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公开(公告)号：DK1370531T3
公开(公告)日：2007-06-25
申请号：DK02715515
申请日：2002-01-18
Applicant: CELLTECH R&D LTD
Inventor： BAILEY STUART , BROWN JULIEN ALISTAIR , BRAND STEPHEN , JOHNSON JAMES ANDREW , PORTER JOHN ROBERT , HEAD JOHN CLIFFORD
IPC: C07D213/81 , A61K31/198 , A61K31/4375 , A61K31/44 , A61K31/4406 , A61K31/497 , A61P3/10 , A61P9/00 , A61P17/00 , A61P17/06 , A61P19/02 , A61P25/00 , A61P29/00 , A61P37/00 , A61P37/06 , A61P43/00 , C07C229/34 , C07C229/36 , C07C229/46 , C07C233/82 , C07C321/22 , C07C323/30 , C07D213/89 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D471/04
Abstract: Phenylalanine enamide derivatives of formula (1) are described: wherein R 1 , R x , R y , R z , X and V are as defined in claim 1. The compounds are able to inhibit the binding of integrins to their ligands and are of use in the prophylaxis and treatment of immuno or inflammatory disorders or disorders involving the inappropriate growth or migration of cells.
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公开(公告)号：AT355276T
公开(公告)日：2006-03-15
申请号：AT02715515
申请日：2002-01-18
Applicant: CELLTECH R&D LTD
Inventor： BAILEY STUART , BROWN JULIEN ALISTAIR , BRAND STEPHEN , JOHNSON JAMES ANDREW , PORTER JOHN ROBERT , HEAD JOHN CLIFFORD
IPC: A61K31/198 , A61K31/4375 , A61K31/44 , A61K31/4406 , A61K31/497 , A61P3/10 , A61P9/00 , A61P17/00 , A61P17/06 , A61P19/02 , A61P25/00 , A61P29/00 , A61P37/00 , A61P37/06 , A61P43/00 , C07C229/34 , C07C229/46 , C07C233/82 , C07C321/22 , C07C323/30 , C07D213/81 , C07D213/89 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D471/04 , C07C229/36
Abstract: Phenylalanine enamide derivatives of formula (1) are described: wherein R 1 , R x , R y , R z , X and V are as defined in claim 1. The compounds are able to inhibit the binding of integrins to their ligands and are of use in the prophylaxis and treatment of immuno or inflammatory disorders or disorders involving the inappropriate growth or migration of cells.
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公开(公告)号：GB2387845B
公开(公告)日：2005-05-11
申请号：GB0318429
申请日：2002-01-18
Applicant: CELLTECH R&D LTD
Inventor： BAILEY STUART , BROWN JULIEN ALISTAIR , BRAND STEPHEN , JOHNSON JAMES ANDREW , PORTER JOHN ROBERT , HEAD JOHN CLIFFORD
IPC: A61K31/198 , A61K31/4375 , A61K31/44 , A61K31/4406 , A61K31/497 , A61P3/10 , A61P9/00 , A61P17/00 , A61P17/06 , A61P19/02 , A61P25/00 , A61P29/00 , A61P37/00 , A61P37/06 , A61P43/00 , C07C229/34 , C07C229/46 , C07C233/82 , C07C321/22 , C07C323/30 , C07D213/81 , C07D213/89 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D471/04 , C07C229/36
Abstract: Phenylalanine enamide derivatives of formula (1) are described: wherein R 1 , R x , R y , R z , X and V are as defined in claim 1. The compounds are able to inhibit the binding of integrins to their ligands and are of use in the prophylaxis and treatment of immuno or inflammatory disorders or disorders involving the inappropriate growth or migration of cells.
