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公开(公告)号：GB2387845B
公开(公告)日：2005-05-11
申请号：GB0318429
申请日：2002-01-18
Applicant: CELLTECH R&D LTD
Inventor： BAILEY STUART , BROWN JULIEN ALISTAIR , BRAND STEPHEN , JOHNSON JAMES ANDREW , PORTER JOHN ROBERT , HEAD JOHN CLIFFORD
IPC: A61K31/198 , A61K31/4375 , A61K31/44 , A61K31/4406 , A61K31/497 , A61P3/10 , A61P9/00 , A61P17/00 , A61P17/06 , A61P19/02 , A61P25/00 , A61P29/00 , A61P37/00 , A61P37/06 , A61P43/00 , C07C229/34 , C07C229/46 , C07C233/82 , C07C321/22 , C07C323/30 , C07D213/81 , C07D213/89 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D471/04 , C07C229/36
Abstract: Phenylalanine enamide derivatives of formula (1) are described: wherein R 1 , R x , R y , R z , X and V are as defined in claim 1. The compounds are able to inhibit the binding of integrins to their ligands and are of use in the prophylaxis and treatment of immuno or inflammatory disorders or disorders involving the inappropriate growth or migration of cells.
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公开(公告)号：NO20033710L
公开(公告)日：2003-10-22
申请号：NO20033710
申请日：2003-08-20
Applicant: CELLTECH R&D LTD
Inventor： BAILEY STUART , BROWN JULIEN ALISTAIR , BRAND STEPHEN , JOHNSON JAMES ANDREW , PORTER JOHN ROBERT , HEAD JOHN CLIFFORD
IPC: A61K31/198 , A61K31/4375 , A61K31/44 , A61K31/4406 , A61K31/497 , A61P3/10 , A61P9/00 , A61P17/00 , A61P17/06 , A61P19/02 , A61P25/00 , A61P29/00 , A61P37/00 , A61P37/06 , A61P43/00 , C07C229/34 , C07C229/46 , C07C233/82 , C07C321/22 , C07C323/30 , C07D213/81 , C07D213/89 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D471/04
Abstract: Phenylalanine enamide derivatives of formula (1) are described: wherein R 1 , R x , R y , R z , X and V are as defined in claim 1. The compounds are able to inhibit the binding of integrins to their ligands and are of use in the prophylaxis and treatment of immuno or inflammatory disorders or disorders involving the inappropriate growth or migration of cells.
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公开(公告)号：NO20033710D0
公开(公告)日：2003-08-20
申请号：NO20033710
申请日：2003-08-20
Applicant: CELLTECH R&D LTD
Inventor： BAILEY STUART , BROWN JULIEN ALISTAIR , BRAND STEPHEN , JOHNSON JAMES ANDREW , PORTER JOHN ROBERT , HEAD JOHN CLIFFORD
IPC: A61K31/198 , A61K31/4375 , A61K31/44 , A61K31/4406 , A61K31/497 , A61P3/10 , A61P9/00 , A61P17/00 , A61P17/06 , A61P19/02 , A61P25/00 , A61P29/00 , A61P37/00 , A61P37/06 , A61P43/00 , C07C229/34 , C07C229/46 , C07C233/82 , C07C321/22 , C07C323/30 , C07D213/81 , C07D213/89 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D471/04 , C07D
Abstract: Phenylalanine enamide derivatives of formula (1) are described: wherein R 1 , R x , R y , R z , X and V are as defined in claim 1. The compounds are able to inhibit the binding of integrins to their ligands and are of use in the prophylaxis and treatment of immuno or inflammatory disorders or disorders involving the inappropriate growth or migration of cells.
