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1.发明专利
公开(公告)号：GB2366800B
公开(公告)日：2005-01-19
申请号：GB0128386
申请日：2001-06-05
Applicant: CELLTECH R&D LTD
Inventor： ATHWAL DILJEET SINGH , BROWN DEREK THOMAS , WEIR ANDREW NEIL , POPPLEWELL ANDREW GEORGE , CHAPMAN ANDREW PAUL , KING DAVID JOHN
IPC: A61K39/395 , A61K47/48 , A61P19/02 , A61P29/00 , A61P37/06 , C07K16/24 , C07K16/46 , C12N1/21 , C12N15/13 , C12P21/02 , C12P21/08 , C12N15/09
Abstract: There is disclosed antibody molecules containing at least one CDR derived from a mouse monoclonal antibody having specificity for human TNF± There is also disclosed a CDR grafted antibody wherein at least one of the CDRs is a hybrid CDR Further disclosed are DNA sequences encoding the chains of the antibody molecules, vectors, transformed host cells and uses of the antibody molecules in the treatment of diseases mediated by TNF±
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公开(公告)号：CA2502152A1
公开(公告)日：2004-04-29
申请号：CA2502152
申请日：2003-10-15
Applicant: CELLTECH R&D LTD
Inventor： HUMPHREYS DAVID PAUL , SPITALI MARIANGELA , ROBINSON MARTYN KIM , CHAPMAN ANDREW PAUL
Abstract: The present invention provides an Ecoli host cell expressing a recombinant antibody characterized in that the Ecolihost cell has been genetically modified in order to change at least one physical property of one or more Ecoli proteins which in the wild type co~purify with said recombinant antibo dy.
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公开(公告)号：ES2197373T3
公开(公告)日：2004-01-01
申请号：ES97947810
申请日：1997-12-10
Applicant: CELLTECH R&D LTD
Inventor： KING DAVID JOHN , CHAPMAN ANDREW PAUL
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公开(公告)号：NO20020554L
公开(公告)日：2002-04-08
申请号：NO20020554
申请日：2002-02-04
Applicant: CELLTECH R&D LTD
Inventor： ATHWAL DILJEET SINGH , BROWN DEREK THOMAS , WEIR ANDREW NEIL CHARLES , POPPLEWELL ANDREW GEORGE , CHAPMAN ANDREW PAUL , KING DAVID JOHN
IPC: A61K39/395 , A61K47/48 , A61P19/02 , A61P29/00 , A61P37/06 , C07K16/24 , C07K16/46 , C12N1/21 , C12N15/09 , C12N15/13 , C12P21/02 , C12P21/08 , C12N15/63 , C12N5/10 , C12N15/70
Abstract: There is disclosed antibody molecules containing at least one CDR derived from a mouse monoclonal antibody having specificity for human TNF± There is also disclosed a CDR grafted antibody wherein at least one of the CDRs is a hybrid CDR Further disclosed are DNA sequences encoding the chains of the antibody molecules, vectors, transformed host cells and uses of the antibody molecules in the treatment of diseases mediated by TNF±
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5.发明专利
公开(公告)号：CA2380298A1
公开(公告)日：2001-12-13
申请号：CA2380298
申请日：2001-06-05
Applicant: CELLTECH R&D LTD
Inventor： KING DAVID JOHN , WEIR ANDREW NEIL CHARLES , POPPLEWELL ANDREW GEORGE , CHAPMAN ANDREW PAUL , BROWN DEREK THOMAS , ATHWAL DILJEET SINGH
IPC: C12N15/09 , A61K39/395 , A61K47/48 , A61P19/02 , A61P29/00 , A61P37/06 , C07K16/24 , C07K16/46 , C12N1/21 , C12N15/13 , C12P21/02 , C12P21/08 , C07K19/00 , C12N15/62 , C12N15/70
Abstract: There is disclosed antibody molecules containing at least one CDR derived fr om a mouse monoclonal antibody having specificity for human TNF.alpha.. There i s also disclosed a CDR grafted antibody wherein at least one of the CDRs is a hybrid CDR. Further disclosed are DNA sequences encoding the chains of the antibody molecules, vectors, transformed host cells and uses of the antibody molecules in the treatment of diseases mediated by TNF.alpha..
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Patent Agency Ranking">
公开(公告)号：ES2230975B2
公开(公告)日：2007-04-16
申请号：ES200250012
申请日：2001-06-05
Applicant: CELLTECH R&D LTD
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7.发明专利
公开(公告)号：OA12282A
公开(公告)日：2006-05-11
申请号：OA1200200368
申请日：2001-06-05
Applicant: CELLTECH R&D LTD
Inventor： ATHWAL DILJEET SINGH , BROWN DEREK THOMAS , CHAPMAN ANDREW PAUL , KING DAVID JOHN , POPPLEWELL ANDREW GEORGE , WEIR ANDREW NEIL CHARLES
IPC: A61K39/395 , A61K47/48 , A61P19/02 , A61P29/00 , A61P37/06 , C07K16/24 , C07K16/46 , C12N1/21 , C12N15/13 , C12P21/02 , C12P21/08 , C12N15/09 , C07K19/00 , C12N15/62 , C12N15/70
Abstract: There is disclosed antibody molecules containing at least one CDR derived from a mouse monoclonal antibody having specificity for human TNF± There is also disclosed a CDR grafted antibody wherein at least one of the CDRs is a hybrid CDR Further disclosed are DNA sequences encoding the chains of the antibody molecules, vectors, transformed host cells and uses of the antibody molecules in the treatment of diseases mediated by TNF±
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公开(公告)号：PT948544E
公开(公告)日：2003-09-30
申请号：PT97947810
申请日：1997-12-10
Applicant: CELLTECH R&D LTD
Inventor： KING DAVID JOHN , CHAPMAN ANDREW PAUL
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9.发明专利
公开(公告)号：NZ516596A
公开(公告)日：2004-07-30
申请号：NZ51659601
申请日：2001-06-05
Applicant: CELLTECH R&D LTD
Inventor： ATHWAL DILJEET SINGH , BROWN DEREK THOMAS , WEIR ANDREW NEIL CHARLES , POPPLEWELL ANDREW GEORGE , CHAPMAN ANDREW PAUL , KING DAVID JOHN
IPC: A61K39/395 , A61K47/48 , A61P19/02 , A61P29/00 , A61P37/06 , C07K16/24 , C07K16/46 , C12N1/21 , C12N15/13 , C12P21/02 , C12P21/08 , C12N15/09 , C07K19/00 , C12N15/62 , C12N15/70
Abstract: The application discloses an antibody molecule having specificity for human TNFalpha , comprising a heavy chain containing at least one CDR derived from a mouse monoclonal antibody. There is also disclosed a CDR grafted antibody wherein at least one of the CDRs is a hybrid CDR. Further disclosed are DNA sequences encoding the chains of the antibody molecules, vectors, transformed host cells and uses of the antibody molecules in the treatment of diseases mediated by TNF alpha.
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公开(公告)号：DK0948544T3
公开(公告)日：2003-08-04
申请号：DK97947810
申请日：1997-12-10
Applicant: CELLTECH R&D LTD
Inventor： KING DAVID JOHN , CHAPMAN ANDREW PAUL
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