公开(公告)号：WO1992014401A1

公开(公告)日：1992-09-03

申请号：PCT/US1992001053

申请日：1992-02-12

Applicant: GEORGETOWN UNIVERSITY

Inventor： GEORGETOWN UNIVERSITY ,  VERRIER, Richard, L. ,  NEARING, Bruce, D.

IPC: A61B05/0452

CPC classification number: A61B5/4035 ,  A61B5/0452 ,  A61B5/04525 ,  A61B5/046

Abstract: A method for dynamic tracking of cardiac vulnerability to ventricular fibrillation is disclosed. A heart is monitored to sense an ECG signal (202) which is amplified (206) and low-pass filtered (208) before it is digitally sampled (210) and stored (212). The location of the T-wave in each R-R interval of the ECG is estimated and each T-wave is partitioned into a plurality of time divisions. The sampled ECG signal in each of the time divisions is summed together and a time series is formed for each of the time divisions such that each time series includes corresponding sums from corresponding time divisions from successive T-waves. Each time series is detrended in order to eliminate the effects of drift and DC bias, and then a method of dynamic estimation is performed on each time series to estimate the amplitude of alternation for each time division (214).

Abstract translation: 公开了一种用于动态跟踪心脏纤维颤动的易感性的方法。 监测心脏以感测在其被数字采样（210）并存储（212）之前被放大（206）和低通滤波（208）的ECG信号（202）。 在ECG的每个R-R间隔中估计T波的位置，并将每个T波分割成多个时分。 每个时分的采样ECG信号被加在一起，并且为每个时分形成时间序列，使得每个时间序列包括来自相继T波的相应时间分段的对应和。 为了消除漂移和直流偏压的影响，每个时间序列被去激活，然后对每个时间序列执行动态估计的方法以估计每个时间分割的交替幅度（214）。

公开(公告)号：WO1997024062A1

公开(公告)日：1997-07-10

申请号：PCT/US1995017022

申请日：1995-12-28

Applicant: THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION

Inventor： THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION ,  BROWN, Charles, G. ,  DZWONCZYK, Roger, R.

IPC: A61B05/0452

CPC classification number: A61N1/3925

Abstract: A non-invasive method of guiding therapeutic interventions to a subject in cardiac arrest. The method includes connecting electrodes to the body (22) of the subject and detecting an analog electrical potential which is proportional to the electrical potential generated by the subject's heart. A predictive parameter determining apparatus (20) samples the analog potential for a selected interval of time to obtain a set of time domain samples. By transforming these time domain samples into a frequency domain power spectrum, apparatus (20) obtains a power distribution of the electrical potential. At least one amplitude parameter of the ECG time domain signal interval or frequency parameter of the power spectrum is determined and monitored. The parameters are predictive of a clinically relevant cardiac arrest outcome for the subject. Therapy is administered to the subject through a defibrillator (21) or a resuscitator (25) as a function of the value of the parameters.

Abstract translation: 在心脏骤停中指导治疗干预措施的非侵入性方法。 该方法包括将电极连接到对象的身体（22），并且检测与受试者心脏产生的电位成正比的模拟电位。 预测参数确定装置（20）在所选择的时间间隔内对模拟电位进行采样以获得一组时域采样。 通过将这些时域样本变换为频域功率谱，装置（20）获得电势的功率分布。 确定并监测ECG时域信号间隔或功率谱频率参数的至少一个振幅参数。 这些参数是预测受试者临床相关的心脏骤停结果。 作为参数值的函数，通过除纤颤器（21）或复苏器（25）对受试者进行治疗。

公开(公告)号：WO1997022296A1

公开(公告)日：1997-06-26

申请号：PCT/CN1995000097

申请日：1995-12-18

Applicant: WANG, Xiangsheng

IPC: A61B05/0452

CPC classification number: A61B5/0456 ,  A61B5/4035

Abstract: A system and method for testing the function of the autonomic nervous system of human body is disclosed. The method comprises the following steps: stimulating the sympathetic nervous system or the parasympathetic nervous system; analysing the R wave of ECG signal sectionally according to different stimulating; analysing it's power spectrum using Auto-Regressive (AR) model so as to obtain the quantitative analysing result of the intensity difference of the excitability between the sympathetic nervous system and the parasympathetic nervous system of the tested body.

Abstract translation: 公开了一种用于测试人体自主神经系统功能的系统和方法。 该方法包括以下步骤：刺激交感神经系统或副交感神经系统; 根据不同的刺激分析ECG信号的R波分段; 使用自动回归（AR）模型对其功率谱进行分析，以获得交感神经系统与受试体的副交感神经系统之间的兴奋性强度差异的定量分析结果。

公开(公告)号：WO1993021824A1

公开(公告)日：1993-11-11

申请号：PCT/US1993000051

申请日：1993-01-04

Applicant: MEDTRONIC, INC.

