中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

7 records (took 0.023 seconds)

    POLYMER MICROFILTERS, DEVICES COMPRISING THE SAME, METHODS OF MANUFACTURING THE SAME, AND USES THEREOF
    2.
    发明申请
    POLYMER MICROFILTERS, DEVICES COMPRISING THE SAME, METHODS OF MANUFACTURING THE SAME, AND USES THEREOF 审中-公开
    聚合物微滤膜，包含该聚合物的装置，其制造方法及其用途

    公开(公告)号：US20140315295A1

    公开(公告)日：2014-10-23

    申请号：US14213183

    申请日：2014-03-14

    Applicant: Creatv MicroTech, Inc.

    Inventor： Olga Makarova ,  Cha-Mei Tang ,  Peixuan Zhu ,  Shuhong Li ,  Daniel Adams ,  Platte T. Amstutz

    IPC: G01N1/34 ,  B01D39/16

    CPC classification number: G01N1/34 ,  B01D39/1692 ,  B01D2239/0421 ,  G01N33/50

    Abstract: A microfilter having a hydrophilic surface and suited for size-based capture and analysis of cells, such as circulating cancer cells, from whole blood and other human fluids is disclosed. The filter material is photo-definable, allowing the formation of precision pores by UV lithography. Exemplary embodiments provide a device that combines a microfilter with 3D nanotopography in culture scaffolds that mimic the 3D in vivo environment to better facilitate growth of captured cells.

    Abstract translation: 公开了一种具有亲水表面并且适合于基于尺寸的捕获和分析来自全血和其它人体液体的细胞例如循环癌细胞的微过滤器。 过滤材料是可光限定的，允许通过UV光刻形成精密孔。 示例性实施方案提供了一种将微型过滤器与模拟3D体内环境的3D纳米形成相结合的装置，以更好地促进捕获的细胞的生长。

    Fabrication of Microfilters and Nanofilters and Their Applications
    6.
    发明申请
    Fabrication of Microfilters and Nanofilters and Their Applications 审中-公开

    公开(公告)号：US20190262778A1

    公开(公告)日：2019-08-29

    申请号：US16265305

    申请日：2019-02-01

    Applicant: Creatv MicroTech, Inc.

    Inventor： Cha-Mei Tang ,  Olga Makarova

    IPC: B01D67/00 ,  A61M1/34 ,  B01D69/12 ,  C12M1/00 ,  B01D71/46 ,  B01D71/64

    Abstract: Micro- and nanofilters with precision pore sizes and pore layout have applications in many fields including capturing circulating tumor cells and fetal cells in blood, water treatment, pathogen detection in water, etc. Methods to fabricate micro- and nanofilters not using track etching or reactive ion etching are provided, allowing easy fabrication of single layer or stack of films simultaneously, and/or stack of films on rolls. Microfilter can be made using one or more layers of material. Invention enables mass production of microfilters with lithographic quality at low cost. Isolation, enumeration and characterization of circulating tumor cells using microfilters provides (i) guides to cancer treatment selection and personalize dosage, (ii) low cost monitoring for treatment response, disease progression and recurrence, (iii) assessment of pharmacodynamic effects, (iv) information on mechanisms of resistance to therapy, and (v) cancer staging. Microfabrication methods are also applicable to fabrication of any free standing patterned polymeric films.

Patent Agency Ranking