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    ALBUMIN-BINDING COMPOUNDS
    1.
    发明申请
    ALBUMIN-BINDING COMPOUNDS 审中-公开
    铝结合化合物

    公开(公告)号：WO2005117984A2

    公开(公告)日：2005-12-15

    申请号：PCT/GB2005002084

    申请日：2005-05-25

    Applicant: CELLTECH R&D LTD ,  EATON MICHAEL ANTHONY WILLIAM ,  NORMAN TIMOTHY JOHN ,  PORTER JOHN ROBERT

    Inventor： EATON MICHAEL ANTHONY WILLIAM ,  NORMAN TIMOTHY JOHN ,  PORTER JOHN ROBERT

    IPC: A61K47/48

    CPC classification number: A61K47/542 ,  A61K47/60

    Abstract: The present invention provides an albumin-binding compound essentially of the following elements: a spacer group, a water-soluble bridging group, a fatty acid chain and an acidic group characterised in that the acidic group is attached to the distal end of the fatty acid chain. The invention also provides an albumin-binding compound to which one or more biologically active moieties are attached.

    Abstract translation: 本发明提供了基本上具有以下元素的白蛋白结合化合物：间隔基，水溶性桥连基团，脂肪酸链和酸性基团，其特征在于酸性基团连接到脂肪酸的末端 链。 本发明还提供了与一个或多个生物活性部分连接的白蛋白结合化合物。

    2.
    发明专利
    未知

    公开(公告)号：AT277916T

    公开(公告)日：2004-10-15

    申请号：AT95903870

    申请日：1994-12-21

    Applicant: CELLTECH R&D LTD

    Inventor： WARRELLOW GRAHAM JOHN ,  BOYD EWAN CAMPBELL ,  ALEXANDER RIKKI PETER ,  EATON MICHAEL ANTHONY WILLIAM

    IPC: A61K31/41 ,  A61K31/415 ,  A61K31/42 ,  A61K31/44 ,  A61K31/4418 ,  A61P11/08 ,  A61P29/00 ,  A61P43/00 ,  C07D213/64 ,  C07D231/20 ,  C07D261/12

    Abstract: Compounds of general formula (1): (1) wherein Y is a halogen atom or a group -OR1 where R1 is an optionally substituted alkyl group; X is -O-, -S- or -N(R8)-, where R8 is a hydrogen atom or an alkyl group; R2 is an optionally substituted alkyl, alkenyl, cycloalkyl or cycloalkenyl group; R3 is a hydrogen or halogen atom or an -OR9 group, where R9 is a hydrogen atom or an optionally substituted alkyl, alkenyl, alkoxyalkyl, or alkanoyl group, or a formyl, carboxamido or thiocarboxamido group; R4 is a group -(CH2)nAr, where Ar is a monocyclic or bicyclic aryl group optionally containing one or more heteroatoms selected from oxygen, sulphur or nitrogen atoms and n is zero or an integer 1,2 or 3; R5 is a C3-9 carbocyclic ketone optionally containing one or more heteroatoms selected from oxygen, sulphur or nitrogen atoms; R6 is a hydrogen atom or an optionally substituted alkyl group; R7 is a hydrogen atom or an optionally substituted alkyl group; and the salts, solvates, hydrates and N-oxides thereof. Compounds according to the invention are potent and selective phosphodiesterase type IV inhibitors and are useful in the prophylaxis and treatment of diseases such as asthma where an unwanted inflammatory response or muscular spasm is present.

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