公开(公告)号：WO1995001919A1

公开(公告)日：1995-01-19

申请号：PCT/US1994007505

申请日：1994-07-06

Applicant: BAXTER DIAGNOSTICS INC.

Inventor： BAXTER DIAGNOSTICS INC. ,  STARK, William, A. ,  PFADENHAUER, Ernest, H.

IPC: B65D47/28

CPC classification number: B65D47/286 ,  G01N35/1002 ,  G01N2035/0405

Abstract: The invention disclosed is a sealed fluent material container (10) having a chamber (22) with an opening (28) provided with a manually operable primary closure mechanism (36) and a secondary closure mechanism (70) that may be operated either manually or automatically. Manual removal of the primary closure mechanism (36) from the chamber opening allows the secondary closure mechanism (70) to extend a laterally moveable tongue (70) from a horizontal guide recess (80) on the top of the container (10) to a normally closed position covering the opening (28). An engageable tab (74) on the secondary closure (70) permits the retraction of the moveable tongue (70) against the biasing means (84) to expose the chamber opening. The container (10) has particular utility for use in automated chemical dispensers, analyzers and related equipment for the analysis and testing of blood, physiological fluids and other biological samples.

Abstract translation: 所公开的发明是一种密封流体物料容器（10），其具有具有开口（28）的腔室（22），该开口设置有可手动操作的主闭合机构（36）和辅助闭合机构（70） 自动。 从腔室开口手动移除主闭合机构（36）允许第二闭合机构（70）将侧向可移动的舌片（70）从容器（10）的顶部上的水平引导凹部（80）延伸到 覆盖开口（28）的常闭位置。 辅助封闭件（70）上的可接合突片（74）允许可动舌片（70）回缩偏压装置（84）以露出腔室开口。 容器（10）特别适用于自动化学分配器，分析仪和相关设备，用于分析和测试血液，生理液体和其他生物样品。

公开(公告)号：WO1994026874A2

公开(公告)日：1994-11-24

申请号：PCT/US1994005392

申请日：1994-05-13

Applicant: BAXTER DIAGNOSTICS INC.

Inventor： BAXTER DIAGNOSTICS INC. ,  WILLIAMS, Gregory ,  BROWN, Gary ,  DANIEL, Craig ,  OLSON, Carolyn ,  GARDNER, William ,  ENSCOE, Glenn ,  JARRARD, Elizabeth

IPC: C12N01/34

CPC classification number: G01N21/255 ,  C12M41/36 ,  C12M41/46 ,  G01N2035/00524 ,  G01N2201/0446 ,  G01N2201/064

Abstract: An improved optical system for use in an instrument for culturing and detecting the presence of microorganisms in human tissue specimens is disclosed. The improved optical detection system is designed to reduce unwanted noise by substantially blocking all light other than light from a sensor positioned on an inside wall of a culture bottle from reaching the photodetector. A control circuit providing a "lock-in" detection system designed to reduce unwanted noise is also disclosed. The detection system is capable of rapidly and automatically detecting whether a specimen bottle has been inserted into the instrument.

Abstract translation: 公开了一种用于培养和检测人体组织样品中微生物的存在的仪器中的改进的光学系统。 改进的光学检测系统被设计成通过基本上阻挡来自定位在培养瓶内壁上的传感器的光以外的所有光来到达光电检测器来减少不需要的噪声。 还公开了一种提供设计用于减少不想要的噪声的“锁定”检测系统的控制电路。 检测系统能够快速，自动地检测样品瓶是否已插入仪器。

公开(公告)号：WO1993025686A1

公开(公告)日：1993-12-23

申请号：PCT/US1993005431

申请日：1993-06-03

Applicant: BAXTER DIAGNOSTICS INC.

Inventor： BAXTER DIAGNOSTICS INC. ,  AEBY, Pierre ,  BLASER, Kurt ,  CRAMERI, Reto ,  SUTER, Marc

IPC: C12N15/13

CPC classification number: C07K16/00 ,  C07K16/40 ,  G01N33/543

Abstract: In accordance with the present invention, there is provided a recombinant rabbit heavy chain variable domain, or single domain antibody having the ability to bind to a solid phase, for example, plastic, without a decrease in antigen capture capacity. The present invention further provides an improved immunological sandwich assay, such as an ELISA, in which the rabbit single domain antibody of the present invention is directly bound to the solid phase as the capture antibody. The resulting assay is less complex than systems currently utilized without any decrease in sensitivity.

Abstract translation: 根据本发明，提供了重组兔重链可变结构域或具有结合固相例如塑料的能力的单结构域抗体，而不降低抗原捕获能力。 本发明还提供了一种改进的免疫学夹心测定法，例如ELISA，其中本发明的兔单结构域抗体直接与固相结合作为捕获抗体。 所得测定法比目前使用的测定法更不复杂，而灵敏度没有任何降低。

公开(公告)号：WO1993014403A1

公开(公告)日：1993-07-22

申请号：PCT/US1992011230

申请日：1992-12-30

Applicant: BAXTER DIAGNOSTICS INC.

