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公开(公告)号：EP2987181B1
公开(公告)日：2018-02-14
申请号：EP14869552.1
申请日：2014-12-09
Applicant: Bio-Rad Laboratories, Inc.
Inventor： RAN, Boaz , SWIHART, Steve , THRUSH, Evan , BARAK, Itay
CPC classification number: H04N5/361 , H01L2924/0002 , H04N5/365 , H01L2924/00
Abstract: One embodiment of the invention is directed to an imaging device comprising an image sensor comprising an array of pixels, and a mask coupled with the image sensor, the mask configured to darken at least one pixel in the array of pixels.
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公开(公告)号：EP3207566A1
公开(公告)日：2017-08-23
申请号：EP15850115.5
申请日：2015-10-06
Applicant: Bio-rad Laboratories, Inc.
Inventor： THRUSH, Evan , SWIHART, Steve , JAYAMOHAN, Hari
CPC classification number: H01L31/024 , G01N21/15 , G01N21/6456 , G01N21/76 , G01N21/763 , G01N2021/158 , H01L27/14618 , H01L27/1462
Abstract: An image sensor assembly having a sensor window positioned in front of an image sensor, having structure and/or characteristics to prevent the formation of condensation on the sensor window. Structure to prevent the formation of condensation includes thin films which can have anti-condensation, anti-reflective, electrically conductive, and/or thermally conductive properties. The sensor window can further have a textured surface to displace water so as to avoid condensation formation on the window surface. The sensor window, and in some embodiments a frame, can be maintained at an elevated temperature proximate to the image sensor during operation to prevent the formation of condensation.
Abstract translation: 一种图像传感器组件，具有位于图像传感器前方的传感器窗口，具有防止在传感器窗口上形成冷凝的结构和/或特性。 防止冷凝形成的结构包括可具有防缩合，抗反射，导电和/或导热性能的薄膜。 传感器窗口可以进一步具有带纹理的表面以置换水，从而避免在窗口表面上形成冷凝水。 在操作期间，传感器窗口并且在一些实施例中框架可以在操作期间被保持在靠近图像传感器的升高的温度以防止冷凝的形成。
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公开(公告)号：EP2989443A1
公开(公告)日：2016-03-02
申请号：EP14869916.8
申请日：2014-12-09
Applicant: Bio-rad Laboratories, Inc.
Inventor： SWIHART, Steve , THRUSH, Evan , RAN, Boaz
IPC: G01N21/27
CPC classification number: H04N5/2355 , G01N21/272 , G01N21/6408 , G01N21/6456 , G01N21/76 , H04N5/2173 , H04N5/2353 , H04N5/35545 , H04N5/361 , H04N5/365
Abstract: Methods and digital imaging devices disclosed herein are adapted to capture images of a specimen in a chemical reaction using a series of short exposures of light emissions from the specimen over a period of time. The series of short exposures is captured using an array of pixels of an image sensor in the digital imaging device that are configured for performing continuous non-destructive read operations to read out a set of non-destructive read images of the specimen from the pixel array. In one embodiment, images are captured by delaying the read out until at or near the end of the chemical reaction to reduce read noise in the images. The signals read out from the image sensor can be continuously monitored and the capturing of images can be discontinued either automatically or based on a command from a user. The captured images can then be displayed in a graphical display.
Abstract translation: 本文公开的方法和数字成像装置适于在一段时间内使用来自样本的一系列短时间曝光来捕获化学反应中的样本的图像。 该系列短暴露是使用在数字成像设备的图像传感器，其被配置用于执行连续的非破坏性读操作，以从所述像素阵列读出的一组试样的非破坏性读出的图像中的像素的阵列捕获 。 在一个实施例中，通过延迟读出直到在化学反应结束或接近结束时捕获图像以减少图像中的读取噪声。 从图像传感器读取的信号可以连续监测，并且图像的捕获可以自动地或基于来自用户的命令而中断。 捕获的图像可以显示在图形显示中。
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公开(公告)号：EP2987006A1
公开(公告)日：2016-02-24
申请号：EP14842718.0
申请日：2014-09-04
Applicant: Bio-Rad Laboratories, Inc.
Inventor： THRUSH, Evan , PEREZ, Evelio , SWIHART, Steve
CPC classification number: G02B21/361 , G01N21/00 , G01N21/76 , G02B17/023 , G02B21/0008 , G03B15/00 , G03B17/17
Abstract: An imaging assembly for the viewing, imaging, and analysis of biological, chemical, and/or biochemical samples in gels or other substrates, in which an adjustable camera and lens module, a reflex mirror, and a focal plane mirror, are configured to bend or fold an optical path in order to image a target region, and where the optical path can be reflected along non-orthogonal angles. The imaging assembly is configured to reduce the overall size of the imaging apparatus due to the angles at which the mirrors and camera and lens assembly are positioned relative to each other, which allows for the imaging of relatively larger samples in the target region.