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14.发明专利
公开(公告)号：SK286991B6
公开(公告)日：2009-09-07
申请号：SK10322003
申请日：2002-01-18
Applicant: CELLTECH R&D LTD
Inventor： BAILEY STUART , BROWN JULIEN ALISTAIR , BRAND STEPHEN , JOHNSON JAMES ANDREW , PORTER JOHN ROBERT , HEAD JOHN CLIFFORD
IPC: C07D213/00 , A61K31/198 , A61K31/4375 , A61K31/44 , A61K31/4406 , A61K31/497 , A61P3/10 , A61P9/00 , A61P17/00 , A61P17/06 , A61P19/02 , A61P25/00 , A61P29/00 , A61P37/00 , A61P37/06 , A61P43/00 , C07C229/00 , C07C229/34 , C07C229/46 , C07C233/82 , C07C321/22 , C07C323/30 , C07D213/81 , C07D213/89 , C07D401/00 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D471/00 , C07D471/04
Abstract: Disclosed are phenylalanine enamide derivatives of formula (1), wherein R1 is a group Ar1L2Ar2Alk- and the salts, solvates, hydrates and N-oxides thereof, pharmaceutical composition comprising said compounds, ethyl (2S)-2-(2-bromo-3oxo- spiro[3.5]non-1-en-1-ylamino)-3-{4-[(3,5- dichloroisonicotinoyl)amino]phenyl}propanoate, pharmaceutical composition comprising said compound and the use of ethyl (2S)-2-(2-bromo-3oxo-spiro[3.5]non-1-en-1-ylamino)-3-{4-[(3,5- dichloroisonicotinoyl)amino]phenyl}propanoate for preparing medicines for the treatment and/or prevention of rheumatoid arthritis, multiple sclerosis, asthma or inflammatory bowel diseases.
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15.发明专利
公开(公告)号：NZ528134A
公开(公告)日：2005-09-30
申请号：NZ52813402
申请日：2002-01-18
Applicant: CELLTECH R&D LTD
Inventor： BAILEY STUART , BROWN JULIEN ALISTAIR , BRAND STEPHEN , JOHNSON JAMES ANDREW , PORTER JOHN ROBERT , HEAD JOHN CLIFFORD
IPC: A61K31/198 , A61K31/4375 , A61K31/44 , A61K31/4406 , A61K31/497 , A61P3/10 , A61P9/00 , A61P17/00 , A61P17/06 , A61P19/02 , A61P25/00 , A61P29/00 , A61P37/00 , A61P37/06 , A61P43/00 , C07C229/34 , C07C229/46 , C07C233/82 , C07C321/22 , C07C323/30 , C07D213/81 , C07D213/89 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D471/04 , C07C229/36
Abstract: Phenylalanine enamide derivatives of formula (I) are described: wherein R1 is a group Ar1L2Ar2Alk- in which: Ar1 is an optionally substituted aromatic or heteroaromatic group; L2 is a covalent bond or a linker atom or group; Ar2 is an optionally substituted arylene or heteroarylene group; and Alk is a chain -CH2-CH(R)-, -CH=C(R)- or -CH(CH2R)- X is an -N(R2) group; V is an oxygen (O) or sulphur (S) atom; RX and RY are joined together to form an optionally substituted spiro linked cycloaliphatic or heterocycloaliphatic group; and RZ represents a halogen atom, or, -L1(Alk1)n(R3)v in which L is a covalent bond or a linker atom or group, Alk1 is an optionally substituted aliphatic or heteroaliphatic chain, R3 is a hydrogen or halogen atom or group selected from -OR3a [where R3a is a hydrogen atom or an optionally substituted alkyl or cycloalkyl], SR3a, -CN or an optionally substituted cycloaliphatic, heterocycloaliphatic, polycycloaliphatic, heteropolycycloaIiphatic, aromatic or heteroaromatic group, n is zero or the integer 1 and v is the integer 1, 2 or 3 provided that when n is zero and L is a covalent bond v is the integer 1; and the salts, solvates, hydrates and N-oxides thereof. Furthermore compounds of formula (I) are able to inhibit the binding of integrins to their ligands and described is the use of compounds of formula (I) for the manufacture of a medicament for the treatment and/or prevention of immuno or inflammatory disorders or disorders involving the inappropriate growth or migration of cells.
