公开(公告)号：WO1996040712A1

公开(公告)日：1996-12-19

申请号：PCT/US1996009769

申请日：1996-06-07

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： CALIFORNIA INSTITUTE OF TECHNOLOGY ,  MEADE, Thomas, J. ,  KAYYEM, Jon, F. ,  FRASER, Scott, E.

IPC: C07H21/00

CPC classification number: C12Q1/6818 ,  B82Y30/00 ,  C07H21/00 ,  C07H23/00 ,  C12Q1/6825 ,  C12Q2563/137 ,  C12Q2563/113 ,  C12Q2565/607 ,  C12Q2565/101 ,  C12Q2565/1015 ,  C12Q2565/401

Abstract: The present invention provides for the selective covalent modification of nucleic acids with redox active moieties such as transition metal complexes. Electron donor and electron acceptor moieties are covalently bound to the ribose-phosphate backbone of a nucleic acid at predetermined positions. The resulting complexes represent a series of new derivatives that are bimolecular templates capable of transferring electrons over very large distances at extremely fast rates. These complexes possess unique structural features wich enable the use of an entirely new class of bioconductors and photoactive probes.

Abstract translation: 本发明提供了用氧化还原活性部分如过渡金属配合物选择性共价修饰核酸。 电子供体和电子受体部分在预定位置上与核酸的核糖 - 磷酸骨架共价结合。 所得的复合物表示一系列新的衍生物，它们是能够以非常快的速率在非常大的距离上传递电子的双分子模板。 这些复合物具有独特的结构特征，可以使用全新的生物传感器和光敏探针。

公开(公告)号：WO1996030750A1

公开(公告)日：1996-10-03

申请号：PCT/US1996004105

申请日：1996-03-26

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： CALIFORNIA INSTITUTE OF TECHNOLOGY ,  LEWIS, Nathan, S. ,  FREUND, Michael, S.

IPC: G01N27/12

CPC classification number: G01N27/126 ,  G01N33/0031 ,  G01N33/497 ,  Y10S435/817

Abstract: Chemical sensors for detecting analytes in fluids comprise first and second conductive elements (e.g., electrical leads) electrically coupled to and separated by a chemically sensitive resistor which provides an electrical path between the conductive elements. The resistor comprises a plurality of alternating nonconductive regions (comprising a nonconductive organic polymer) and conductive regions (comprising a conductive material) transverse to the electrical path. The resistor provides a difference in resistance between the conductive elements when contacted with a fluid comprising a chemical analyte at a first concentration, than when contacted with a fluid comprising the chemical analyte at a second different concentration. Arrays of such sensors are constructed with at least two sensors having different chemically sensitive resistors providing dissimilar such differences in resistance. Variability in chemical sensitivity from sensor to sensor is provided by qualitatively or quantitatively varying the composition of the conductive and/or nonconductive regions. An electronic nose for detecting an analyte in a fluid may be constructed by using such arrays in conjunction with an electrical measuring device electrically connected to the conductive elements of each sensor.

Abstract translation: 用于检测流体中的分析物的化学传感器包括电耦合到化学敏感电阻器并且由化学敏感电阻器分隔的第一和第二导电元件（例如电引线），其提供导电元件之间的电路径。 电阻器包括多个交替的非导电区域（包括非导电有机聚合物）和横向于电路径的导电区域（包括导电材料）。 当与包含第一浓度的化学分析物的流体接触时，电阻器在与包含化学分析物的流体以第二不同浓度接触时与导电元件之间的电阻差异。 这种传感器的阵列由具有不同化学敏感电阻器的至少两个传感器构成，提供不同的电阻差异。 通过定性地或定量地改变导电和/或非导电区域的组成来提供从传感器到传感器的化学敏感性的变化。 用于检测流体中的分析物的电子鼻可以通过使用这样的阵列结合电连接到每个传感器的导电元件的电测量装置来构造。

公开(公告)号：WO1996024333A1

公开(公告)日：1996-08-15

申请号：PCT/US1996001807

申请日：1996-02-09

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： CALIFORNIA INSTITUTE OF TECHNOLOGY ,  MALE-BRUNNE, Roxanne

IPC: A61K09/127

CPC classification number: C12N15/88 ,  A61K9/1272

Abstract: A lipid construct comprising an aminmannose derivatized cholesterol suitable for targeting smooth muscle cells and tissue. Preferred formulations contain 6-(cholest-5-en-3 beta -yloxyl)hexyl-6-amino-6-deoxy-1-thio- alpha -D-mannopyranoside in liposome formulations wherein the formulations are delivered generally to arteries using percutaneous transluminal coronary angioplasty procedures. These formulations have applications in the reduction of restenosis.

