公开(公告)号：CA2197046A1

公开(公告)日：1997-08-10

申请号：CA2197046

申请日：1997-02-07

Applicant: HOECHST AG

Inventor： PAPENFUHS THEODOR ,  DIERDORF ANDREAS ,  KRAUSE STEFAN ,  NEUMANN-GRIMM DORIS

IPC: B01J23/40 ,  C07B61/00 ,  C07C227/08 ,  C07C227/18 ,  C07C229/56 ,  C07C249/02 ,  C07C229/54

Abstract: Process for the preparation of N-carboxymethyleneanthranilic acid esters Process for the preparation of N-carboxymethyleneanthranilic acid esters of the formula (3) (3) by reacting a compound of the formula (1) (1) in which R' is hydrogen or a straight-chain or branched alkyl radical having 1 to 4 carbon atoms and R1, R2, R3 and R4 are identical or different and independently of one another are hydrogen, halogen, NO2, a straight-chain or branched alkyl, alkoxy or halogenated alkyl radical having in each case 1 to 6 carbon atoms, with a glyoxylic acid ester of the formula (2) OHC-COOR (2) in which R is a straight-chain or branched alkyl radical having 1 to 20 carbon atoms, phenyl radical or benzyl radical, which are unsubstituted or mono- or polysubstituted by halogen or an alkyl or alkoxy group having in each case 1 to 4 carbon atoms, in the presence of a solvent at 0 to 200.degree.C, optionally separating off the water formed during the reaction, and reducing the reaction product with hydrogen in the presence of a hydrogenation catalyst at a temperature of 0 to 200.degree.C under a pressure of 1 to 150 bar.