中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

35 records (took 0.031 seconds)

    Viral complement control proteins for eye disorders
    1.
    发明授权
    Viral complement control proteins for eye disorders 失效
    用于眼睛疾病的病毒补体对照蛋白

    公开(公告)号：US08043609B2

    公开(公告)日：2011-10-25

    申请号：US11612751

    申请日：2006-12-19

    Applicant: Pascal Deschatelets ,  Paul Olson ,  Cedric Francois

    Inventor： Pascal Deschatelets ,  Paul Olson ,  Cedric Francois

    IPC: A61K35/00 ,  C07K5/00

    CPC classification number: A61K38/162 ,  A61K9/0051 ,  A61K38/17

    Abstract: The present invention provides compositions and methods for treating and/or preventing age related macular degeneration and other conditions involving macular degeneration or choroidal neovascularization, ocular inflammation, or any combination of these. Certain of the compositions comprise a poxvirus complement control protein or a complement binding fragment or variant thereof. Other compositions comprise a poxvirus complement control protein linked to a moiety that binds to a component present on or at the surface of cell or noncellular molecular entity, e.g., a component present in the eye of a subject at risk of or suffering from age related macular degeneration or a related condition or choroidal neovascularization, ocular inflammation, or any combination of these. Certain of the methods comprise administering a poxvirus complement control protein or complement binding fragment or variant thereof to a subject.

    Abstract translation: 本发明提供用于治疗和/或预防年龄相关性黄斑变性和涉及黄斑变性或脉络膜新生血管形成，眼部炎症或其任何组合的其它病症的组合物和方法。 某些组合物包含痘病毒补体对照蛋白或其补体结合片段或变体。 其他组合物包含与结合存在于细胞或非细胞分子实体的表面或其表面上的组分连接的部分的痘病毒补体对照蛋白，例如存在于患有年龄相关性黄斑的风险的患者的眼睛中的组分 变性或相关病症或脉络膜新生血管形成，眼部炎症或这些的任何组合。 某些方法包括向受试者施用痘病毒补体对照蛋白或补体结合片段或其变体。

    COMPOSITIONS AND METHODS FOR TREATMENT OF TRAUMA
    2.
    发明申请
    COMPOSITIONS AND METHODS FOR TREATMENT OF TRAUMA 审中-公开
    组合物和治疗TRAUMA的方法

    公开(公告)号：US20110092446A1

    公开(公告)日：2011-04-21

    申请号：US12669957

    申请日：2008-07-21

    Applicant: Cedric Francois ,  Pascal Deschatelets ,  Paul Olson

    Inventor： Cedric Francois ,  Pascal Deschatelets ,  Paul Olson

    IPC: A61K38/12 ,  C12Q1/68 ,  C07K7/64

    CPC classification number: A61K38/12 ,  C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/136 ,  C12Q2600/156

    Abstract: The present invention features the use of a complement inhibitor, e.g., a compstatin analog for treating an individual who has suffered a severe injury. In some embodiments, the complement inhibitor may be administered within 24 hours following the injury and optionally also at later time points. The complement inhibitor may, for example, be administered prior to transporting the patient to a health care facility, during transport of the patient to a health care facility, or in the emergency department. Further provided are methods of selecting individuals for such therapy. Further provided are methods of identifying individuals at increased risk of poor outcome following trauma. In certain embodiments the methods comprise determining whether the genotype of the patient includes an allele of a polymorphism in or near a complement-related gene, wherein said allele is associated with risk of poor outcome following trauma.

    Abstract translation: 本发明的特征在于补体抑制剂例如化合物类似物用于治疗遭受严重损伤的个体的用途。 在一些实施方案中，补体抑制剂可以在损伤后24小时内和任选地也在稍后的时间点施用。 例如，补体抑制剂可以在将患者运送到保健设施之前，在将患者运送到保健设施或急诊部门期间进行给药。 还提供了选择这种治疗的个体的方法。 进一步提供的是识别创伤后不良结局风险增加的个体的方法。 在某些实施方案中，所述方法包括确定患者的基因型是否包括在补体相关基因中或其附近的多态性的等位基因，其中所述等位基因与创伤后的结果不良的风险相关。

    Flame-retardant synthetic resin articles containing flame-retardant superabsorbent polymer (SAP) particles
    6.
    发明授权
    Flame-retardant synthetic resin articles containing flame-retardant superabsorbent polymer (SAP) particles 失效
    含有阻燃超吸收聚合物（SAP）颗粒的阻燃合成树脂制品

