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1.发明专利Cyclobutene-group-containing phenylalanine enamide derivative used as integrin inhibitor 审中-公开含有CYPOBUTENE-GROUP的苯乙烯胺衍生物用作INTEGRIN INHIBITOR
公开(公告)号：JP2009057371A
公开(公告)日：2009-03-19
申请号：JP2008188089
申请日：2008-07-22
Applicant: Celltech R & D Ltd , セルテック アール アンド ディ リミテッド
Inventor： BAILEY STUART , BROWN JULIEN ALISTAIR , BRAND STEPHEN , JOHNSON JAMES ANDREW , PORTER JOHN ROBERT , HEAD JOHN CLIFFORD
IPC: C07C229/36 , A61K31/198 , A61K31/223 , A61K31/352 , A61K31/4375 , A61K31/44 , A61K31/4406 , A61K31/443 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/497 , A61P1/04 , A61P3/10 , A61P9/00 , A61P11/06 , A61P17/00 , A61P17/02 , A61P17/06 , A61P19/02 , A61P25/00 , A61P29/00 , A61P37/00 , A61P37/06 , A61P43/00 , C07C229/34 , C07C229/46 , C07C233/81 , C07C233/82 , C07C321/22 , C07C323/30 , C07D213/81 , C07D213/89 , C07D311/96 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D471/04
CPC classification number: C07D213/81 , C04B35/632 , C07C229/10 , C07C229/46 , C07C233/81 , C07C233/82 , C07C323/30 , C07C2601/04 , C07C2603/94 , C07C2603/96 , C07D213/79 , C07D213/89 , C07D311/96 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D471/04
Abstract: PROBLEM TO BE SOLVED: To provide a compound inhibiting the binding of integrin with a ligand and useful in the prevention and treatment of immune or inflammatory diseases associated with inappropriate cell proliferation or migration. SOLUTION: The compound is represented by formula (1) and is exemplified by 3-oxocyclobut-1-enylamino-group-containing methyl(2S)-2-ä(3-oxospiro[3,5]-non-1-en-1-yl)amino}-3-(2,6-dimethoxy[1,1'-biphenyl]-4-yl)propanoate. COPYRIGHT: (C)2009,JPO&INPIT
Abstract translation: 要解决的问题：提供抑制整联蛋白与配体结合并可用于预防和治疗与不适当细胞增殖或迁移相关的免疫或炎性疾病的化合物的问题。 解决方案：化合物由式（1）表示，并且例示为含有3-氧代环丁-1-烯基氨基的（2S）-2-（3-氧代螺[3,5] - 壬-1 丁-1-基）氨基} -3-（2,6-二甲氧基[1,1'-联苯] -4-基）丙酸乙酯。 版权所有（C）2009，JPO＆INPIT
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2.发明专利
公开(公告)号：NZ540232A
公开(公告)日：2007-06-29
申请号：NZ54023202
申请日：2002-01-18
Applicant: CELLTECH R&D LTD
Inventor： BAILEY STUART , BROWN JULIEN ALISTAIR , BRAND STEPHEN , JOHNSON JAMES ANDREW , PORTER JOHN ROBERT , HEAD JOHN CLIFFORD
IPC: A61K31/198 , A61K31/4375 , A61K31/44 , A61K31/4406 , A61K31/497 , A61P3/10 , A61P9/00 , A61P17/00 , A61P17/06 , A61P19/02 , A61P25/00 , A61P29/00 , A61P37/00 , A61P37/06 , A61P43/00 , C07C229/34 , C07C229/46 , C07C233/82 , C07C321/22 , C07C323/30 , C07D213/81 , C07D213/89 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D471/04 , C07C229/36
Abstract: Disclosed are phenylalanine enamide derivatives of formula (1) wherein: R1 is a group Ar1L2Alk- as defined in the specification; X is an -N(R2)- group wherein R2 is H or C1-6alkyl; V is O; Rx, Ry and Rz may be the same or different and each represent L1(Alk1)n(R3)v as defined in the specification; n is zero or 1; and v is 1, 2 or 3. Compounds of the type disclosed are selective inhibitors of alpha-4 integrins.