Abstract translation: 包含适合靶向平滑肌细胞和组织的氨基甘露糖衍生的胆固醇的脂质构建体。 优选的制剂在脂质体制剂中含有6-（胆甾-5-烯-3β-氧基）己基-6-氨基-6-脱氧-1-硫代-α-D-吡喃甘露糖苷，其中将制剂通常用经皮经腔 冠状动脉成形术。 这些制剂在减少再狭窄方面具有应用。

公开(公告)号：WO1996018402A1

公开(公告)日：1996-06-20

申请号：PCT/US1995016377

申请日：1995-12-14

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： CALIFORNIA INSTITUTE OF TECHNOLOGY ,  MEADE, Thomas, J. ,  GRAY, Herry, B. ,  TAKEUCHI, Toshihiko

IPC: A61K31/555

CPC classification number: C07H21/00 ,  C07C251/12 ,  C07C251/16 ,  C07F15/065 ,  Y10S424/06

Abstract: The present invention is directed to cobalt compounds that can exchange or bind functional moieties such as histidine on a protein's surface resulting in the inactivation of a biological activity of the protein due to the complexing of the functional moiety to the cobalt compound.

Abstract translation: 本发明涉及可在蛋白质表面上交换或结合功能部分如组氨酸的钴化合物，由于功能部分与钴化合物的络合而使蛋白质的生物活性失活。

公开(公告)号：WO1996016327A1

公开(公告)日：1996-05-30

申请号：PCT/US1995014315

申请日：1995-11-07

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： CALIFORNIA INSTITUTE OF TECHNOLOGY ,  ARNOLD, Frances, H. ,  SASAKI, Darryl, Y. ,  SHNEK, Deborah ,  PACK, Daniel

IPC: G01N21/77

CPC classification number: G01N31/221 ,  C09B57/10 ,  G01N31/22 ,  G01N33/533

Abstract: A fluorescent metal-chelating amphiphile having structures (a) or (b) wherein A is a hydrophobic fluorophore, X and Y are aliphatic hydrocarbons having from 9 to 25 carbon atoms, B is a hydrophilic spacer, C is a metal chelator, and L is either an ether or ester linkage. The fluorescent metal-chelating amphiphile is combined with a matrix lipid to form lipid-based sensors which provide fluorometric detection of metal ions in liquids.

Abstract translation: 具有结构（a）或（b）的荧光金属螯合两亲物，其中A是疏水性荧光团，X和Y是具有9至25个碳原子的脂族烃，B是亲水间隔基，C是金属螯合剂，L 是醚或酯键。 荧光金属螯合两亲物与基质脂质组合以形成基于脂质的传感器，其提供液体中金属离子的荧光检测。

公开(公告)号：WO1996003124A1

公开(公告)日：1996-02-08

申请号：PCT/US1995008569

申请日：1995-07-05

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： CALIFORNIA INSTITUTE OF TECHNOLOGY ,  MYERS, Andrew, Gordon

IPC: A61K31/47

CPC classification number: C07D491/08 ,  C07B59/002 ,  C07F7/1804

Abstract: Non-naturally occurring dynemicin analogs are provided, which are useful as DNA cleaving agents, cytotoxic agents, and/or anti-tumor compounds. Methods of making dynemicin analogs are also provided.

Abstract translation: 提供非天然存在的Dynemicin类似物，其可用作DNA切割剂，细胞毒性剂和/或抗肿瘤化合物。 还提供了制备Dynemicin类似物的方法。

公开(公告)号：WO1995022405A1

公开(公告)日：1995-08-24

申请号：PCT/US1995002069

申请日：1995-02-17

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： CALIFORNIA INSTITUTE OF TECHNOLOGY ,  DAVIS, Mark, E. ,  WAN, Kam, T.

IPC: B01J31/24

CPC classification number: B01J31/0202 ,  B01J31/1616 ,  B01J31/2452 ,  B01J2231/323 ,  B01J2531/0266 ,  B01J2531/42 ,  B01J2531/44 ,  B01J2531/56 ,  B01J2531/821 ,  B01J2531/822 ,  B01J2531/827 ,  B01J2531/828 ,  B01J2531/847 ,  B01J2531/96 ,  B01J2540/32 ,  C07B53/00 ,  C07C45/505 ,  C07C51/353 ,  C07C51/36 ,  C07C51/487 ,  C07C67/31 ,  Y02P20/588 ,  C07C65/24 ,  C07C59/64 ,  C07C69/675

Abstract: The present invention relates to water soluble chiral sulfonated 2,2'-bis(diphenylphosphino)-1,1'-binaphthyl compounds and their use as organometallic catalysts for asymmetric synthesis of optically active compounds in hydrogenation, hydroboration, hydrosilylation, hydride reduction, hydroformylation, alkylation, allylic alkylation, arylation, alkenylation, epoxidation, hydrocyanation, disilylation, cyclization and isomeration processes.

Abstract translation: 本发明涉及水溶性手性磺化2,2'-双（二苯基膦基）-1,1'-联萘化合物及其在氢化，氢硼化，氢化硅烷化，氢化还原，加氢甲酰化中不对称合成光学活性化合物的有机金属催化剂的用途 烷基化，烯丙基烷基化，芳基化，链烯基化，环氧化，氢氰化，二甲硅烷基化，环化和异构化过程。

公开(公告)号：WO1993023882A1

公开(公告)日：1993-11-25

申请号：PCT/US1993003553

申请日：1993-04-14

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： CALIFORNIA INSTITUTE OF TECHNOLOGY ,  MCCALDIN, James, O. ,  MCGILL, Thomas, C. ,  PHILLIPS, Mark, C.

