公开(公告)号：AT239040T

公开(公告)日：2003-05-15

申请号：AT97947810

申请日：1997-12-10

Applicant: CELLTECH R&D LTD

Inventor： KING DAVID JOHN ,  CHAPMAN ANDREW PAUL

IPC: A61K39/395 ,  A61K47/48 ,  A61P1/00 ,  A61P11/06 ,  A61P17/10 ,  A61P19/02 ,  A61P25/00 ,  A61P29/00 ,  A61P31/12 ,  A61P35/00 ,  A61P37/00 ,  A61P37/08 ,  C07K16/00 ,  C07K16/22 ,  C07K16/24 ,  C07K16/30 ,  C12N15/09

公开(公告)号：ZA200200097B

公开(公告)日：2003-01-06

申请号：ZA200200097

申请日：2002-01-04

Applicant: CELLTECH R&D LTD

Inventor： ATHWAL DILJEET SINGH ,  BROWN DEREK THOMAS ,  WEIR ANDREW NEIL CHARLES ,  POPPLEWELL ANDREW GEORGE ,  CHAPMAN ANDREW PAUL ,  KING DAVID JOHN

IPC: A61K39/395 ,  A61K47/48 ,  A61P19/02 ,  A61P29/00 ,  A61P37/06 ,  C12N15/09 ,  C07K16/24 ,  C07K16/46 ,  C12N1/21 ,  C12N15/13 ,  C12P21/02 ,  C12P21/08 ,  C12N ,  C07K ,  A61K ,  A61P

Abstract: There is disclosed antibody molecules containing at least one CDR derived from a mouse monoclonal antibody having specificity for human TNF± There is also disclosed a CDR grafted antibody wherein at least one of the CDRs is a hybrid CDR Further disclosed are DNA sequences encoding the chains of the antibody molecules, vectors, transformed host cells and uses of the antibody molecules in the treatment of diseases mediated by TNF±

公开(公告)号：SK3152002A3

公开(公告)日：2002-07-02

申请号：SK3152002

申请日：2001-06-05

Applicant: CELLTECH R&D LTD

Inventor： ATHWAL DILJEET SINGH ,  BROWN DEREK THOMAS ,  WEIR ANDREW NEIL CHARLES ,  POPPLEWELL ANDREW GEORGE ,  CHAPMAN ANDREW PAUL ,  KING DAVID JOHN

IPC: A61K39/395 ,  A61K47/48 ,  A61P19/02 ,  A61P29/00 ,  A61P37/06 ,  C07K16/24 ,  C07K16/46 ,  C12N1/21 ,  C12N15/13 ,  C12P21/02 ,  C12P21/08 ,  C12N15/09 ,  C07K19/00 ,  C12N15/62 ,  C12N15/70

Abstract: There is disclosed antibody molecules containing at least one CDR derived from a mouse monoclonal antibody having specificity for human TNF± There is also disclosed a CDR grafted antibody wherein at least one of the CDRs is a hybrid CDR Further disclosed are DNA sequences encoding the chains of the antibody molecules, vectors, transformed host cells and uses of the antibody molecules in the treatment of diseases mediated by TNF±

公开(公告)号：NO20020554A

公开(公告)日：2002-04-08

申请号：NO20020554

申请日：2002-02-04

Applicant: CELLTECH R&D LTD

Inventor： ATHWAL DILJEET SINGH ,  BROWN DEREK THOMAS ,  WEIR ANDREW NEIL CHARLES ,  POPPLEWELL ANDREW GEORGE ,  CHAPMAN ANDREW PAUL ,  KING DAVID JOHN

IPC: C12N15/09 ,  A61K39/395 ,  A61K47/48 ,  A61P19/02 ,  A61P29/00 ,  A61P37/06 ,  C07K16/24 ,  C07K16/46 ,  C12N1/21 ,  C12N15/13 ,  C12P21/02 ,  C12P21/08 ,  C12N5/10 ,  C12N15/63 ,  C12N15/70

CPC classification number: C07K16/241 ,  A61K47/6845 ,  A61K47/6875 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/565

公开(公告)号：NO20020554D0

公开(公告)日：2002-02-04

申请号：NO20020554

申请日：2002-02-04

Applicant: CELLTECH R&D LTD

Inventor： ATHWAL DILJEET SINGH ,  BROWN DEREK THOMAS ,  WEIR ANDREW NEIL CHARLES ,  POPPLEWELL ANDREW GEORGE ,  CHAPMAN ANDREW PAUL ,  KING DAVID JOHN

IPC: A61K39/395 ,  C12N15/09 ,  A61K47/48 ,  A61P19/02 ,  A61P29/00 ,  A61P37/06 ,  C07K16/24 ,  C07K16/46 ,  C12N1/21 ,  C12N15/13 ,  C12P21/02 ,  C12P21/08 ,  C12N

Abstract: There is disclosed antibody molecules containing at least one CDR derived from a mouse monoclonal antibody having specificity for human TNF± There is also disclosed a CDR grafted antibody wherein at least one of the CDRs is a hybrid CDR Further disclosed are DNA sequences encoding the chains of the antibody molecules, vectors, transformed host cells and uses of the antibody molecules in the treatment of diseases mediated by TNF±

公开(公告)号：CA2380298C

公开(公告)日：2010-09-28

申请号：CA2380298

申请日：2001-06-05

Applicant: CELLTECH R&D LTD

Inventor： ATHWAL DILJEET SINGH ,  BROWN DEREK THOMAS ,  WEIR ANDREW NEIL CHARLES ,  POPPLEWELL ANDREW GEORGE ,  CHAPMAN ANDREW PAUL ,  KING DAVID JOHN

IPC: C12N15/09 ,  C12N15/13 ,  A61K39/395 ,  A61K47/48 ,  A61P19/02 ,  A61P29/00 ,  A61P37/06 ,  C07K16/24 ,  C07K16/46 ,  C07K19/00 ,  C12N1/21 ,  C12N15/62 ,  C12N15/70 ,  C12P21/02 ,  C12P21/08

Abstract: There is disclosed antibody molecules containing at least one CDR derived from a mouse monoclonal antibody having specificity for human TNF.alpha.. There is also disclosed a CDR grafted antibody wherein at least one of the CDRs is a hybrid CDR. Further disclosed are DNA sequences encoding the chains of the antibody molecules, vectors, transformed host cells and uses of the antibody molecules in the treatment of diseases mediated by TNF.alpha..

