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公开(公告)号：WO2019046091A2
公开(公告)日：2019-03-07
申请号：PCT/US2018/047701
申请日：2018-08-23
Applicant: BIO-RAD LABORATORIES, INC.
Inventor： THRUSH, Evan , SWIHART, Steve
Abstract: Devices and methods are disclosed for the substantially uniform epi-illumination of samples such as western blots using high power lasers. The uniformity of illumination is provided by particular configurations of optical diffusers, spatial or temporal laser modalities, or numbers of lasers. The increased excitation light produced by the high power lasers can enhance fluorescence emission signal strength and reduce required imaging exposure times.
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公开(公告)号：WO2016130555A1
公开(公告)日：2016-08-18
申请号：PCT/US2016/017164
申请日：2016-02-09
Applicant: BIO-RAD LABORATORIES, INC.
Inventor： MCKEE, Clayton T. , SWIHART, Steve
IPC: G01N27/406 , G01N27/447 , G01N33/544
CPC classification number: G01N27/44739
Abstract: Kits, systems, and methods are provided for transferring biological macromolecules from an electrophoresis slab gel to a blotting membrane using conductive polymer electrodes.
Abstract translation: 提供了使用导电聚合物电极将生物大分子从电泳板凝胶转移到印迹膜的试剂盒，系统和方法。
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公开(公告)号：WO2019046091A3
公开(公告)日：2019-03-07
申请号：PCT/US2018/047701
申请日：2018-08-23
Applicant: BIO-RAD LABORATORIES, INC.
Inventor： THRUSH, Evan , SWIHART, Steve
IPC: G01N21/01 , G01N33/52 , A61K49/10 , H01S5/06 , H01S5/0625
Abstract: Devices and methods are disclosed for the substantially uniform epi-illumination of samples such as western blots using high power lasers. The uniformity of illumination is provided by particular configurations of optical diffusers, spatial or temporal laser modalities, or numbers of lasers. The increased excitation light produced by the high power lasers can enhance fluorescence emission signal strength and reduce required imaging exposure times.
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公开(公告)号：WO2015035001A1
公开(公告)日：2015-03-12
申请号：PCT/US2014/054017
申请日：2014-09-04
Applicant: BIO-RAD LABORATORIES, INC.
Inventor： THRUSH, Evan , PEREZ, Evelio , SWIHART, Steve
CPC classification number: G02B21/361 , G01N21/00 , G01N21/76 , G02B17/023 , G02B21/0008 , G03B15/00 , G03B17/17
Abstract: An imaging assembly for the viewing, imaging, and analysis of biological, chemical, and/or biochemical samples in gels or other substrates, in which an adjustable camera and lens module, a reflex mirror, and a focal plane mirror, are configured to bend or fold an optical path in order to image a target region, and where the optical path can be reflected along non-orthogonal angles. The imaging assembly is configured to reduce the overall size of the imaging apparatus due to the angles at which the mirrors and camera and lens assembly are positioned relative to each other, which allows for the imaging of relatively larger samples in the target region.
Abstract translation: 用于观察，成像和分析凝胶或其它基底中的生物，化学和/或生物化学样品的成像组件，其中可调节的相机和透镜模块，反射镜和焦平面镜配置成弯曲 或折叠光路以便对目标区域进行成像，并且其中可以沿非正交角度反射光路。 成像组件被配置为由于反射镜和相机和透镜组件相对于彼此定位的角度而减小成像装置的总体尺寸，这允许在目标区域中对较大样本进行成像。
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公开(公告)号：WO2015168240A1
公开(公告)日：2015-11-05
申请号：PCT/US2015/028214
申请日：2015-04-29
Applicant: BIO-RAD LABORATORIES, INC.
Inventor： THRUSH, Evan , SWIHART, Steve , BHATT, Neeraj
CPC classification number: G01N21/6456 , G01N21/6486 , G01N2021/6439 , G01N2021/6471 , G01N2021/6482 , G01N2201/062 , G01N2201/0627 , G01N2201/0638 , G01N2201/12
Abstract: An imaging assembly and processing system that includes a sample platform having a target region which can hold a sample, where the sample can be marked with fluorescent or phosphorescent markers. The imaging assembly can have an excitation light module proximate to the sample platform that emits light to excite the markers, and a lens module positioned to receive emission light from excited markers in target region. At least one series filter assembly or interference filter can be arranged in front of, behind, or both in front of and behind the lens module. The assembly includes a light sensor and a processor and imaging module configured to process data captured by the light sensor. Images of the sample are generated based on the emission light from the sample that transmit through and are filtered by the lens assembly and series filter assembly or interference filter.