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公开(公告)号：ES2223639T3
公开(公告)日：2005-03-01
申请号：ES00987574
申请日：2000-12-22
Applicant: CELLTECH R&D LTD
Inventor： LANGHAM BARRY JOHN , ALEXANDER RIKKI PETER , HEAD JOHN CLIFFORD , LINSLEY JANEEN MARSHA , PORTER JOHN ROBERT , ARCHIBALD SARAH CATHERINE
IPC: C07C229/34 , C07C229/36 , C07D471/04 , C07C225/20 , C07C229/46 , C07D295/12 , A61K31/13 , A61K31/435 , A61P29/00
Abstract: Un compuesto de fórmula (1): en la que R1 es un grupo Ar1Ar2Alk- en el que: Ar1 es un grupo aromático o heteroaromático opcionalmente sustituido; Ar2 es un grupo fenileno opcionalmente sustituido o un grupo heteroarileno de seis miembros que contiene nitrógeno; y Alk es una cadena en la que R es un ácido carboxílico (-CO2H) o un derivado o bióstero del mismo; R2 es un átomo de hidrógeno o un grupo alquilo C1-6; L1 es un enlace covalente o un átomo o grupo de engarce; n es cero o el número entero 1; Alk1 es una cadena alifática opcionalmente sustituida; R3 es un átomo de hidrógeno o un grupo heteroalifático, cicloalifático, heterocicloalifático, policicloalifático, heteropolicicloalifático, aromático o heteroaromático opcionalmente sustituido; y las sales, solvatos, hidratos y N-óxidos del mismo.
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公开(公告)号：NO20033710L
公开(公告)日：2003-10-22
申请号：NO20033710
申请日：2003-08-20
Applicant: CELLTECH R&D LTD
Inventor： BAILEY STUART , BROWN JULIEN ALISTAIR , BRAND STEPHEN , JOHNSON JAMES ANDREW , PORTER JOHN ROBERT , HEAD JOHN CLIFFORD
IPC: A61K31/198 , A61K31/4375 , A61K31/44 , A61K31/4406 , A61K31/497 , A61P3/10 , A61P9/00 , A61P17/00 , A61P17/06 , A61P19/02 , A61P25/00 , A61P29/00 , A61P37/00 , A61P37/06 , A61P43/00 , C07C229/34 , C07C229/46 , C07C233/82 , C07C321/22 , C07C323/30 , C07D213/81 , C07D213/89 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D471/04
Abstract: Phenylalanine enamide derivatives of formula (1) are described: wherein R 1 , R x , R y , R z , X and V are as defined in claim 1. The compounds are able to inhibit the binding of integrins to their ligands and are of use in the prophylaxis and treatment of immuno or inflammatory disorders or disorders involving the inappropriate growth or migration of cells.
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Patent Agency Ranking
公开(公告)号：NO20033710D0
公开(公告)日：2003-08-20
申请号：NO20033710
申请日：2003-08-20
Applicant: CELLTECH R&D LTD
Inventor： BAILEY STUART , BROWN JULIEN ALISTAIR , BRAND STEPHEN , JOHNSON JAMES ANDREW , PORTER JOHN ROBERT , HEAD JOHN CLIFFORD
IPC: A61K31/198 , A61K31/4375 , A61K31/44 , A61K31/4406 , A61K31/497 , A61P3/10 , A61P9/00 , A61P17/00 , A61P17/06 , A61P19/02 , A61P25/00 , A61P29/00 , A61P37/00 , A61P37/06 , A61P43/00 , C07C229/34 , C07C229/46 , C07C233/82 , C07C321/22 , C07C323/30 , C07D213/81 , C07D213/89 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D471/04 , C07D
Abstract: Phenylalanine enamide derivatives of formula (1) are described: wherein R 1 , R x , R y , R z , X and V are as defined in claim 1. The compounds are able to inhibit the binding of integrins to their ligands and are of use in the prophylaxis and treatment of immuno or inflammatory disorders or disorders involving the inappropriate growth or migration of cells.