公开(公告)号：AP2092A

公开(公告)日：2010-02-28

申请号：AP2002002690

申请日：2001-06-05

Applicant: CELLTECH R&D LTD

Inventor： ATHWAL DILJEET SINGH ,  BROWN DEREK THOMAS ,  WEIR ANDREW NEIL CHARLES ,  POPPLEWELL ANDREW GEORGE ,  CHAPMAN ANDREW PAUL ,  KING DAVID JOHN

IPC: C12N15/09 ,  A61K39/00 ,  A61K39/395 ,  A61K47/00 ,  A61K47/48 ,  A61P19/02 ,  A61P29/00 ,  A61P37/06 ,  C07K16/24 ,  C07K16/46 ,  C12N1/21 ,  C12N15/00 ,  C12N15/13 ,  C12P21/02 ,  C12P21/08

Abstract: There is disclosed antibody molecules containing at least one CDR derived from a mouse monoclonal antibody having specificity for human TNFa. There is also disclosed a CDR grafted antibody wherein at least one of the CDRs is a hybrid CDR. Further disclosed are DNA sequences encoding the chains of the antibody molecules, vectors, transformed host cells and uses of the antibody molecules in the treatment of diseases mediated by TNFa.

公开(公告)号：PL353960A1

公开(公告)日：2003-12-15

申请号：PL35396001

申请日：2001-06-05

Applicant: CELLTECH R&D LTD

Inventor： ATHWAL DILJEET SINGH ,  BROWN DEREK THOMAS ,  WEIR ANDREW NEIL CHARLES ,  POPPLEWELL ANDREW GEORGE ,  CHAPMAN ANDREW PAUL ,  KING DAVID JOHN

IPC: A61K39/395 ,  A61K47/48 ,  A61P19/02 ,  A61P29/00 ,  A61P37/06 ,  C12N15/09 ,  C07K16/24 ,  C07K16/46 ,  C12N1/21 ,  C12N15/13 ,  C12P21/02 ,  C12P21/08 ,  C12N15/62

Abstract: There is disclosed antibody molecules containing at least one CDR derived from a mouse monoclonal antibody having specificity for human TNF± There is also disclosed a CDR grafted antibody wherein at least one of the CDRs is a hybrid CDR Further disclosed are DNA sequences encoding the chains of the antibody molecules, vectors, transformed host cells and uses of the antibody molecules in the treatment of diseases mediated by TNF±

公开(公告)号：ECSP024210A

公开(公告)日：2002-05-23

申请号：ECSP024210

申请日：2002-02-06

Applicant: CELLTECH R&D LTD

Inventor： POPPLEWELL ANDREW GEORGE ,  ATHWAL DILJEET SINGH ,  BROWN DEREK THOMAS ,  WEIR ANDREW NEIL CHARLES ,  CHAPMAN ANDREW PAUL ,  KING DAVID JOHN

IPC: C12N15/09 ,  A61K39/395 ,  A61K47/48 ,  A61P19/02 ,  A61P29/00 ,  A61P37/06 ,  C07K16/24 ,  C07K16/46 ,  C12N1/21 ,  C12N15/13 ,  C12P21/02 ,  C12P21/08

Abstract: Se describen moléculas de anticuerpo que contienen al menos una CDR procedente de un anticuerpo monoclonal de ratón que tiene especificidad por el TNF a humano. También se describe un anticuerpo de CDR injertadas en el que al menos una de las CDR es una CDR híbrida. También se describen secuencias de ADN que codifican las cadenas de las moléculas de anticuerpo, vectores, células huésped transformadas y usos de las moléculas de anticuerpo en el tratamiento de enfermedades mediadas por TNFap.

公开(公告)号：CZ2002837A3

公开(公告)日：2002-05-15

申请号：CZ2002837

申请日：2001-06-05

Applicant: CELLTECH R&D LTD

Inventor： ATHWAL DILJEET SINGH ,  BROWN DEREK THOMAS ,  WEIR ANDREW NEIL CHARLES ,  POPPLEWELL ANDREW GEORGE ,  CHAPMAN ANDREW PAUL ,  KING DAVID JOHN

IPC: C12N15/09 ,  A61K39/395 ,  A61K47/48 ,  A61P19/02 ,  A61P29/00 ,  A61P37/06 ,  C07K16/24 ,  C07K16/46 ,  C12N1/21 ,  C12N15/13 ,  C12P21/02 ,  C12P21/08 ,  C07K19/00 ,  C12N15/62 ,  C12N15/70

Abstract: There is disclosed antibody molecules containing at least one CDR derived from a mouse monoclonal antibody having specificity for human TNF± There is also disclosed a CDR grafted antibody wherein at least one of the CDRs is a hybrid CDR Further disclosed are DNA sequences encoding the chains of the antibody molecules, vectors, transformed host cells and uses of the antibody molecules in the treatment of diseases mediated by TNF±