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    Viral complement control proteins for eye disorders
    15.
    发明申请
    Viral complement control proteins for eye disorders 失效
    用于眼睛疾病的病毒补体对照蛋白

    公开(公告)号：US20060142191A1

    公开(公告)日：2006-06-29

    申请号：US11247886

    申请日：2005-10-08

    Applicant: Cedric Francois ,  Pascal Deschatelets ,  Paul Olson

    Inventor： Cedric Francois ,  Pascal Deschatelets ,  Paul Olson

    IPC: A61K38/16

    CPC classification number: A61K38/162 ,  C07K14/005 ,  C07K2319/33 ,  C12N2710/24122

    Abstract: The present invention provides compositions and methods for treating and/or preventing age related macular degeneration and other conditions involving macular degeneration or choroidal neovascularization. Certain of the compositions comprise a poxvirus complement control protein or a complement binding fragment or variant thereof. Other compositions comprise a poxvirus complement control protein linked to a moiety that binds to a component present on or at the surface of cell or noncellular molecular entity, e.g., a component present in the eye of a subject at risk of or suffering from age related macular degeneration or a related condition or choroidal neovascularization. Certain of the methods comprise administering a poxvirus complement control protein or complement binding fragment or variant thereof to a subject.

    Abstract translation: 本发明提供用于治疗和/或预防年龄相关性黄斑变性和涉及黄斑变性或脉络膜新生血管形成的其它病症的组合物和方法。 某些组合物包含痘病毒补体对照蛋白或其补体结合片段或变体。 其他组合物包含与结合存在于细胞或非细胞分子实体的表面或其表面上的组分连接的部分的痘病毒补体对照蛋白，例如存在于患有年龄相关性黄斑的风险的患者的眼睛中的组分 变性或相关病症或脉络膜新生血管形成。 某些方法包括向受试者施用痘病毒补体对照蛋白或补体结合片段或其变体。

    Compositions and methods for enhancing phagocytosis or phagocyte activity
    16.
    发明申请
    Compositions and methods for enhancing phagocytosis or phagocyte activity 有权
    用于增强吞噬作用或吞噬细胞活性的组合物和方法

    公开(公告)号：US20050113297A1

    公开(公告)日：2005-05-26

    申请号：US10923940

    申请日：2004-08-23

    Applicant: Cedric Francois ,  Pascal Deschatelets ,  Paul Olson ,  Alec Machiels

    Inventor： Cedric Francois ,  Pascal Deschatelets ,  Paul Olson ,  Alec Machiels

    IPC: A61K38/17 ,  A61K47/48 ,  C12N5/08

    CPC classification number: B82Y5/00 ,  A61K47/544 ,  A61K47/62 ,  A61K47/6911 ,  A61K47/6913

    Abstract: The present invention provides a system for enhancing clearance or destruction of undesirable cells or noncellular molecular entities by tagging such cells or noncellular molecular entities with a marker that targets the cells or noncellular molecular entities for phagocytosis (phagocytic marker). The target cells can be, for example, endothelial cells, tumor cells, leukocytes, or virus-infected cells. In certain embodiments of the invention the tagging is accomplished by administering a composition comprising an antibody or ligand linked to the phagcytotic marker, wherein the antibody or ligand binds to a cell type specific marker present on or in the cell surface of a target cell. In preferred embodiments of the invention, the phagocytic marker comprises phosphatidylserine or a group derived from phosphatidylserine, thrombospondin-1, annexin I, or a derivative of any of these.

    Abstract translation: 本发明提供了一种用于通过用靶向细胞或非细胞分子实体进行吞噬作用（吞噬标记）的标记来标记这样的细胞或非细胞分子实体来增强不需要的细胞或非细胞分子实体的清除或破坏的系统。 靶细胞可以是例如内皮细胞，肿瘤细胞，白细胞或病毒感染的细胞。 在本发明的某些实施方案中，标记通过施用包含与噬菌体标记物连接的抗体或配体的组合物来实现，其中所述抗体或配体结合存在于靶细胞的细胞表面上或细胞表面的细胞类型特异性标志物。 在本发明的优选实施方案中，吞噬标记物包含磷脂酰丝氨酸或衍生自磷脂酰丝氨酸，血小板反应素-1，膜联蛋白I或其任何衍生物的基团。

    Cell-reactive, long-acting, or targeted compstatin analogs and uses thereof
    17.
    发明授权
    Cell-reactive, long-acting, or targeted compstatin analogs and uses thereof 有权