IPC: H01L33/00

CPC classification number: H01L33/28 ,  H01L33/0029 ,  H01S5/0421 ,  H01S5/3201 ,  H01S5/321 ,  H01S5/3211 ,  H01S5/322 ,  H01S5/327

Abstract: TYPE-II semiconductor heterojunction light emitting devices formed on a substrate (10) are described wherein a graded injection layer (18) is used to accelerate electrons over the electron barrier formed by the junction. Further, wide band gap semiconductor LEDs and lasers are proposed formed of II-VI materials which emit light in the blue and green wavelengths. Particularly, a system composed of n-CdSe:A1/MgxCd1-xSe/MgyZn1-yTe/p-ZnTe are described where the value of y determines the wavelength of the emitted light in the green or blue region and x varies across the graded injection layer for raising the energy levels of excited electrons.

Abstract translation: 描述形成在衬底（10）上的类型II半导体异质结发光器件，其中使用渐变注入层（18）来加速由结形成的电子势垒上的电子。 此外，提出了由发射蓝色和绿色波长的光的II-VI材料形成的宽带隙半导体LED和激光器。 特别地，描述了由n-CdSe：A1 / MgxCd1-xSe / MgyZn1-yTe / p-ZnTe组成的系统，其中y的值确定绿色或蓝色区域中发射的光的波长，并且x在渐变注入 提高激发电子能级的层。

公开(公告)号：WO1991006641A1

公开(公告)日：1991-05-16

申请号：PCT/US1990006083

申请日：1990-10-26

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： CALIFORNIA INSTITUTE OF TECHNOLOGY ,  BAILEY, James, E. ,  KHOSLA, Chaitan, S.

IPC: C12N15/00

CPC classification number: C12N1/38 ,  C07K14/805

Abstract: The invention related to a gene promoter/regulator (Region A in Fig. 1) which is useful in subjecting expression of protein or polypeptides in a host cell to selective regulation by external control. In particular, this regulation may be accomplished to different extends by the level of dissolved oxygen, presence of cAMP-CAP, and/or a complex nitrogen source in the culture or environment. The invention also relates to a method of improving production of proteins in a host by coproduction of hemoglobin in the host.

Abstract translation: 本发明涉及可用于使宿主细胞中的蛋白质或多肽表达通过外部对照进行选择性调节的基因启动子/调节子（图1中的区域A）。 特别地，该调节可以通过溶解氧的水平，cAMP-CAP的存在和/或培养物或环境中的复杂氮源来延伸。 本发明还涉及通过在宿主中共同产生血红蛋白来改善宿主中蛋白质产生的方法。

公开(公告)号：WO2002048749A2

公开(公告)日：2002-06-20

申请号：PCT/US2001046965

申请日：2001-12-04

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： CALIFORNIA INSTITUTE OF TECHNOLOGY ,  PSALTIS, Demetri ,  MOSER, Christophe ,  STECKMAN, Greg ,  BUSE, Karsten ,  NEE, Ingo ,  HUKRIEDE, Joerg

IPC: G02B

CPC classification number: G02B6/29316 ,  G02B6/12007 ,  G02B6/124 ,  G02B6/1342 ,  G02B6/29395 ,  G02B6/30 ,  G02B2006/1204 ,  G02B2006/121 ,  G02B2006/12107 ,  G02B2006/12145 ,  G02B2006/12173 ,  G02B2006/1218 ,  G02F1/035 ,  G02F2201/307 ,  G02F2203/055

Abstract: Embodiments of the present invention are directed to a method and apparatus for integrated optical wavelength division multiplexing using a bench of channel waveguides. In one embodiment, a plurality of waveguides is formed on a single substrate. Different waveguides are constructed to filter different channels carried on a single optical fiber. In one embodiment, optical fibers are attached to the ends of each waveguide. To select a specific filter, the fiber attached to the appropriate waveguide is used. In another embodiment, optical fibers are not attached to the ends of each waveguide. To select a specific filter, the reading head holding the fibers or the waveguide substrate is moved. In another embodiment, a voltage is supplied across the waveguide. Adjusting the voltage also adjusts which channel the waveguide will filter. In one embodiment, a circulator is used to extract the filtered channel.

Abstract translation: 本发明的实施例涉及一种使用信道波导台的集成光波分复用的方法和装置。 在一个实施例中，多个波导形成在单个基板上。 构造不同的波导以对单个光纤上承载的不同通道进行滤波。 在一个实施例中，光纤连接到每个波导的端部。 为了选择特定的滤光片，使用连接到适当波导管的光纤。 在另一个实施例中，光纤不连接到每个波导的端部。 为了选择特定的滤光器，保持纤维或波导基板的读取头移动。 在另一个实施例中，跨越波导提供电压。 调整电压还可以调整波导将要过滤的通道。 在一个实施例中，循环器用于提取滤波的通道。