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公开(公告)号：HU0303160A2
公开(公告)日：2003-12-29
申请号：HU0303160
申请日：2002-01-18
Applicant: CELLTECH R&D LTD
Inventor： BAILEY STUART , BRAND STEPHEN , BROWN JULIEN ALISTAIR , HEAD JOHN CLIFFORD , JOHNSON JAMES ANDREW , PORTER JOHN ROBERT
IPC: A61K31/198 , A61K31/4375 , A61K31/44 , A61K31/4406 , A61K31/497 , A61P3/10 , A61P9/00 , A61P17/00 , A61P17/06 , A61P19/02 , A61P25/00 , A61P29/00 , A61P37/00 , A61P37/06 , A61P43/00 , C07C229/34 , C07C229/46 , C07C233/82 , C07C321/22 , C07C323/30 , C07D213/81 , C07D213/89 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D471/04
Abstract: Phenylalanine enamide derivatives of formula (1) are described: wherein R 1 , R x , R y , R z , X and V are as defined in claim 1. The compounds are able to inhibit the binding of integrins to their ligands and are of use in the prophylaxis and treatment of immuno or inflammatory disorders or disorders involving the inappropriate growth or migration of cells.
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公开(公告)号：DE60218436D1
公开(公告)日：2007-04-12
申请号：DE60218436
申请日：2002-01-18
Applicant: CELLTECH R&D LTD
Inventor： BAILEY SLOUGH , BROWN JULIEN ALISTAIR , BRAND SLOUGH , JOHNSON JAMES ANDREW , PORTER JOHN ROBERT , HEAD JOHN CLIFFORD
IPC: C07D213/81 , A61K31/198 , A61K31/4375 , A61K31/44 , A61K31/4406 , A61K31/497 , A61P3/10 , A61P9/00 , A61P17/00 , A61P17/06 , A61P19/02 , A61P25/00 , A61P29/00 , A61P37/00 , A61P37/06 , A61P43/00 , C07C229/34 , C07C229/36 , C07C229/46 , C07C233/82 , C07C321/22 , C07C323/30 , C07D213/89 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D471/04
Abstract: Phenylalanine enamide derivatives of formula (1) are described: wherein R 1 , R x , R y , R z , X and V are as defined in claim 1. The compounds are able to inhibit the binding of integrins to their ligands and are of use in the prophylaxis and treatment of immuno or inflammatory disorders or disorders involving the inappropriate growth or migration of cells.
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5.发明专利
公开(公告)号：HK1059087A1
公开(公告)日：2004-06-18
申请号：HK04102092
申请日：2004-03-22
Applicant: CELLTECH R&D LTD
Inventor： BAILEY STUART , BROWN JULIEN ALISTAIR , BRAND STEPHEN , JOHNSON JAMES ANDREW , PORTER JOHN ROBERT , HEAD JOHN CLIFFORD
IPC: C07D20060101 , A61K31/198 , A61K31/4375 , A61K31/44 , A61K31/4406 , A61K31/497 , A61P20060101 , A61P3/10 , A61P9/00 , A61P17/00 , A61P17/06 , A61P19/02 , A61P25/00 , A61P29/00 , A61P37/00 , A61P37/06 , A61P43/00 , C07C20060101 , C07C229/34 , C07C229/46 , C07C233/82 , C07C321/22 , C07C323/30 , C07D213/81 , C07D213/89 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D471/04
Abstract: Phenylalanine enamide derivatives of formula (1) are described: wherein R 1 , R x , R y , R z , X and V are as defined in claim 1. The compounds are able to inhibit the binding of integrins to their ligands and are of use in the prophylaxis and treatment of immuno or inflammatory disorders or disorders involving the inappropriate growth or migration of cells.
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Patent Agency Ranking
公开(公告)号：BR0207166A
公开(公告)日：2004-02-10
申请号：BR0207166
申请日：2002-01-18
Applicant: CELLTECH R&D LTD
Inventor： BAILEY STUART , BROWN JULIEN ALISTAIR , BRAND STEPHEN , JOHNSON JAMES ANDREW , PORTER JOHN ROBERT , HEAD JOHN CLIFFORD
IPC: A61K31/198 , A61K31/4375 , A61K31/44 , A61K31/4406 , A61K31/497 , A61P3/10 , A61P9/00 , A61P17/00 , A61P17/06 , A61P19/02 , A61P25/00 , A61P29/00 , A61P37/00 , A61P37/06 , A61P43/00 , C07C229/34 , C07C229/46 , C07C233/82 , C07C321/22 , C07C323/30 , C07D213/81 , C07D213/89 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D471/04 , C07C229/36
Abstract: Phenylalanine enamide derivatives of formula (1) are described: wherein R 1 , R x , R y , R z , X and V are as defined in claim 1. The compounds are able to inhibit the binding of integrins to their ligands and are of use in the prophylaxis and treatment of immuno or inflammatory disorders or disorders involving the inappropriate growth or migration of cells.