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Patent Agency Ranking16.发明专利
公开(公告)号：ZA200305372B
公开(公告)日：2004-07-12
申请号：ZA200305372
申请日：2003-07-11
Applicant: CELLTECH R&D LTD
Inventor： BAILEY STUART , BROWN JULIEN ALISTAIR , BRAND STEPHEN , JOHNSON JAMES ANDREW , PORTER JOHN ROBERT , HEAD JOHN CLIFFORD
IPC: A61P20060101 , C07C20060101 , C07D20060101 , C07D , A61P , C07C
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17.发明专利
公开(公告)号：SK10322003A3
公开(公告)日：2004-02-03
申请号：SK10322003
申请日：2002-01-18
Applicant: CELLTECH R&D LTD
Inventor： BAILEY STUART , BROWN JULIEN ALISTAIR , BRAND STEPHEN , JOHNSON JAMES ANDREW , PORTER JOHN ROBERT , HEAD JOHN CLIFFORD
IPC: A61K31/198 , A61K31/4375 , A61K31/44 , A61K31/4406 , A61K31/497 , A61P3/10 , A61P9/00 , A61P17/00 , A61P17/06 , A61P19/02 , A61P25/00 , A61P29/00 , A61P37/00 , A61P37/06 , A61P43/00 , C07C229/34 , C07C229/46 , C07C233/82 , C07C321/22 , C07C323/30 , C07D213/81 , C07D213/89 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D471/04 , C07C229/36
Abstract: Phenylalanine enamide derivatives of formula (1) are described: wherein R 1 , R x , R y , R z , X and V are as defined in claim 1. The compounds are able to inhibit the binding of integrins to their ligands and are of use in the prophylaxis and treatment of immuno or inflammatory disorders or disorders involving the inappropriate growth or migration of cells.
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公开(公告)号：PT1370531E
公开(公告)日：2007-04-30
申请号：PT02715515
申请日：2002-01-18
Applicant: CELLTECH R&D LTD
Inventor： BAILEY STUART , BROWN JULIEN ALISTAIR , BRAND STEPHEN , JOHNSON JAMES ANDREW , PORTER JOHN ROBERT , HEAD JOHN CLIFFORD
IPC: C07D213/81 , A61K31/198 , A61K31/4375 , A61K31/44 , A61K31/4406 , A61K31/497 , A61P3/10 , A61P9/00 , A61P17/00 , A61P17/06 , A61P19/02 , A61P25/00 , A61P29/00 , A61P37/00 , A61P37/06 , A61P43/00 , C07C229/34 , C07C229/36 , C07C229/46 , C07C233/82 , C07C321/22 , C07C323/30 , C07D213/89 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D471/04
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19.发明专利
公开(公告)号：PL364142A1
公开(公告)日：2004-12-13
申请号：PL36414202
申请日：2002-01-18
Applicant: CELLTECH R&D LTD
Inventor： BAILEY STUART , BROWN JULIEN ALISTAIR , BRAND STEPHEN , JOHNSON JAMES ANDREW , PORTER JOHN ROBERT , HEAD JOHN CLIFFORD
IPC: A61K31/198 , A61K31/4375 , A61K31/44 , A61K31/4406 , A61K31/497 , A61P3/10 , A61P9/00 , A61P17/00 , A61P17/06 , A61P19/02 , A61P25/00 , A61P29/00 , A61P37/00 , A61P37/06 , A61P43/00 , C07C229/34 , C07C229/46 , C07C233/82 , C07C321/22 , C07C323/30 , C07D213/81 , C07D213/89 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D471/04
Abstract: Phenylalanine enamide derivatives of formula (1) are described: wherein R 1 , R x , R y , R z , X and V are as defined in claim 1. The compounds are able to inhibit the binding of integrins to their ligands and are of use in the prophylaxis and treatment of immuno or inflammatory disorders or disorders involving the inappropriate growth or migration of cells.
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20.发明专利
公开(公告)号：CZ20032259A3
公开(公告)日：2004-01-14
申请号：CZ20032259
申请日：2002-01-18
Applicant: CELLTECH R&D LTD
Inventor： BAILEY STUART , BROWN JULIEN ALISTAIR , BRAND STEPHEN , JOHNSON JAMES ANDREW , PORTER JOHN ROBERT , HEAD JOHN CLIFFORD
IPC: A61K31/198 , A61K31/4375 , A61K31/44 , A61K31/4406 , A61K31/497 , A61P3/10 , A61P9/00 , A61P17/00 , A61P17/06 , A61P19/02 , A61P25/00 , A61P29/00 , A61P37/00 , A61P37/06 , A61P43/00 , C07C229/34 , C07C229/46 , C07C233/82 , C07C321/22 , C07C323/30 , C07D213/81 , C07D213/89 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D471/04 , C07C229/36 , A61K31/435
Abstract: Phenylalanine enamide derivatives of formula (1) are described: wherein R 1 , R x , R y , R z , X and V are as defined in claim 1. The compounds are able to inhibit the binding of integrins to their ligands and are of use in the prophylaxis and treatment of immuno or inflammatory disorders or disorders involving the inappropriate growth or migration of cells.
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