公开(公告)号：NO972707A

公开(公告)日：1997-12-15

申请号：NO972707

申请日：1997-06-12

Applicant: HOFFMANN LA ROCHE

Inventor： CIVELLI OLIVIER ,  MARTIN JAMES RICHARD ,  MONSMA FREDERICK ,  MOREAU JEAN-LUC ,  NOTHACKER HANS-PETER ,  REINSCHEID RAINER

IPC: G01N33/53 ,  A61K38/00 ,  A61K38/10 ,  A61P25/08 ,  A61P25/20 ,  A61P25/26 ,  G01N33/15 ,  G01N33/566 ,  G01N33/94 ,  G01N33/68

CPC classification number: G01N33/9486 ,  G01N33/566 ,  G01N2500/00

公开(公告)号：CA2372040C

公开(公告)日：2008-12-02

申请号：CA2372040

申请日：2000-05-05

Applicant: HOFFMANN LA ROCHE

Inventor： HUNKELER WALTER ,  HOFFMANN-EMERY FABIENNE ,  MARTIN JAMES RICHARD ,  JENCK FRANCOIS ,  SLEIGHT ANDREW

IPC: C07D487/04 ,  A61K31/5513 ,  A61K31/5517 ,  A61P25/08 ,  A61P25/20 ,  A61P25/22

Abstract: The present invention relates to compound 7-Chlore-3-(5-dimethylaminomethyl- [1,2,4]oxadiazol-3-yl)-5-methyl-4,5-dihydro -imidazo[1,5-a][1,4]benzodiazepin-6-one (I), and to the use of the compound of formula (I) for the manufacture of medicaments to be used as anxiolytic and/or anticonvulsant and/or non-sedative sleep-inducing medicaments.

公开(公告)号：AT231865T

公开(公告)日：2003-02-15

申请号：AT00936713

申请日：2000-05-05

Applicant: HOFFMANN LA ROCHE

Inventor： JENCK FRANCOIS ,  HOFFMANN-EMERY FABIENNE ,  HUNKELER WALTER ,  MARTIN JAMES RICHARD ,  SLEIGHT ANDREW

IPC: A61K31/5513 ,  A61K31/5517 ,  A61P25/08 ,  A61P25/20 ,  A61P25/22 ,  C07D487/04 ,  C07D243/00 ,  C07D235/00

Abstract: The present invention relates to compound 7-Chloro-3-(5-dimethylaminomethyl-[1,2,4]oxadiazol-3-yl)-5-methyl-4,5-dihydro-imidazo[1,5-a][1,4]benzodiazepin-6-one (I)and to the use of the compound of formula I for the manufacture of medicaments to be used as anxiolytic and/or anticonvulsant and/or non-sedative sleep-inducing medicaments.

公开(公告)号：AU5211400A

公开(公告)日：2000-12-05

申请号：AU5211400

申请日：2000-05-05

Applicant: HOFFMANN LA ROCHE

Inventor： JENCK FRANCOIS ,  HOFFMANN-EMERY FABIENNE ,  HUNKELER WALTER ,  MARTIN JAMES RICHARD ,  SLEIGHT ANDREW

IPC: A61K31/5513 ,  A61K31/5517 ,  A61P25/08 ,  A61P25/20 ,  A61P25/22 ,  C07D487/04

Abstract: The present invention relates to compound 7-Chloro-3-(5-dimethylaminomethyl-[1,2,4]oxadiazol-3-yl)-5-methyl-4,5-dihydro-imidazo[1,5-a][1,4]benzodiazepin-6-one (I)and to the use of the compound of formula I for the manufacture of medicaments to be used as anxiolytic and/or anticonvulsant and/or non-sedative sleep-inducing medicaments.

公开(公告)号：PL320527A1

公开(公告)日：1997-12-22

申请号：PL32052797

申请日：1997-06-12

Applicant: HOFFMANN LA ROCHE

Inventor： CIVELLI OLIVIER ,  MARTIN JAMES RICHARD ,  MONSMA FREDERICK ,  MOREAU JEAN-LUC ,  NOTHACKER HANS-PETER ,  REINSCHEID RAINER

IPC: G01N33/53 ,  A61K38/00 ,  A61K38/10 ,  A61P25/08 ,  A61P25/20 ,  A61P25/26 ,  G01N33/15 ,  G01N33/566 ,  G01N33/94

Abstract: The present invention relates to a method of screening for a therapeutically useful compound which comprises testing an LC132 receptor agonist in a screening assay for psychiatric and/or neurological disorders. More particularly, the screening method is based on contacting an LC132 receptor with an agent suspected of being an agonist of the LC132 receptor function, followed by the detection of the binding and/or the agonist activity of the compound and then testing of an agent with LC132 agonist activity in an antiepileptic, anticonvulsant or anxiolytic screening assay.