Inventor： MEDTRONIC, INC. ,  SCHWARTZ, Peter, J.

IPC: A61B05/0452

CPC classification number: A61N1/36114 ,  A61N1/3621 ,  A61N1/36585

Abstract: A method and apparatus for stimulating the right or left vagus nerve with continuous and/or phasic electrical pulses, the latter in a specific relationship with the R-wave of the patient's electrogram. The automatic detection of the need for vagal stimulation is responsive to increases in the heart rate greater than a predetermined threshold, the occurrence of frequent or complex ventricular arrhythmias, and/or a change in the ST segment elevation greater than a predetermined or programmed threshold. The system is described with a microprocessor driven, brady therapy device with programming and telemetry capabilities for recording in memory the aforementioned stimulation triggering indicia, including electrogram segments for periods of time preceding and following each instance of vagal stimulation for telemetry out on command.

Abstract translation: 用连续和/或相位电脉冲刺激右或左迷走神经的方法和装置，后者与患者电描记图的R波具有特定关系。 对迷走神经刺激的需要的自动检测响应大于预定阈值的心率增加，频率或复杂心室心律不齐的发生，和/或ST段抬高的变化大于预定或编程的阈值。 该系统用具有编程和遥测能力的微处理器驱动的缓冲治疗装置来描述，用于在记忆中记录上述刺激触发标记，包括在每个迷走神经刺激实例之前和之后的时间段上的电描绘段，用于遥测遥测。

公开(公告)号：WO1998002090A1

公开(公告)日：1998-01-22

申请号：PCT/US1997012509

申请日：1997-07-17

Applicant: CAMBRIDGE HEART, INC.

Inventor： CAMBRIDGE HEART, INC. ,  ALBRECHT, Paul ,  ARNOLD, Jeffrey, M. ,  COHEN, Richard, J. ,  LANDER, Paul

IPC: A61B05/0452

CPC classification number: A61B5/0452 ,  A61B5/04085 ,  A61B5/05

Abstract: A localized cardiac measure, such as a localized measure of myocardial ischemia, is obtained by applying sensors (110) to a subject, where the sensors are configured to produce electrical signals representative of cardiac activity of the subject. The subject's heart is then physiologically stressed by, for example, exercise stress testing (145), and electrical signals are received from at least two of the sensors. The received signals then are processed (130) to obtain a localized cardiac measure (135, 140).

Abstract translation: 通过将传感器（110）应用于受试者来获得局部心脏测量，例如心肌缺血的局部测量，其中传感器被配置为产生代表受试者心脏活动的电信号。 然后通过例如运动压力测试（145）对受试者的心脏进行生理压力，并且从至少两个传感器接收电信号。 然后对接收的信号进行处理（130）以获得局部心脏测量（135,140）。

公开(公告)号：WO1997040742A1

公开(公告)日：1997-11-06

申请号：PCT/US1997007220

申请日：1997-05-01

Applicant: TOTTS GAP MEDICAL RESEARCH LABORATORIES, INC.

Inventor： TOTTS GAP MEDICAL RESEARCH LABORATORIES, INC. ,  SKINNER, James, E.

IPC: A61B05/0452

CPC classification number: A61B5/0464 ,  A61B5/0476 ,  A61B5/4094 ,  A61B5/7203 ,  G06F19/00

Abstract: Disclosed is a method and a device in which electrophysiological signals are acquired, and analyzed to provide a basis of prediction of clinical outcomes such as sudden cardiac death and cerebral epilepsy.

Abstract translation: 公开了一种方法和装置，其中获取电生理信号并进行分析，以提供临床结果的预测的基础，例如心脏猝死和脑癫痫。

公开(公告)号：WO1995010979A1

公开(公告)日：1995-04-27

申请号：PCT/US1994011740

申请日：1994-10-14

Applicant: EP TECHNOLOGIES, INC.

Inventor： EP TECHNOLOGIES, INC. ,  KUCK, Karl-Heinz ,  THOMPSON, Russell, B.