Inventor： BAXTER DIAGNOSTICS INC. ,  BOCHES, Francee ,  BROTHERTON, Mary ,  REGAN, Jeffrey ,  SMITH, Dennis ,  TIMMONS, Richard

IPC: G01N33/531

CPC classification number: G01N33/543 ,  G01N33/54306

Abstract: This invention is directed to a multi-test immunochemical reagent and method to use the same in radial partition immunoassays. More particularly, this invention relates to a human immunochemical reagent having antiserum to a specific animal species adsorbed on to an inert porous medium.

Abstract translation: 本发明涉及一种多测试免疫化学试剂及其在径向分布免疫测定中使用该试剂的方法。 更具体地说，本发明涉及对吸附在惰性多孔介质上的特定动物物种具有抗血清的人类免疫化学试剂。

公开(公告)号：WO1993011431A1

公开(公告)日：1993-06-10

申请号：PCT/US1992009973

申请日：1992-11-20

Applicant: BAXTER DIAGNOSTICS INC.

Inventor： BAXTER DIAGNOSTICS INC. ,  SHAH, Dinesh, O. ,  NATH, Nrapendra

IPC: G01N33/53

CPC classification number: C07K14/005 ,  C12N2740/14022 ,  G01N33/56988

Abstract: The present invention relates to a serological method for detection of antibodies to HTLV-II in a blood sample using a synthetic peptide coated on a solid phase consisting of the amino acids of Sequence Id. Nos. 1-7. Additionally, this invention relates to a diagnostic test kit for the detection of HTLV-II.

Abstract translation: 本发明涉及使用包含在由序列Id的氨基酸组成的固相上的合成肽检测血液样品中HTLV-II的抗体的血清学方法。 第1-7号。 另外本发明涉及用于检测HTLV-II的诊断试剂盒。

公开(公告)号：WO1993011260A1

公开(公告)日：1993-06-10

申请号：PCT/US1992009972

申请日：1992-11-20

Applicant: BAXTER DIAGNOSTICS INC.

Inventor： BAXTER DIAGNOSTICS INC. ,  DENIS, Rosa, M., F. ,  RUIZ, Juan, A.

IPC: C12Q01/56

CPC classification number: C12Q1/56 ,  C12Q2337/12 ,  G01N33/86 ,  G01N2333/75 ,  G01N2333/968

Abstract: This invention relates to a method for measuring the fibrinolytic capacity of whole plasma. This method comprises coating a solid support with a plasminogen binding material such as polylysine, fibrinogen or fibrin, adding a plasma sample or control and then measuring the amount of plasmin bound to the support. This method is particularly advantageous as the immobilized plasminogen binding material provides a surface which mimics the in vivo surface of a fibrin clot.

Abstract translation: 本发明涉及一种测量全血浆纤维蛋白溶解能力的方法。 该方法包括用纤维蛋白溶酶原结合材料如聚赖氨酸，纤维蛋白原或纤维蛋白包被固体支持物，加入血浆样品或对照，然后测量与载体结合的纤溶酶的量。 该方法是特别有利的，因为固定的纤溶酶原结合材料提供了模拟纤维蛋白凝块体内表面的表面。

公开(公告)号：WO1993009253A1

公开(公告)日：1993-05-13

申请号：PCT/US1992009470

申请日：1992-11-04

Applicant: BAXTER DIAGNOSTICS INC.

Inventor： BAXTER DIAGNOSTICS INC. ,  KINK, John, A. ,  RYAN, Terence, E. ,  TODD, John, A. ,  SAEED, Badr

IPC: C12Q01/70

CPC classification number: C07K14/005 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/23 ,  C07K2319/40 ,  C12N2770/24222 ,  G01N33/5767

Abstract: An assay for detection of serum antibodies having specificity to hepatitis C viral antigens utilizes the carboxy-terminal 102 amino acids of the c33c region of nonstructural gene 3 of HCV containing substantially all the epitopes of the gene 3 protein. In the preferred embodiment the recombinant 102 amino acid peptide is coated onto a solid support, and incubated in the presence of serum obtained from a patient infected with HCV. The presence of antibodies bound to the antigen coated support is detected in a sandwich format utilizing a second reporter-conjugated antibody.

Abstract translation: 用于检测对丙型肝炎病毒抗原具有特异性的血清抗体的检测法利用HCV基因3蛋白基本上所有表位的非结构基因3的c33c区的羧基末端102个氨基酸。 在优选的实施方案中，将重组102氨基酸肽包被在固体支持物上，并在从感染HCV的患者获得的血清存在下温育。 使用第二报告基因共轭抗体以夹心形式检测与抗原包被的载体结合的抗体的存在。

公开(公告)号：WO1992022571A1

公开(公告)日：1992-12-23

申请号：PCT/US1992003635

申请日：1992-04-29

Applicant: BAXTER DIAGNOSTICS INC.

