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    METHOD TO DETECT HORMONE TREATMENT IN ANIMALS
    11.
    发明申请
    METHOD TO DETECT HORMONE TREATMENT IN ANIMALS 审中-公开
    检测动物中的激素治疗方法

    公开(公告)号：WO1997009615A1

    公开(公告)日：1997-03-13

    申请号：PCT/US1996014069

    申请日：1996-09-04

    Applicant: CORNELL RESEARCH FOUNDATION, INC.

    Inventor： CORNELL RESEARCH FOUNDATION, INC. ,  SPITSBERG, Vitaly, L. ,  GOREWIT, Donald, C.

    IPC: G01N33/06

    CPC classification number: G01N33/04 ,  G01N33/74

    Abstract: The invention relates to measuring the decrease in phosphorylation of the fatty acid binding protein found in the milk fat globule membrane of bovine or human milk to detect growth hormone treatment in animals. MFGM of cows treated with bST displays weaker FABP autophosphorylation activity than non treated cows. MFGM isolated from cows treated with bST have significantly reduced levels of phosphorylated FABP. The bST test of the present invention can be used not only to determine whether the animal producing the milk has been treated with bST, it can also be used to determine the efficacy of bST on milk production. Dairy managers could thus base their decision on whether to continue bST treatment on such a test.

    Abstract translation: 本发明涉及测量牛或人乳的乳脂肪球膜中发现的脂肪酸结合蛋白的磷酸化降低，以检测动物中的生长激素治疗。 用bST处理的奶牛的MFGM显示比未处理的牛更弱的FABP自磷酸化活性。 用bST处理的奶牛分离的MFGM具有显着降低的磷酸化FABP水平。 本发明的bST试验不仅可用于确定生产乳的动物是否已经用bST处理，还可以用于确定bST对产奶的功效。 因此，乳制品经理可以决定是否继续进行bST治疗。

    COMPOSITIONS AND METHODS TO PROMOTE HOMOLOGOUS RECOMBINATION IN EUKARYOTIC CELLS AND ORGANISMS
    14.
    发明申请
    COMPOSITIONS AND METHODS TO PROMOTE HOMOLOGOUS RECOMBINATION IN EUKARYOTIC CELLS AND ORGANISMS 审中-公开
    促进真核细胞和有机体中的同源重组的组合物和方法

    公开(公告)号：WO1996022364A1

    公开(公告)日：1996-07-25

    申请号：PCT/US1996000265

    申请日：1996-01-16

    Applicant: CORNELL RESEARCH FOUNDATION, INC. ,  THOMAS JEFFERSON UNIVERSITY

    Inventor： CORNELL RESEARCH FOUNDATION, INC. ,  THOMAS JEFFERSON UNIVERSITY ,  HOLLOMAN, William, K. ,  KMIEC, Eric, B.

    IPC: C12N09/00

    CPC classification number: C12N9/00

    Abstract: The invention concerns genes encoding recombinases that can be used to promote homologous recombination in eukaryotic cells. The application teaches methods by which a recombinase of one species can be used to isolate a homologous recombinase of a different species and methods to identify the isolated homologs. Recombinases from Ustilago maydis and Saccharomyces cerevisiae are specifically included in the invention. The invention encompasses the method of producing an isolated recombinase protein in a prokaryotic cell and recovering the product in an active form. The invention also encompasses a genetically engineered gene which encodes a non-naturally occurring recombinase that causes a greater rate of recombination than does the naturally occurring recombinase. The invention further encompasses the use of recombinase proteins and of recombinase genes to promote homologous recombination, including recombination between a host cell genome and a chimeric oligonucleotide, i.e., an oligonucleotide having both RNA and DNA bases.

    Abstract translation: 本发明涉及编码可用于促进真核细胞中的同源重组的重组酶的基因。 该申请教导了可以使用一种重组酶来分离不同物种的同源重组酶的方法，以及鉴定分离的同系物的方法。 来自Ustilago maydis和Saccharomyces cerevisiae的重组酶特异性地包括在本发明中。 本发明包括在原核细胞中产生分离的重组酶蛋白并以活性形式回收产物的方法。 本发明还包括编码非天然存在的重组酶的遗传工程改造的基因，其导致比天然存在的重组酶更高的重组速率。 本发明还包括使用重组酶蛋白和重组酶基因来促进同源重组，包括宿主细胞基因组和嵌合寡核苷酸之间的重组，即具有RNA和DNA碱基的寡核苷酸。

    BINARY BAC VECTOR
    15.
    发明申请
    BINARY BAC VECTOR 审中-公开
    二进制矢量

    公开(公告)号：WO1996021725A1

    公开(公告)日：1996-07-18

    申请号：PCT/US1996000044

    申请日：1996-01-11

    Applicant: CORNELL RESEARCH FOUNDATION, INC.

    Inventor： CORNELL RESEARCH FOUNDATION, INC. ,  HAMILTON, Carol, M.

    IPC: C12N01/21

    CPC classification number: C12N9/1055 ,  C12N15/74 ,  C12N15/8205

    Abstract: The present invention is directed to a vector for transferring heterologous DNA into a plant cell. The vector is based on the bacterial artificial chromosome (BAC) vector designed for the construction of genomic libraries with large DNA inserts, and the binary (BIN) vector designed for Agrobacterium-mediated plant transformation. The BIBAC vector according to the subject invention allows the construction of plant genomic libraries with large DNA inserts that can be directly introduced into plants by transformation mediated by Agrobacterium.

