公开(公告)号：US11136611B2

公开(公告)日：2021-10-05

申请号：US16487978

申请日：2018-02-23

Applicant: BASF SE

Inventor： Wolfgang Siegel ,  Melanie Weingarten ,  Michael Breuer ,  Mathias Schelwies

IPC: C12P41/00 ,  C12P7/40 ,  C12P17/04

Abstract: The invention provides an improved method of isolating the 3-(E)-isomer of an unsaturated carboxylic acid from a mixture of corresponding (E/Z)isomers. More particularly, the present invention relates to an improved method for the biocatalytic preparation of (3E,7E)-homofarnesylic acid; as well as a novel biocatalytic method for the improved preparation of homofarnesol, in particular of (3E,7E)-homofarnesol and homofarnesol preparations having an increased content of (3E,7E)-homofarnesol. The present invention also relates to methods of preparing(−)-ambroxby applying (3E,7E)-homofarnesylic acid or (3E,7E)-homofarnesol as obtained according to the invention as starting material.

公开(公告)号：US10301244B2

公开(公告)日：2019-05-28

申请号：US15964400

申请日：2018-04-27

Applicant: BASF SE

Inventor： Mathias Schelwies ,  Rocco Paciello ,  Gunnar Heydrich ,  Günter Wegner ,  Gerd-Dieter Tebben ,  Martin Haubner ,  Andreas Keller ,  Oliver Bey ,  Stephanie Renz ,  Georg Seeber

IPC: C07C45/50 ,  C07C45/62 ,  C07C29/17 ,  C07C29/56

Abstract: The present invention relates to a process for the preparation of an optically active carbonyl compound by asymmetric hydrogenation of a prochiral α,β-unsaturated carbonyl compound with hydrogen in the presence of at least one optically active transition metal catalyst that is soluble in the reaction mixture and which has rhodium as catalytically active transition metal and a chiral, bidentate bisphosphine ligand, wherein the reaction mixture during the hydrogenation of the prochiral α,β-unsaturated carbonyl compound additionally comprises at least one compound of the general formula (I): in which R1, R2: are identical or different and are C6- to C10-aryl which is unsubstituted or carries one or more, e.g. 1, 2, 3, 4 or 5, substituents which are selected from C1- to C6-alkyl, C3- to C6-cycloalkyl, C6- to C10-aryl, C1- to C6-alkoxy and amino; Z is a group CHR3R4 or aryl which is unsubstituted or carries one or more, e.g. 1, 2, 3, 4 or 5, substituents which are selected from C1- to C6-alkyl, C3- to C6-cycloalkyl, C6- to C10-aryl, C1- to C6-alkoxy and amino, wherein R3 and R4 are as defined in the claims and the description.

公开(公告)号：US12172956B2

公开(公告)日：2024-12-24

申请号：US16969680

申请日：2019-02-13

Applicant: BASF SE

Inventor： Mathias Schelwies ,  Wolfgang Siegel ,  Rocco Paciello ,  Andreas Keller

IPC: C07C51/353 ,  C07C51/09 ,  C12P7/6427 ,  C12P7/6436

Abstract: The present invention relates to a method for isomerizing a 3-(Z)-unsaturated carboxylic acid of the formula 1-Z or a salt thereof, wherein R2 is C1-C24-alkyl, C2-C24-alkenyl having 1, 2, 3 or more than 3 C—C double bonds, unsubstituted or substituted C5-C12-cycloalkyl, or unsubstituted or substituted aryl; R1 is hydrogen or has one of the definitions specified for R2; with the proviso that R2 has a higher priority than R1 in accordance with IUPAC; to give a 3-(E)-unsaturated carboxylic acid of the formula I-E or a salt thereof, wherein the isomerization of the compound of the formula 1-Z is effected in the presence of an anhydride of an organic acid and a base or in the presence of a ketene of formula CR11R12C(0), wherein R11 and R12 are as defined in the claims and in the specification and a base. In particular, the present invention relates to a method for preparing compositions with increased content of (3E,7E)-homofarnesylic acid starting from compositions comprising (3Z,7E)- and (3E,7E)-homofarnesylic acid.