Inventor： BAXTER DIAGNOSTICS INC. ,  LEAHY, David, C. ,  TODD, John, A. ,  JOLLEY, Michael, E.

IPC: C07K07/00

CPC classification number: C07K14/005 ,  C12N2770/24222

Abstract: An assay for antigens of hepatitis C virus utilizes a synthetic peptide comprising the first 38 amino acids of the capsid region containing at least two immunodominant epitopes. The assay detects antibodies in the sera of patients infected with the Non-A Non-B hepatitis virus. Of particular efficacy is a competitive inhibition assay, which incorporates in the liquid phase an inhibitor consisting of a peptide containing only one of the immunodominant capsid epitopes, which is capable of inhibiting binding of antibodies to all target epitopes present on the solid substrate.

Abstract translation: 对丙型肝炎病毒抗原的测定利用了包含至少两个免疫显性表位的衣壳区的前38个氨基酸的合成肽。 该检测法检测感染了非A非乙型肝炎病毒的患者血清中的抗体。 特别的功效是竞争性抑制测定，其在液相中包含由仅含有一种免疫显性衣壳表位的肽组成的抑制剂，其能够抑制抗体与固体底物上存在的所有靶表位的结合。

公开(公告)号：WO1992022201A1

公开(公告)日：1992-12-23

申请号：PCT/US1992004995

申请日：1992-06-15

Applicant: BAXTER DIAGNOSTICS INC.

Inventor： BAXTER DIAGNOSTICS INC. ,  WANG, Chao-Huei, J. ,  SHAH, Dinesh, O.

IPC: A01N01/02

CPC classification number: H01F1/37 ,  A61K47/6923 ,  A61K47/6927 ,  A61K47/6933 ,  B03C1/01 ,  C07K17/00 ,  C12N11/08 ,  C12Q1/6834 ,  G01N33/5434 ,  G01N2446/10 ,  G01N2446/40 ,  H01F1/36

Abstract: This invention provides a novel process of producing magnetically responsive polymer particles comprising polymeric core particles coated evenly with a layer of polymer containing magnetically responsive metal oxide. A wide variety of polymeric particles with sizes ranging from 1 to 100 microns can be used as core particles and transformed into magnetically responsive polymer particles. The surface of these magnetically responsive polymer particles can be coated further with another layer of functionalized polymer. These magnetically responsive polymer particles can be used for passive or covalent coupling of biological material such as antigens, antibodies, enzymes or DNA/RNA hybridization and used as solid phase for various types of immunoassays, DNA/RNA hybridization probes assays, affinity purification, cell separation and other medical, diagnostic, and industrial applications.

Abstract translation: 本发明提供一种制备磁响应聚合物颗粒的新方法，其包括均匀地涂覆含有磁响应金属氧化物的聚合物层的聚合物芯颗粒。 尺寸范围为1至100微米的多种聚合物颗粒可用作核心颗粒并转化为磁响应聚合物颗粒。 这些磁响应聚合物颗粒的表面可以进一步被另一层官能化聚合物涂覆。 这些磁响应聚合物颗粒可用于生物材料如抗原，抗体，酶或DNA / RNA杂交的被动或共价偶联，并用作各种类型免疫测定的固相，DNA / RNA杂交探针测定，亲和纯化，细胞 分离等医疗，诊断和工业应用。

公开(公告)号：WO1992001229A1

公开(公告)日：1992-01-23

申请号：PCT/US1991004405

申请日：1991-06-21

Applicant: BAXTER DIAGNOSTICS INC.

Inventor： BAXTER DIAGNOSTICS INC. ,  HEMKER, Hendrik, Coenraad ,  KESSELS, Hendricus, Johannes ,  BEGUIN, Suzette, Lucette

IPC: G01N33/84

CPC classification number: G01N33/86 ,  C12Q1/56 ,  G01N2333/755 ,  G01N2333/96444

Abstract: A chromogenic assay for determination of blood coagulation Factor VIII:Ca, using an indicator of Factor Xa simultaneously as a mesure of Factor VIII:Ca concentration and as an inhibitor of Factor Xa. This technique can be applied to measure the concentration of an activating enzyme using the rate of conversion of the indicator molecule of the product of that enzyme as an indirect indicator of enzyme concentration.

Abstract translation: 用于测定凝血因子VIII：Ca的显色分析，使用因子Xa的指标同时作为因子VIII的测定：Ca浓度和作为因子Xa的抑制剂。 该技术可以应用于使用酶的产物的指示剂分子的转化率作为酶浓度的间接指标来测量活化酶的浓度。