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公开(公告)号：WO03031475A8
公开(公告)日：2004-10-14
申请号：PCT/GB0204619
申请日：2002-10-10
Applicant: CELLTECH R&D LTD , POPPLEWELL ANDREW GEORGE , TICKLE SIMON PETER , ZINKEWICH-PEOTTI KAREN , MORRISON ROBERT KENDALL
Inventor： POPPLEWELL ANDREW GEORGE , TICKLE SIMON PETER , ZINKEWICH-PEOTTI KAREN , MORRISON ROBERT KENDALL
IPC: C12N15/09 , A61K39/395 , A61K47/48 , A61P17/00 , A61P17/06 , A61P19/02 , A61P29/00 , A61P35/00 , A61P35/04 , A61P37/00 , C07K16/28 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/13 , C12P21/02 , C12P21/08 , C07K16/46 , C12N15/70 , G01N33/577
CPC classification number: C07K16/2863 , A61K2039/505 , C07K2317/24 , C07K2317/55 , C07K2317/565
Abstract: There are disclosed antibody molecules containing at least one CDR derived from a mouse monoclonal antibody having specificity for human KDR. There is also disclosed a CDR grafted antibody wherein at least one of the CDRs is a hybrid CDR. Further disclosed are DNA sequences encoding the chains of the antibody molecules, vectors, transformed host cells and uses of the antibody molecules in the treatment of diseases in which VEGF and/or KDR are implicated.
Abstract translation: 公开了含有至少一种衍生自对人KDR具有特异性的小鼠单克隆抗体的CDR的抗体分子。 还公开了CDR移植抗体，其中至少一个CDR是杂交CDR。 进一步公开的是编码抗体分子链，载体，转化的宿主细胞的链DNA序列以及抗体分子用于治疗其中涉及VEGF和/或KDR的疾病的用途。
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公开(公告)号：CA2484420C
公开(公告)日：2014-09-16
申请号：CA2484420
申请日：2003-05-02
Applicant: CELLTECH R&D LTD
IPC: C07K16/18 , C12N15/13 , A61K31/7088 , A61K38/16 , A61K39/395 , A61K48/00 , A61P35/00 , C07K16/28 , C12N5/10 , C12N15/63 , C12N15/85 , C12P21/00 , C12P21/08
Abstract: There is disclosed antibody molecules containing at least one CDR derived from a mouse monoclonal antibody having specificity for human CD22. There is also disclosed a CDR grafted antibody wherein at least one of the CDRs is a modified CDR. Further disclosed are DNA sequences encoding the chains of the antibody molecules, vectors, transformed host cells and uses of the antibody molecules in the treatment of diseases mediated by cells expressing CD22.
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公开(公告)号：NZ536757A
公开(公告)日：2006-06-30
申请号：NZ53675703
申请日：2003-05-02
Applicant: CELLTECH R&D LTD
IPC: C07K16/18 , A61K38/16 , A61K39/395 , A61P35/00 , C07K16/28 , C12N15/13 , C12N15/63 , C12P21/00 , C12N15/85 , C12N5/10 , A61K31/7088
Abstract: An antibody molecule containing at least one CDR derived from a mouse monoclonal antibody having specificity for human CD22. Also disclosed is a CDR grafted antibody wherein at least one of the CDRs is a modified CDR. Also disclosed are the DNA sequences encoding the chains of the antibody molecules, vectors, transformed host cells and uses of the antibody molecules in the treatment of diseases medicated by cells expressing CD22.
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公开(公告)号：CA2484420A1
公开(公告)日：2003-11-13
申请号：CA2484420
申请日：2003-05-02
Applicant: CELLTECH R&D LTD
IPC: C07K16/18 , A61K38/16 , A61K39/395 , A61P35/00 , C07K16/28 , C12N15/13 , C12N15/63 , C12P21/00 , A61K48/00 , C12P21/08 , C12N5/10 , A61K31/7088 , C12N15/85
Abstract: There is disclosed antibody molecules containing at least one CDR derived fr om a mouse monoclonal antibody having specificity for human CD22. There is also disclosed a CDR grafted antibody wherein at least one of the CDRs is a modified CDR. Further disclosed are DNA sequences encoding the chains of the antibody molecules, vectors, transformed host cells and uses of the antibody molecules in the treatment of diseases mediated by cells expressing CD22.
