公开(公告)号：CA2379431A1

公开(公告)日：2001-02-22

申请号：CA2379431

申请日：2000-08-16

Applicant: CELLTECH R&D LTD

Inventor： CATTERALL CATHERINE FIONA ,  EATON MICHAEL ANTHONY WILLIAM ,  PARKER DAVID ,  NORMAN TIMOTHY JOHN ,  BAKER TERENCE SEWARD ,  WEIR ANDREW NEIL CHARLES

IPC: A61K9/14 ,  A61K47/16 ,  A61K47/42 ,  A61K47/48 ,  A61K48/00 ,  C07C229/08 ,  C07C233/36 ,  C07C237/10 ,  C07C271/20 ,  C07C271/22 ,  C12N15/87

Abstract: Targeted lipids and lipid particles are described which are assemblies of multipolar lipids, targeting molecules such as antibodies and polyanions. Th e lipids are of particular use for the delivery of bioactive substances such a s nucleic acids to cells in vitro and especially in vivo.

公开(公告)号：WO9952858A3

公开(公告)日：2000-04-06

申请号：PCT/GB9901076

申请日：1999-04-08

Applicant: CELLTECH THERAPEUTICS LTD ,  EATON MICHAEL ANTHONY WILLIAM ,  NORMAN TIMOTHY JOHN ,  PARKER DAVID ,  BAKER TERENCE S ,  WEIR ANDREW NEIL CHARLES ,  CATTERALL CATHERINE FIONA

Inventor： EATON MICHAEL ANTHONY WILLIAM ,  NORMAN TIMOTHY JOHN ,  PARKER DAVID ,  BAKER TERENCE SEWARD ,  WEIR ANDREW NEIL CHARLES ,  CATTERALL CATHERINE FIONA

IPC: A61K47/30 ,  A61K31/16 ,  A61K38/00 ,  A61K45/00 ,  A61K47/48 ,  A61K49/00 ,  A61P43/00 ,  C07C235/10 ,  C07C235/12 ,  C07C237/10 ,  C07C271/20

CPC classification number: A61K9/1272 ,  A61K31/225 ,  A61K31/685 ,  A61K47/543 ,  A61K47/6929 ,  C07C235/10 ,  C07C235/12 ,  C07C237/10 ,  C07C271/20

Abstract: Bipolar lipids are described which are able to form complexes with polyanions. The lipids comprise a cationic head linked to a hydrophobic backbone and a hydrophilic tail and are capable of self assembly to form stable complexes in aqueous solutions. The lipids are of particular use for the delivery of bioactive substances such as nucleic acids to cells in vitro and especially in vivo.

Abstract translation: 描述了能够与聚阴离子形成复合物的双相脂质。 脂质包含连接到疏水骨架和亲水尾部的阳离子头，并且能够自组装以在水溶液中形成稳定的络合物。 脂质特别用于在体外，特别是体内将生物活性物质例如核酸递送至细胞。

公开(公告)号：WO0112154A2

公开(公告)日：2001-02-22

申请号：PCT/GB0003170

申请日：2000-08-16

Applicant: CELLTECH CHIROSCIENCE LTD ,  BAKER TERENCE S ,  WEIR ANDREW NEIL CHARLES ,  CATTERALL CATHERINE FIONA ,  EATON MICHAEL ANTHONY WILLIAM ,  NORMAN TIMOTHY JOHN ,  PARKER DAVID

Inventor： BAKER TERENCE SEWARD ,  WEIR ANDREW NEIL CHARLES ,  CATTERALL CATHERINE FIONA ,  EATON MICHAEL ANTHONY WILLIAM ,  NORMAN TIMOTHY JOHN ,  PARKER DAVID

IPC: A61K9/14 ,  A61K47/16 ,  A61K47/42 ,  A61K47/48 ,  A61K48/00 ,  C07C229/08 ,  C07C233/36 ,  C07C237/10 ,  C07C271/20 ,  C07C271/22 ,  C12N15/87 ,  A61K9/00

CPC classification number: C12N15/87 ,  A61K47/6801 ,  A61K47/6849 ,  A61K47/6907 ,  A61K48/00

Abstract: Targeted lipids and lipid particles are described which are assemblies of multipolar lipids, targeting molecules such as antibodies and polyanions. The lipids are of particular use for the delivery of bioactive substances such as nucleic acids to cells in vitro and especially in vivo .

Abstract translation: 描述了靶向脂质和脂质颗粒，其是多极脂质的组装体，靶向分子例如抗体和聚阴离子。 脂质特别用于将体外生物活性物质例如核酸递送至细胞，特别是体内。