IPC: A61B05/0452

CPC classification number: A61B5/6855 ,  A61B5/0422 ,  A61B18/1492 ,  A61B2018/1497 ,  A61B2562/0209 ,  A61B2562/043 ,  A61B2562/046

Abstract: A multiple electrode array (18) senses electrical events in heart tissue at different orientations in a localized region. First, second, and third electrode elements (60, 62, 64) are spaced apart along different axes. The electrodes (60, 62, 64) are electrically isolated from each other. The spaced apart and electrically isolated electrodes (60, 62, 64) sense multiple bipolar signals measured along the different axes. The electrode array (18) can, without changing position, continuously record multiple electrical events at different relative orientations within a localized area. The spacing and orientation of electrodes on the array (18) permit the physician to detect a small volume signal (like one associated with an accessory pathway), and to differentiate it from nearby large volume signals (like those associated with atrial and ventricular potentials).

Abstract translation: 多电极阵列（18）以局部区域中的不同取向感测心脏组织中的电事件。 第一，第二和第三电极元件（60,62,64）沿着不同的轴线间隔开。 电极（60,62,64）彼此电隔离。 间隔开和电隔离的电极（60,62,64）感测沿着不同轴测量的多个双极信号。 电极阵列（18）可以在不改变位置的情况下连续记录局部区域内的不同相对取向的多个电气事件。 阵列（18）上的电极的间距和取向允许医生检测小体积信号（如与附件通路相关联的信号），并将其与附近的大体积信号（如与心房和心室电位相关的信号）区分开来， 。

公开(公告)号：WO1995015116A1

公开(公告)日：1995-06-08

申请号：PCT/US1994013736

申请日：1994-11-30

Applicant: GEORGETOWN UNIVERSITY

Inventor： GEORGETOWN UNIVERSITY ,  VERRIER, Richard, L. ,  NEARING, Bruce, D.

IPC: A61B05/0452

CPC classification number: A61B5/0452 ,  A61B5/02405 ,  A61B5/04525 ,  A61B5/046 ,  A61B5/4035 ,  Y10S128/925

Abstract: A method and apparatus for predicting susceptibility to sudden cardiac death (208) involves simultaneously assessing cardiac electrical stability (206), represented by either the beat-to-beat alternation in the T-wave of the patient's ECG or dispersion of the QT interval and the autonomic influence on the heart (204), represented by either the magnitude of heart rate variability in the ECG or by baroreceptor sensitivity.

Abstract translation: 用于预测心源性猝死易感性的方法和装置（208）涉及同时评估心电稳定性（206），其由患者ECG的T波中的搏动间歇交替或QT间期的分散或 对心脏的自主影响（204），由心电图中心率变异性的大小或压力感受器灵敏度表示。

公开(公告)号：WO1994006350A1

公开(公告)日：1994-03-31

申请号：PCT/US1993008782

申请日：1993-09-16

Applicant: GEORGETOWN UNIVERSITY

Inventor： GEORGETOWN UNIVERSITY ,  VERRIER, Richard, L. ,  NEARING, Bruce, D.

IPC: A61B05/0452

CPC classification number: A61B5/0452 ,  A61B5/02405 ,  A61B5/04525 ,  A61B5/046 ,  A61B5/4035 ,  A61B5/7275 ,  G06K9/00536

Abstract: A method and apparatus for the non-invasive, dynamic tracking and diagnosing of cardiac vulnerability to ventricular fibrillation features simultaneous analysis of T-wave alternans (206) and heart rate variability (204). T-wave alternation is an absolute predictor of cardiac electrical instability. Heart rate variability is a measure of autonomic influence, a major factor in triggering cardiac arrythmias. By simultaneously analyzing both phenomena (208) the extent and cause of cardiac vulnerability can be assessed.

Abstract translation: 用于非侵入性，动态跟踪和诊断心脏纤维颤动的易感性的方法和装置，其特征在于同时分析T波交替（206）和心率变异性（204）。 T波交替是心电不稳定的绝对预测因子。 心率变异性是衡量自主神经影响的重要因素，也是引发心脏心律失常的主要因素。 通过同时分析这两种现象（208），可以评估心脏易感性的程度和原因。

公开(公告)号：WO1992016143A1

公开(公告)日：1992-10-01

申请号：PCT/US1992001880

申请日：1992-03-10

Applicant: INCONTROL, INC.

Inventor： INCONTROL, INC. ,  ADAMS, John, M. ,  ALFERNESS, Clifford, A.

IPC: A61B05/0452

CPC classification number: A61B5/6852 ,  A61B5/0031 ,  A61B5/0422

Abstract: An implantable device (30) assists in the diagnosis of myocardial ischemia of a human heart and includes a plurality of electrodes (50-54) and a like plurality of sense amplifiers (72-76) for generating an electrogram for each of the electrodes (50-54). An analog to digital converter (80) reads the voltage magnitudes of the electrogram ST segments which are then stored in a memory (60). An implantable receiver/transmitter (63) is arranged to transmit the magnitudes of the electrogram ST segments to a nonimplanted external receiver.