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公开(公告)号：IS7173A
公开(公告)日：2004-03-05
申请号：IS7173
申请日：2004-03-05
Applicant: CELLTECH R&D LTD
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Patent Agency Ranking
公开(公告)号：CA2565294A1
公开(公告)日：2005-12-22
申请号：CA2565294
申请日：2005-06-10
Applicant: CELLTECH R&D LTD
Inventor： LAWSON ALASTAIR DAVID GRIFFITH , TICKLE SIMON PETER
IPC: G01N33/531 , C07K16/00 , G01N33/543 , G01N33/569 , G01N33/58 , G01N33/68
Abstract: The present invention provides an automated homogeneous assay for identifying an antibody-producing cell producing an antibody which binds to a selected antigen, especially a high yielding antibody-producing cell.
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公开(公告)号：HU0401618A2
公开(公告)日：2004-11-29
申请号：HU0401618
申请日：2002-10-10
Applicant: CELLTECH R&D LTD
Inventor： POPPLEWELL ANDREW GEORGE , TICKLE SIMON PETER , ZINKEWICH-PEOTTI KAREN , MORRISON ROBERT KENDALL
IPC: C12N15/09 , A61K39/395 , A61K47/48 , A61P17/00 , A61P17/06 , A61P19/02 , A61P29/00 , A61P35/00 , A61P35/04 , A61P37/00 , C07K16/28 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/13 , C12P21/02 , C12P21/08 , C07K16/00
Abstract: There are disclosed antibody molecules containing at least on CDR derived from a mouse monoclonal antibody having specificity for human KDR. There is also disclosed a CDR grafted antibody wherein at least one of the CDRs is a hybrid CDR. Further disclosed are DNA sequences encoding the chains of the antibody molecules, vectors, transformed host cells and uses of the antibody molecules in the treatment of diseases in which VEGF and/or KDR are implicated.
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公开(公告)号：BR0212756A
公开(公告)日：2004-11-16
申请号：BR0212756
申请日：2002-10-10
Applicant: CELLTECH R&D LTD
Inventor： POPPLEWELL ANDREW GEORGE , TICKLE SIMON PETER , ZINKEWICH-PEOTTI KAREN , MORRISON ROBERT KENDALL
IPC: C12N15/09 , A61K39/395 , A61K47/48 , A61P17/00 , A61P17/06 , A61P19/02 , A61P29/00 , A61P35/00 , A61P35/04 , A61P37/00 , C07K16/28 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/13 , C12P21/02 , C12P21/08 , C07K16/46 , C12N15/70 , G01N33/577
Abstract: There are disclosed antibody molecules containing at least on CDR derived from a mouse monoclonal antibody having specificity for human KDR. There is also disclosed a CDR grafted antibody wherein at least one of the CDRs is a hybrid CDR. Further disclosed are DNA sequences encoding the chains of the antibody molecules, vectors, transformed host cells and uses of the antibody molecules in the treatment of diseases in which VEGF and/or KDR are implicated.
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公开(公告)号：EA010970B1
公开(公告)日：2008-12-30
申请号：EA200400519
申请日：2002-10-10
Applicant: CELLTECH R&D LTD
Inventor： POPPLEWELL ANDREW GEORGE , TICKLE SIMON PETER , ZINKEWICH-PEOTTI KAREN , MORRISON ROBERT KENDALL
IPC: C07K16/28 , C12N15/09 , A61K39/395 , A61K47/48 , A61P17/00 , A61P17/06 , A61P19/02 , A61P29/00 , A61P35/00 , A61P35/04 , A61P37/00 , C07K16/46 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/13 , C12N15/70 , C12P21/02 , C12P21/08 , G01N33/577
Abstract: Заявленымолекулыантител, содержащиепоменьшеймереодин CDR, полученныйизмышиногомоноклональногоантитела, обладающегоспецифичностьюпоотношениюк KDR человека. Такжезаявлено CDR-привитоеантитело, гдепоменьшеймереодиниз CDR являетсягибридным CDR. Крометого, заявленыпоследовательностиДНК, кодирующиецепимолекулантител, векторы, трансформированныеклетки-хозяеваи применениямолекулантителдлялечениязаболеваний, вкоторыевовлечены VEGF и/или KDR.
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公开(公告)号：PL373277A1
公开(公告)日：2005-08-22
申请号：PL37327703
申请日：2003-05-02
Applicant: CELLTECH R&D LTD
IPC: C07K16/18 , A61K38/16 , A61K39/395 , A61P35/00 , C07K16/28 , C12N15/13 , C12N15/63 , C12P21/00 , C12N15/85 , C12N5/10
Abstract: There is disclosed antibody molecules containing at least one CDR derived from a mouse monoclonal antibody having specificity for human CD22. There is also disclosed a CDR grafted antibody wherein at least one of the CDRs is a modified CDR. Further disclosed are DNA sequences encoding the chains of the antibody molecules, vectors, transformed host cells and uses of the antibody molecules in the treatment of diseases mediated by cells expressing CD22.
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