Abstract translation: 一种成像组件和处理系统，其包括具有可容纳样品的目标区域的样品平台，其中可以用荧光或磷光标记物标记样品。 成像组件可以具有靠近样本平台的激发光模块，其发射光以激发标记;以及透镜模块，其定位成接收来自目标区域中的激发标记的发射光。 至少一个串联滤波器组件或干涉滤波器可以布置在透镜模块的前面，后面或者两者之间。 组件包括光传感器，以及被配置为处理由光传感器捕获的数据的处理器和成像模块。 基于来自样品的发射光，通过透镜组件和串联滤光器组件或干涉滤光器滤光而产生样品的图像。
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Patent Agency Ranking
公开(公告)号：WO2015089031A1
公开(公告)日：2015-06-18
申请号：PCT/US2014/069281
申请日：2014-12-09
Applicant: BIO-RAD LABORATORIES, INC.
Inventor： SWIHART, Steve , THRUSH, Evan , RAN, Boaz
IPC: G01N21/27
CPC classification number: H04N5/2355 , G01N21/272 , G01N21/6408 , G01N21/6456 , G01N21/76 , H04N5/2173 , H04N5/2353 , H04N5/35545 , H04N5/361 , H04N5/365
Abstract: Methods and digital imaging devices disclosed herein are adapted to capture images of a specimen in a chemical reaction using a series of short exposures of light emissions from the specimen over a period of time. The series of short exposures is captured using an array of pixels of an image sensor in the digital imaging device that are configured for performing continuous non-destructive read operations to read out a set of non-destructive read images of the specimen from the pixel array. In one embodiment, images are captured by delaying the read out until at or near the end of the chemical reaction to reduce read noise in the images. The signals read out from the image sensor can be continuously monitored and the capturing of images can be discontinued either automatically or based on a command from a user. The captured images can then be displayed in a graphical display.
Abstract translation: 本文公开的方法和数字成像装置适于在一段时间内使用来自样品的一系列短的曝光来捕获化学反应中的样本的图像。 使用数字成像设备中的图像传感器的像素阵列来捕获一系列短曝光，其被配置为执行连续的非破坏性读取操作，以从像素阵列读出样本的一组非破坏性读取图像 。 在一个实施例中，通过延迟读出直到化学反应结束或接近化学反应结束来捕获图像，以减少图像中的读取噪声。 可以连续地监视从图像传感器读出的信号，并且可以自动地或基于来自用户的命令中断图像的捕获。 然后可以在图形显示中显示捕获的图像。
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公开(公告)号：WO2017015164A1
公开(公告)日：2017-01-26
申请号：PCT/US2016/042658
申请日：2016-07-15
Applicant: BIO-RAD LABORATORIES, INC.
Inventor： SWIHART, Steve , THRUSH, Evan , URI, Yoachanan , RAN, Boaz , BARAK, Itay , MCDONALD, Kevin
CPC classification number: G02B6/08 , G01N21/6454 , G01N27/44721 , G01N2021/6484 , G02B5/22 , G02B5/28
Abstract: Devices, systems, methods, and kits for contact imaging are provided. A contact imaging device includes an imaging sensor, a fixed fiber faceplate mechanically coupled to the imaging sensor, and an optical filtering layer mechanically coupled to the fixed fiber faceplate. The optical filtering layer can include an interference filter, an absorptive filter, and/or a removable fiber faceplate. The contact imaging device can be used to image fluorescent samples by filtering out excitation light on the basis of wavelength and/or angle of incidence.