    Abstract translation: 本发明涉及将异源DNA转移到植物细胞中的载体。 载体基于设计用于构建具有大DNA插入物的基因组文库的细菌人造染色体（BAC）载体，以及为土壤杆菌介导的植物转化设计的二元（BIN）载体。 根据本发明的BIBAC载体允许用大的DNA插入物构建植物基因组文库，其可以通过农杆菌介导的转化直接引入植物中。

    CHICKEN INFECTIOUS ANEMIA VIRUS VACCINE
    17.
    发明申请
    CHICKEN INFECTIOUS ANEMIA VIRUS VACCINE 审中-公开
    鸡感染性ANEMIA VIRUS VACCINE

    公开(公告)号：WO1996001116A1

    公开(公告)日：1996-01-18

    申请号：PCT/US1995008440

    申请日：1995-07-05

    Applicant: CORNELL RESEARCH FOUNDATION, INC.

    Inventor： CORNELL RESEARCH FOUNDATION, INC. ,  SCHAT, Karel, A. ,  SOINE, Christiane ,  LUCIO, Benjamin ,  RENSHAW, Randy

    IPC: A61K31/70

    CPC classification number: C07K14/005 ,  A61K39/00 ,  C12N2750/10022 ,  C12N2750/10034 ,  C12N2750/12022 ,  Y10S424/816

    Abstract: Novel sequences in the genome of a wild type isolate of chicken infectious anemia virus are described. The amino acid sequence of a polypeptide, VP1, encoded by a novel sequence is also disclosed. Additionally, disclosed are the unexpected properties of the isolate which are related to novel amino acids positioned in the amino acid sequence of this isolate's VP1, as compared to the sequence of VP1 found in cell culture-adapted strains; and use of the novel sequences and their respective polypeptides in strategies to control chicken infectious anemia such as by vaccination.

    Abstract translation: 描述了鸡传染性贫血病毒野生型分离株的基因组中的新序列。 还公开了由新序列编码的多肽VP1的氨基酸序列。 另外，与在细胞培养适应菌株中发现的VP1序列相比，披露了与分离株VP1的氨基酸序列中的新氨基酸有关的分离物的意想不到的性质; 以及在策略中使用新的序列及其各自的多肽来控制鸡感染性贫血，例如通过接种疫苗。

    HUMAN BONE MARROW ENDOTHELIAL CELLS
    19.
    发明申请
    HUMAN BONE MARROW ENDOTHELIAL CELLS 审中-公开
    人骨髓内皮细胞

    公开(公告)号：WO1996000778A1

    公开(公告)日：1996-01-11

    申请号：PCT/US1995007989

    申请日：1995-06-26

    Applicant: CORNELL RESEARCH FOUNDATION, INC.

    Inventor： CORNELL RESEARCH FOUNDATION, INC. ,  ASCH, Adam, S. ,  RAFII, Shahin

    IPC: C12N05/00

    CPC classification number: C12N5/0669 ,  C12N5/0644 ,  C12N5/0647 ,  C12N5/069 ,  C12N2502/28 ,  C12N2509/00

    Abstract: The present invention relates to bone marrow endothelial cells characterized by their ability to support adhesion of megakaryocytes and bone marrow mononuclear cells as well as by their being a source for one or more cytokines supporting either progenitor cell proliferation, differentiation of pluripotent progenitor cells to megakaryocytes, or platelet formation by megakaryocytes. The bone marrow endothelial cells of the present invention are isolated by recovering bone marrow spicules from bone marrow, digesting the bone marrow spicules with one or more proteolytic enzymes, recovering microvessel fragments from the digested bone marrow spicules, and growing the microvessel fragments to form bone marrow endothelial cells.

    Abstract translation: 本发明涉及骨髓内皮细胞，其特征在于其支持巨核细胞和骨髓单核细胞粘附的能力，以及它们作为支持祖细胞增殖，多能祖细胞分化为巨核细胞的一种或多种细胞因子的来源， 或巨核细胞的血小板形成。 本发明的骨髓内皮细胞通过从骨髓中回收骨髓针刺，用一种或多种蛋白水解酶消化骨髓针刺，从消化的骨髓针头回收微血管碎片，并使微血管碎片生长形成骨来分离 骨髓内皮细胞。

    THERMOSTABLE CELLULASE FROM A THERMOMONOSPORA GENE
    20.
    发明申请
    THERMOSTABLE CELLULASE FROM A THERMOMONOSPORA GENE 审中-公开
    热稳定性细胞因子从热霉菌属基因

    公开(公告)号：WO1996000281A1

    公开(公告)日：1996-01-04

    申请号：PCT/US1995009069

    申请日：1995-06-23

    Applicant: CORNELL RESEARCH FOUNDATION, INC.

    Inventor： CORNELL RESEARCH FOUNDATION, INC. ,  WILSON, David, B. ,  WALKER, Larry, P. ,  ZHANG, Sheng

    IPC: C12N01/20

    CPC classification number: C12N9/2437 ,  C12P19/14 ,  C12Y302/01091

    Abstract: The invention relates to a gene isolated from Thermomonospora fusca, wherein the gene encodes a thermostable cellulase. Disclosed is the nucleotide sequence of the T. fusca gene; and nucleic acid molecules comprising the gene, or a fragment of the gene, that can be used to recombinantly express the cellulase or a catalytically active polypeptide thereof, respectively. The isolated and purified recombinant cellulase or catalytically active polypeptide may be used to hydrolyze substrate either by itself; or in combination with other cellulases, with the resultant combination having unexpected hydrolytic activity.

    Abstract translation: 本发明涉及从热带菌属（Thermomonospora fusca）分离的基因，其中该基因编码热稳定性纤维素酶。 披露了T. fusca基因的核苷酸序列; 和包含可用于分别重组表达纤维素酶或其催化活性多肽的基因或该基因片段的核酸分子。 分离和纯化的重组纤维素酶或催化活性多肽本身可以用于水解底物; 或与其它纤维素酶组合，所得组合具有意想不到的水解活性。

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