公开(公告)号：US11969246B2

公开(公告)日：2024-04-30

申请号：US18319085

申请日：2023-05-17

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Samson Chen ,  Axel Scherer ,  Dvin I. Adalian ,  Peter Petillo ,  Muhammad Musab Jilani ,  Xiomara L. Madero ,  Deepan Kishore Kumar

IPC: C12N11/14 ,  A61B5/145 ,  A61B5/1459 ,  A61B5/1486 ,  C12N9/02 ,  C12N11/02 ,  G01N27/327

CPC classification number: A61B5/14865 ,  A61B5/14532 ,  A61B5/1459 ,  C12N9/0004 ,  C12N11/02 ,  C12N11/14 ,  G01N27/3272 ,  C12Y101/01001 ,  C12Y101/03003 ,  C12Y101/03005 ,  C12Y101/03007 ,  C12Y101/03008 ,  C12Y101/0301 ,  C12Y101/03011 ,  C12Y101/03012 ,  C12Y101/03015 ,  C12Y101/03016 ,  C12Y101/03018 ,  C12Y101/03019 ,  C12Y101/0302 ,  C12Y101/03023 ,  C12Y101/03027 ,  C12Y101/03029 ,  C12Y101/0303 ,  C12Y101/03037 ,  C12Y101/03038 ,  C12Y101/0304 ,  C12Y101/03041

Abstract: A sensor implanted in tissues and including a sensing layer is fabricated by mixing the signal transduction enzyme with non-reactive components including buffer salts and fillers, and spin coating the enzyme onto a substrate. The signal transduction enzyme is crosslinked by introducing the coated substrate in a vacuum chamber. In the chamber, a crosslinker evaporates and is deposited onto the enzyme, therefore crosslinking the enzyme.

公开(公告)号：US10996185B2

公开(公告)日：2021-05-04

申请号：US15601503

申请日：2017-05-22

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Samson Chen ,  Axel Scherer ,  Muhammad M. Jilani

IPC: G01N27/30 ,  G01N27/327

Abstract: A cycle of positive and negative voltage pulses applied to an electrode sensor removes passivation of an electrode surface. The conditioned sensors have improved sensitivity to concentrations for analytes of interest. The electrode surfaces can also be passivated on purpose to reduce sensitivity. The voltages applied are varied according to the solution present.

公开(公告)号：US09606060B2

公开(公告)日：2017-03-28

申请号：US13740112

申请日：2013-01-11

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Samson Chen ,  Aditya Rajagopal ,  Axel Scherer

IPC: G01N21/64

CPC classification number: G01N21/6486 ,  G01N21/6408

Abstract: A device and method are described in which the lifetime of a fluorescent species or fluorophores is detected in the absence of any optical filter. Based on the measured fluorescent lifetimes, molecules or compounds attached to a fluorophores such as small organic molecules, polymers, peptides, saccharides and nucleic acids can be identified or assayed.

公开(公告)号：US08707545B2

公开(公告)日：2014-04-29

申请号：US14038702

申请日：2013-09-26

Applicant: California Institute of Technology

Inventor： Samson Chen ,  Aditya Rajagopal ,  Axel Scherer

IPC: G01N15/00

CPC classification number: H05K3/10 ,  B01L3/502707 ,  B01L3/502715 ,  B01L2300/0645 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0867 ,  H01L23/473 ,  H01L2924/0002 ,  H05K1/0272 ,  H05K3/284 ,  H05K2201/10189 ,  H05K2203/1327 ,  Y10T29/49 ,  Y10T29/49002 ,  Y10T29/49155 ,  Y10T29/49165 ,  Y10T137/85938 ,  Y10T436/11 ,  Y10T436/25 ,  Y10T436/2575 ,  H01L2924/00

Abstract: A printed circuit board structure is coated with an encapsulant within which microfluidic channels have been formed. The microfluidic channels are formed by soldering fluidic connections to metal traces on a surface of the printed circuit board structure prior to encapsulation. The metal traces are removed by etching after encapsulation to form microchannels within the encapsulant.

Abstract translation: 印刷电路板结构涂覆有已经形成微流体通道的密封剂。 在封装之前，通过将流体连接焊接到印刷电路板结构的表面上的金属迹线来形成微流体通道。 在封装后通过蚀刻去除金属迹线，以在密封剂内形成微通道。