公开(公告)号：CA2379431A1

公开(公告)日：2001-02-22

申请号：CA2379431

申请日：2000-08-16

Applicant: CELLTECH R&D LTD

Inventor： CATTERALL CATHERINE FIONA ,  EATON MICHAEL ANTHONY WILLIAM ,  PARKER DAVID ,  NORMAN TIMOTHY JOHN ,  BAKER TERENCE SEWARD ,  WEIR ANDREW NEIL CHARLES

IPC: A61K9/14 ,  A61K47/16 ,  A61K47/42 ,  A61K47/48 ,  A61K48/00 ,  C07C229/08 ,  C07C233/36 ,  C07C237/10 ,  C07C271/20 ,  C07C271/22 ,  C12N15/87

Abstract: Targeted lipids and lipid particles are described which are assemblies of multipolar lipids, targeting molecules such as antibodies and polyanions. Th e lipids are of particular use for the delivery of bioactive substances such a s nucleic acids to cells in vitro and especially in vivo.