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公开(公告)号：PT1370531E
公开(公告)日：2007-04-30
申请号：PT02715515
申请日：2002-01-18
Applicant: CELLTECH R&D LTD
Inventor： BAILEY STUART , BROWN JULIEN ALISTAIR , BRAND STEPHEN , JOHNSON JAMES ANDREW , PORTER JOHN ROBERT , HEAD JOHN CLIFFORD
IPC: C07D213/81 , A61K31/198 , A61K31/4375 , A61K31/44 , A61K31/4406 , A61K31/497 , A61P3/10 , A61P9/00 , A61P17/00 , A61P17/06 , A61P19/02 , A61P25/00 , A61P29/00 , A61P37/00 , A61P37/06 , A61P43/00 , C07C229/34 , C07C229/36 , C07C229/46 , C07C233/82 , C07C321/22 , C07C323/30 , C07D213/89 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D471/04
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公开(公告)号：CA2562701A1
公开(公告)日：2005-12-01
申请号：CA2562701
申请日：2005-05-17
Applicant: CELLTECH R&D LTD
Inventor： BAKER TERENCE SEWARD , NORMAN TIMOTHY JOHN , MCKAY CATHERINE , PORTER JOHN ROBERT
IPC: C07K16/46 , A61K38/00 , A61K47/48 , C07D207/44 , C07D403/12 , C07D403/14
Abstract: The present invention provides a compound consisting essentially of the following elements : one or more reactive groups ; and two or more cross- linked antibodies or fragments thereof ; characterised in that the or each reactive group is suitable for attaching an effector molecule but does not react with any of the antibodies or fragments thereof.
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19.发明专利
公开(公告)号：PL364142A1
公开(公告)日：2004-12-13
申请号：PL36414202
申请日：2002-01-18
Applicant: CELLTECH R&D LTD
Inventor： BAILEY STUART , BROWN JULIEN ALISTAIR , BRAND STEPHEN , JOHNSON JAMES ANDREW , PORTER JOHN ROBERT , HEAD JOHN CLIFFORD
IPC: A61K31/198 , A61K31/4375 , A61K31/44 , A61K31/4406 , A61K31/497 , A61P3/10 , A61P9/00 , A61P17/00 , A61P17/06 , A61P19/02 , A61P25/00 , A61P29/00 , A61P37/00 , A61P37/06 , A61P43/00 , C07C229/34 , C07C229/46 , C07C233/82 , C07C321/22 , C07C323/30 , C07D213/81 , C07D213/89 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D471/04
Abstract: Phenylalanine enamide derivatives of formula (1) are described: wherein R 1 , R x , R y , R z , X and V are as defined in claim 1. The compounds are able to inhibit the binding of integrins to their ligands and are of use in the prophylaxis and treatment of immuno or inflammatory disorders or disorders involving the inappropriate growth or migration of cells.
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20.发明专利
公开(公告)号：CZ20032259A3
公开(公告)日：2004-01-14
申请号：CZ20032259
申请日：2002-01-18
Applicant: CELLTECH R&D LTD
Inventor： BAILEY STUART , BROWN JULIEN ALISTAIR , BRAND STEPHEN , JOHNSON JAMES ANDREW , PORTER JOHN ROBERT , HEAD JOHN CLIFFORD
IPC: A61K31/198 , A61K31/4375 , A61K31/44 , A61K31/4406 , A61K31/497 , A61P3/10 , A61P9/00 , A61P17/00 , A61P17/06 , A61P19/02 , A61P25/00 , A61P29/00 , A61P37/00 , A61P37/06 , A61P43/00 , C07C229/34 , C07C229/46 , C07C233/82 , C07C321/22 , C07C323/30 , C07D213/81 , C07D213/89 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D471/04 , C07C229/36 , A61K31/435
Abstract: Phenylalanine enamide derivatives of formula (1) are described: wherein R 1 , R x , R y , R z , X and V are as defined in claim 1. The compounds are able to inhibit the binding of integrins to their ligands and are of use in the prophylaxis and treatment of immuno or inflammatory disorders or disorders involving the inappropriate growth or migration of cells.
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