METHOD FOR THE PREPARATION OF 1,3-DISUBSTITUTED 4,5- CIS-DICARBOXY-2-IMIDAZOLIDONES

    公开(公告)号:CA1180338A

    公开(公告)日:1985-01-02

    申请号:CA418177

    申请日:1982-12-21

    Applicant: BASF AG

    Abstract: IMPROVED METHOD FOR THE PREPARATION OF 1,3-DISUBSTITUTED 4,5-CIS-DICARBOXY-2-IMIDAZOLIDONES A process for the preparation 1,3-disubstituted 4,5-cis-dicarboxy-2-imidazolidones useful as intermediates in the preparation of Vitamin H (biotin), said intermediates have the general formula in which R is an aliphatic hydrocarbon radical having 1 to 8 carbon atoms, an aralkyl radical or an aromatic hydrocarbon radical, preferably an allyl radical or a benzyl radical, comprising reacting a defined diaminosuccinic acid with phosgene in the presence of an alkali metal hydroxide.

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