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    POLYMER MICROFILTRATION DEVICES, METHODS OF MANUFACTURING THE SAME AND THE USES OF THE MICROFILTRATION DEVICES
    11.
    发明申请
    POLYMER MICROFILTRATION DEVICES, METHODS OF MANUFACTURING THE SAME AND THE USES OF THE MICROFILTRATION DEVICES 审中-公开
    聚合物微滤装置，其制造方法和微滤装置的用途

    公开(公告)号：US20140322743A1

    公开(公告)日：2014-10-30

    申请号：US14359467

    申请日：2012-11-21

    Applicant: Creatv Microtech, Inc.

    Inventor： Cha-Mei Tang ,  Yunqi Zhang

    IPC: G01N33/50 ,  B01D39/16 ,  B01L3/00 ,  B01L9/00

    CPC classification number: G01N33/5005 ,  B01D29/00 ,  B01D39/16 ,  B01D39/1692 ,  B01L3/50 ,  B01L3/502 ,  B01L3/5635 ,  B01L9/00 ,  B01L2300/0681 ,  G01N1/4005 ,  G01N1/4077 ,  G01N2001/4088 ,  Y10T29/49826 ,  Y10T29/49963

    Abstract: A microfilter comprising a polymer layer formed from epoxy-based photo-definable dry film, and a plurality of apertures each extending through the polymer layer. A microfilter comprising two or more polymer layers formed from epoxy-based photo-definable dry film, and a plurality of apertures or open areas each extending through the polymer layer. A method of forming a microfilter is also disclosed. The method includes providing a first layer of epoxy-based photo-definable dry film disposed on a substrate, exposing the first layer to energy through a mask to form a pattern, defined by the mask, in the first layer of dry film, forming, from the exposed first layer of dry film, a polymer layer having a plurality of apertures extending therethrough, the plurality of apertures having a distribution defined by the pattern, and removing the polymer layer from the substrate. Unique filter holder designs and methods appropriate to hold microfilters to collect the rare cells and allow performing assays in the filter holder are provided. The invention also describes the use of the microfilter and filter holder to collect rare cells from body fluids and perform assays. Rare cells collected on the microfilter in accordance with embodiments of the present invention can be used for medical and biological research applications.

    Abstract translation: 一种包含由环氧基可光定影干膜形成的聚合物层的微过滤器，以及遍及聚合物层的多个孔。 一种包含由环氧基可光限制的干膜形成的两个或更多个聚合物层的微过滤器，以及各自延伸穿过聚合物层的多个孔或开口区域。 还公开了一种形成微过滤器的方法。 该方法包括提供设置在基底上的第一层环氧基光可定义干膜，将第一层暴露于能量通过掩模，以在第一层干膜中形成由掩模限定的图案， 从曝光的第一层干膜，具有延伸穿过其中的多个孔的聚合物层，所述多个孔具有由图案限定的分布，以及从基底去除聚合物层。 提供了独特的过滤器支架设计和适用于容纳微过滤器以收集稀有细胞并允许在过滤器保持器中进行测定的方法。 本发明还描述了微过滤器和过滤器保持器从体液中收集稀有细胞并进行测定的用途。 根据本发明的实施方案收集在微过滤器上的稀有细胞可用于医学和生物研究应用。

    FREESTANDING HIGH-ASPECT-RATIO GOLD MASKS FOR LOW-ENERGY, PHASE-BASED X-RAY MICROSCOPY
    12.
    发明公开
    FREESTANDING HIGH-ASPECT-RATIO GOLD MASKS FOR LOW-ENERGY, PHASE-BASED X-RAY MICROSCOPY 审中-公开

    公开(公告)号：US20240312665A1

    公开(公告)日：2024-09-19

    申请号：US18377523

    申请日：2023-10-06

    Applicant: Creatv MicroTech, Inc.

    Inventor： Olga V. Makarova ,  Ralu Divan ,  Nicolaie Moldovan ,  David A. Czaplewski ,  Cha-Mei Tang

    IPC: G21K1/10 ,  G21K7/00

    CPC classification number: G21K1/10 ,  G21K7/00

    Abstract: High-resolution, X-ray phase contrast microscopy, a key technique with promising potential in biomedical imaging and diagnostics, is based on narrow-slit high-aspect-ratio gold gratings. We present the development, fabrication details, and experimental testing of the freestanding 10-μm-thick gold membrane masks with an array of 0.9-1.5 □m void slit apertures for a novel low-energy X-ray microscope. The overall mask size is 4 mm×4 mm, with a grating pitch of 7.5 □m, 6.0-6.6-□m-wide gold bars are supported by 3-□m-wide crosslinks at 400 □m intervals. The fabrication process is based on gold electroplating into a silicon mold coated with various thin films to form a voltage barrier, plating base, and sacrificial layer, followed by the mold removal to obtain the freestanding gold membrane with void slit apertures. We discuss key aspects for the materials and processes, including gold structures homogeneity, residual stresses, and prevention of collapsing of the grid elements. We further demonstrate the possibility to obtain high-resolution, high contrast 2D images of biological samples using an incoherent, rotating anode X-ray tube.

    Fabrication of Microfilters and Nanofilters and Their Applications
    15.
    发明申请
    Fabrication of Microfilters and Nanofilters and Their Applications 审中-公开

    公开(公告)号：US20190262778A1

    公开(公告)日：2019-08-29

    申请号：US16265305

    申请日：2019-02-01

    Applicant: Creatv MicroTech, Inc.

    Inventor： Cha-Mei Tang ,  Olga Makarova

    IPC: B01D67/00 ,  A61M1/34 ,  B01D69/12 ,  C12M1/00 ,  B01D71/46 ,  B01D71/64

    Abstract: Micro- and nanofilters with precision pore sizes and pore layout have applications in many fields including capturing circulating tumor cells and fetal cells in blood, water treatment, pathogen detection in water, etc. Methods to fabricate micro- and nanofilters not using track etching or reactive ion etching are provided, allowing easy fabrication of single layer or stack of films simultaneously, and/or stack of films on rolls. Microfilter can be made using one or more layers of material. Invention enables mass production of microfilters with lithographic quality at low cost. Isolation, enumeration and characterization of circulating tumor cells using microfilters provides (i) guides to cancer treatment selection and personalize dosage, (ii) low cost monitoring for treatment response, disease progression and recurrence, (iii) assessment of pharmacodynamic effects, (iv) information on mechanisms of resistance to therapy, and (v) cancer staging. Microfabrication methods are also applicable to fabrication of any free standing patterned polymeric films.

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