公开(公告)号：WO1997002841A1

公开(公告)日：1997-01-30

申请号：PCT/US1996011222

申请日：1996-07-09

Applicant: GEORGETOWN UNIVERSITY ,  ARAUJO, John, C. ,  DONIGER, Jay ,  ROSENTHAL, Leonard, J.

Inventor： GEORGETOWN UNIVERSITY

IPC: A61K48/00

CPC classification number: C07K14/005 ,  A61K38/00 ,  A61K48/00 ,  C12N2710/16522

Abstract: The HHV-6 transcription suppressor (ts) gene acts at the level of transcription to shut-off expression of the HIV LTR promoter and of the H-ras gene, a gene whose mutational activation is associated with numerous human cancers. The ts gene is delivered to cells by a pharmaceutically acceptable vehicle and acts as either a preventative or therapeutical agent against cancer or against viral infections.

Abstract translation: HHV-6转录抑制基因（ts）基因在转录水平上起作用以阻断HIV LTR启动子和H-ras基因的表达，H-ras基因是突变激活与许多人类癌症相关的基因。 ts基因通过药学上可接受的载体递送到细胞，并且作为预防或治疗剂以抗癌或抗病毒感染。

公开(公告)号：WO1996040062A1

公开(公告)日：1996-12-19

申请号：PCT/US1996008619

申请日：1996-06-06

Applicant: GEORGETOWN UNIVERSITY

Inventor： GEORGETOWN UNIVERSITY ,  THIERRY, Alain ,  DRITSCHILO, Anatoly

IPC: A61K09/127

CPC classification number: C12N15/88 ,  A61K9/127 ,  A61K9/1277

Abstract: An improved method for encapsulating high molecular weight nucleic acids in liposomes, which provides for high nucleic acid entrapment efficiencies, is provided. The resulting compositions provide enhanced in vitro and in vivo transfection and are useful, for example, in producing cell lines expressing a desired nucleic acid sequence.

Abstract translation: 提供了一种用于将高分子量核酸包封在脂质体中的改进方法，其提供了高的核酸捕获效率。 所得组合物提供增强的体外和体内转染，并且可用于例如生产表达所需核酸序列的细胞系。

公开(公告)号：WO1996003152A1

公开(公告)日：1996-02-08

申请号：PCT/US1995009143

申请日：1995-07-28

Applicant: GEORGETOWN UNIVERSITY

Inventor： GEORGETOWN UNIVERSITY ,  KORBA, Brent, E. ,  GERIN, John, L.

IPC: A61K48/00

CPC classification number: C12N15/1131 ,  A61K38/00 ,  C12N2310/3125 ,  C12N2310/315

Abstract: Antisense oligonucleotides that hybridize to segments of the preS1, S, C, and epsilon regions of the hepatitis B virus (HBV) RNA pregenome inhibit replication of the virus. The figure illustrates the relative positions of antisense oligonucleotides targeted against the HBV S gene. Pharmaceutical compositions which contain these oligonucleotides as the active ingredients are effective against HBV infection.

Abstract translation: 与乙型肝炎病毒（HBV）RNA pregenome的preS1，S，C和ε区域的区段杂交的反义寡核苷酸抑制病毒的复制。 该图说明了针对HBV S基因的反义寡核苷酸的相对位置。 含有这些寡核苷酸作为活性成分的药物组合物对HBV感染有效。

公开(公告)号：WO1995030909A1

公开(公告)日：1995-11-16

申请号：PCT/US1995005837

申请日：1995-05-10

Applicant: GEORGETOWN UNIVERSITY

Inventor： GEORGETOWN UNIVERSITY ,  MOSCOVITCH, Marko

IPC: G01T01/00

CPC classification number: G01T1/04 ,  G01T1/026 ,  G01T3/08

Abstract: A dosimetry method and associated apparatus characterized by the steps of storing information in a three-dimensional optical memory element (20), then exposing the optical memory element to neutron or other high LET radiation to alter the information stored in the optical memory element as a function of the radiation to which the optical memory element is exposed, and then retrieving the altered information from the optical memory element. In a preferred embodiment, subsequent analysis of the altered information uses a neural network computer apparatus (30). The altered information is used to provide a measure of both the radiation dose and energy. The optical memory may be a 3-D ORAM (20) with a volume of a transparent polymer doped with a light sensitive chemical and, in particular, spirobenzopyran. Also, a spectrometer (40) for monitoring neutron and other types of radiation, an electronic dosimeter (50) for providing real-time monitoring of radiation exposure, and associated methodologies, are all based on use of an optical memory element.