    公开(公告)号：US07329461B2

    公开(公告)日：2008-02-12

    申请号：US11121942

    申请日：2005-05-05

    Applicant: Martin E. Rogers ,  Pascal Deschatelets ,  Janice P. Phillips

    Inventor： Martin E. Rogers ,  Pascal Deschatelets ,  Janice P. Phillips

    IPC: C08K5/49

    CPC classification number: C08J3/203 ,  C08K3/016 ,  C08K3/32 ,  Y10T428/31504

    Abstract: Flame-retardant synthetic resin articles and methods of making the same are provided whereby flame-retardant SAP particles are incorporated into synthetic resins, especially curable thermosettable resins. The SAP particles are most preferably hydrated with an aqueous flame-retardant solution. In this regard, the flame-retardant solution may consist essentially of water alone or a water solution containing one or more water soluble inorganic flame retardants. When SAP particles are hydrated with an aqueous inorganic flame retardant solution, the SAP particles may thereafter be dried to remove substantially the water component. In such a manner, the inorganic flame retardant will remain as a dried residue physically entrained within the SAP particles. As such, the SAP particles serve as a physical matrix in which the inorganic flame retardant is homogenously dispersed. The SAP particles may then be blended with a synthetic resin as is or alternatively may be ground into more finely divided particles which contain the dried residue of the aqueous inorganic flame retardant solution and then blended with a suitable synthetic resin.

    Abstract translation: 提供阻燃合成树脂制品及其制备方法，其中阻燃SAP颗粒被引入合成树脂，特别是可固化的可热固树脂中。 SAP颗粒最优选用含水阻燃溶液水合。 在这方面，阻燃溶液可以基本上由单独的水或含有一种或多种水溶性无机阻燃剂的水溶液组成。 当SAP颗粒与含水无机阻燃剂溶液水合时，此后可将SAP颗粒干燥以除去基本上水分。 以这种方式，无机阻燃剂将保留为物理夹带在SAP颗粒内的干燥残余物。 因此，SAP颗粒用作其中无机阻燃剂均匀分散的物理基体。 然后可以将SAP颗粒与合成树脂共混，或者可以研磨成更细的颗粒，其含有无机阻燃剂水溶液的干燥残余物，然后与合适的合成树脂混合。

    Flame-retardant synthetic resin articles containing flame-retardant superabsorbent polymer (SAP) particles
    8.
    发明申请
    Flame-retardant synthetic resin articles containing flame-retardant superabsorbent polymer (SAP) particles 失效
    含有阻燃超吸收聚合物（SAP）颗粒的阻燃合成树脂制品

    公开(公告)号：US20050203224A1

    公开(公告)日：2005-09-15

    申请号：US11121942

    申请日：2005-05-05

    Applicant: Martin Rogers ,  Pascal Deschatelets ,  Janice Phillips

    Inventor： Martin Rogers ,  Pascal Deschatelets ,  Janice Phillips

    IPC: C08J20060101 ,  C08J3/20 ,  C08J3/26 ,  C08K3/32 ,  C08K5/49

    CPC classification number: C08J3/203 ,  C08K3/016 ,  C08K3/32 ,  Y10T428/31504

    Abstract: Flame-retardant synthetic resin articles and methods of making the same are provided whereby flame-retardant SAP particles are incorporated into synthetic resins, especially curable thermosettable resins. The SAP particles are most preferably hydrated with an aqueous flame-retardant solution. In this regard, the flame-retardant solution may consist essentially of water alone or a water solution containing one or more water soluble inorganic flame retardants. When SAP particles are hydrated with an aqueous inorganic flame retardant solution, the SAP particles may thereafter be dried to remove substantially the water component. In such a manner, the inorganic flame retardant will remain as a dried residue physically entrained within the SAP particles. As such, the SAP particles serve as a physical matrix in which the inorganic flame retardant is homogenously dispersed. The SAP particles may then be blended with a synthetic resin as is or alternatively may be ground into more finely divided particles which contain the dried residue of the aqueous inorganic flame retardant solution and then blended with a suitable synthetic resin.

    Abstract translation: 提供阻燃合成树脂制品及其制备方法，其中阻燃SAP颗粒被引入合成树脂，特别是可固化的可热固树脂中。 SAP颗粒最优选用含水阻燃溶液水合。 在这方面，阻燃溶液可以基本上由单独的水或含有一种或多种水溶性无机阻燃剂的水溶液组成。 当SAP颗粒与含水无机阻燃剂溶液水合时，此后可将SAP颗粒干燥以除去基本上水分。 以这种方式，无机阻燃剂将保留为物理夹带在SAP颗粒内的干燥残余物。 因此，SAP颗粒用作其中无机阻燃剂均匀分散的物理基体。 然后可以将SAP颗粒与合成树脂共混，或者可以研磨成更细的颗粒，其含有无机阻燃剂水溶液的干燥残余物，然后与合适的合成树脂混合。

Patent Agency Ranking