公开(公告)号：CA1337006C

公开(公告)日：1995-09-12

申请号：CA578917

申请日：1988-09-30

Applicant: BASF AG

Inventor： GOERTZ HANS-HELMUT ,  STRAUB FERDINAND ,  VOGEL FRIEDRICH ,  FROSCH FRANZ ,  NAEGELE PAUL ,  RAUBENHEIMER HANS-JUERGEN

IPC: C08F2/06 ,  C08F4/04 ,  C08F8/14 ,  C08F216/18 ,  C08F222/16 ,  C08F222/06 ,  A61K7/11

Abstract: Copolymers of monoalkyl maleates and vinyl alkyl ethers are prepared by free radical copolymerization of maleic anhydride and a vinyl alkyl ether followed by reaction with an alkanol, by a process in which the vinyl alkyl ether component is present in excess in the reaction mixture in each phase of the polymerization, the free radical copolymerization is carried out in acetone and the acetone is removed by distillation during or after ester formation at up to 70.degree.C.

公开(公告)号：ES2024462B3

公开(公告)日：1992-03-01

申请号：ES87111649

申请日：1987-08-12

Applicant: BASF AG

Inventor： NUBER ADOLF ,  SANNER AXEL ,  STRAUB FERDINAND ,  VOGEL FRIEDRICH

IPC: A61K8/00 ,  A61K8/31 ,  A61K8/34 ,  A61K8/35 ,  A61K8/36 ,  A61K8/41 ,  A61K8/81 ,  A61Q5/06 ,  C08F8/44 ,  C08F26/10 ,  C08F220/04 ,  C08F220/06 ,  C08F220/10 ,  C08F220/12 ,  C08F220/18 ,  C08F226/10

公开(公告)号：CA1204120A

公开(公告)日：1986-05-06

申请号：CA431302

申请日：1983-06-28

Applicant: BASF AG

Inventor： VOGEL FRIEDRICH ,  PAUST JOACHIM ,  NUERRENBACH AXEL

IPC: C07C17/16 ,  C07D311/72 ,  C07F3/02 ,  C07F9/143 ,  C07F9/54 ,  C07F9/32

Abstract: The present invention relates to a compound having the general formula (II) (II) in all its isomeric forms, in which Z is selected from the group consisting of wherein R2 is alkyl of 1 to 4 carbon atoms, and the dotted line indicates that the compound may have an additional double bond. These compounds can be used to make intermediate compounds having the general formula I (I) in which R1 is H, an alkyl, arylalkyl or an aliphatic acyl radical; X and Y together provide an additional bond or Y is OH and X is H; and in which the dotted line can represent an additional bond. The compounds of general formula (I) can in turn be used to make .alpha.-tocopherol or a 6-0-derivative thereof.

公开(公告)号：CA1326935C

公开(公告)日：1994-02-08

申请号：CA545854

申请日：1987-09-01

Applicant: BASF AG

Inventor： SANNER AXEL ,  VOGEL FRIEDRICH

IPC: C08F2/18 ,  C08F2/00 ,  C08F2/20 ,  C08F2/38 ,  C08F6/00 ,  C08F20/52 ,  C08F220/04 ,  C08F220/06 ,  C08F220/10 ,  C08F220/12 ,  C08F220/54 ,  C08F220/56

Abstract: A process is disclosed for the preparation of a terpolymer of from 46 to 56% by weight of N-tert-butylacrylamide, from 37 to 45% by weight of ethyl acrylate and from 6 to 9% by weight of acrylic acid, the percentages being based on the weight of the monomers, wherein a suspension polymerization is carried out in which a) the monomers are introduced individually or as a mixture, with stirring, into water which contains from 0.05 to 1.5% by weight of a protective colloid and from 0.1 to 1.0% by weight of a regulator, the percentages being based on the total weight of the monomers, so that a 25-50% strength by weight mixture is formed, b) the resulting, stirred mixture is heated to 60-80.degree.C and stirred at this temperature for from 15 minutes to 1 hour until a homogeneous emulsion has formed, c) from 0.1 to 1.0% by weight of initiator, based on the total weight of the monomers, is then metered in in the course of from 1 to 9 hours in such a way that a polymerization temperature of from 70 to 100.degree.C is maintained, and d) after the subsequent complete polymerization, the resulting terpolymer having a molecular weight of from 20,000 to 80,000 is filtered off, washed with water and dried.

公开(公告)号：ES2022832B3

公开(公告)日：1991-12-16

申请号：ES87107116

申请日：1987-05-16

Applicant: BASF AG

Inventor： GOERTZ HANS-HELMUT DR ,  STRAUB FERDINAND ,  SANNER AXEL ,  KOLB ALBRECHT ,  RAUBENHEIMER HANS-JUERGEN ,  VOGEL FRIEDRICH

IPC: C07D233/58 ,  C07D521/00 ,  C08F26/00 ,  C08F26/06

公开(公告)号：CA1191157A

公开(公告)日：1985-07-30

申请号：CA412662

申请日：1982-10-01

Applicant: BASF AG

Inventor： ERNST HANSGEORG ,  VOGEL FRIEDRICH ,  PAUST JOACHIM

IPC: C07C17/16 ,  B01J27/122 ,  C07B61/00 ,  C07C17/00 ,  C07C17/26 ,  C07C17/263 ,  C07C19/01 ,  C07C19/075 ,  C07C29/147 ,  C07C29/40 ,  C07C51/363 ,  C07C51/487 ,  C07C53/19 ,  C07C67/00 ,  C07D311/72 ,  C07C19/02

Abstract: (2R,6R)-l-Chloro-2,6,10-tri-methyl-undecane I, (R)-(+)-.beta.-chloro isobutyric acid II, (S)-(+)-1-bromo-3-chloro-2-methylpropane IV and (2R)-(+)-l-chloro-2,6 dimethyl-heptane V are novel optically active units for the synthesis of the side chain of (R,R,R)-.alpha.-tocopherol. In the process according to the invention, the optically active C14-chloride I is obtained in 6 simple reaction steps starting from II, via the novel intermediates IV and V, in accordance with the following equation: (II) (III) (IV) (V) (VII) + (IV) (I)

公开(公告)号：CA1180338A

公开(公告)日：1985-01-02

申请号：CA418177

申请日：1982-12-21

Applicant: BASF AG

Inventor： TRAUTMANN WALTER ,  VOGEL FRIEDRICH

IPC: C07D233/32

Abstract: IMPROVED METHOD FOR THE PREPARATION OF 1,3-DISUBSTITUTED 4,5-CIS-DICARBOXY-2-IMIDAZOLIDONES A process for the preparation 1,3-disubstituted 4,5-cis-dicarboxy-2-imidazolidones useful as intermediates in the preparation of Vitamin H (biotin), said intermediates have the general formula in which R is an aliphatic hydrocarbon radical having 1 to 8 carbon atoms, an aralkyl radical or an aromatic hydrocarbon radical, preferably an allyl radical or a benzyl radical, comprising reacting a defined diaminosuccinic acid with phosgene in the presence of an alkali metal hydroxide.