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公开(公告)号：NO20033710A
公开(公告)日：2003-10-22
申请号：NO20033710
申请日：2003-08-20
Applicant: CELLTECH R&D LTD
Inventor： BAILEY STUART , BROWN JULIEN ALISTAIR , BRAND STEPHEN , JOHNSON JAMES ANDREW , PORTER JOHN ROBERT , HEAD JOHN CLIFFORD
IPC: A61K31/198 , A61K31/4375 , A61K31/44 , A61K31/4406 , A61K31/497 , A61P3/10 , A61P9/00 , A61P17/00 , A61P17/06 , A61P19/02 , A61P25/00 , A61P29/00 , A61P37/00 , A61P37/06 , A61P43/00 , C07C229/34 , C07C229/46 , C07C233/82 , C07C321/22 , C07C323/30 , C07D213/81 , C07D213/89 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D471/04
CPC classification number: C07D213/81 , C04B35/632 , C07C229/10 , C07C229/46 , C07C233/81 , C07C233/82 , C07C323/30 , C07C2601/04 , C07C2603/94 , C07C2603/96 , C07D213/79 , C07D213/89 , C07D311/96 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D471/04
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公开(公告)号：DE60218436T2
公开(公告)日：2007-10-31
申请号：DE60218436
申请日：2002-01-18
Applicant: CELLTECH R&D LTD
Inventor： BAILEY SLOUGH , BROWN JULIEN ALISTAIR , BRAND SLOUGH , JOHNSON JAMES ANDREW , PORTER JOHN ROBERT , HEAD JOHN CLIFFORD
IPC: C07D213/81 , A61K31/198 , A61K31/4375 , A61K31/44 , A61K31/4406 , A61K31/497 , A61P3/10 , A61P9/00 , A61P17/00 , A61P17/06 , A61P19/02 , A61P25/00 , A61P29/00 , A61P37/00 , A61P37/06 , A61P43/00 , C07C229/34 , C07C229/36 , C07C229/46 , C07C233/82 , C07C321/22 , C07C323/30 , C07D213/89 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D471/04
Abstract: Phenylalanine enamide derivatives of formula (1) are described: wherein R 1 , R x , R y , R z , X and V are as defined in claim 1. The compounds are able to inhibit the binding of integrins to their ligands and are of use in the prophylaxis and treatment of immuno or inflammatory disorders or disorders involving the inappropriate growth or migration of cells.
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公开(公告)号：DK1370531T3
公开(公告)日：2007-06-25
申请号：DK02715515
申请日：2002-01-18
Applicant: CELLTECH R&D LTD
Inventor： BAILEY STUART , BROWN JULIEN ALISTAIR , BRAND STEPHEN , JOHNSON JAMES ANDREW , PORTER JOHN ROBERT , HEAD JOHN CLIFFORD
IPC: C07D213/81 , A61K31/198 , A61K31/4375 , A61K31/44 , A61K31/4406 , A61K31/497 , A61P3/10 , A61P9/00 , A61P17/00 , A61P17/06 , A61P19/02 , A61P25/00 , A61P29/00 , A61P37/00 , A61P37/06 , A61P43/00 , C07C229/34 , C07C229/36 , C07C229/46 , C07C233/82 , C07C321/22 , C07C323/30 , C07D213/89 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D471/04
Abstract: Phenylalanine enamide derivatives of formula (1) are described: wherein R 1 , R x , R y , R z , X and V are as defined in claim 1. The compounds are able to inhibit the binding of integrins to their ligands and are of use in the prophylaxis and treatment of immuno or inflammatory disorders or disorders involving the inappropriate growth or migration of cells.
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公开(公告)号：AT355276T
公开(公告)日：2006-03-15
申请号：AT02715515
申请日：2002-01-18
Applicant: CELLTECH R&D LTD
Inventor： BAILEY STUART , BROWN JULIEN ALISTAIR , BRAND STEPHEN , JOHNSON JAMES ANDREW , PORTER JOHN ROBERT , HEAD JOHN CLIFFORD
IPC: A61K31/198 , A61K31/4375 , A61K31/44 , A61K31/4406 , A61K31/497 , A61P3/10 , A61P9/00 , A61P17/00 , A61P17/06 , A61P19/02 , A61P25/00 , A61P29/00 , A61P37/00 , A61P37/06 , A61P43/00 , C07C229/34 , C07C229/46 , C07C233/82 , C07C321/22 , C07C323/30 , C07D213/81 , C07D213/89 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D471/04 , C07C229/36
Abstract: Phenylalanine enamide derivatives of formula (1) are described: wherein R 1 , R x , R y , R z , X and V are as defined in claim 1. The compounds are able to inhibit the binding of integrins to their ligands and are of use in the prophylaxis and treatment of immuno or inflammatory disorders or disorders involving the inappropriate growth or migration of cells.
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