公开(公告)号：US20230339847A1

公开(公告)日：2023-10-26

申请号：US17920833

申请日：2021-04-19

Applicant: BASF SE

Inventor： Mathias Schelwies ,  Florian Vogt ,  Christopher Koradin ,  Rocco Paciello ,  Roland Goetz

IPC: C07C231/10 ,  C07C253/30 ,  C07D271/06 ,  B01J31/24

CPC classification number: C07C231/10 ,  C07C253/30 ,  C07D271/06 ,  B01J31/2414 ,  B01J2531/824 ,  B01J2231/4288

Abstract: The present invention relates to a process for the preparation of aromatic carboxyamides of formula I, which can be obtained by a palladium-catalyzed carbonylation reaction of aromatic chlorides of formula II, amines of formula III and carbon monoxide in the presence of 1,5,7-triazabi-cyclo[4.4.0]dec-5-ene. The invention further relates to a process for the preparation of aryl-5-trifluoromethyl-1,2,4-oxadiazoles, which are known for controlling phytopathogenic fungi.

公开(公告)号：US11708316B2

公开(公告)日：2023-07-25

申请号：US17623642

申请日：2020-06-24

Applicant: BASF SE

Inventor： Mathias Schelwies ,  Jonas Schwaben ,  Rocco Paciello

IPC: C07C41/26 ,  C07C29/149 ,  C07C29/156

CPC classification number: C07C41/26 ,  C07C29/149 ,  C07C29/156 ,  C07C2602/28 ,  C07C29/149 ,  C07C33/26 ,  C07C29/149 ,  C07C31/278 ,  C07C29/149 ,  C07C33/02 ,  C07C29/149 ,  C07C33/22 ,  C07C29/149 ,  C07C31/08 ,  C07C29/149 ,  C07C31/125 ,  C07C29/149 ,  C07C33/20 ,  C07C41/26 ,  C07C43/23 ,  C07C29/149 ,  C07C31/20

Abstract: Method for hydrogenating an ester with molecular hydrogen to the corresponding alcohols in the presence of a ruthenium complex (I), wherein said complex comprises a tridentate ligand L of the general formula (II)




n and m are each independently 0 or 1, and the solid-dashed double lines represent a single or double bond, with the proviso that in the case of n=1 both solid-dashed double lines represent a single bond and m is 1, and in the case of n=0 one solid-dashed double line represents a single bond and the other solid-dashed double line represents a double bond, wherein in the case of a double bond on the side facing the phenyl ring m=1, in the case of a double bond on the side facing the pyridyl ring m=0, or both solid-dashed double lines represent a single bond and m is 1.

公开(公告)号：US20230167050A1

公开(公告)日：2023-06-01

申请号：US17921206

申请日：2021-04-19

Applicant: BASF SE

Inventor： Mathias Schelwies ,  Christopher Koradin ,  Rocco Paciello ,  Roland Goetz ,  Florian Vogt

IPC: C07C233/64 ,  C07D271/06

CPC classification number: C07C233/64 ,  C07D271/06

Abstract: Preparation of aromatic carboxyamides by palladium-catalyzed carbonylation reaction The present invention relates to a process for the preparation of aromatic carboxyamides of formula I, which can be obtained by palladium-catalyzed carbonylation reaction of aromatic chlorides of formula II, amines of formula III and carbon monoxide in the presence of a base. The invention further relates to a process for the preparation of aryl-5-trifluoromethyl-1,2,4-oxadiazoles, which are known for controlling phytopathogenic fungi.

公开(公告)号：US11192873B2

公开(公告)日：2021-12-07

申请号：US16487161

申请日：2018-02-13

Applicant: BASF SE

Inventor： Mathias Schelwies ,  Rocco Paciello ,  Ralf Pelzer ,  Wolfgang Siegel

IPC: C07C51/12 ,  C07C57/02 ,  C07D307/92

Abstract: The present invention relates to a process for carbonylating allyl alcohols at low temperature, low pressure and/or low catalyst loading. In an alternative embodiment, an acylation product of the allyl alcohol is used for the carbonylation. The present invention likewise relates to the preparation of conversion products of these carbonylation products and specifically of (−)-ambrox.