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    HUMAN PAPILLOMAVIRUS DETECTION ASSAY
    1.
    发明申请
    HUMAN PAPILLOMAVIRUS DETECTION ASSAY 审中-公开
    人乳头瘤病毒检测测定

    公开(公告)号：WO1994026934A2

    公开(公告)日：1994-11-24

    申请号：PCT/US1994005085

    申请日：1994-05-06

    Applicant: BAXTER DIAGNOSTICS INC. ,  BROWN, Janice, T.

    Inventor： BAXTER DIAGNOSTICS INC.

    IPC: C12Q01/70

    CPC classification number: C12Q1/708

    Abstract: A two-step nucleic acid hybridization probe assay for certain types of human papilloma virus (HPV) associated with cervical cell dysplasia and malignancy comprises a fluid phase capture hybridization step in which amplified specific gene E6/E7 messenger RNA from a biological specimen is hybridized to a biotinylated capture reagent to form a complex, attachment of the capture reagent complex to a solid phase by reaction with immobilized streptavidin, a second hybridization step in which a virus type-specific enzyme-conjugated detection probe hybridizes with the complexed amplified messenger RNA, and detection of the complexed detection probe by color or fluorophor production following a wash of the solid phase and addition of an appropriate chromogenic or fluorogenic substrate. The assay has enhanced sensitivity compared to conventional tests and is specific for actual expression of HPV oncogenes in cervical specimens, and not merely indicative of viral presence.

    Abstract translation: 与宫颈细胞发育不良和恶性肿瘤相关的某些类型的人乳头状瘤病毒（HPV）的两步核酸杂交探针测定包括流体相捕获杂交步骤，其中来自生物样品的扩增的特异性基因E6 / E7信使RNA与 生物素化的捕获试剂以形成复合物，通过与固定链霉亲和素反应将捕获试剂复合物与固相连接，第二杂交步骤，其中病毒型特异性酶结合的检测探针与复合扩增的信使RNA杂交，以及 通过固相洗涤后的彩色或荧光物质生成检测复合检测探针，并加入合适的显色或荧光底物。 该测定与常规测试相比具有增强的灵敏度，并且特异性地针对宫颈标本中HPV致癌基因的实际表达，而不仅仅是病毒存在的指示。

    METHOD AND APPARATUS FOR THE STEPWISE MOVEMENT OF ITEMS
    2.
    发明申请
    METHOD AND APPARATUS FOR THE STEPWISE MOVEMENT OF ITEMS 审中-公开
    方法和设备的步骤运动的项目

    公开(公告)号：WO1994024570A1

    公开(公告)日：1994-10-27

    申请号：PCT/US1994001540

    申请日：1994-02-09

    Applicant: BAXTER DIAGNOSTICS INC.

    Inventor： BAXTER DIAGNOSTICS INC. ,  HUBER, Michael, D. ,  FRYE, Stephen, L. ,  MAZZA, John, C.

    IPC: G01N35/02

    CPC classification number: G01N35/0092 ,  G01N35/025 ,  G01N2035/0097 ,  Y10S436/807 ,  Y10T436/11 ,  Y10T436/113332 ,  Y10T436/115831 ,  Y10T436/12

    Abstract: A sample analyzer is disclosed for analyzing the characteristics of a plurality of samples. The analyzer includes a movable sample support for holding samples arranged in a first plurality of holders in a sequence for movement in a first direction. An indexing drive for the sample support advances the sample support in the first direction in a set of one or more increments, wherein one increment in the set is a net amount equal to a second plurality of holders greater than one holder and less than the first plurality such that the second plurality is relatively prime with respect to the first plurality.

    Abstract translation: 公开了用于分析多个样品的特性的样品分析仪。 分析仪包括可移动的样品支撑件，用于保持以第一方向移动的顺序排列在第一多个保持器中的样品。 用于样本支撑件的分度驱动器以一个或多个增量的集合在第一方向上推进样本支撑，其中该组中的一个增量是等于多于一个持有者的第二多个保持器的净量，并且小于第一 多个，使得第二多个相对于第一多个相对于素数。

    SEALABLE VESSEL FOR CONTAINING AND PROCESSING ANALYTICAL SAMPLES
    4.
    发明申请
    SEALABLE VESSEL FOR CONTAINING AND PROCESSING ANALYTICAL SAMPLES 审中-公开
    用于包含和加工分析样品的密封容器

    公开(公告)号：WO1994004929A1

    公开(公告)日：1994-03-03

    申请号：PCT/US1993007951

    申请日：1993-08-24

    Applicant: BAXTER DIAGNOSTICS INC.

