by adding the oxidation number for each group A and B or X and Y, which is 0 if A is methylene, 1 if A is methoxymethylene and 2 if A is carbonyl, 0 if B is H and 1 if B is methoxy.