公开(公告)号：US20200157064A1

公开(公告)日：2020-05-21

申请号：US16634202

申请日：2018-07-21

Applicant: BASF SE

Inventor： Christopher Koradin ,  Wassilios Grammenos ,  Michael Rack ,  Kailaskumar Borate ,  Roland Goetz

IPC: C07D271/06

Abstract: The present invention relates to a process for the preparation of substituted 3-aryl-5-trifluoromethyl-1,2,4-oxadiazoles (compounds I), which can be obtained through reaction of hydroxyamidine compounds of formula II with trifluoroacetyl halides IIa.

公开(公告)号：US20230339847A1

公开(公告)日：2023-10-26

申请号：US17920833

申请日：2021-04-19

Applicant: BASF SE

Inventor： Mathias Schelwies ,  Florian Vogt ,  Christopher Koradin ,  Rocco Paciello ,  Roland Goetz

IPC: C07C231/10 ,  C07C253/30 ,  C07D271/06 ,  B01J31/24

CPC classification number: C07C231/10 ,  C07C253/30 ,  C07D271/06 ,  B01J31/2414 ,  B01J2531/824 ,  B01J2231/4288

Abstract: The present invention relates to a process for the preparation of aromatic carboxyamides of formula I, which can be obtained by a palladium-catalyzed carbonylation reaction of aromatic chlorides of formula II, amines of formula III and carbon monoxide in the presence of 1,5,7-triazabi-cyclo[4.4.0]dec-5-ene. The invention further relates to a process for the preparation of aryl-5-trifluoromethyl-1,2,4-oxadiazoles, which are known for controlling phytopathogenic fungi.

公开(公告)号：US20230167050A1

公开(公告)日：2023-06-01

申请号：US17921206

申请日：2021-04-19

Applicant: BASF SE

Inventor： Mathias Schelwies ,  Christopher Koradin ,  Rocco Paciello ,  Roland Goetz ,  Florian Vogt

IPC: C07C233/64 ,  C07D271/06

CPC classification number: C07C233/64 ,  C07D271/06

Abstract: Preparation of aromatic carboxyamides by palladium-catalyzed carbonylation reaction The present invention relates to a process for the preparation of aromatic carboxyamides of formula I, which can be obtained by palladium-catalyzed carbonylation reaction of aromatic chlorides of formula II, amines of formula III and carbon monoxide in the presence of a base. The invention further relates to a process for the preparation of aryl-5-trifluoromethyl-1,2,4-oxadiazoles, which are known for controlling phytopathogenic fungi.

公开(公告)号：US11021452B2

公开(公告)日：2021-06-01

申请号：US16634202

申请日：2018-07-21

Applicant: BASF SE

Inventor： Christopher Koradin ,  Wassilios Grammenos ,  Michael Rack ,  Kailaskumar Borate ,  Roland Goetz

IPC: C07D271/06

Abstract: The present invention relates to a process for the preparation of substituted 3-aryl-5-trifluoromethyl-1,2,4-oxadiazoles (compounds I), which can be obtained through reaction of hydroxyamidine compounds of formula II with trifluoroacetyl halides IIa.

公开(公告)号：US09861104B2

公开(公告)日：2018-01-09

申请号：US14383731

申请日：2013-03-11

Applicant: BASF SE

Inventor： Torsten Knieriem ,  Tiziana Chiodo ,  Christopher Koradin ,  Tanja Weber ,  Walter Weishaar

IPC: A01N53/00 ,  A01N25/08 ,  A01N43/90

CPC classification number: A01N53/00 ,  A01N25/08 ,  A01N43/90 ,  A01N25/04 ,  A01N2300/00

Abstract: The present invention relates to a method for producing an aqueous suspension concentrate formulation and novel suspension concentrate formulations of the compound of formula I. The method comprises: a) providing an aqueous slurry of coarse particles of the compound of the formula I, where the compound of the formula I is at least partially present in its crystalline form B, which, in an X-ray powder diffractogram at 25° C. and Cu-Kα radiation, shows at least three, preferably at least four, in particular at least 5 or at least 7 or at least 9 or all of the following reflexes, given as 2θ values: 8.0±0.2°, 9.5±0.2°, 10.7±0.2°, 11.0±0.2°, 11.2±0.2°, 11.7±0.2°, 14.2±0.2°, 15.6±0.2°, 16.5±0.2°, 17.7±0.2°, 21.5±0.2°; b) comminuting the coarse particles in the slurry of the compound of formula I, which is at least partially present in its form B, in the presence of the at least one surfactant.