    Inventor： BAXTER DIAGNOSTICS INC. ,  COAKLEY, Joseph ,  GODSEY, James ,  SHERMAN, David

    IPC: G01N35/00

    CPC classification number: G01N35/1097 ,  B01L3/502 ,  B01L2400/0644 ,  Y10T436/25

    Abstract: A sealable container for holding an analytical sample for processing is disclosed. The container includes a body (12) with a dispensing port (26) and an insert member (14) slidably received in the body (12). The insert member and the body are movable relative to each other between a first position, in which the outlet port (18) is substantially aligned with the dispensing port (26), and a second position, in which the outlet port is substantially out of alignment with the dispensing port. Sealing means (48), which may take the form of O-rings between the insert member and the body, provide a substantially airtight, hermetic seal between a reaction chamber formed in the insert member and the body so that the reaction chamber can be sealed or isolated from the outside environment. The container is particularly adapted to contain the processes of nucleic acid amplification and to thereby reduce the problems of sample crosscontamination encountered in such processes. A method of processing an analytical sample using such a container is also disclosed.

    Abstract translation: 公开了用于保持用于处理的分析样品的可密封容器。 容器包括具有分配端口（26）的本体（12）和可滑动地容纳在主体（12）中的插入构件（14）。 插入构件和本体可以在第一位置和第二位置之间相对移动，在第一位置，出口（18）基本上与分配端口（26）对准，第二位置，出口基本上不在 与分配口对齐。 可以在插入构件和主体之间呈O形环形式的密封装置（48）在形成在插入构件中的反应室和主体之间提供基本上气密的密封，使得反应室可以被密封 或与外部环境隔离。 容器特别适于包含核酸扩增的过程，从而减少在这些方法中遇到的样品交叉污染的问题。 还公开了使用这种容器处理分析样品的方法。

    SAMPLE TUBE CARRIER
    5.
    发明申请
    SAMPLE TUBE CARRIER 审中-公开
    样品管

    公开(公告)号：WO1994000238A1

    公开(公告)日：1994-01-06

    申请号：PCT/US1993005734

    申请日：1993-06-15

    Applicant: BAXTER DIAGNOSTICS INC.

    Inventor： BAXTER DIAGNOSTICS INC. ,  STARK, William, A. ,  HARDIMAN, Kempton, H. ,  SCRIBNER, Richard, A. ,  MAZZA, John

    IPC: B01L09/06

    CPC classification number: B01L9/06 ,  B65G2201/0261 ,  G01N35/04

    Abstract: A self-adjusting linkable carrier (10, 12, 14) for sample tubes (16), cuvettes, cells and the like comprising a longitudinally symmetrical vertically oriented polygonal body having two pairs of orthogonally disposed opposed vertical faces (26, 28, 30, 32) and a horizontal bottom sliding surface (34) is disclosed. The top surface (36) of the body is provided with a central bore (38) opening into a vertical cavity (40) adapted to releasably receive and retain a wide variety of sample tube configurations in a stable vertical orientation. Machine readable indicia (60) may be provided on the external surface and vertical slots (66, 68, 70, 72) are provided in each external face (26, 28, 30, 32) to provide access to the central vertical cavity (40). A releasably locking horizontally aligned dovetail feature (74, 76) is provided to link adjacent carriers into conveniently handled racks or magazines which may be assembled and disassembled by machine. Additional horizontally sliding indexing elements (92, 94) are provided to facilitate the stable storage and transport of the carrier.

    Abstract translation: 一种用于样品管（16），比色杯，细胞等的自调节可连接载体（10,12,14），包括纵向对称的垂直取向的多边体，其具有两对正交设置的相对的垂直面（26,28,30， 32）和水平底部滑动表面（34）。 主体的顶表面（36）设置有中心孔（38），该中心孔（38）通向适于可释放地容纳并保持稳定垂直取向的各种样品管构造的垂直空腔（40）。 机器可读标记（60）可以设置在外表面上，并且垂直槽（66,68,70,72）设置在每个外表面（26,28,30,32）中，以提供对中心垂直腔（40）的通路 ）。 提供可释放地锁定的水平对准的燕尾形特征（74,76）以将相邻的托架连接成方便地处理的机架或机架，这些机架或机架可由机器组装和拆卸。 提供附加的水平滑动分度元件（92,94）以便于载体的稳定的储存和运输。

    BINDING PROTEIN CAPTURE ASSAY
    6.
    发明申请
    BINDING PROTEIN CAPTURE ASSAY 审中-公开
    绑定蛋白质捕获测定

    公开(公告)号：WO1993014405A1

    公开(公告)日：1993-07-22

    申请号：PCT/US1992011243

    申请日：1992-12-28

    Applicant: BAXTER DIAGNOSTICS INC.

    Inventor： BAXTER DIAGNOSTICS INC. ,  BOCHES, Francee, S. ,  HILYARD, Kathy, F. ,  MONTICELLO, James, E. ,  SMITH, Dennis, E.

