公开(公告)号：PL370344A1

公开(公告)日：2005-05-16

申请号：PL37034402

申请日：2002-10-10

Applicant: CELLTECH R&D LTD

Inventor： POPPLEWELL ANDREW GEORGE ,  TICKLE SIMON PETER ,  ZINKEWICH-PEOTTI KAREN ,  MORRISON ROBERT KENDALL

IPC: C12N15/09 ,  A61K39/395 ,  A61K47/48 ,  A61P17/00 ,  A61P17/06 ,  A61P19/02 ,  A61P29/00 ,  A61P35/00 ,  A61P35/04 ,  A61P37/00 ,  C07K16/28 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/13 ,  C12P21/02 ,  C12P21/08 ,  C07K16/46

Abstract: There are disclosed antibody molecules containing at least on CDR derived from a mouse monoclonal antibody having specificity for human KDR. There is also disclosed a CDR grafted antibody wherein at least one of the CDRs is a hybrid CDR. Further disclosed are DNA sequences encoding the chains of the antibody molecules, vectors, transformed host cells and uses of the antibody molecules in the treatment of diseases in which VEGF and/or KDR are implicated.

公开(公告)号：NO20044742L

公开(公告)日：2004-12-22

申请号：NO20044742

申请日：2004-11-02

Applicant: CELLTECH R&D LTD

Inventor： POPPLEWELL ANDREW GEORGE ,  TICKLE SIMON PETER ,  LADYMAN HEATHER MARGARET

IPC: C07K16/18 ,  A61K38/16 ,  A61K39/395 ,  A61P35/00 ,  C07K16/28 ,  C12N15/13 ,  C12N15/63 ,  C12P21/00

Abstract: There is disclosed antibody molecules containing at least one CDR derived from a mouse monoclonal antibody having specificity for human CD22. There is also disclosed a CDR grafted antibody wherein at least one of the CDRs is a modified CDR. Further disclosed are DNA sequences encoding the chains of the antibody molecules, vectors, transformed host cells and uses of the antibody molecules in the treatment of diseases mediated by cells expressing CD22.

公开(公告)号：NO20044742A

公开(公告)日：2004-12-22

申请号：NO20044742

申请日：2004-11-02

Applicant: CELLTECH R&D LTD

Inventor： POPPLEWELL ANDREW GEORGE ,  TICKLE SIMON PETER ,  LADYMAN HEATHER MARGARET

IPC: C07K16/18 ,  A61K38/16 ,  A61K39/395 ,  A61P35/00 ,  C07K16/28 ,  C12N15/13 ,  C12N15/63 ,  C12P21/00

CPC classification number: C07K16/464 ,  A61K2039/505 ,  A61K2039/507 ,  C07K16/2803 ,  C07K16/2851 ,  C07K16/3061 ,  C07K2317/20 ,  C07K2317/24 ,  C07K2317/40 ,  C07K2317/41 ,  C07K2317/52 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/76 ,  C07K2317/92

公开(公告)号：NO20040987A

公开(公告)日：2004-05-10

申请号：NO20040987

申请日：2004-03-08

Applicant: CELLTECH R&D LTD

Inventor： POPPLEWELL ANDREW GEORGE ,  TICKLE SIMON PETER ,  ZINKEWICH-PEOTTI KAREN ,  MORRISON ROBERT KENDALL

IPC: C07K16/28 ,  C12N15/09 ,  A61K39/395 ,  A61K47/48 ,  A61P17/00 ,  A61P17/06 ,  A61P19/02 ,  A61P29/00 ,  A61P35/00 ,  A61P35/04 ,  A61P37/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/13 ,  C12P21/02 ,  C12P21/08 ,  C07K16/46 ,  C12N15/70 ,  G01N33/577

CPC classification number: C07K16/2863 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/55 ,  C07K2317/565

公开(公告)号：CA2458464A1

公开(公告)日：2003-04-17

申请号：CA2458464

申请日：2002-10-10

Applicant: CELLTECH R&D LTD

Inventor： TICKLE SIMON PETER ,  ZINKEWICH-PEOTTI KAREN ,  POPPLEWELL ANDREW GEORGE ,  MORRISON ROBERT KENDALL

IPC: C12N15/09 ,  A61K39/395 ,  A61K47/48 ,  A61P17/00 ,  A61P17/06 ,  A61P19/02 ,  A61P29/00 ,  A61P35/00 ,  A61P35/04 ,  A61P37/00 ,  C07K16/28 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/13 ,  C12P21/02 ,  C12P21/08 ,  A61K47/30 ,  C12N15/70

Abstract: There are disclosed antibody molecules containing at least one CDR derived from a mouse monoclonal antibody having specificity for human KDR. There is also disclosed a CDR grafted antibody wherein at least one of the CDRs is a hybrid CDR. Further disclosed are DNA sequences encoding the chains of the antibody molecules, vectors, transformed host cells and uses of the antibody molecules in the treatment of diseases in which VEGF and/or KDR are implicat ed.

公开(公告)号：ZA200401910B

公开(公告)日：2005-03-09

申请号：ZA200401910

申请日：2004-03-09

Applicant: CELLTECH R&D LTD

Inventor： POPPLEWELL ANDREW GEORGE ,  TICKLE SIMON PETER ,  ZINKEWICH-PEOTTI KAREN ,  MORRISON ROBERT KENDALL

IPC: C12N15/09 ,  A61K39/395 ,  A61K47/48 ,  A61P17/00 ,  A61P17/06 ,  A61P19/02 ,  A61P29/00 ,  A61P35/00 ,  A61P35/04 ,  A61P37/00 ,  C07K16/28 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/13 ,  C12P21/02 ,  C12P21/08 ,  C07K

Abstract: There are disclosed antibody molecules containing at least on CDR derived from a mouse monoclonal antibody having specificity for human KDR. There is also disclosed a CDR grafted antibody wherein at least one of the CDRs is a hybrid CDR. Further disclosed are DNA sequences encoding the chains of the antibody molecules, vectors, transformed host cells and uses of the antibody molecules in the treatment of diseases in which VEGF and/or KDR are implicated.

公开(公告)号：NO20040987L

公开(公告)日：2004-05-10

申请号：NO20040987

申请日：2004-03-08

Applicant: CELLTECH R&D LTD

Inventor： POPPLEWELL ANDREW GEORGE ,  TICKLE SIMON PETER ,  ZINKEWICH-PEOTTI KAREN ,  MORRISON ROBERT KENDALL

IPC: C07K16/28 ,  C12N15/09 ,  A61K39/395 ,  A61K47/48 ,  A61P17/00 ,  A61P17/06 ,  A61P19/02 ,  A61P29/00 ,  A61P35/00 ,  A61P35/04 ,  A61P37/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/13 ,  C12P21/02 ,  C12P21/08 ,  C07K16/46 ,  C12N15/70 ,  G01N33/577

Abstract: There are disclosed antibody molecules containing at least on CDR derived from a mouse monoclonal antibody having specificity for human KDR. There is also disclosed a CDR grafted antibody wherein at least one of the CDRs is a hybrid CDR. Further disclosed are DNA sequences encoding the chains of the antibody molecules, vectors, transformed host cells and uses of the antibody molecules in the treatment of diseases in which VEGF and/or KDR are implicated.