公开(公告)号：US09598428B2

公开(公告)日：2017-03-21

申请号：US14760302

申请日：2014-01-15

Applicant: BASF SE

Inventor： Melanie Bonnekessel ,  Wolfgang Reichert ,  Ralf Hoock ,  Thomas Kaeding ,  Christopher Koradin ,  Andreas Pletsch ,  Manfred Ehresmann ,  Hartwig Schroeder

IPC: A01N43/90 ,  A01N53/00 ,  C07D493/04

CPC classification number: C07D493/04 ,  A01N43/90 ,  A01N53/00

Abstract: The present invention relates to a method for preparing the pyripyropene compound of the formula (I) which method comprises the following steps: i) subjecting a pyripyropene compound of formula Pyripyropene A to an alkaline hydrolysis to yield a 1,7,11 -trideacetylpyripyropene A, ii) reacting 1,7,11-trideacetylpyripyropene A obtained in step i) with cyclopropane carbonyl chloride to yield a raw product containing the pyripyropene compound of formula (I); iii) subjecting the raw product of step ii) to crystallization to yield a crystalline pyripyropene compound of formula (I) and a mother liquor; and iv) recycling the mother liquor or a pyripyropene compound containing fraction thereof to the alkaline hydrolysis of step i).

公开(公告)号：US20240262816A1

公开(公告)日：2024-08-08

申请号：US18282874

申请日：2022-03-25

Applicant: BASF SE

Inventor： Martin John McLaughlin ,  Christopher Koradin ,  Rahul Kaduskar ,  Harish Shinde ,  Roland Goetz

IPC: C07D417/12 ,  B01J31/18

CPC classification number: C07D417/12 ,  B01J31/189

Abstract: The present invention relates to a method for preparing an enantiomerically enriched form of 2-[2-(2-chlorothiazol-5-yl)-2-hydroxy-ethyl]sulfanyl-6-hydroxy-3-methyl-5-phenyl-pyrimidin-4-one of the formula (I) by hydrogenation of 2-[2-(2-chlorothia-201-5-yl)-2-oxo-ethyl]sulfanyl-6-hydroxy-3-methyl-5-phenyl-pyrimidin-4-one (1) in the presence of a chiral transition metal catalyst.

公开(公告)号：US20240116916A1

公开(公告)日：2024-04-11

申请号：US18272913

申请日：2022-01-21

Applicant: BASF SE

Inventor： Martin John McLaughlin ,  Christopher Koradin ,  Rahul Kaduskar ,  Harish Shinde ,  Roland Gotez ,  Guillaume Michel Jacques Garivet

IPC: C07D417/12 ,  B01J31/18

CPC classification number: C07D417/12 ,  B01J31/1805 ,  C07B2200/07

Abstract: The present invention relates to a method for preparing 2-[2-(2-chlorothiazol-5-yl)-2- hydroxy-ethyl]sulfanyl-6-hydroxy-3-methyl-5-phenyl-pyrimidin-4-one or a tautomer thereof or enantiomerically enriched forms thereof, to 2-[2-(2-chlorothiazol-5-yl)-2-hydroxy-ethyl]sulfanyl-6-hydroxy-3-methyl-5-phenyl-pyrimidin-4-one or a tautomer thereof or enantiomerically enriched forms thereof, and to the use thereof as intermediate in the preparation of 2,3-dihydrothiazolo[3,2-a]pyrimidinium compounds, specifically of 3-(2-chlorothiazol-5-yl)-8-methyl-7-oxo-6-phenyl-2,3-dihydrothiazolo [3,2-a]pyrimidin-4-ium-5-olate and enantiomerically enriched forms thereof.

公开(公告)号：US20240051929A1

公开(公告)日：2024-02-15

申请号：US17641989

申请日：2020-09-28

Applicant: BASF SE

Inventor： Harish Shinde ,  Rahul Kaduskar ,  Christopher Koradin ,  Martin John McLaughlin ,  Roland Goetz ,  Sunil Khamkar

IPC: C07D277/32

CPC classification number: C07D277/32

Abstract: The present invention relates to a process for the preparation 2-chloro-1-(2-chlorothiazol-5-yl)ethanone.

公开(公告)号：US20230416273A1

公开(公告)日：2023-12-28

申请号：US18272884

申请日：2022-01-21

Applicant: BASF SE

Inventor： Christopher Koradin ,  Martin John McLaughlin ,  Harish Shinde ,  Rahul Kaduskar ,  Ronald Goetz ,  Guillaaume Michel Jaques Garivet

IPC: C07D513/04

CPC classification number: C07D513/04

Abstract: The present invention relates to a method for preparing an enantiomerically enriched form of 3-(2-chlorothiazol-5-yl)-8-methyl-7-oxo-6-phenyl-2,3-dihydrothiazolo[3,2-a]pyrimidin-4-ium-5-olate.