公开(公告)号：ZA9607366B

公开(公告)日：1997-02-28

申请号：ZA9607366

申请日：1996-08-30

Applicant: HOECHST AG

Inventor： PAPENFUHS THEODOR ,  PFIRMANN RALF ,  KRAUSE STEFAN ,  NEUMANN-GRIMM DORIS

IPC: C07C229/56 ,  C07C

CPC classification number: C07C229/56

公开(公告)号：CA2208239A1

公开(公告)日：1997-12-20

申请号：CA2208239

申请日：1997-06-19

Applicant: HOECHST AG

Inventor： NEUMANN-GRIMM DORIS ,  KRAUSE STEFAN ,  PAPENFUHS THEODOR

IPC: C07C227/08 ,  C07C227/18 ,  C07C229/56

Abstract: The present invention relates to a process for the preparation of N-(2-carboxy-5 -chloro-phenyl)glycine of the formula (1) (see fig. I) which comprises reacting 2,4-dichlorobenzoic acid of the formula (2) (see fig. II) with glycine and a base in water at a temperature of 50 to 200.degree.C in the p resence of copper and oxygen at a pH of 7 to 13.

公开(公告)号：ZA967367B

公开(公告)日：1997-02-28

申请号：ZA967367

申请日：1996-08-30

Applicant: HOECHST AG

Inventor： PAPENFUHS THEODOR ,  PFIRMANN RALF ,  KRAUSE STEFAN ,  NEUMANN-GRIMM DORIS

IPC: C07C227/18 ,  C07C229/58 ,  C07C

公开(公告)号：ZA9607367B

公开(公告)日：1997-02-28

申请号：ZA9607367

申请日：1996-08-30

Applicant: HOECHST AG

Inventor： PAPENFUHS THEODOR ,  PFIRMANN RALF ,  KRAUSE STEFAN ,  NEUMANN-GRIMM DORIS

IPC: C07C227/18 ,  C07C229/58 ,  C07C

CPC classification number: C07C227/18

公开(公告)号：PL320656A1

公开(公告)日：1997-12-22

申请号：PL32065697

申请日：1997-06-19

Applicant: HOECHST AG

Inventor： KRAUSE STEFAN ,  NEUMANN-GRIMM DORIS ,  PAPENFUHS THEODOR

IPC: C07C227/08 ,  C07C227/18 ,  C07C229/56

Abstract: Preparation of N-(2-carboxy-5-chloro-phenyl)glycine of formula (I) comprises reacting 2,4-dichlorobenzoic acid of formula (II) with glycine and a base in water at 50-200 degrees C in the presence of copper and oxygen at pH 7-13.

公开(公告)号：ZA967366B

公开(公告)日：1997-02-28

申请号：ZA967366

申请日：1996-08-30

Applicant: HOECHST AG

Inventor： PAPENFUHS THEODOR ,  PFIRMANN RALF ,  KRAUSE STEFAN ,  NEUMANN-GRIMM DORIS

IPC: C07C229/56 ,  C07C

公开(公告)号：ZA967365B

公开(公告)日：1997-02-28

申请号：ZA967365

申请日：1996-08-30

Applicant: HOECHST AG

Inventor： PFIRMANN RALF ,  PAPENFUHS THEODOR ,  KRAUSE STEFAN ,  NEUMANN-GRIMM DORIS

IPC: C07D239/96 ,  C07D

Abstract: PCT No. PCT/EP96/03632 Sec. 371 Date May 22, 1998 Sec. 102(e) Date May 22, 1998 PCT Filed Aug. 19, 1996 PCT Pub. No. WO97/08154 PCT Pub. Date Mar. 6, 1997A process for producing 1,2,3,4-tetrahydro-2,4-dioxo-quinazoline-1-yl acetic acid derivatives of the formula (I) in which R1, R2, R3 and R4 are mutually independently hydrogen, halogen, OH, NO2, (C1-C6) alkoxy, (C1-C6) alkyl, halogen-substituted (C1-C6) alkyl, R5 is hydrogen, (C1-C6) alkyl, phenyl where the alkyl or phenyl radical may also be substituted by halogen atoms; in which an anthranilic acid derivative of formula (II), in which R1 to R5 have the above meaning and R6 is hydrogen, (C1-C6) alkyl or phenyl, where the alkyl or phenyl radical may also be substituted by halogen atoms, is reacted with a metal cyanate and hydrogen chloride in the presence of an inert solvent.

公开(公告)号：ZA9607365B

公开(公告)日：1997-02-28

申请号：ZA9607365

申请日：1996-08-30

Applicant: HOECHST AG

Inventor： PAPENFUHS THEODOR ,  PFIRMANN RALF ,  KRAUSE STEFAN ,  NEUMANN-GRIMM DORIS

IPC: C07D239/96 ,  C07D

CPC classification number: C07D239/96

公开(公告)号：HU9701064A2

公开(公告)日：1999-05-28

申请号：HU9701064

申请日：1997-06-18

Applicant: HOECHST AG

Inventor： KRAUSE STEFAN ,  NEUMANN-GRIMM DORIS ,  PAPENFUHS THEODOR

IPC: C07C227/08 ,  C07C227/18 ,  C07C229/56

Abstract: Preparation of N-(2-carboxy-5-chloro-phenyl)glycine of formula (I) comprises reacting 2,4-dichlorobenzoic acid of formula (II) with glycine and a base in water at 50-200 degrees C in the presence of copper and oxygen at pH 7-13.

公开(公告)号：HU9701064D0

公开(公告)日：1997-08-28

申请号：HU9701064

申请日：1997-06-18

Applicant: HOECHST AG

Inventor： KRAUSE STEFAN ,  NEUMANN-GRIMM DORIS ,  PAPENFUHS THEODOR

IPC: C07C227/08 ,  C07C227/18 ,  C07C229/56

Abstract: Preparation of N-(2-carboxy-5-chloro-phenyl)glycine of formula (I) comprises reacting 2,4-dichlorobenzoic acid of formula (II) with glycine and a base in water at 50-200 degrees C in the presence of copper and oxygen at pH 7-13.