公开(公告)号：ES2079860T3

公开(公告)日：1996-01-16

申请号：ES92906507

申请日：1991-10-30

Applicant: BAXTER INT

Inventor： MARGALIT RIMONA

IPC: A61K31/00 ,  A61K9/127 ,  A61K31/165 ,  A61K31/196 ,  A61P3/00 ,  C07C231/12 ,  C07C231/14 ,  C07C231/24 ,  C07C233/04 ,  C07C233/07 ,  C07C233/65

公开(公告)号：ES2077403T3

公开(公告)日：1995-11-16

申请号：ES92905800

申请日：1991-10-30

Applicant: BAXTER INT

Inventor： MARGALIT RIMONA

IPC: A61K9/127 ,  A61K38/22

公开(公告)号：AT127685T

公开(公告)日：1995-09-15

申请号：AT92906507

申请日：1991-10-30

Applicant: BAXTER INT

Inventor： MARGALIT RIMONA

IPC: A61K31/00 ,  A61K9/127 ,  A61K31/165 ,  A61K31/196 ,  A61P3/00 ,  C07C231/12 ,  C07C231/14 ,  C07C231/24 ,  C07C233/04 ,  C07C233/07 ,  C07C233/65

公开(公告)号：AU651414B2

公开(公告)日：1994-07-21

申请号：AU9037091

申请日：1991-10-30

Applicant: BAXTER INT

Inventor： MARGALIT RIMONA

IPC: A61K9/127 ,  A61K47/48

Abstract: Methodologies have been developed and certain recognizing substances and crosslinking reagents have been identified to modify liposomes. Crosslinking reagents link residues on the liposomal surface to the residues offered by certain recognizing substances. The crosslinking reagents include glutaraldehyde (GAD) and a water soluble carbodiimide, preferably, 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC). The recognizing substances include gelatin, collagen, and hyaluronic acid (HA). Following these methodologies, recognizing substances can be utilized as an adhesive or glue to attach the liposomes onto a target area. These "bioadhesive" liposomes offer potential advantages as a microscopic drug delivery system.

公开(公告)号：AU9037091A

公开(公告)日：1992-09-15

申请号：AU9037091

申请日：1991-10-30

Applicant: BAXTER INT

Inventor： MARGALIT RIMONA

IPC: A61K9/127 ,  A61K47/48

Abstract: Methodologies have been developed and certain recognizing substances and crosslinking reagents have been identified to modify liposomes. Crosslinking reagents link residues on the liposomal surface to the residues offered by certain recognizing substances. The crosslinking reagents include glutaraldehyde (GAD) and a water soluble carbodiimide, preferably, 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC). The recognizing substances include gelatin, collagen, and hyaluronic acid (HA). Following these methodologies, recognizing substances can be utilized as an adhesive or glue to attach the liposomes onto a target area. These "bioadhesive" liposomes offer potential advantages as a microscopic drug delivery system.

公开(公告)号：AU1347892A

公开(公告)日：1992-09-15

申请号：AU1347892

申请日：1991-10-30

Applicant: BAXTER INT

Inventor： MARGALIT RIMONA

IPC: A61K9/127 ,  A61K38/22

公开(公告)号：AU699887B2

公开(公告)日：1998-12-17

申请号：AU3894895

申请日：1995-10-03

Applicant: BAXTER INT

Inventor： MARGALIT RIMONA

IPC: A61K9/127

Abstract: Recognizing substances, including epidermal growth factor, gelatin, collagen and hyaluronic acid, have been covalently bound to liposomal surfaces and utilized to attach liposomes onto a cellular or an extracellular matrix (ECM) target site. These "bioadhesive" liposomes offer several advantages including the mutual protection of both the drug and biological environment; an increase in drug bioavailability and retention at the target site; and improved adherence or adhesion to the designated target site.

公开(公告)号：DE69113036T2

公开(公告)日：1996-05-02

申请号：DE69113036

申请日：1991-10-30

Applicant: BAXTER INT

Inventor： MARGALIT RIMONA

IPC: A61K31/00 ,  A61K9/127 ,  A61K31/165 ,  A61K31/196 ,  A61P3/00 ,  C07C231/12 ,  C07C231/14 ,  C07C231/24 ,  C07C233/04 ,  C07C233/07 ,  C07C233/65

公开(公告)号：CA2176566A1

公开(公告)日：1996-04-11

申请号：CA2176566

申请日：1995-10-03

Applicant: BAXTER INT

Inventor： MARGALIT RIMONA

IPC: A61K9/127 ,  B01J13/02

Abstract: Recognizing substances, including epidermal growth factor, gelatin, collagen and hyaluronic acid, have been covalently bound to liposomal surfaces and utilized to attach liposomes onto a cellular or an extracellular matrix (ECM) target site. These "bioadhesive" liposomes offer several advantages including the mutual protection of both the drug and biological environment; an increase in drug bioavailability and retention at the target site; and improved adherence or adhesion to the designated target site

公开(公告)号：AT132367T

公开(公告)日：1996-01-15

申请号：AT92900243

申请日：1991-10-30

Applicant: BAXTER INT

Inventor： MARGALIT RIMONA

IPC: A61K9/127 ,  A61K47/48

Abstract: Methodologies have been developed and certain recognizing substances and crosslinking reagents have been identified to modify liposomes. Crosslinking reagents link residues on the liposomal surface to the residues offered by certain recognizing substances. The crosslinking reagents include glutaraldehyde (GAD) and a water soluble carbodiimide, preferably, 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC). The recognizing substances include gelatin, collagen, and hyaluronic acid (HA). Following these methodologies, recognizing substances can be utilized as an adhesive or glue to attach the liposomes onto a target area. These "bioadhesive" liposomes offer potential advantages as a microscopic drug delivery system.