Abstract translation: 一种成像组件，用于凝胶或其他基质中的生物，化学和/或生物化学样品的观察，成像和分析，其中可调节的照相机和镜头模块，反射镜和焦平面镜被配置为弯曲 或折叠光路以便成像目标区域，并且其中光路可以沿着非正交角度被反射。 成像组件被配置成由于镜子和照相机和透镜组件相对于彼此定位的角度而减小成像装置的整体尺寸，这允许成像目标区域中的相对较大的样本。
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公开(公告)号：EP2989443B1
公开(公告)日：2019-07-10
申请号：EP14869916.8
申请日：2014-12-09
Applicant: BIO-RAD LABORATORIES, INC.
Inventor： SWIHART, Steve , THRUSH, Evan , RAN, Boaz
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Patent Agency Ranking
公开(公告)号：EP2986957A1
公开(公告)日：2016-02-24
申请号：EP15785338.3
申请日：2015-04-29
Applicant: Bio-rad Laboratories, Inc.
Inventor： THRUSH, Evan , SWIHART, Steve , BHATT, Neeraj
CPC classification number: G01N21/6456 , G01N21/6486 , G01N2021/6439 , G01N2021/6471 , G01N2021/6482 , G01N2201/062 , G01N2201/0627 , G01N2201/0638 , G01N2201/12
Abstract: An imaging assembly and processing system that includes a sample platform having a target region which can hold a sample, where the sample can be marked with fluorescent or phosphorescent markers. The imaging assembly can have an excitation light module proximate to the sample platform that emits light to excite the markers, and a lens module positioned to receive emission light from excited markers in target region. At least one series filter assembly or interference filter can be arranged in front of, behind, or both in front of and behind the lens module. The assembly includes a light sensor and a processor and imaging module configured to process data captured by the light sensor. Images of the sample are generated based on the emission light from the sample that transmit through and are filtered by the lens assembly and series filter assembly or interference filter.
Abstract translation: 一种成像组件和处理系统，其包括具有可容纳样品的目标区域的样品平台，其中可以用荧光或磷光标记物标记样品。 成像组件可以具有靠近样本平台的激发光模块，其发射光以激发标记;以及透镜模块，定位成接收来自目标区域中的激发标记的发射光。 至少一个串联滤波器组件或干涉滤波器可以布置在镜头模块前面，后面或者两者之间。 组件包括光传感器，以及配置成处理由光传感器捕获的数据的处理器和成像模块。 样品的图像基于来自透射的样品的发射光产生，并由透镜组件和串联滤光器组件或干涉滤光器滤波。
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公开(公告)号：EP3325943A1
公开(公告)日：2018-05-30
申请号：EP16828336.4
申请日：2016-07-15
Applicant: Bio-Rad Laboratories, Inc.
Inventor： SWIHART, Steve , THRUSH, Evan , URI, Yoachanan , RAN, Boaz , BARAK, Itay , MCDONALD, Kevin
CPC classification number: G02B6/08 , G01N21/6454 , G01N27/44721 , G01N2021/6484 , G02B5/22 , G02B5/28
Abstract: Devices, systems, methods, and kits for contact imaging are provided. A contact imaging device includes an imaging sensor, a fixed fiber faceplate mechanically coupled to the imaging sensor, and an optical filtering layer mechanically coupled to the fixed fiber faceplate. The optical filtering layer can include an interference filter, an absorptive filter, and/or a removable fiber faceplate. The contact imaging device can be used to image fluorescent samples by filtering out excitation light on the basis of wavelength and/or angle of incidence.
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公开(公告)号：EP2987181A1
公开(公告)日：2016-02-24
申请号：EP14869552.1
申请日：2014-12-09
Applicant: Bio-Rad Laboratories, Inc.
Inventor： RAN, Boaz , SWIHART, Steve , THRUSH, Evan , BARAK, Itay
IPC: H01L23/552
CPC classification number: H04N5/361 , H01L2924/0002 , H04N5/365 , H01L2924/00
Abstract: One embodiment of the invention is directed to an imaging device comprising an image sensor comprising an array of pixels, and a mask coupled with the image sensor, the mask configured to darken at least one pixel in the array of pixels.
Abstract translation: 本发明的一个实施例针对包括图像传感器的成像装置，该图像传感器包括像素阵列以及与该图像传感器耦合的掩模，该掩模被配置为使像素阵列中的至少一个像素变暗。
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公开(公告)号：EP3676598A2
公开(公告)日：2020-07-08
申请号：EP18850493.0
申请日：2018-08-23
Applicant: Bio-Rad Laboratories, Inc.
Inventor： THRUSH, Evan , SWIHART, Steve
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公开(公告)号：EP3256843A1
公开(公告)日：2017-12-20
申请号：EP16749717.1
申请日：2016-02-09
Applicant: Bio-rad Laboratories, Inc.
Inventor： MCKEE, Clayton T. , SWIHART, Steve
IPC: G01N27/406 , G01N27/447 , G01N33/544
CPC classification number: G01N27/44739
Abstract: Kits, systems, and methods are provided for transferring biological macromolecules from an electrophoresis slab gel to a blotting membrane using conductive polymer electrodes.
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