Abstract translation: 提供了用于接触成像的设备，系统，方法和套件。 接触成像装置包括成像传感器，机械耦合到成像传感器的固定光纤面板以及机械耦合到固定光纤面板的光学滤光层。 光学滤光层可以包括干涉滤光器，吸收滤光器和/或可移除的光纤面板。 接触成像装置可用于通过基于波长和/或入射角滤除激发光来对荧光样品进行成像。
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公开(公告)号：WO2016060885A1
公开(公告)日：2016-04-21
申请号：PCT/US2015/054185
申请日：2015-10-06
Applicant: BIO-RAD LABORATORIES, INC.
Inventor： THRUSH, Evan , SWIHART, Steve , JAYAMOHAN, Hari
CPC classification number: H01L31/024 , G01N21/15 , G01N21/6456 , G01N21/76 , G01N21/763 , G01N2021/158 , H01L27/14618 , H01L27/1462
Abstract: An image sensor assembly having a sensor window positioned in front of an image sensor, having structure and/or characteristics to prevent the formation of condensation on the sensor window. Structure to prevent the formation of condensation includes thin films which can have anti-condensation, anti-reflective, electrically conductive, and/or thermally conductive properties. The sensor window can further have a textured surface to displace water so as to avoid condensation formation on the window surface. The sensor window, and in some embodiments a frame, can be maintained at an elevated temperature proximate to the image sensor during operation to prevent the formation of condensation.
Abstract translation: 图像传感器组件，其具有位于图像传感器前面的传感器窗口，其具有防止在传感器窗口上形成冷凝的结构和/或特性。 防止形成冷凝物的结构包括可以具有抗冷凝，抗反射，导电和/或导热性能的薄膜。 传感器窗口还可以具有纹理表面以移动水，以避免在窗表面上形成冷凝。 在操作期间，传感器窗口以及在一些实施例中可以在靠近图像传感器的高温下保持，以防止形成冷凝。
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公开(公告)号：WO2015089081A1
公开(公告)日：2015-06-18
申请号：PCT/US2014/069359
申请日：2014-12-09
Applicant: BIO-RAD LABORATORIES, INC.
Inventor： RAN, Boaz , SWIHART, Steve , THRUSH, Evan , BARAK, Itay
IPC: H01L23/552
CPC classification number: H04N5/361 , H01L2924/0002 , H04N5/365 , H01L2924/00
Abstract: One embodiment of the invention is directed to an imaging device comprising an image sensor comprising an array of pixels, and a mask coupled with the image sensor, the mask configured to darken at least one pixel in the array of pixels.
Abstract translation: 本发明的一个实施例涉及一种包括包括像素阵列的图像传感器和与图像传感器耦合的掩模的成像装置，该掩模被配置为使像素阵列中的至少一个像素变暗。
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公开(公告)号：WO2015017348A2
公开(公告)日：2015-02-05
申请号：PCT/US2014/048484
申请日：2014-07-28
Applicant: BIO-RAD LABORATORIES, INC.
Inventor： SWIHART, Steve , THRUSH, Evan , PEREZ, Evelio , MCDONALD, Kevin
IPC: G02B15/14
CPC classification number: G02B15/14
Abstract: An imaging assembly for the viewing, imaging, and analysis of chemiluminescent or bioluminescent samples in gels or other substrates, in which an adjustable camera and lens module having a prime or fixed lens or a focusing lens is moved to change the field of view by shifting the focal plane of the camera and lens module. The imaging assembly can also include a mirror to bend or fold the optical path between the camera and lens module and the target area having a sample, in which the mirror can move in the same vertical direction as the camera and lens module. Further, the camera and lens module can be configured to more move in a diagonal direction relative to the location of the imaging target area. The imaging assembly can further have a duct system adaptable to adjust with the movement of the camera and lens module.
Abstract translation: 用于在凝胶或其他基底中观察，成像和分析化学发光或生物发光样品的成像组件，其中具有主要或固定透镜或聚焦透镜的可调节相机和透镜模块被移动 通过移动相机和镜头模块的焦平面来改变视野。 成像组件还可以包括反射镜，以在照相机和镜头模块与具有样品的目标区域之间弯曲或折叠光路，其中反射镜可以在与照相机和镜头模块相同的垂直方向上移动。 此外，相机和镜头模块可以被配置为相对于成像目标区域的位置在对角线方向上更多地移动。 成像组件可以进一步具有适于随照相机和镜头模块的移动而调整的管道系统。
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