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公开(公告)号：DK0525132T3
公开(公告)日：1996-02-05
申请号：DK92900243
申请日：1991-10-30
Applicant: BAXTER INT
Inventor： MARGALIT RIMONA
Abstract: Methodologies have been developed and certain recognizing substances and crosslinking reagents have been identified to modify liposomes. Crosslinking reagents link residues on the liposomal surface to the residues offered by certain recognizing substances. The crosslinking reagents include glutaraldehyde (GAD) and a water soluble carbodiimide, preferably, 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC). The recognizing substances include gelatin, collagen, and hyaluronic acid (HA). Following these methodologies, recognizing substances can be utilized as an adhesive or glue to attach the liposomes onto a target area. These "bioadhesive" liposomes offer potential advantages as a microscopic drug delivery system.
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公开(公告)号：AT125697T
公开(公告)日：1995-08-15
申请号：AT92905800
申请日：1991-10-30
Applicant: BAXTER INT
Inventor： MARGALIT RIMONA
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公开(公告)号：AU656173B2
公开(公告)日：1995-01-27
申请号：AU1259292
申请日：1991-10-30
Applicant: BAXTER INT
Inventor： MARGALIT RIMONA , ROSEMAN THEODORE , WOOD RAY W
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公开(公告)号：AU649796B2
公开(公告)日：1994-06-02
申请号：AU1347892
申请日：1991-10-30
Applicant: BAXTER INT
Inventor： MARGALIT RIMONA
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公开(公告)号：CA2079450A1
公开(公告)日：1992-08-15
申请号：CA2079450
申请日：1991-10-30
Applicant: BAXTER INT
Inventor： MARGALIT RIMONA , ROSEMAN THEODORE , WOOD RAY W
IPC: A61K9/127
Abstract: 2079450 9214446 PCTABS00015 Recognizing substances, epidermal growth factor, gelatin, collagen and hyaluronic acid, have been covalently bound to liposomal surfaces and utilized to attach liposomes onto a cellular target site. These "bioadhesive" liposomes offer several advantages in the area of topically and locally administered free drug. These advantages include the mutual protection of both the drug and biological environment; an increase in drug bioavailability and retention at the target site; and improved adherence or adhesion to the designated target site.
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Patent Agency Ranking
公开(公告)号：CA2079447C
公开(公告)日：2004-02-10
申请号：CA2079447
申请日：1991-10-30
Applicant: BAXTER INT
Inventor： MARGALIT RIMONA
IPC: A61K31/00 , A61K9/127 , A61K31/165 , A61K31/196 , A61P3/00 , C07C231/12 , C07C231/14 , C07C231/24 , C07C233/04 , C07C233/07 , C07C233/65
Abstract: Drug-encapsulating liposomes have been successfully modified through the covalent binding of recognizing substances without significant interference with the rate constant of drug efflux from the liposomes. Through data processing according to two mechanisms, the acceptability of the bioadhesive liposomes as sustained release drug delivery systems for topical or local ad- ministration is shown.
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公开(公告)号：DE69111804T2
公开(公告)日：1996-05-02
申请号：DE69111804
申请日：1991-10-30
Applicant: BAXTER INT
Inventor： MARGALIT RIMONA
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公开(公告)号：DE69116144D1
公开(公告)日：1996-02-15
申请号：DE69116144
申请日：1991-10-30
Applicant: BAXTER INT
Inventor： MARGALIT RIMONA
Abstract: Methodologies have been developed and certain recognizing substances and crosslinking reagents have been identified to modify liposomes. Crosslinking reagents link residues on the liposomal surface to the residues offered by certain recognizing substances. The crosslinking reagents include glutaraldehyde (GAD) and a water soluble carbodiimide, preferably, 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC). The recognizing substances include gelatin, collagen, and hyaluronic acid (HA). Following these methodologies, recognizing substances can be utilized as an adhesive or glue to attach the liposomes onto a target area. These "bioadhesive" liposomes offer potential advantages as a microscopic drug delivery system.
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公开(公告)号：DK0525167T3
公开(公告)日：1995-11-13
申请号：DK92906507
申请日：1991-10-30
Applicant: BAXTER INT
Inventor： MARGALIT RIMONA
IPC: A61K31/00 , A61K9/127 , A61K31/165 , A61K31/196 , A61P3/00 , C07C231/12 , C07C231/14 , C07C231/24 , C07C233/04 , C07C233/07 , C07C233/65
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公开(公告)号：DK0525163T3
公开(公告)日：1995-09-25
申请号：DK92905800
申请日：1991-10-30
Applicant: BAXTER INT
Inventor： MARGALIT RIMONA
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