Abstract translation: 一种剂量测定方法和相关设备，其特征在于以下步骤：将信息存储在三维光学存储元件（20）中，然后将光学存储元件暴露于中子或其它高LET辐射，以将存储在光学存储元件中的信息改变为 光存储器元件暴露于其中的辐射的功能，然后从光学存储元件检索改变的信息。 在优选实施例中，改变信息的后续分析使用神经网络计算机设备（30）。 改变的信息用于提供辐射剂量和能量的量度。 光学存储器可以是具有掺杂有光敏化学品，特别是螺苯并吡喃的透明聚合物的体积的3-D ORAM（20）。 而且，用于监测中子和其它类型的辐射的光谱仪（40），用于提供对辐射暴露的实时监测的电子剂量计（50）以及相关方法都是基于光学存储元件的使用。

公开(公告)号：WO1995015116A1

公开(公告)日：1995-06-08

申请号：PCT/US1994013736

申请日：1994-11-30

Applicant: GEORGETOWN UNIVERSITY

Inventor： GEORGETOWN UNIVERSITY ,  VERRIER, Richard, L. ,  NEARING, Bruce, D.

IPC: A61B05/0452

CPC classification number: A61B5/0452 ,  A61B5/02405 ,  A61B5/04525 ,  A61B5/046 ,  A61B5/4035 ,  Y10S128/925

Abstract: A method and apparatus for predicting susceptibility to sudden cardiac death (208) involves simultaneously assessing cardiac electrical stability (206), represented by either the beat-to-beat alternation in the T-wave of the patient's ECG or dispersion of the QT interval and the autonomic influence on the heart (204), represented by either the magnitude of heart rate variability in the ECG or by baroreceptor sensitivity.

Abstract translation: 用于预测心源性猝死易感性的方法和装置（208）涉及同时评估心电稳定性（206），其由患者ECG的T波中的搏动间歇交替或QT间期的分散或 对心脏的自主影响（204），由心电图中心率变异性的大小或压力感受器灵敏度表示。

公开(公告)号：WO1995007299A1

公开(公告)日：1995-03-16

申请号：PCT/US1994009770

申请日：1994-09-12

Applicant: GEORGETOWN UNIVERSITY

Inventor： GEORGETOWN UNIVERSITY ,  OLLERT, Markus, W. ,  ZIEGELMULLER, Patrick ,  GRUNWALD, Thomas ,  BREDEHORST, Reinhard ,  VOGEL, Carl-Wilhelm

IPC: C07K14/46

CPC classification number: C07K19/00 ,  C07K14/46

Abstract: A novel functionally active derivative of cobra venom factor is described in which the beta -chain has been cleaved by treatment with a protease. Gel-electrophoretic analyses of the purified derivative revealed the absence of an intact beta -chain and a decrease of the molecular weight.

Abstract translation: 描述了眼镜蛇毒因子的新型功能活性衍生物，其中β-链通过用蛋白酶处理而被切割。 纯化的衍生物的凝胶电泳分析显示不存在完整的β-链和分子量的降低。

公开(公告)号：WO1995006441A1

公开(公告)日：1995-03-09

申请号：PCT/US1994009895

申请日：1994-09-01

Applicant: GEORGETOWN UNIVERSITY

Inventor： GEORGETOWN UNIVERSITY ,  RUBENSTEIN, Jon, R. ,  PAHIRA, John, J. ,  TAYLOR, Alan, G.