    公开(公告)号：US10125171B2

    公开(公告)日：2018-11-13

    申请号：US14116591

    申请日：2012-05-11

    Applicant: Cedric Francois ,  Pascal Deschatelets

    Inventor： Cedric Francois ,  Pascal Deschatelets

    IPC: A61K38/38 ,  A61K47/60 ,  C07K14/76 ,  C07K7/64 ,  A61K38/00 ,  C07K7/08 ,  C07K14/47 ,  A61K47/64

    Abstract: In some aspects, the present invention provides cell-reactive compstatin analogs and compositions comprising cell-reactive compstatin analogs. In some aspects, the invention further provides methods of using cell-reactive compstatin analogs, e.g., to inhibit complement-mediated damage to a cell, tissue, or organ. In some aspects, the invention provides long-acting compstatin analogs and compositions comprising long-acting compstatin analogs. In some aspects, the invention further provides methods of using long-acting compstatin analogs, e.g., to inhibit complement-mediated damage to a cell, tissue, or organ. In some aspects, the invention provides targeted compstatin analogs and compositions comprising targeted compstatin analogs. In some aspects, the invention further provides methods of using targeted compstatin analogs, e.g., to inhibit complement-mediated damage to a cell, tissue, or organ.

    Methods of treating chronic disorders with complement inhibitors
    18.
    发明授权
    Methods of treating chronic disorders with complement inhibitors 有权

    公开(公告)号：US10039802B2

    公开(公告)日：2018-08-07

    申请号：US14128447

    申请日：2012-06-22

    Applicant: Cedric Francois ,  Pascal Deschatelets

    Inventor： Cedric Francois ,  Pascal Deschatelets

    IPC: A61K38/10 ,  A61K39/395 ,  G01N33/68 ,  A61K38/12 ,  A61B5/145 ,  A61B5/00

    Abstract: In some aspects, the invention provides methods of treating a subject in need of treatment for a chronic complement-mediated disorder. In some aspects, the invention provides methods of treating a subject in need of treatment for a Th17-associated disorder. In some aspects, the invention provides methods of treating a subject in need of treatment for a chronic respiratory system disorder. In some aspects, the invention provides methods of administering a complement inhibitor to a subject. In some embodiments, a method of treating a subject comprises administering multiple doses of a complement inhibitor to the subject according to a dosing schedule that leverages the prolonged effect of complement inhibition in chronic respiratory disorders. In some embodiments, a subject has chronic obstructive pulmonary disease. In some embodiments, a subject has asthma.

    METHODS OF TREATING CHRONIC DISORDERS WITH COMPLEMENT INHIBITORS
    20.
    发明申请
    METHODS OF TREATING CHRONIC DISORDERS WITH COMPLEMENT INHIBITORS 审中-公开
    用补充抑制剂治疗慢性疾病的方法

    公开(公告)号：US20140371133A1

    公开(公告)日：2014-12-18

    申请号：US14128447

    申请日：2012-06-22

    Applicant: Cedric Francois ,  Pascal Deschatelets

    Inventor： Cedric Francois ,  Pascal Deschatelets

    IPC: A61K38/12 ,  G01N33/68

    CPC classification number: A61K38/12 ,  A61B5/14546 ,  A61B5/414 ,  A61K38/10 ,  A61K39/3955 ,  G01N33/6869 ,  G01N33/6884 ,  G01N2800/12 ,  G01N2800/122 ,  G01N2800/14 ,  G01N2800/24

    Abstract: In some aspects, the invention provides methods of treating a subject in need of treatment for a chronic complement-mediated disorder. In some aspects, the invention provides methods of treating a subject in need of treatment for a Th17-associated disorder. In some aspects, the invention provides methods of treating a subject in need of treatment for a chronic respiratory system disorder. In some aspects, the invention provides methods of administering a complement inhibitor to a subject. In some embodiments, a method of treating a subject comprises administering multiple doses of a complement inhibitor to the subject according to a dosing schedule that leverages the prolonged effect of complement inhibition in chronic respiratory disorders. In some embodiments, a subject has chronic obstructive pulmonary disease. In some embodiments, a subject has asthma.

    Abstract translation: 在一些方面，本发明提供了治疗需要治疗慢性补体介导的病症的受试者的方法。 在一些方面，本发明提供治疗需要治疗Th17相关病症的受试者的方法。 在一些方面，本发明提供治疗需要治疗慢性呼吸系统疾病的受试者的方法。 在一些方面，本发明提供了向受试者施用补体抑制剂的方法。 在一些实施方案中，治疗受试者的方法包括根据给药方案对受试者施用多个剂量的补体抑制剂，所述给药方案利用长期呼吸障碍中补体抑制的延长作用。 在一些实施方案中，受试者具有慢性阻塞性肺疾病。 在一些实施方案中，受试者具有哮喘。

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