    IPC: G01N33/543

    CPC classification number: G01N33/78 ,  G01N33/82

    Abstract: This invention relates to binding protein assays. In particular, this invention relates to binding protein assays for B12 and folate in serum or plasma. More specifically, this invention provides a sequential assay that uses a combination of specific binding proteins, and anti-binding protein antibodies to measure B12 and folate in serum or plasma.

    Abstract translation: 本发明涉及结合蛋白测定。 特别地，本发明涉及血清或血浆中B12和叶酸的结合蛋白测定。 更具体地，本发明提供使用特异性结合蛋白和抗结合蛋白抗体的组合来测量血清或血浆中B12和叶酸的顺序测定法。

    SYSTEMS FOR CONDUCTING MULTIPLE ANALYTICAL PROCEDURES USING A CENTRAL PROCESSING HUB
    7.
    发明申请
    SYSTEMS FOR CONDUCTING MULTIPLE ANALYTICAL PROCEDURES USING A CENTRAL PROCESSING HUB 审中-公开
    使用中央处理机构执行多个分析程序的系统

    公开(公告)号：WO1993012430A1

    公开(公告)日：1993-06-24

    申请号：PCT/US1992011131

    申请日：1992-12-18

    Applicant: BAXTER DIAGNOSTICS INC.

    Inventor： BAXTER DIAGNOSTICS INC. ,  KELSO, David, M. ,  KAUL, Jeffrey, W. ,  KOCUR, Wolodymyr

    IPC: G01N35/02

    CPC classification number: G01N35/0098 ,  G01N35/026 ,  G01N35/028 ,  G01N2035/0425

    Abstract: Systems for conducting analytical procedures include multiple work stations (22 to 36) that are each individually accessible through a common processing hub (100). A shuttle mechanism operates within the common processing hub (100) for conveying materials to and from the work stations (22 to 36) through their associated hub accesses. The common hub (100) creates a compact operating zone in which access to the processing stations (22 to 36) can be arranged at different arcuate positions, as well as vertically stacked one above the other, thereby providing a processing module with a relatively small ''footprint''. The systems are capable of sequentially transporting a number of test carriers (12) in nonlinear, discontinuous paths among the various processing stations (22 to 36) to thereby perform different precribed processing tasks upon different carriers (12) at the same time.

    Abstract translation: 用于进行分析程序的系统包括可通过公共处理集线器（100）各自单独访问的多个工作站（22至36）。 穿梭机构在公共处理集线器（100）内操作，用于通过其相关联的集线器访问将材料输送到工作站（22至36）和从工作站（22至36）传送材料。 公共集线器（100）创建一个紧凑的操作区域，其中对处理站（22至36）的访问可以被布置在不同的弧形位置以及垂直地堆叠在另一个之上，从而提供具有相对较小的处理模块 ''脚印''。 这些系统能够在各种处理站（22至36）之间以非线性非连续路径顺序地传输多个测试载体（12），从而在不同的载体（12）同时执行不同的预处理任务。

    RAPID INDUCIBLE BETA-LACTAMASE SCREEN TEST
    8.
    发明申请
    RAPID INDUCIBLE BETA-LACTAMASE SCREEN TEST 审中-公开
    快速诱导BETA-LACTAMASE屏幕测试

    公开(公告)号：WO1992019763A1

    公开(公告)日：1992-11-12

    申请号：PCT/US1992003636

    申请日：1992-04-29

    Applicant: BAXTER DIAGNOSTICS INC.

    Inventor： BAXTER DIAGNOSTICS INC. ,  JOHNSTON, Judith ,  FELLAND, Tracy ,  BASCOMB, Shoshana ,  GODSEY, James, H.

    IPC: C12Q01/02

    CPC classification number: C12Q1/18 ,  Y10S435/975

    Abstract: In an assay for determination of beta-lactam antibiotic resistance in a target bacterial strain, the strain is grown in the presence of both a beta-lactamase inducing antibiotic and a beta-lactam indicator antibiotic which kills or inhibits the growth of bacteria unable to hydrolyze beta-lactam antibiotics. Growth, indicative of drug resistance in the target strain, is monitored by detecting a fluorophor released by the enzymatic cleavage of a metabolizable fluorogenic compound.

    Abstract translation: 在用于测定目标细菌菌株中β-内酰胺抗生素抗性的测定中，该菌株在β-内酰胺酶诱导抗生素和β-内酰胺指示剂抗生素存在下生长，其杀死或抑制不能水解的细菌的生长 β-内酰胺类抗生素。 通过检测通过可代谢的荧光化合物的酶裂解释放的荧光体来监测靶标菌株中耐药性的生长。

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