IPC: A61B19/08

CPC classification number: A61B90/04 ,  A61B2090/0813 ,  Y10T428/233 ,  Y10T428/237

Abstract: A radiation shield (5) includes an aperture (15) connected to an edge of the shield by a slit (20), which is held closed by a releasable flap (25). Instrumentation can be inserted through the aperture to contact a patient over which the shield (5) is draped. By releasing the flap (25) and thereby opening the aperture (15) toward the edge of the shield, the shield (5) can be removed from the patient without removing the instrumentation inserted through the aperture (15). A secondary shield (37) is releasably secured over the aperture (15), affording further protection. Because the shield is placed within the septic field during use, the shield includes a sterilizable outer covering (155).

Abstract translation: 辐射屏蔽（5）包括通过狭缝（20）连接到屏蔽的边缘的孔（15），狭缝（20）由可释放的翼片（25）保持闭合。 仪器可以穿过孔插入以接触护罩（5）所覆盖的患者。 通过释放翼片（25）并从而朝向屏蔽件的边缘打开孔口（15），可以在不去除穿过孔口（15）插入的仪器的情况下从患者移除护罩（5）。 次级屏蔽（37）可释放地固定在孔（15）上，从而进一步保护。 因为在使用过程中护罩被放置在脓毒症区域内，护罩包括可消毒的外覆盖物（155）。

公开(公告)号：WO1994020122A1

公开(公告)日：1994-09-15

申请号：PCT/US1994002154

申请日：1994-03-07

Applicant: GEORGETOWN UNIVERSITY

Inventor： GEORGETOWN UNIVERSITY ,  SOBEL, Douglas, O.

IPC: A61K37/00

CPC classification number: C07K14/565 ,  A61K38/212 ,  A61K38/215 ,  C07K14/56 ,  A61K2300/00

Abstract: A method is provided for preventing or treating an autoimmune disorder and/or recurrent autoimmune disorder in a transplant tissue in a mammal, which entails administering an effective amount of a single subtype of alpha - and/or beta -interferon or a hybrid or analog of either or mixture thereof to the mammal.

Abstract translation: 提供了一种用于预防或治疗哺乳动物移植组织中的自身免疫疾病和/或复发性自身免疫病症的方法，其需要施用有效量的单 - 亚型的α-和/或β-干扰素或其混合物或类似物 或其混合物与哺乳动物。

公开(公告)号：WO1994006350A1

公开(公告)日：1994-03-31

申请号：PCT/US1993008782

申请日：1993-09-16

Applicant: GEORGETOWN UNIVERSITY

Inventor： GEORGETOWN UNIVERSITY ,  VERRIER, Richard, L. ,  NEARING, Bruce, D.

IPC: A61B05/0452

CPC classification number: A61B5/0452 ,  A61B5/02405 ,  A61B5/04525 ,  A61B5/046 ,  A61B5/4035 ,  A61B5/7275 ,  G06K9/00536

Abstract: A method and apparatus for the non-invasive, dynamic tracking and diagnosing of cardiac vulnerability to ventricular fibrillation features simultaneous analysis of T-wave alternans (206) and heart rate variability (204). T-wave alternation is an absolute predictor of cardiac electrical instability. Heart rate variability is a measure of autonomic influence, a major factor in triggering cardiac arrythmias. By simultaneously analyzing both phenomena (208) the extent and cause of cardiac vulnerability can be assessed.

Abstract translation: 用于非侵入性，动态跟踪和诊断心脏纤维颤动的易感性的方法和装置，其特征在于同时分析T波交替（206）和心率变异性（204）。 T波交替是心电不稳定的绝对预测因子。 心率变异性是衡量自主神经影响的重要因素，也是引发心脏心律失常的主要因素。 通过同时分析这两种现象（208），可以评估心脏易感性的程度和原因。

公开(公告)号：WO1992007066A1

公开(公告)日：1992-04-30

申请号：PCT/US1991007286

申请日：1991-10-11

Applicant: GEORGETOWN UNIVERSITY

Inventor： GEORGETOWN UNIVERSITY ,  CHEN, Wen-Tien

IPC: C12N09/50

CPC classification number: C12N9/50 ,  C12N9/6421 ,  G01N33/57492 ,  G01N2333/50 ,  Y10S530/828

Abstract: A novel 170kD membrane protease is isolated from malignant human melanoma cell line LOX and RPMI7951. The protease is useful in a method of diagnosing cellular transformation.