公开(公告)号：NO972707L

公开(公告)日：1997-12-15

申请号：NO972707

申请日：1997-06-12

Applicant: HOFFMANN LA ROCHE

Inventor： CIVELLI OLIVIER ,  MARTIN JAMES RICHARD ,  MONSMA FREDERICK ,  MOREAU JEAN-LUC ,  NOTHACKER HANS-PETER ,  REINSCHEID RAINER

IPC: G01N33/53 ,  A61K38/00 ,  A61K38/10 ,  A61P25/08 ,  A61P25/20 ,  A61P25/26 ,  G01N33/15 ,  G01N33/566 ,  G01N33/94 ,  G01N33/68

Abstract: The present invention relates to a method of screening for a therapeutically useful compound which comprises testing an LC132 receptor agonist in a screening assay for psychiatric and/or neurological disorders. More particularly, the screening method is based on contacting an LC132 receptor with an agent suspected of being an agonist of the LC132 receptor function, followed by the detection of the binding and/or the agonist activity of the compound and then testing of an agent with LC132 agonist activity in an antiepileptic, anticonvulsant or anxiolytic screening assay.

公开(公告)号：ES2189759T3

公开(公告)日：2003-07-16

申请号：ES00936713

申请日：2000-05-05

Applicant: HOFFMANN LA ROCHE

Inventor： JENCK FRANCOIS ,  HOFFMANN-EMERY FABIENNE ,  HUNKELER WALTER ,  MARTIN JAMES RICHARD ,  SLEIGHT ANDREW

IPC: A61K31/5513 ,  A61K31/5517 ,  A61P25/08 ,  A61P25/20 ,  A61P25/22 ,  C07D487/04

Abstract: The present invention relates to compound 7-Chloro-3-(5-dimethylaminomethyl-[1,2,4]oxadiazol-3-yl)-5-methyl-4,5-dihydro-imidazo[1,5-a][1,4]benzodiazepin-6-one (I)and to the use of the compound of formula I for the manufacture of medicaments to be used as anxiolytic and/or anticonvulsant and/or non-sedative sleep-inducing medicaments.

公开(公告)号：TR200103237T2

公开(公告)日：2002-04-22

申请号：TR200103237

申请日：2000-05-05

Applicant: HOFFMANN LA ROCHE

Inventor： JENCK FRANCOIS ,  HOFFMANN-EMERY FABIENNE ,  HUNKELER WALKER ,  MARTIN JAMES RICHARD ,  SLEIGHT ANDREW

IPC: A61K31/5513 ,  A61K31/5517 ,  A61P25/08 ,  A61P25/20 ,  A61P25/22 ,  C07D487/04

Abstract: The present invention relates to compound 7-Chloro-3-(5-dimethylaminomethyl-[1,2,4]oxadiazol-3-yl)-5-methyl-4,5-dihydro-imidazo[1,5-a][1,4]benzodiazepin-6-one (I)and to the use of the compound of formula I for the manufacture of medicaments to be used as anxiolytic and/or anticonvulsant and/or non-sedative sleep-inducing medicaments.

公开(公告)号：TR9700482A2

公开(公告)日：1998-01-21

申请号：TR9700482

申请日：1997-06-09

Applicant: HOFFMANN LA ROCHE

Inventor： CIVELLI OLIVIER ,  MARTIN JAMES RICHARD ,  MONSMA FREDERICK ,  MOREAU JEAN-LUC ,  NOTHACKER HANS-PETER ,  REINSCHEID RAINER

IPC: G01N33/53 ,  A61K38/00 ,  A61K38/10 ,  A61P25/08 ,  A61P25/20 ,  A61P25/26 ,  G01N33/15 ,  G01N33/566 ,  G01N33/94 ,  C07K14/00 ,  A61K

CPC classification number: G01N33/9486 ,  G01N33/566 ,  G01N2500/00

公开(公告)号：TR199700482A2

公开(公告)日：1998-01-21

申请号：TR9700482

申请日：1997-06-09

Applicant: HOFFMANN LA ROCHE

Inventor： CIVELLI OLIVIER ,  MARTIN JAMES RICHARD ,  MONSMA FREDERICK ,  MOREAU JEAN-LUC ,  NOTHACKER HANS-PETER ,  REINSCHEID RAINER

IPC: G01N33/53 ,  A61K38/00 ,  A61K38/10 ,  A61P25/08 ,  A61P25/20 ,  A61P25/26 ,  G01N33/15 ,  G01N33/566 ,  G01N33/94 ,  C07K14/00 ,  A61K

Abstract: The present invention relates to a method of screening for a therapeutically useful compound which comprises testing an LC132 receptor agonist in a screening assay for psychiatric and/or neurological disorders. More particularly, the screening method is based on contacting an LC132 receptor with an agent suspected of being an agonist of the LC132 receptor function, followed by the detection of the binding and/or the agonist activity of the compound and then testing of an agent with LC132 agonist activity in an antiepileptic, anticonvulsant or anxiolytic screening assay.